Publications by authors named "Stefan Pfister"

100Publications

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis.

Authors:
Abigail K Suwala Damian Stichel Daniel Schrimpf Matthias Kloor Annika K Wefers Annekathrin Reinhardt Sybren L N Maas Christian P Kratz Leonille Schweizer Martin Hasselblatt Matija Snuderl Malak Sameer J Abedalthagafi Zied Abdullaev Camelia M Monoranu Markus Bergmann Arnulf Pekrun Christian Freyschlag Eleonora Aronica Christof M Kramm Felix Hinz Philipp Sievers Andrey Korshunov Marcel Kool Stefan M Pfister Dominik Sturm David T W Jones Wolfgang Wick Andreas Unterberg Christian Hartmann Andrew Dodgshun Uri Tabori Pieter Wesseling Felix Sahm Andreas von Deimling David E Reuss

Acta Neuropathol 2020 Nov 20. Epub 2020 Nov 20.

Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-020-02243-6DOI Listing
November 2020

An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma.

Authors:
Thomas K Albert Marta Interlandi Martin Sill Monika Graf Natalia Moreno Kerstin Menck Astrid Rohlmann Viktoria Melcher Sonja Korbanka Gerd Meyer Zu Hörste Tobias Lautwein Michael C Frühwald Christian F Krebs Dörthe Holdhof Melanie Schoof Annalen Bleckmann Markus Missler Martin Dugas Ulrich Schüller Natalie Jäger Stefan M Pfister Kornelius Kerl

Neuro Oncol 2020 Nov 11. Epub 2020 Nov 11.

Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1093/neuonc/noaa254DOI Listing
November 2020

The AIEOP 2nd series of children and adolescents intracranial Ependymoma. An integrated molecular and clinical characterization with a long-term follow-up.

Authors:
Maura Massimino Francesco Barretta Piergiorgio Modena Hendrik Witt Simone Minasi Stefan M Pfister Kristian W Pajtler Manila Antonelli Lorenza Gandola Maria Luisa Garrè Daniele Bertin Angela Mastronuzzi Maurizio Mascarin Lucia Quaglietta Elisabetta Viscardi Iacopo Sardi Antonio Ruggiero Bianca Pollo Annamaria Buccoliero Luna Boschetti Elisabetta Schiavello Luisa Chiapparini Alessandra Erbetta Isabella Morra Marco Gessi Vittoria Donofrio Carlo Patriarca Felice Giangaspero Pascal Johann Francesca Romana Buttarelli

Neuro Oncol 2020 Nov 2. Epub 2020 Nov 2.

Neurology and Psichiatry, Departments of La Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1093/neuonc/noaa257DOI Listing
November 2020

DNA Methylation based glioblastoma subclassification is related to tumoral T cell infiltration and patient survival.

Authors:
Joost Dejaegher Lien Solie Zoé Hunin Raf Sciot David Capper Christin Siewert Sofie Van Cauter Guido Wilms Johan van Loon Nadine Ectors Steffen Fieuws Stefan M Pfister Stefaan W Van Gool Steven De Vleeschouwer

Neuro Oncol 2020 Nov 1. Epub 2020 Nov 1.

Research Group Experimental Neurosurgery and Neuroanatomy, KU Leuven, Leuven, Belgium and Leuven Brain Institute.

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http://dx.doi.org/10.1093/neuonc/noaa247DOI Listing
November 2020

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR.

Authors:
Philipp Sievers Martin Sill Daniel Schrimpf Damian Stichel David E Reuss Dominik Sturm Jürgen Hench Stephan Frank Lenka Krskova Ales Vicha Michal Zapotocky Brigitte Bison David Castel Jacques Grill Marie-Anne Debily Patrick N Harter Matija Snuderl Christof M Kramm Guido Reifenberger Andrey Korshunov Nada Jabado Pieter Wesseling Wolfgang Wick David A Solomon Arie Perry Thomas S Jacques Chris Jones Olaf Witt Stefan M Pfister Andreas von Deimling David T W Jones Felix Sahm

Neuro Oncol 2020 Nov 1. Epub 2020 Nov 1.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noaa251DOI Listing
November 2020

Advances and Challenges in Pediatric and Childhood Cancers.

Authors:
Cynthia Hawkins Stefan Pfister David T W Jones Nirali N Shah Richard J Gilbertson E Alejandro Sweet-Cordero Michael A Dyer Yael P Mossé Michelle Haber Steven G DuBois

Cancer Cell 2020 Oct;38(4):429-432

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http://dx.doi.org/10.1016/j.ccell.2020.09.013DOI Listing
October 2020

Functional precision medicine identifies new therapeutic candidates for medulloblastoma.

Authors:
Jessica M Rusert Edwin F Juarez Sebastian Brabetz James Jensen Alexandra Garancher Lianne Q Chau Silvia K Tacheva-Grigorova Sameerah Wahab Yoko T Udaka Darren Finlay Huriye Seker-Cin Brendan Reardon Susanne Gröbner Jonathan Serrano Jonas Ecker Lin Qi Mari Kogiso Yuchen Du Patricia A Baxter Jacob J Henderson Michael E Berens Kristiina Vuori Till Milde Yoon-Jae Cho Xiao-Nan Li James M Olson Iris Reyes Matija Snuderl Terence C Wong David P Dimmock Shareef A Nahas Denise Malicki John R Crawford Michael L Levy Eliezer M Van Allen Stefan M Pfister Pablo Tamayo Marcel Kool Jill P Mesirov Robert J Wechsler-Reya

Cancer Res 2020 Oct 12. Epub 2020 Oct 12.

Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute

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http://dx.doi.org/10.1158/0008-5472.CAN-20-1655DOI Listing
October 2020

Response to trametinib treatment in progressive pediatric low-grade glioma patients.

Authors:
Florian Selt Cornelis M van Tilburg Brigitte Bison Philipp Sievers Inga Harting Jonas Ecker Kristian W Pajtler Felix Sahm Annabelle Bahr Michèle Simon David T W Jones Lennart Well Victor-Felix Mautner David Capper Pablo Hernáiz Driever Astrid Gnekow Stefan M Pfister Olaf Witt Till Milde

J Neurooncol 2020 Sep 7;149(3):499-510. Epub 2020 Oct 7.

Hopp Children's Cancer Center (KiTZ), Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-020-03640-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609413PMC
September 2020

Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth.

Authors:
Evelina Miele Agnese Po Angela Mastronuzzi Andrea Carai Zein Mersini Besharat Natalia Pediconi Luana Abballe Giuseppina Catanzaro Claudia Sabato Enrico De Smaele Gianluca Canettieri Lucia Di Marcotullio Alessandra Vacca Antonello Mai Massimo Levrero Stefan M Pfister Marcel Kool Felice Giangaspero Franco Locatelli Elisabetta Ferretti

Mol Oncol 2020 Sep 13. Epub 2020 Sep 13.

Department of Experimental Medicine, Sapienza University, Rome, 00161, Italy.

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http://dx.doi.org/10.1002/1878-0261.12800DOI Listing
September 2020

Drivers underpinning the malignant transformation of giant cell tumour of bone.

