Publications by authors named "Stefan Pusch"

60Publications

Large-Scale Drug Screening in Patient-Derived IDH Glioma Stem Cells Identifies Several Efficient Drugs among FDA-Approved Antineoplastic Agents.

Cells 2020 06 3;9(6). Epub 2020 Jun 3.

Department of Neurosurgery, Division of Experimental Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/cells9061389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348988PMC
June 2020

cMyc and ERK activity are associated with resistance to ALK inhibitory treatment in glioblastoma.

J Neurooncol 2020 Jan 28;146(1):9-23. Epub 2019 Nov 28.

Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-019-03348-zDOI Listing
January 2020

(±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus P1210 Isolated from the Halophyte sp.

J Org Chem 2019 09 27;84(17):11203-11209. Epub 2019 Aug 27.

Institute of Organic Chemistry , Johannes Gutenberg University Mainz , 55128 Mainz , Germany.

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http://dx.doi.org/10.1021/acs.joc.9b01229DOI Listing
September 2019

Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E.

Cancer Res 2019 Oct 7;79(19):4994-5007. Epub 2019 Aug 7.

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0054DOI Listing
October 2019

Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction.

Chemistry 2019 Jul 28;25(38):8965-8969. Epub 2019 May 28.

Johannes Gutenberg University, Institute of Organic Chemistry, Duesbergweg 10-14, 55128, Mainz, Germany.

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http://dx.doi.org/10.1002/chem.201901175DOI Listing
July 2019

Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation.

Int J Cancer 2019 07 20;145(2):461-473. Epub 2019 Jan 20.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.32107DOI Listing
July 2019

Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma.

Int J Mol Sci 2018 Sep 25;19(10). Epub 2018 Sep 25.

Department of Neurosurgery, Division of Experimental Neurosurgery, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/ijms19102903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212863PMC
September 2018

Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective.

J Med Chem 2018 10 18;61(20):8981-9003. Epub 2018 Jun 18.

Department of Pharmaceutical Engineering and Department of Biochemical Engineering , China Pharmaceutical University , 639 Longmian Avenue , Nanjing 211198 , P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00159DOI Listing
October 2018

Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry.

Acta Neuropathol Commun 2018 03 2;6(1):21. Epub 2018 Mar 2.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Im Neuenheimer Feld, 224, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s40478-018-0523-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834865PMC
March 2018

Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening.

Bioorg Med Chem Lett 2018 02 13;28(3):388-393. Epub 2017 Dec 13.

Department of Pharmaceutical Engineering & Department of Biochemical Engineering, School of Engineering, China Pharmaceutical University, 539 Longmian Avenue, Nanjing 211198, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.12.030DOI Listing
February 2018

Mechanism and cis/trans Selectivity of Vinylogous Nazarov-type [6π] Photocyclizations †.

J Org Chem 2018 01 3;83(2):964-972. Epub 2018 Jan 3.

Institute of Organic Chemistry, Johannes Gutenberg University Mainz , Duesbergweg 10-14, 55128 Mainz, Germany.

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http://dx.doi.org/10.1021/acs.joc.7b02982DOI Listing
January 2018

Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1.

Bioorg Med Chem 2017 12 13;25(24):6379-6387. Epub 2017 Oct 13.

Department of Pharmaceutical Engineering & Department of Biochemical Engineering, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.10.009DOI Listing
December 2017

Polyethylene bio-degradation by caterpillars?

Curr Biol 2017 08;27(15):R744-R745

Institute of Organic Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2017.07.004DOI Listing
August 2017

Characterization of the synthetic cannabinoid MDMB-CHMCZCA.

Beilstein J Org Chem 2016 21;12:2808-2815. Epub 2016 Dec 21.

Johannes Gutenberg University Mainz, Institute of Organic Chemistry, Duesbergweg 10-14, 55128 Mainz, Germany.

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http://dx.doi.org/10.3762/bjoc.12.279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238538PMC
December 2016

Haloperoxidase Mimicry by CeO Nanorods Combats Biofouling.

Adv Mater 2017 Jan 29;29(4). Epub 2016 Nov 29.

Institut für Anorganische Chemie und Analytische Chemie, Johannes Gutenberg-Universität, Duesbergweg 10-14, D-55128, Mainz, Germany.

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http://dx.doi.org/10.1002/adma.201603823DOI Listing
January 2017

Absolute Configuration Determination of 2,3-Dihydro-1H,5H-pyrazolo[1,2-a]pyrazoles Using Chiroptical Methods at Different Wavelengths.

J Org Chem 2016 12 17;81(23):11802-11812. Epub 2016 Nov 17.

Faculty of Chemistry and Chemical Technology, University of Ljubljana , Večna pot 113, SI-1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1021/acs.joc.6b02270DOI Listing
December 2016

Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma.

Hepatology 2016 09 15;64(3):828-42. Epub 2016 Jul 15.

Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/hep.28684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098049PMC
September 2016

A Light-Induced Vinylogous Nazarov-Type Cyclization.

Org Lett 2016 07 9;18(13):3043-5. Epub 2016 Jun 9.

Institute of Organic Chemistry, Johannes Gutenberg University , Duesbergweg 10-14, 55128 Mainz, Germany.

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http://dx.doi.org/10.1021/acs.orglett.6b01449DOI Listing
July 2016

A Photoinduced Cobalt-Catalyzed Synthesis of Pyrroles through in Situ-Generated Acylazirines.

J Org Chem 2016 05 29;81(10):4170-8. Epub 2016 Apr 29.

Institute of Organic Chemistry, Johannes Gutenberg University , Duesbergweg 10-14, 55128 Mainz, Germany.

