Stefan Rose-John

Stefan Rose-John

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Stefan Rose-John

Stefan Rose-John

Publications by authors named "Stefan Rose-John"

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The IL-6-neutralizing sIL-6R-sgp130 buffer system is disturbed in patients with type 2 diabetes.

Am J Physiol Endocrinol Metab 2019 Aug 25;317(2):E411-E420. Epub 2019 Jun 25.

Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany.

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http://dx.doi.org/10.1152/ajpendo.00166.2019DOI Listing
August 2019

Interleukin 6 Dependent Synaptic Plasticity in a Social Defeat-Susceptible Prefrontal Cortex Circuit.

Neuroscience 2019 Aug 10;414:280-296. Epub 2019 Jul 10.

Universidad Autónoma de San Luis Potosí, Facultad de Ciencias, San Luis Potosí, San Luis Potosí, Mexico; University of Texas at Dallas, Richardson, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2019.07.002DOI Listing
August 2019

IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease.

Brain Behav Immun 2019 Aug 8. Epub 2019 Aug 8.

Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.08.005DOI Listing
August 2019

The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients.

Front Aging Neurosci 2019 23;11:182. Epub 2019 Jul 23.

Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.3389/fnagi.2019.00182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664027PMC
July 2019

Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3.

Mol Ther Nucleic Acids 2019 Jun 2;16:419-433. Epub 2019 Apr 2.

Signal Transduction Laboratory, Life Sciences Research Unit, University of Luxembourg, 6, Avenue du Swing, 4367 Belvaux, Luxembourg. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2019.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479786PMC
June 2019

The ADAM17 Protease Promotes Tobacco Smoke Carcinogen-induced Lung Tumourigenesis.

Carcinogenesis 2019 Jun 27. Epub 2019 Jun 27.

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1093/carcin/bgz123DOI Listing
June 2019

Impaired mechanical, heat, and cold nociception in a murine model of genetic TACE/ADAM17 knockdown.

FASEB J 2019 Mar 26;33(3):4418-4431. Epub 2018 Dec 26.

Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria; and.

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http://dx.doi.org/10.1096/fj.201801901RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404580PMC
March 2019

Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 9;1865(2):308-321. Epub 2018 Nov 9.

Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, Austria; Center for Biomarker Research in Medicine, Graz, Austria; Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183045
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http://dx.doi.org/10.1016/j.bbadis.2018.11.006DOI Listing
February 2019

Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage.

Cytokine 2019 Feb 14;114:1-5. Epub 2018 Dec 14.

Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.11.023DOI Listing
February 2019

Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer.

Methods Mol Biol 2018 ;1725:127-140

Institute of Biochemistry, Kiel University, Kiel, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7568-6_11DOI Listing
January 2019

Interleukin 6 trans-signalling and risk of future cardiovascular events.

Cardiovasc Res 2019 Jan;115(1):213-221

Department of Clinical Science, Danderyd Hospital, S-182 88 Stockholm, Sweden.

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http://dx.doi.org/10.1093/cvr/cvy191DOI Listing
January 2019

Interleukin-6: designing specific therapeutics for a complex cytokine.

Nat Rev Drug Discov 2018 06 4;17(6):395-412. Epub 2018 May 4.

Institute of Biochemistry, Kiel University, Kiel, Germany.

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http://dx.doi.org/10.1038/nrd.2018.45DOI Listing
June 2018

Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma.

Naunyn Schmiedebergs Arch Pharmacol 2018 05 1;391(5):523-536. Epub 2018 Mar 1.

Institute of Orthopedic Research and Biomechanics, Trauma Research Center Ulm, University Medical Center Ulm, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00210-018-1483-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889421PMC
May 2018

Interleukin-6 Family Cytokines.

Authors:
Stefan Rose-John

Cold Spring Harb Perspect Biol 2018 02 1;10(2). Epub 2018 Feb 1.

Institute of Biochemistry, Kiel University, Olshausenstrasse 40, Kiel, Germany.

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http://dx.doi.org/10.1101/cshperspect.a028415DOI Listing
February 2018

Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.

Am J Pathol 2018 02 13;188(2):474-490. Epub 2017 Nov 13.

Institute of Orthopedic Research and Biomechanics, Trauma Research Center Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.10.011DOI Listing
February 2018

Frontline Science: Proliferation of Ly6C monocytes during urinary tract infections is regulated by IL-6 trans-signaling.

J Leukoc Biol 2018 01 28;103(1):13-22. Epub 2017 Dec 28.