Authors:
Matthew W Fittall Iben Lyskjaer Peter Ellery Patrick Lombard Jannat Ijaz Anna-Christina Strobl Dahmane Oukrif Maxime Tarabichi Martin Sill Christian Koelsche Gunhild Mechtersheimer Jonas Demeulemeester Roberto Tirabosco Fernanda Amary Peter J Campbell Stefan M Pfister David Tw Jones Nischalan Pillay Peter Van Loo Sam Behjati Adrienne M Flanagan

J Pathol 2020 Aug 31. Epub 2020 Aug 31.

Department of Pathology (research), University College London Cancer Institute, London, UK.

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http://dx.doi.org/10.1002/path.5537DOI Listing
August 2020

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma.

Authors:
Jonas Ecker Venu Thatikonda Gianluca Sigismondo Florian Selt Gintvile Valinciute Ina Oehme Carina Müller Juliane L Buhl Johannes Ridinger Diren Usta Nan Qin Cornelis M van Tilburg Christel Herold-Mende Marc Remke Felix Sahm Frank Westermann Marcel Kool Robert J Wechsler-Reya Lukas Chavez Jeroen Krijgsveld Natalie Jäger Stefan M Pfister Olaf Witt Till Milde

Neuro Oncol 2020 Aug 21. Epub 2020 Aug 21.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noaa191DOI Listing
August 2020

Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation.

Authors:
Lena M Kutscher Konstantin Okonechnikov Nadja V Batora Jessica Clark Patricia B G Silva Mikaella Vouri Sjoerd van Rijn Laura Sieber Britta Statz Micah D Gearhart Ryo Shiraishi Norman Mack Brent A Orr Andrey Korshunov Brian L Gudenas Kyle S Smith Audrey L Mercier Olivier Ayrault Mikio Hoshino Marcel Kool Katja von Hoff Norbert Graf Gudrun Fleischhack Vivian J Bardwell Stefan M Pfister Paul A Northcott Daisuke Kawauchi

Genes Dev 2020 Sep 20;34(17-18):1161-1176. Epub 2020 Aug 20.

Hopp-Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1101/gad.337584.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462063PMC
September 2020

Infratentorial IDH-mutant astrocytoma is a distinct subtype.

Authors:
Rouzbeh Banan Damian Stichel Anja Bleck Bujung Hong Ulrich Lehmann Abigail Suwala Annekathrin Reinhardt Daniel Schrimpf Rolf Buslei Christine Stadelmann Karoline Ehlert Marco Prinz Till Acker Jens Schittenhelm David Kaul Leonille Schweizer David Capper Patrick N Harter Nima Etminan David T W Jones Stefan M Pfister Christel Herold-Mende Wolfgang Wick Felix Sahm Andreas von Deimling Christian Hartmann David E Reuss

Acta Neuropathol 2020 Oct 10;140(4):569-581. Epub 2020 Aug 10.

Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-020-02194-yDOI Listing
October 2020

Rapid and Sensitive Quantification of Osimertinib in Human Plasma Using a Fully Validated MALDI-IM-MS/MS Assay.

Authors:
Margaux Fresnais André Roth Kathrin I Foerster Dirk Jäger Stefan M Pfister Walter E Haefeli Jürgen Burhenne Rémi Longuespée

Cancers (Basel) 2020 Jul 14;12(7). Epub 2020 Jul 14.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/cancers12071897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409122PMC
July 2020

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma.

Authors:
Johannes Gojo Bernhard Englinger Li Jiang Jens M Hübner McKenzie L Shaw Olivia A Hack Sibylle Madlener Dominik Kirchhofer Ilon Liu Jason Pyrdol Volker Hovestadt Emanuele Mazzola Nathan D Mathewson Maria Trissal Daniela Lötsch Christian Dorfer Christine Haberler Angela Halfmann Lisa Mayr Andreas Peyrl Rene Geyeregger Benjamin Schwalm Monica Mauermann Kristian W Pajtler Till Milde Marni E Shore Jack E Geduldig Kristine Pelton Thomas Czech Orr Ashenberg Kai W Wucherpfennig Orit Rozenblatt-Rosen Sanda Alexandrescu Keith L Ligon Stefan M Pfister Aviv Regev Irene Slavc Walter Berger Mario L Suvà Marcel Kool Mariella G Filbin

Cancer Cell 2020 Jul;38(1):44-59.e9

Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479515PMC
July 2020

Molecular tumor classification using DNA methylome analysis.

Authors:
Martin Sill Christoph Plass Stefan M Pfister Daniel B Lipka

Hum Mol Genet 2020 Oct;29(R2):R205-R213

Division of Translational Medical Oncology, Section Translational Cancer Epigenomics, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/hmg/ddaa147DOI Listing
October 2020

CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas.

Authors:
Philipp Sievers Thomas Hielscher Daniel Schrimpf Damian Stichel David E Reuss Anna S Berghoff Marian C Neidert Hans-Georg Wirsching Christian Mawrin Ralf Ketter Werner Paulus Guido Reifenberger Katrin Lamszus Manfred Westphal Nima Etminan Miriam Ratliff Christel Herold-Mende Stefan M Pfister David T W Jones Michael Weller Patrick N Harter Wolfgang Wick Matthias Preusser Andreas von Deimling Felix Sahm

Acta Neuropathol 2020 09 8;140(3):409-413. Epub 2020 Jul 8.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-020-02188-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423850PMC
September 2020

ETMR: a tumor entity in its infancy.

Authors:
Sander Lambo Katja von Hoff Andrey Korshunov Stefan M Pfister Marcel Kool

Acta Neuropathol 2020 09 29;140(3):249-266. Epub 2020 Jun 29.

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-020-02182-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423804PMC
September 2020

INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies.

Authors:
Cornelis M van Tilburg Ruth Witt Melanie Heiss Kristian W Pajtler Christoph Plass Isabel Poschke Michael Platten Inga Harting Oliver Sedlaczek Angelika Freitag David Meyrath Lenka Taylor Gnana Prakash Balasubramanian Natalie Jäger Elke Pfaff Barbara C Jones Till Milde Stefan M Pfister David T W Jones Annette Kopp-Schneider Olaf Witt

BMC Cancer 2020 Jun 5;20(1):523. Epub 2020 Jun 5.

KiTZ Clinical Trial Unit, Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12885-020-07008-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275428PMC
June 2020

An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data.

Authors:
Alexander C Sommerkamp Sebastian Uhrig Damian Stichel Pascal St-Onge Pengbo Sun Natalie Jäger Andreas von Deimling Felix Sahm Stefan M Pfister Andrey Korshunov Daniel Sinnett Nada Jabado Annika K Wefers David T W Jones

Acta Neuropathol 2020 08 31;140(2):237-239. Epub 2020 May 31.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-020-02167-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360662PMC
August 2020

A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in -Driven Pediatric Low-Grade Glioma Cells.

Authors:
Diren Usta Romain Sigaud Juliane L Buhl Florian Selt Viktoria Marquardt David Pauck Jennifer Jansen Stefan Pusch Jonas Ecker Thomas Hielscher Johanna Vollmer Alexander C Sommerkamp Tobias Rubner Darren Hargrave Cornelis M van Tilburg Stefan M Pfister David T W Jones Marc Remke Tilman Brummer Olaf Witt Till Milde

Mol Cancer Ther 2020 08 25;19(8):1736-1750. Epub 2020 May 25.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-1021DOI Listing
August 2020

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors.