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http://dx.doi.org/10.1021/acs.joc.6b00511DOI Listing
May 2016

Quantitative Imaging of D-2-Hydroxyglutarate in Selected Histological Tissue Areas by a Novel Bioluminescence Technique.

Front Oncol 2016 7;6:46. Epub 2016 Mar 7.

Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany.

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http://dx.doi.org/10.3389/fonc.2016.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779886PMC
March 2016

A photochemical one-pot three-component synthesis of tetrasubstituted imidazoles.

Org Lett 2014 Oct 6;16(20):5430-3. Epub 2014 Oct 6.

Institute of Organic Chemistry, Johannes Gutenberg University , Duesbergweg 10-14, 55128 Mainz, Germany.

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http://dx.doi.org/10.1021/ol502667hDOI Listing
October 2014

Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.

Glia 2015 Jan 5;63(1):78-90. Epub 2014 Aug 5.

German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany.

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http://dx.doi.org/10.1002/glia.22734DOI Listing
January 2015

A vaccine targeting mutant IDH1 induces antitumour immunity.

Nature 2014 Aug 25;512(7514):324-7. Epub 2014 Jun 25.

1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature13387DOI Listing
August 2014

Mutant IDH1 inhibits PI3K/Akt signaling in human glioma.

Cancer 2014 Aug 25;120(16):2440-7. Epub 2014 Apr 25.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/cncr.28732DOI Listing
August 2014

D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma.

Acta Neuropathol Commun 2014 Feb 14;2:19. Epub 2014 Feb 14.

German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), INF 280, Heidelberg D-69120, Germany.

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http://dx.doi.org/10.1186/2051-5960-2-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937031PMC
February 2014

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy.

Proc Natl Acad Sci U S A 2014 Jan 23;111(1):409-14. Epub 2013 Dec 23.

German Cancer Consortium, Clinical Cooperation Units Neurooncology and Neuropathology, Helmholtz Group Experimental Neuroimmunology, Small Animal Imaging Facility, Biostatistics, and Functional Proteome Analysis, German Cancer Research Center, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1073/pnas.1314469111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890826PMC
January 2014

Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death.

Apoptosis 2013 Nov;18(11):1416-1425

Experimental Neurosurgery, Neuroscience Center, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s10495-013-0877-8DOI Listing
November 2013

Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate.

Acta Neuropathol 2012 Dec 2;124(6):883-91. Epub 2012 Nov 2.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-012-1060-yDOI Listing
December 2012

A general G1/S-phase cell-cycle control module in the flowering plant Arabidopsis thaliana.

PLoS Genet 2012 2;8(8):e1002847. Epub 2012 Aug 2.

Department of Molecular Mechanisms of Phenotypic Plasticity, Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, Université de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1371/journal.pgen.1002847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410867PMC
December 2012

CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas.

Acta Neuropathol 2012 Jun 17;123(6):853-60. Epub 2012 May 17.

Department of Neuropathology, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 220/221, 69120 Heidelberg, Germany.

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http://link.springer.com/content/pdf/10.1007/s00401-012-0993
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http://dx.doi.org/10.1007/s00401-012-0993-5DOI Listing
June 2012

Identification of kinase substrates by bimolecular complementation assays.

Plant J 2012 Apr 10;70(2):348-56. Epub 2012 Jan 10.

Unigruppe am Max-Planck-Institut für Züchtungsforschung, Max-Delbrück-Laboratorium, Lehrstuhl für Botanik III, Universität Köln, Carl-von-Linné-Weg 10, D-50829 Köln, Germany.

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http://dx.doi.org/10.1111/j.1365-313X.2011.04862.xDOI Listing
April 2012

Bimolecular-fluorescence complementation assay to monitor kinase-substrate interactions in vivo.

Methods Mol Biol 2011 ;779:245-57

German Cancer Research Center (DKFZ), Ruprecht-Karls Universität Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-61779-264-9_14DOI Listing
December 2011

Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody.

Acta Neuropathol 2011 Jul 3;122(1):11-9. Epub 2011 Jun 3.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 220/221, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-011-0841-zDOI Listing
July 2011

Detection of 2-hydroxyglutarate in formalin-fixed paraffin-embedded glioma specimens by gas chromatography/mass spectrometry.

Brain Pathol 2012 Jan 16;22(1):26-31. Epub 2011 Aug 16.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg.

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http://dx.doi.org/10.1111/j.1750-3639.2011.00506.xDOI Listing
January 2012

Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1.

Plant Cell 2009 Nov 30;21(11):3641-54. Epub 2009 Nov 30.

Unigruppe am Max-Planck-Institut für Züchtungsforschung, Max-Delbrück-Laboratorium, Lehrstuhl für Botanik III, Universität zu Köln, Köln, Germany.

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http://dx.doi.org/10.1105/tpc.109.070417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798325PMC
November 2009

PCR- and restriction endonuclease-based detection of IDH1 mutations.

Brain Pathol 2010 Mar 18;20(2):298-300. Epub 2009 Aug 18.

Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2009.00327.xDOI Listing
March 2010

T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue.

Plant Cell 2007 Mar 16;19(3):972-85. Epub 2007 Mar 16.

University of Cologne, University Group at the Max Planck Institute for Plant Breeding Research, Max Delbrück Laboratory, Department of Botany III, 50829 Cologne, Germany.

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http://dx.doi.org/10.1105/tpc.107.050401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867360PMC
March 2007

Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1.

Plant Physiol 2006 Aug 9;141(4):1293-305. Epub 2006 Jun 9.

University group at the Max-Planck-Institute for Plant Breeding, Max-Delbrück-Laboratorium, Department of Botany III, University of Cologne, 50829 Cologne, Germany.

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http://dx.doi.org/10.1104/pp.106.081406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533933PMC
August 2006