Department of Immunodynamics, Institute for Experimental Immunology and Imaging, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1189/jlb.3HI0517-198RDOI Listing
January 2018

The ADAM17 Metalloproteinase Maintains Arterial Elasticity.

Thromb Haemost 2018 01 5;118(1):210-213. Epub 2018 Jan 5.

Institute of Laboratory Medicine, University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1160/TH17-07-0494DOI Listing
January 2018

The shedding protease ADAM17: Physiology and pathophysiology.

Biochim Biophys Acta Mol Cell Res 2017 Nov 11;1864(11 Pt B):2059-2070. Epub 2017 Jul 11.

Institute of Biochemistry, University of Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2017.07.001DOI Listing
November 2017

Proteolytic steps within signaling cascades make these signaling pathways irreversible.

Authors:
Stefan Rose-John

Biochim Biophys Acta Mol Cell Res 2017 Nov 24;1864(11 Pt B):2057-2058. Epub 2017 Aug 24.

Institute of Biochemistry, University of Kiel, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2017.08.007DOI Listing
November 2017

A new multiple trauma model of the mouse.

BMC Musculoskelet Disord 2017 Nov 21;18(1):468. Epub 2017 Nov 21.

Department of Trauma Surgery, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.

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http://dx.doi.org/10.1186/s12891-017-1813-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697084PMC
November 2017

The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation.

Authors:
Stefan Rose-John

Clin Pharmacol Ther 2017 Oct 29;102(4):591-598. Epub 2017 Jul 29.

Institute of Biochemistry, University of Kiel, Germany.

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http://dx.doi.org/10.1002/cpt.782DOI Listing
October 2017

Interleukin 6 trans-signaling regulates basal synaptic transmission and sensitivity to pentylenetetrazole-induced seizures in mice.

Synapse 2017 09 13;71(9). Epub 2017 May 13.

Faculty of Science, Universidad Autónoma de San Luis Potosí, Av. Salvador Nava S/N, San Luis Potosí, San Luis Potosí, 78290, México.

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http://dx.doi.org/10.1002/syn.21984DOI Listing
September 2017

Factor XII-Driven Inflammatory Reactions with Implications for Anaphylaxis.

Front Immunol 2017 15;8:1115. Epub 2017 Sep 15.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.01115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605561PMC
September 2017

Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice.

Cytokine 2017 08 6;96:8-15. Epub 2017 Mar 6.

Christian-Albrechts-University of Kiel, University Medical Center, Department of Ophthalmology, Kiel, Germany.

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http://dx.doi.org/10.1016/j.cyto.2017.02.023DOI Listing
August 2017

The role of IL-6 in host defence against infections: immunobiology and clinical implications.

Nat Rev Rheumatol 2017 Jul 15;13(7):399-409. Epub 2017 Jun 15.

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nrrheum.2017.83DOI Listing
July 2017

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

J Hepatol 2017 05 23;66(5):978-986. Epub 2016 Dec 23.

Institute of Molecular Immunology and Experimental Oncology, Klinikum München rechts der Isar, Technische Universität München, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278163074
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http://dx.doi.org/10.1016/j.jhep.2016.12.015DOI Listing
May 2017

Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells.

Stem Cells 2017 04 1;35(4):898-908. Epub 2017 Feb 1.

Department of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany.

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http://dx.doi.org/10.1002/stem.2565DOI Listing
April 2017

Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.

Cytokine 2017 04 1;92:118-123. Epub 2017 Feb 1.

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, Victoria 3168, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10434666173003
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http://dx.doi.org/10.1016/j.cyto.2017.01.015DOI Listing
April 2017

The balance between Treg and TH cells: CD11b and interleukin-6.

Eur J Immunol 2017 04;47(4):629-632

Biochemisches Institut, Universität Kiel, Kiel, Germany.

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http://doi.wiley.com/10.1002/eji.201746988
Publisher Site
http://dx.doi.org/10.1002/eji.201746988DOI Listing
April 2017

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.

Cell Rep 2017 04;19(2):267-280

Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Str. 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.043DOI Listing
April 2017

Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth.

Haematologica 2017 02 22;102(2):381-390. Epub 2016 Sep 22.

Division of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.3324/haematol.2016.145060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286946PMC
February 2017

Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.

Arterioscler Thromb Vasc Biol 2017 Feb 22;37(2):247-257. Epub 2016 Dec 22.

From the Institute of Laboratory Medicine (A.N., B.H.N., K.S., A.H., A.K., D.T., L.M.H.) and Institute for Cardiovascular Prevention (Z.Z., C.Weber, S.S.), Ludwig-Maximilians-University Munich, Germany; Institute of Biochemistry, Christian Albrechts University, Kiel, Germany (A.C., S.R.-J.); Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland (C.Wolfrum); and German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Germany (C. Weber, S.S.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308682DOI Listing
February 2017

Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts.