Authors:
Johanna Theruvath Elena Sotillo Christopher W Mount Claus Moritz Graef Alberto Delaidelli Sabine Heitzeneder Louai Labanieh Shaurya Dhingra Amaury Leruste Robbie G Majzner Peng Xu Sabine Mueller Derek W Yecies Martina A Finetti Daniel Williamson Pascal D Johann Marcel Kool Stefan Pfister Martin Hasselblatt Michael C Frühwald Olivier Delattre Didier Surdez Franck Bourdeaut Stephanie Puget Sakina Zaidi Siddhartha S Mitra Samuel Cheshier Poul H Sorensen Michelle Monje Crystal L Mackall

Nat Med 2020 05 27;26(5):712-719. Epub 2020 Apr 27.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/s41591-020-0821-8DOI Listing
May 2020

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort.

Authors:
Martin Mynarek Katja von Hoff Torsten Pietsch Holger Ottensmeier Monika Warmuth-Metz Brigitte Bison Stefan Pfister Andrey Korshunov Tanvi Sharma Natalie Jaeger Marina Ryzhova Olga Zheludkova Andrey Golanov Elisabeth Jane Rushing Martin Hasselblatt Arend Koch Ulrich Schüller Andreas von Deimling Felix Sahm Martin Sill Markus J Riemenschneider Hildegard Dohmen Camelia Maria Monoranu Clemens Sommer Ori Staszewski Christian Mawrin Jens Schittenhelm Wolfgang Brück Katharina Filipski Christian Hartmann Matthias Meinhardt Klaus Pietschmann Christine Haberler Irene Slavc Nicolas U Gerber Michael Grotzer Martin Benesch Paul Gerhardt Schlegel Frank Deinlein André O von Bueren Carsten Friedrich Björn-Ole Juhnke Denise Obrecht Gudrun Fleischhack Robert Kwiecien Andreas Faldum Rolf Dieter Kortmann Marcel Kool Stefan Rutkowski

J Clin Oncol 2020 Jun 24;38(18):2028-2040. Epub 2020 Apr 24.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1200/JCO.19.03057DOI Listing
June 2020

Germline Elongator mutations in Sonic Hedgehog medulloblastoma.

Authors:
Sebastian M Waszak Giles W Robinson Brian L Gudenas Kyle S Smith Antoine Forget Marija Kojic Jesus Garcia-Lopez Jennifer Hadley Kayla V Hamilton Emilie Indersie Ivo Buchhalter Jules Kerssemakers Natalie Jäger Tanvi Sharma Tobias Rausch Marcel Kool Dominik Sturm David T W Jones Aksana Vasilyeva Ruth G Tatevossian Geoffrey Neale Bérangère Lombard Damarys Loew Joy Nakitandwe Michael Rusch Daniel C Bowers Anne Bendel Sonia Partap Murali Chintagumpala John Crawford Nicholas G Gottardo Amy Smith Christelle Dufour Stefan Rutkowski Tone Eggen Finn Wesenberg Kristina Kjaerheim Maria Feychting Birgitta Lannering Joachim Schüz Christoffer Johansen Tina V Andersen Martin Röösli Claudia E Kuehni Michael Grotzer Marc Remke Stéphanie Puget Kristian W Pajtler Till Milde Olaf Witt Marina Ryzhova Andrey Korshunov Brent A Orr David W Ellison Laurence Brugieres Peter Lichter Kim E Nichols Amar Gajjar Brandon J Wainwright Olivier Ayrault Jan O Korbel Paul A Northcott Stefan M Pfister

Nature 2020 04 1;580(7803):396-401. Epub 2020 Apr 1.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-020-2164-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430762PMC
April 2020

Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.

Authors:
Matthew Clarke Alan Mackay Britta Ismer Jessica C Pickles Ruth G Tatevossian Scott Newman Tejus A Bale Iris Stoler Elisa Izquierdo Sara Temelso Diana M Carvalho Valeria Molinari Anna Burford Louise Howell Alex Virasami Amy R Fairchild Aimee Avery Jane Chalker Mark Kristiansen Kelly Haupfear James D Dalton Wilda Orisme Ji Wen Michael Hubank Kathreena M Kurian Catherine Rowe Mellissa Maybury Stephen Crosier Jeffrey Knipstein Ulrich Schüller Uwe Kordes David E Kram Matija Snuderl Leslie Bridges Andrew J Martin Lawrence J Doey Safa Al-Sarraj Christopher Chandler Bassel Zebian Claire Cairns Rachael Natrajan Jessica K R Boult Simon P Robinson Martin Sill Ira J Dunkel Stephen W Gilheeney Marc K Rosenblum Debbie Hughes Paula Z Proszek Tobey J Macdonald Matthias Preusser Christine Haberler Irene Slavc Roger Packer Ho-Keung Ng Shani Caspi Mara Popović Barbara Faganel Kotnik Matthew D Wood Lissa Baird Monika Ashok Davare David A Solomon Thale Kristin Olsen Petter Brandal Michael Farrell Jane B Cryan Michael Capra Michael Karremann Jens Schittenhelm Martin U Schuhmann Martin Ebinger Winand N M Dinjens Kornelius Kerl Simone Hettmer Torsten Pietsch Felipe Andreiuolo Pablo Hernáiz Driever Andrey Korshunov Lotte Hiddingh Barbara C Worst Dominik Sturm Marc Zuckermann Olaf Witt Tabitha Bloom Clare Mitchell Evelina Miele Giovanna Stefania Colafati Francesca Diomedi-Camassei Simon Bailey Andrew S Moore Timothy E G Hassall Stephen P Lowis Maria Tsoli Mark J Cowley David S Ziegler Matthias A Karajannis Kristian Aquilina Darren R Hargrave Fernando Carceller Lynley V Marshall Andreas von Deimling Christof M Kramm Stefan M Pfister Felix Sahm Suzanne J Baker Angela Mastronuzzi Andrea Carai Maria Vinci David Capper Sergey Popov David W Ellison Thomas S Jacques David T W Jones Chris Jones

Cancer Discov 2020 Jul 1;10(7):942-963. Epub 2020 Apr 1.

Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-19-1030DOI Listing
July 2020

Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers.

Authors:
Nil A Schubert Caitlin D Lowery Guillaume Bergthold Jan Koster Thomas F Eleveld Ana Rodríguez David T W Jones Gilles Vassal Louis F Stancato Stefan M Pfister Hubert N Caron Jan J Molenaar

Eur J Cancer 2020 05 27;130:168-181. Epub 2020 Mar 27.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2020.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203547PMC
May 2020

Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation.

Authors:
David Castel Thomas Kergrohen Arnault Tauziède-Espariat Alan Mackay Samia Ghermaoui Emmanuèle Lechapt Stefan M Pfister Christof M Kramm Nathalie Boddaert Thomas Blauwblomme Stéphanie Puget Kévin Beccaria Chris Jones David T W Jones Pascale Varlet Jacques Grill Marie-Anne Debily

Acta Neuropathol 2020 06 19;139(6):1109-1113. Epub 2020 Mar 19.

Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, 114 rue Édouard Vaillant, Villejuif, 94800, France.

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http://dx.doi.org/10.1007/s00401-020-02142-wDOI Listing
June 2020

Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials.

Authors:
David S Hong Steven G DuBois Shivaani Kummar Anna F Farago Catherine M Albert Kristoffer S Rohrberg Cornelis M van Tilburg Ramamoorthy Nagasubramanian Jordan D Berlin Noah Federman Leo Mascarenhas Birgit Geoerger Afshin Dowlati Alberto S Pappo Stefan Bielack François Doz Ray McDermott Jyoti D Patel Russell J Schilder Makoto Tahara Stefan M Pfister Olaf Witt Marc Ladanyi Erin R Rudzinski Shivani Nanda Barrett H Childs Theodore W Laetsch David M Hyman Alexander Drilon

Lancet Oncol 2020 04 24;21(4):531-540. Epub 2020 Feb 24.

Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30856-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497841PMC
April 2020

Implications of new understandings of gliomas in children and adults with NF1: report of a consensus conference.

Authors:
Roger J Packer Antonio Iavarone David T W Jones Jaishri O Blakeley Eric Bouffet Michael J Fisher Eugene Hwang Cynthia Hawkins Lindsay Kilburn Tobey MacDonald Stefan M Pfister Brian Rood Fausto J Rodriguez Uri Tabori Vijay Ramaswamy Yuan Zhu Jason Fangusaro Stephen A Johnston David H Gutmann

Neuro Oncol 2020 06;22(6):773-784

Department of Neurology; Washington University, St Louis, Missouri, USA.

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http://dx.doi.org/10.1093/neuonc/noaa036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283027PMC
June 2020

Pilocytic astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response.

Authors:
Christian F Aichmüller Murat Iskar David T W Jones Andrey Korshunov Bernhard Radlwimmer Marcel Kool Aurelie Ernst Stefan M Pfister Peter Lichter Marc Zapatka

Neuro Oncol 2020 09;22(9):1327-1338

Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noaa035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523467PMC
September 2020

Rapid and Sensitive Drug Quantification in Tissue Sections Using Matrix Assisted Laser Desorption Ionization-Ion Mobility-Mass Spectrometry Profiling.

Authors:
Margaux Fresnais Alexander Muck Marius Majewsky Britta Statz Sonja Krausert Julia Benzel David Castel Ludivine Le Dret Stefan Pfister Walter E Haefeli Jürgen Burhenne Rémi Longuespée

J Am Soc Mass Spectrom 2020 Mar 23;31(3):742-751. Epub 2020 Jan 23.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/jasms.0c00005DOI Listing
March 2020

Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data.

Authors:
Máté E Maros David Capper David T W Jones Volker Hovestadt Andreas von Deimling Stefan M Pfister Axel Benner Manuela Zucknick Martin Sill

Nat Protoc 2020 02 13;15(2):479-512. Epub 2020 Jan 13.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41596-019-0251-6DOI Listing
February 2020

Ecology of West Nile Virus in the Danube Delta, Romania: Phylogeography, Xenosurveillance and Mosquito Host-Feeding Patterns.

Authors:
Alexandru Tomazatos Stephanie Jansen Stefan Pfister Edina Török Iulia Maranda Cintia Horváth Lujza Keresztes Marina Spînu Egbert Tannich Hanna Jöst Jonas Schmidt-Chanasit Daniel Cadar Renke Lühken

Viruses 2019 12 14;11(12). Epub 2019 Dec 14.

Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.

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http://dx.doi.org/10.3390/v11121159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950446PMC
December 2019

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia.

Authors:
Cornelis M van Tilburg Till Milde Ruth Witt Jonas Ecker Thomas Hielscher Angelika Seitz Jens-Peter Schenk Juliane L Buhl Dennis Riehl Michael C Frühwald Arnulf Pekrun Claudia Rossig Regina Wieland Christian Flotho Uwe Kordes Bernd Gruhn Thorsten Simon Christin Linderkamp Felix Sahm Lenka Taylor Angelika Freitag Jürgen Burhenne Kathrin I Foerster Andreas D Meid Stefan M Pfister Irini Karapanagiotou-Schenkel Olaf Witt

Clin Epigenetics 2019 12 10;11(1):188. Epub 2019 Dec 10.

KiTZ Clinical Trial Unit, Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13148-019-0775-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902473PMC
December 2019

Medulloblastomics revisited: biological and clinical insights from thousands of patients.

Authors:
Volker Hovestadt Olivier Ayrault Fredrik J Swartling Giles W Robinson Stefan M Pfister Paul A Northcott

Nat Rev Cancer 2020 01 9;20(1):42-56. Epub 2019 Dec 9.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/s41568-019-0223-8DOI Listing
January 2020

Probing Medulloblastoma Initiation at the Single-Cell Level.

Authors:
Konstantin Okonechnikov Stefan M Pfister Lena M Kutscher

Trends Cancer 2019 12 28;5(12):759-761. Epub 2019 Oct 28.

Hopp-Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2019.10.002DOI Listing
December 2019

The molecular landscape of ETMR at diagnosis and relapse.

Authors:
Sander Lambo Susanne N Gröbner Tobias Rausch Sebastian M Waszak Christin Schmidt Aparna Gorthi July Carolina Romero Monika Mauermann Sebastian Brabetz Sonja Krausert Ivo Buchhalter Jan Koster Danny A Zwijnenburg Martin Sill Jens-Martin Hübner Norman Mack Benjamin Schwalm Marina Ryzhova Volker Hovestadt Simon Papillon-Cavanagh Jennifer A Chan Pablo Landgraf Ben Ho Till Milde Olaf Witt Jonas Ecker Felix Sahm David Sumerauer David W Ellison Brent A Orr Anna Darabi Christine Haberler Dominique Figarella-Branger Pieter Wesseling Jens Schittenhelm Marc Remke Michael D Taylor Maria J Gil-da-Costa Maria Łastowska Wiesława Grajkowska Martin Hasselblatt Peter Hauser Torsten Pietsch Emmanuelle Uro-Coste Franck Bourdeaut Julien Masliah-Planchon Valérie Rigau Sanda Alexandrescu Stephan Wolf Xiao-Nan Li Ulrich Schüller Matija Snuderl Matthias A Karajannis Felice Giangaspero Nada Jabado Andreas von Deimling David T W Jones Jan O Korbel Katja von Hoff Peter Lichter Annie Huang Alexander J R Bishop Stefan M Pfister Andrey Korshunov Marcel Kool

Nature 2019 12 4;576(7786):274-280. Epub 2019 Dec 4.

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-019-1815-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908757PMC
December 2019

EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.

Authors:
Enrico Franceschi Silvia Hofer Alba A Brandes Didier Frappaz Rolf-Dieter Kortmann Jacoline Bromberg Volodia Dangouloff-Ros Nathalie Boddaert Elke Hattingen Benedikt Wiestler Steven C Clifford Dominique Figarella-Branger Felice Giangaspero Christine Haberler Torsten Pietsch Kristian W Pajtler Stefan M Pfister Raphael Guzman Walter Stummer Stephanie E Combs Clemens Seidel Dagmar Beier Martin G McCabe Michael Grotzer Florence Laigle-Donadey Ana S Guerreiro Stücklin Ahmed Idbaih Matthias Preusser Martin van den Bent Michael Weller Peter Hau

Lancet Oncol 2019 12;20(12):e715-e728

Wilhelm Sander-NeuroOncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30669-2DOI Listing
December 2019

DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study.