Bone 2016 11 20;92:85-93. Epub 2016 Aug 20.

Department of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, Hamburg 20246, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2016.08.016DOI Listing
November 2016

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.

J Immunol 2016 11 3;197(9):3705-3715. Epub 2016 Oct 3.

Institute of Biochemistry, Medical Faculty, Christian Albrechts University, 24098 Kiel, Germany; and.

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http://dx.doi.org/10.4049/jimmunol.1600909DOI Listing
November 2016

Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.

J Med Chem 2016 Oct 13;59(20):9541-9559. Epub 2016 Oct 13.

Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster , Corrensstraße 48, 48149 Münster, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01291DOI Listing
October 2016

IL-6 pathway in the liver: From physiopathology to therapy.

J Hepatol 2016 06 8;64(6):1403-15. Epub 2016 Feb 8.

Institute of Biochemistry, Christian-Albrechts-University Kiel, Olshausenstrasse 40, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.02.004DOI Listing
June 2016

The role of interleukin-6 signaling in nervous tissue.

Biochim Biophys Acta 2016 Jun 23;1863(6 Pt A):1218-27. Epub 2016 Mar 23.

Institute of Biochemistry, Christian-Albrechts-Universität zu Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.03.018DOI Listing
June 2016

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.

Cancer Discov 2016 06 13;6(6):664-79. Epub 2016 Apr 13.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448406PMC
June 2016

Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts.

Croat Med J 2016 Apr;57(2):89-98

Olexandr Korchynskyi, Department of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of the National Academy of Sciences of Ukraine (NASU), 14/16, Drahomanov St., Lviv 79005, Ukraine,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856197PMC
http://dx.doi.org/10.3325/cmj.2016.57.89DOI Listing
April 2016

Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.

Proc Natl Acad Sci U S A 2016 Mar 2;113(11):3006-11. Epub 2016 Mar 2.

Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia; Laboratory of Experimental Immunology, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603950, Russia; Research Group Inflammation Biology, German Rheumatism Research Center, a Leibniz Institute, 10117 Berlin, Germany; Department of Immunology, Faculty of Biology and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 199991, Russia;

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http://dx.doi.org/10.1073/pnas.1520175113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801281PMC
March 2016

IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.

Cancer Res 2016 Feb 7;76(4):866-76. Epub 2016 Jan 7.

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2388DOI Listing
February 2016

A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.

Biochem Biophys Res Commun 2016 Feb 22;470(4):870-6. Epub 2016 Jan 22.

Institute of Biochemistry, Kiel University, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.01.127DOI Listing
February 2016

Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells.

BMC Cancer 2015 Dec 16;15:975. Epub 2015 Dec 16.

Division of Molecular Oncology, Institute for Experimental Cancer Research, University Hospital Schleswig-Holstein, 24105, Kiel, Germany.

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http://dx.doi.org/10.1186/s12885-015-1950-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682226PMC
December 2015

Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture.

Brain Behav Immun 2015 Nov 2;50:178-185. Epub 2015 Jul 2.

Department of Biochemistry, University of Kiel, Germany.

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http://dx.doi.org/10.1016/j.bbi.2015.07.001DOI Listing
November 2015

Interleukin-6: Biology, signaling and strategies of blockade.

Cytokine Growth Factor Rev 2015 Oct 4;26(5):475-87. Epub 2015 Jul 4.

Institute of Biochemistry, Christian-Albrechts-University, Olshausenstrasse 40, 24098 Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2015.07.004DOI Listing
October 2015

"Family reunion"--A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines.

Cytokine Growth Factor Rev 2015 Oct 6;26(5):471-4. Epub 2015 Jul 6.

Institute of Biology, Otto-von-Guericke-University, Universitätsplatz 2, 39106 Magdeburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2015.07.011DOI Listing
October 2015

The soluble interleukin-6 receptor and related proteins.

Authors:
Stefan Rose-John

Best Pract Res Clin Endocrinol Metab 2015 Oct 8;29(5):787-97. Epub 2015 Jul 8.

Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.beem.2015.07.001DOI Listing
October 2015

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.

J Exp Med 2015 Sep 24;212(10):1641-62. Epub 2015 Aug 24.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Enfants Malades Hospital, 75015 Paris, France University Paris Descartes, Imagine Institute, 75006 Paris, France

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http://dx.doi.org/10.1084/jem.20140280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577846PMC
September 2015