Authors:
Jessica C Pickles Amy R Fairchild Thomas J Stone Lorelle Brownlee Ashirwad Merve Shireena A Yasin Aimee Avery Saira W Ahmed Olumide Ogunbiyi Jamie Gonzalez Zapata Abigail F Peary Marie Edwards Lisa Wilkhu Carryl Dryden Dariusz Ladon Mark Kristiansen Catherine Rowe Kathreena M Kurian James A R Nicoll Clare Mitchell Tabitha Bloom David A Hilton Safa Al-Sarraj Lawrence Doey Paul N Johns Leslie R Bridges Aruna Chakrabarty Azzam Ismail Nitika Rathi Khaja Syed G Alistair Lammie Clara Limback-Stanic Colin Smith Antonia Torgersen Frances Rae Rebecca M Hill Steven C Clifford Yura Grabovska Daniel Williamson Matthew Clarke Chris Jones David Capper Martin Sill Andreas von Deimling Stefan M Pfister David T W Jones Darren Hargrave Jane Chalker Thomas S Jacques

Lancet Child Adolesc Health 2020 02 27;4(2):121-130. Epub 2019 Nov 27.

Developmental Biology and Cancer Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(19)30342-6DOI Listing
February 2020

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker.

Authors:
Andrey Korshunov Konstantin Okonechnikov Felix Sahm Marina Ryzhova Damian Stichel Daniel Schrimpf David R Ghasemi Kristian W Pajtler Manila Antonelli Vittoria Donofrio Angela Mastronuzzi Sabrina Rossi Francesca Diomedi Camassei Anna Maria Buccoliero Christine Haberler Irene Slavc Sonika Dahiya Belen Casalini Philipp Sievers Jochen Meyer Ella Kumirova Olga Zheludkova Andrey Golanov David T W Jones Stefan M Pfister Marcel Kool Andreas von Deimling

Acta Neuropathol 2020 03 28;139(3):583-596. Epub 2019 Nov 28.

Clinical Cooperation Unit Neuropathology (B300), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02102-zDOI Listing
March 2020

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.

Authors:
Elke Pfaff Christian Aichmüller Martin Sill Damian Stichel Matija Snuderl Matthias A Karajannis Martin U Schuhmann Jens Schittenhelm Martin Hasselblatt Christian Thomas Andrey Korshunov Marina Rhizova Andrea Wittmann Anna Kaufhold Murat Iskar Petra Ketteler Dietmar Lohmann Brent A Orr David W Ellison Katja von Hoff Martin Mynarek Stefan Rutkowski Felix Sahm Andreas von Deimling Peter Lichter Marcel Kool Marc Zapatka Stefan M Pfister David T W Jones

Acta Neuropathol 2020 02 25;139(2):243-257. Epub 2019 Nov 25.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02101-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275775PMC
February 2020

DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.

Authors:
Felix K F Kommoss Damian Stichel Daniel Schrimpf Mark Kriegsmann Basile Tessier-Cloutier Aline Talhouk Jessica N McAlpine Kenneth T E Chang Dominik Sturm Stefan M Pfister Laura Romero-Pérez Thomas Kirchner Thomas G P Grünewald Rolf Buslei Hans-Peter Sinn Gunhild Mechtersheimer Peter Schirmacher Dietmar Schmidt Hans-Anton Lehr Felix Sahm David G Huntsman C Blake Gilks Friedrich Kommoss Andreas von Deimling Christian Koelsche

J Cancer Res Clin Oncol 2020 Jan 25;146(1):97-104. Epub 2019 Nov 25.

Department of Pathology, Institute of Pathology, Heidelberg University Hospital, INF 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00432-019-03093-wDOI Listing
January 2020

Genome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients.

Authors:
Matthias Bleeke Pascal Johann Susanne Gröbner Julia Alten Gunnar Cario Hansjörg Schäfer Wolfram Klapper Joseph Khoury Stefan Pfister Ingo Müller

Pediatr Blood Cancer 2020 02 18;67(2):e28074. Epub 2019 Nov 18.

Division of Pediatric Stem Cell Transplant and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/pbc.28074DOI Listing
February 2020

YAP1-fusions in pediatric NF2-wildtype meningioma.

Authors:
Philipp Sievers Jason Chiang Daniel Schrimpf Damian Stichel Nagarajan Paramasivam Martin Sill Tenzin Gayden Belen Casalini David E Reuss James Dalton Kristian W Pajtler Daniel Hänggi Christel Herold-Mende Elisabeth Rushing Andrey Korshunov Christian Mawrin Michael Weller Matthias Schlesner Wolfgang Wick Nada Jabado David T W Jones Stefan M Pfister Andreas von Deimling David W Ellison Felix Sahm

Acta Neuropathol 2020 01 16;139(1):215-218. Epub 2019 Nov 16.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02095-9DOI Listing
January 2020

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation.

Authors:
Philipp Sievers Daniel Schrimpf Damian Stichel David E Reuss Martin Hasselblatt Christian Hagel Ori Staszewski Jürgen Hench Stephan Frank Sebastian Brandner Andrey Korshunov Wolfgang Wick Stefan M Pfister Guido Reifenberger Andreas von Deimling Felix Sahm David T W Jones

Acta Neuropathol 2020 02 15;139(2):403-406. Epub 2019 Nov 15.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02097-7DOI Listing
February 2020

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.

Authors:
Hye-Jung E Chun Pascal D Johann Katy Milne Marc Zapatka Annette Buellesbach Naveed Ishaque Murat Iskar Serap Erkek Lisa Wei Basile Tessier-Cloutier Jake Lever Emma Titmuss James T Topham Reanne Bowlby Eric Chuah Karen L Mungall Yussanne Ma Andrew J Mungall Richard A Moore Michael D Taylor Daniela S Gerhard Steven J M Jones Andrey Korshunov Manfred Gessler Kornelius Kerl Martin Hasselblatt Michael C Frühwald Elizabeth J Perlman Brad H Nelson Stefan M Pfister Marco A Marra Marcel Kool

Cell Rep 2019 11 7;29(8):2338-2354.e7. Epub 2019 Nov 7.

Hopp Children's Cancer Center, Heidelberg 69120, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905433PMC
November 2019

Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.

Authors:
Hiromichi Suzuki Sachin A Kumar Shimin Shuai Ander Diaz-Navarro Ana Gutierrez-Fernandez Pasqualino De Antonellis Florence M G Cavalli Kyle Juraschka Hamza Farooq Ichiyo Shibahara Maria C Vladoiu Jiao Zhang Namal Abeysundara David Przelicki Patryk Skowron Nicole Gauer Betty Luu Craig Daniels Xiaochong Wu Antoine Forget Ali Momin Jun Wang Weifan Dong Seung-Ki Kim Wieslawa A Grajkowska Anne Jouvet Michelle Fèvre-Montange Maria Luisa Garrè Amulya A Nageswara Rao Caterina Giannini Johan M Kros Pim J French Nada Jabado Ho-Keung Ng Wai Sang Poon Charles G Eberhart Ian F Pollack James M Olson William A Weiss Toshihiro Kumabe Enrique López-Aguilar Boleslaw Lach Maura Massimino Erwin G Van Meir Joshua B Rubin Rajeev Vibhakar Lola B Chambless Noriyuki Kijima Almos Klekner László Bognár Jennifer A Chan Claudia C Faria Jiannis Ragoussis Stefan M Pfister Anna Goldenberg Robert J Wechsler-Reya Swneke D Bailey Livia Garzia A Sorana Morrissy Marco A Marra Xi Huang David Malkin Olivier Ayrault Vijay Ramaswamy Xose S Puente John A Calarco Lincoln Stein Michael D Taylor

Nature 2019 10 9;574(7780):707-711. Epub 2019 Oct 9.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-019-1650-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141958PMC
October 2019

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities.

Authors:
Annekathrin Reinhardt Damian Stichel Daniel Schrimpf Christian Koelsche Annika K Wefers Azadeh Ebrahimi Philipp Sievers Kristin Huang M Belén Casalini Francisco Fernández-Klett Abigail Suwala Michael Weller Dorothee Gramatzki Joerg Felsberg Guido Reifenberger Albert Becker Volkmar H Hans Marco Prinz Ori Staszewski Till Acker Hildegard Dohmen Christian Hartmann Werner Paulus Katharina Heß Benjamin Brokinkel Jens Schittenhelm Rolf Buslei Martina Deckert Christian Mawrin Ekkehard Hewer Ute Pohl Zane Jaunmuktane Sebastian Brandner Andreas Unterberg Daniel Hänggi Michael Platten Stefan M Pfister Wolfgang Wick Christel Herold-Mende Andrey Korshunov David E Reuss Felix Sahm David T W Jones David Capper Andreas von Deimling

Acta Neuropathol Commun 2019 10 28;7(1):163. Epub 2019 Oct 28.

Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s40478-019-0801-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816155PMC
October 2019

Germline Mutations Predispose to Pediatric Medulloblastoma.

Authors:
Matthias Begemann Sebastian M Waszak Giles W Robinson Natalie Jäger Tanvi Sharma Cordula Knopp Florian Kraft Olga Moser Martin Mynarek Lea Guerrini-Rousseau Laurence Brugieres Pascale Varlet Torsten Pietsch Daniel C Bowers Murali Chintagumpala Felix Sahm Jan O Korbel Stefan Rutkowski Thomas Eggermann Amar Gajjar Paul Northcott Miriam Elbracht Stefan M Pfister Udo Kontny Ingo Kurth

J Clin Oncol 2020 01 14;38(1):43-50. Epub 2019 Oct 14.

RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1200/JCO.19.00577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943973PMC
January 2020

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

Authors:
Annika K Wefers Damian Stichel Daniel Schrimpf Roland Coras Mélanie Pages Arnault Tauziède-Espariat Pascale Varlet Daniel Schwarz Figen Söylemezoglu Ute Pohl José Pimentel Jochen Meyer Ekkehard Hewer Anna Japp Abhijit Joshi David E Reuss Annekathrin Reinhardt Philipp Sievers M Belén Casalini Azadeh Ebrahimi Kristin Huang Christian Koelsche Hu Liang Low Olinda Rebelo Dina Marnoto Albert J Becker Ori Staszewski Michel Mittelbronn Martin Hasselblatt Jens Schittenhelm Edmund Cheesman Ricardo Santos de Oliveira Rosane Gomes P Queiroz Elvis Terci Valera Volkmar H Hans Andrey Korshunov Adriana Olar Keith L Ligon Stefan M Pfister Zane Jaunmuktane Sebastian Brandner Ruth G Tatevossian David W Ellison Thomas S Jacques Mrinalini Honavar Eleonora Aronica Maria Thom Felix Sahm Andreas von Deimling David T W Jones Ingmar Blumcke David Capper

Acta Neuropathol 2020 01 28;139(1):193-209. Epub 2019 Sep 28.

Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1007/s00401-019-02078-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477753PMC
January 2020

Molecular correlates of cerebellar mutism syndrome in medulloblastoma.

Authors:
Rashad Jabarkheel Nisreen Amayiri Derek Yecies Yuhao Huang Sebastian Toescu Liana Nobre Donald J Mabbott Sniya V Sudhakar Prateek Malik Suzanne Laughlin Maisa Swaidan Maysa Al Hussaini Awni Musharbash Geeta Chacko Leni G Mathew Paul G Fisher Darren Hargrave Ute Bartels Uri Tabori Stefan M Pfister Kristian Aquilina Michael D Taylor Gerald A Grant Eric Bouffet Kshitij Mankad Kristen W Yeom Vijay Ramaswamy

Neuro Oncol 2020 02;22(2):290-297

Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/noz158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442348PMC
February 2020

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis.

Authors:
Kristian W Pajtler Yiju Wei Konstantin Okonechnikov Patricia B G Silva Mikaella Vouri Lei Zhang Sebastian Brabetz Laura Sieber Melissa Gulley Monika Mauermann Tatjana Wedig Norman Mack Yuka Imamura Kawasawa Tanvi Sharma Marc Zuckermann Felipe Andreiuolo Eric Holland Kendra Maass Huiqin Körkel-Qu Hai-Kun Liu Felix Sahm David Capper Jens Bunt Linda J Richards David T W Jones Andrey Korshunov Lukas Chavez Peter Lichter Mikio Hoshino Stefan M Pfister Marcel Kool Wei Li Daisuke Kawauchi

Nat Commun 2019 09 2;10(1):3914. Epub 2019 Sep 2.

Hopp-Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41467-019-11884-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718408PMC
September 2019

EORTC SPECTA-AYA: A unique molecular profiling platform for adolescents and young adults with cancer in Europe.

Authors:
Teresa de Rojas Bernd Kasper Winette Van der Graaf Stefan M Pfister Franck Bielle Teresa Ribalta Patrick Shenjere Matthias Preusser Stefan Fröhling Vassilis Golfinopoulos Marie Morfouace Martin G McCabe

Int J Cancer 2020 Aug 14;147(4):1180-1184. Epub 2019 Sep 14.

Division of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/ijc.32651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383917PMC
August 2020

RF_Purify: a novel tool for comprehensive analysis of tumor-purity in methylation array data based on random forest regression.

Authors:
Pascal David Johann Natalie Jäger Stefan M Pfister Martin Sill

BMC Bioinformatics 2019 Aug 16;20(1):428. Epub 2019 Aug 16.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12859-019-3014-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697926PMC
August 2019

MYCN amplification drives an aggressive form of spinal ependymoma.

Authors:
David R Ghasemi Martin Sill Konstantin Okonechnikov Andrey Korshunov Stephen Yip Peter W Schutz David Scheie Anders Kruse Patrick N Harter Marina Kastelan Marlies Wagner Christian Hartmann Julia Benzel Kendra K Maass Mustafa Khasraw Ronald Sträter Christian Thomas Werner Paulus Christian P Kratz Hendrik Witt Daisuke Kawauchi Christel Herold-Mende Felix Sahm Sebastian Brandner Marcel Kool David T W Jones Andreas von Deimling Stefan M Pfister David E Reuss Kristian W Pajtler

Acta Neuropathol 2019 12 14;138(6):1075-1089. Epub 2019 Aug 14.

Hopp-Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02056-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851394PMC
December 2019

Resolving medulloblastoma cellular architecture by single-cell genomics.

Authors:
Volker Hovestadt Kyle S Smith Laure Bihannic Mariella G Filbin McKenzie L Shaw Alicia Baumgartner John C DeWitt Andrew Groves Lisa Mayr Hannah R Weisman Alyssa R Richman Marni E Shore Liliana Goumnerova Celeste Rosencrance Robert A Carter Timothy N Phoenix Jennifer L Hadley Yiai Tong Jim Houston Richard A Ashmun Michael DeCuypere Tanvi Sharma Diane Flasch Antonina Silkov Keith L Ligon Scott L Pomeroy Miguel N Rivera Orit Rozenblatt-Rosen Jessica M Rusert Robert J Wechsler-Reya Xiao-Nan Li Andreas Peyrl Johannes Gojo Dominik Kirchhofer Daniela Lötsch Thomas Czech Christian Dorfer Christine Haberler Rene Geyeregger Angela Halfmann Charles Gawad John Easton Stefan M Pfister Aviv Regev Amar Gajjar Brent A Orr Irene Slavc Giles W Robinson Bradley E Bernstein Mario L Suvà Paul A Northcott

Nature 2019 08 24;572(7767):74-79. Epub 2019 Jul 24.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/s41586-019-1434-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754173PMC
August 2019

Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours.

Authors:
David T W Jones Ana Banito Thomas G P Grünewald Michelle Haber Natalie Jäger Marcel Kool Till Milde Jan J Molenaar Arash Nabbi Trevor J Pugh Gudrun Schleiermacher Malcolm A Smith Frank Westermann Stefan M Pfister

Nat Rev Cancer 2019 08 12;19(8):420-438. Epub 2019 Jul 12.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41568-019-0169-xDOI Listing
August 2019

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions.

Authors:
Damian Stichel Daniel Schrimpf Belén Casalini Jochen Meyer Annika K Wefers Philipp Sievers Andrey Korshunov Christian Koelsche David E Reuss Annekathrin Reinhardt Azadeh Ebrahimi Francisco Fernández-Klett Tobias Kessler Dominik Sturm Jonas Ecker Till Milde Christel Herold-Mende Olaf Witt Stefan M Pfister Wolfgang Wick David T W Jones Andreas von Deimling Felix Sahm

Acta Neuropathol 2019 11 5;138(5):827-835. Epub 2019 Jul 5.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02039-3DOI Listing
November 2019

Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1.

Authors:
Philipp Sievers Romain Appay Daniel Schrimpf Damian Stichel David E Reuss Annika K Wefers Annekathrin Reinhardt Roland Coras Viktoria C Ruf Simone Schmid Karin de Stricker Henning B Boldt Bjarne Winther Kristensen Jeanette Krogh Petersen Benedicte P Ulhøi Maria Gardberg Eleonora Aronica Martin Hasselblatt Wolfgang Brück Franck Bielle Karima Mokhtari Benoît Lhermitte Wolfgang Wick Christel Herold-Mende Daniel Hänggi Sebastian Brandner Felice Giangaspero David Capper Elisabeth Rushing Pieter Wesseling Stefan M Pfister Dominique Figarella-Branger Andreas von Deimling Felix Sahm David T W Jones

Acta Neuropathol 2019 09 27;138(3):497-504. Epub 2019 Jun 27.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02038-4DOI Listing
September 2019

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.

Authors:
Miller Huang Jignesh Tailor Qiqi Zhen Aaron H Gillmor Matthew L Miller Holger Weishaupt Justin Chen Tina Zheng Emily K Nash Lauren K McHenry Zhenyi An Fubaiyang Ye Yasuhiro Takashima James Clarke Harold Ayetey Florence M G Cavalli Betty Luu Branden S Moriarity Shirin Ilkhanizadeh Lukas Chavez Chunying Yu Kathreena M Kurian Thierry Magnaldo Nicolas Sevenet Philipp Koch Steven M Pollard Peter Dirks Michael P Snyder David A Largaespada Yoon Jae Cho Joanna J Phillips Fredrik J Swartling A Sorana Morrissy Marcel Kool Stefan M Pfister Michael D Taylor Austin Smith William A Weiss

Cell Stem Cell 2019 09 13;25(3):433-446.e7. Epub 2019 Jun 13.

Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Departments of Pediatrics, Neurosurgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731167PMC
September 2019

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.

Authors:
Pratiti Bandopadhayay Federica Piccioni Ryan O'Rourke Patricia Ho Elizabeth M Gonzalez Graham Buchan Kenin Qian Gabrielle Gionet Emily Girard Margo Coxon Matthew G Rees Lisa Brenan Frank Dubois Ofer Shapira Noah F Greenwald Melanie Pages Amanda Balboni Iniguez Brenton R Paolella Alice Meng Claire Sinai Giovanni Roti Neekesh V Dharia Amanda Creech Benjamin Tanenbaum Prasidda Khadka Adam Tracy Hong L Tiv Andrew L Hong Shannon Coy Rumana Rashid Jia-Ren Lin Glenn S Cowley Fred C Lam Amy Goodale Yenarae Lee Kathleen Schoolcraft Francisca Vazquez William C Hahn Aviad Tsherniak James E Bradner Michael B Yaffe Till Milde Stefan M Pfister Jun Qi Monica Schenone Steven A Carr Keith L Ligon Mark W Kieran Sandro Santagata James M Olson Prafulla C Gokhale Jacob D Jaffe David E Root Kimberly Stegmaier Cory M Johannessen Rameen Beroukhim

Nat Commun 2019 06 3;10(1):2400. Epub 2019 Jun 3.

Broad Institute of MIT and Harvard, Cambridge, USA.

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http://dx.doi.org/10.1038/s41467-019-10307-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546744PMC
June 2019

Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.

Authors:
Jason Fangusaro Arzu Onar-Thomas Tina Young Poussaint Shengjie Wu Azra H Ligon Neal Lindeman Anuradha Banerjee Roger J Packer Lindsay B Kilburn Stewart Goldman Ian F Pollack Ibrahim Qaddoumi Regina I Jakacki Paul G Fisher Girish Dhall Patricia Baxter Susan G Kreissman Clinton F Stewart David T W Jones Stefan M Pfister Gilbert Vezina Jessica S Stern Ashok Panigrahy Zoltan Patay Benita Tamrazi Jeremy Y Jones Sofia S Haque David S Enterline Soonmee Cha Michael J Fisher Laurence Austin Doyle Malcolm Smith Ira J Dunkel Maryam Fouladi

Lancet Oncol 2019 07 28;20(7):1011-1022. Epub 2019 May 28.

Department of Haematology and Oncology, Cincinnati Children's Hospital, Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/S1470-2045(19)30277-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628202PMC
July 2019

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.

Authors:
Kenneth Aldape Kevin M Brindle Louis Chesler Rajesh Chopra Amar Gajjar Mark R Gilbert Nicholas Gottardo David H Gutmann Darren Hargrave Eric C Holland David T W Jones Johanna A Joyce Pamela Kearns Mark W Kieran Ingo K Mellinghoff Melinda Merchant Stefan M Pfister Steven M Pollard Vijay Ramaswamy Jeremy N Rich Giles W Robinson David H Rowitch John H Sampson Michael D Taylor Paul Workman Richard J Gilbertson

Nat Rev Clin Oncol 2019 08;16(8):522-523

CRUK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1038/s41571-019-0236-yDOI Listing
August 2019

TelomereHunter - in silico estimation of telomere content and composition from cancer genomes.

Authors:
Lars Feuerbach Lina Sieverling Katharina I Deeg Philip Ginsbach Barbara Hutter Ivo Buchhalter Paul A Northcott Sadaf S Mughal Priya Chudasama Hanno Glimm Claudia Scholl Peter Lichter Stefan Fröhling Stefan M Pfister David T W Jones Karsten Rippe Benedikt Brors

BMC Bioinformatics 2019 May 28;20(1):272. Epub 2019 May 28.

Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12859-019-2851-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540518PMC
May 2019

Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes.

Authors:
Tanvi Sharma Edward C Schwalbe Daniel Williamson Martin Sill Volker Hovestadt Martin Mynarek Stefan Rutkowski Giles W Robinson Amar Gajjar Florence Cavalli Vijay Ramaswamy Michael D Taylor Janet C Lindsey Rebecca M Hill Natalie Jäger Andrey Korshunov Debbie Hicks Simon Bailey Marcel Kool Lukas Chavez Paul A Northcott Stefan M Pfister Steven C Clifford

Acta Neuropathol 2019 08 10;138(2):309-326. Epub 2019 May 10.

Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00401-019-02020-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660496PMC
August 2019

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma.

Authors:
Nagarajan Paramasivam Daniel Hübschmann Umut H Toprak Naveed Ishaque Marian Neidert Daniel Schrimpf Damian Stichel David Reuss Philipp Sievers Annekathrin Reinhardt Annika K Wefers David T W Jones Zuguang Gu Johannes Werner Sebastian Uhrig Hans-Georg Wirsching Matthias Schick Melanie Bewerunge-Hudler Katja Beck Stephanie Brehmer Steffi Urbschat Marcel Seiz-Rosenhagen Daniel Hänggi Christel Herold-Mende Ralf Ketter Roland Eils Zvi Ram Stefan M Pfister Wolfgang Wick Michael Weller Rachel Grossmann Andreas von Deimling Matthias Schlesner Felix Sahm

Acta Neuropathol 2019 08 8;138(2):295-308. Epub 2019 May 8.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02008-wDOI Listing
August 2019

Molecular progression of SHH-activated medulloblastomas.

Authors:
Andrey Korshunov Konstantin Okonechnikov Felix Sahm Marina Ryzhova Damian Stichel Philipp Sievers Jochen Meyer Daniel Schrimpf Olga Zheludkova Andrey Golanov Peter Lichter David T W Jones Stefan M Pfister Andreas von Deimling Marcel Kool

Acta Neuropathol 2019 08 27;138(2):327-330. Epub 2019 Apr 27.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02022-yDOI Listing
August 2019

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Authors:
Elke Pfaff Ahmed El Damaty Gnana Prakash Balasubramanian Mirjam Blattner-Johnson Barbara C Worst Sebastian Stark Hendrik Witt Kristian W Pajtler Cornelis M van Tilburg Ruth Witt Till Milde Martin Jakobs Petra Fiesel Michael C Frühwald Pablo Hernáiz Driever Ulrich W Thomale Martin U Schuhmann Markus Metzler Konrad Bochennek Thorsten Simon Matthias Dürken Michael Karremann Stephanie Knirsch Martin Ebinger André O von Bueren Torsten Pietsch Christel Herold-Mende David E Reuss Karl Kiening Peter Lichter Angelika Eggert Christof M Kramm Stefan M Pfister David T W Jones Heidi Bächli Olaf Witt

Eur J Cancer 2019 06 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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June 2019

Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1.

Authors:
Christian Thomas Friederike Knerlich-Lukoschus Harald Reinhard Pascal D Johann Dominik Sturm Felix Sahm Susanne Bens Julia Vogt Karolina Nemes Florian Oyen Uwe Kordes Reiner Siebert Reinhard Schneppenheim Martina Messing-Jünger Torsten Pietsch Andreas von Deimling Werner Paulus Stefan M Pfister Marcel Kool Michael C Frühwald Martin Hasselblatt

Acta Neuropathol 2019 05 3;137(5):847-850. Epub 2019 Apr 3.

Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany.

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http://dx.doi.org/10.1007/s00401-019-02001-3DOI Listing
May 2019

DECIPHER pooled shRNA library screen identifies PP2A and FGFR signaling as potential therapeutic targets for diffuse intrinsic pontine gliomas.

Authors:
Kathrin Schramm Murat Iskar Britta Statz Natalie Jäger Daniel Haag Mikołaj Słabicki Stefan M Pfister Marc Zapatka Jan Gronych David T W Jones Peter Lichter

Neuro Oncol 2019 07;21(7):867-877

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noz057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620639PMC
July 2019

EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.

Authors:
Jens-Martin Hübner Torsten Müller Dimitris N Papageorgiou Monika Mauermann Jeroen Krijgsveld Robert B Russell David W Ellison Stefan M Pfister Kristian W Pajtler Marcel Kool

Neuro Oncol 2019 07;21(7):878-889

Division of Pediatric Neurooncology, German Cancer Consortium, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620627PMC
July 2019

DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.

Authors:
Christian Koelsche Mark Kriegsmann Felix K F Kommoss Damian Stichel Katharina Kriegsmann Christian Vokuhl Thomas G P Grünewald Laura Romero-Pérez Thomas Kirchner Enrique de Alava Juan Diaz-Martin Wolfgang Hartmann Daniel Baumhoer Cristina R Antonescu Karoly Szuhai Uta Flucke Uta Dirksen Stefan M Pfister David T W Jones Gunhild Mechtersheimer Andreas von Deimling

J Cancer Res Clin Oncol 2019 May 20;145(5):1273-1281. Epub 2019 Mar 20.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00432-019-02895-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607515PMC
May 2019

Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series.

Authors:
Martin Benesch Martin Mynarek Hendrik Witt Monika Warmuth-Metz Torsten Pietsch Brigitte Bison Stefan M Pfister Kristian W Pajtler Marcel Kool Ulrich Schüller Klaus Pietschmann Björn-Ole Juhnke Stephan Tippelt Gudrun Fleischhack Irene Schmid Christof M Kramm Peter Vorwerk Andreas Beilken Carl Friedrich Classen Pablo Hernáiz Driever Gabriele Kropshofer Thomas Imschweiler Andreas Lemmer Rolf-Dieter Kortmann Stefan Rutkowski Katja von Hoff

Oncologist 2019 09 8;24(9):e921-e929. Epub 2019 Mar 8.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738295PMC
September 2019

cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF mutation.

Authors:
David W Ellison Cynthia Hawkins David T W Jones Arzu Onar-Thomas Stefan M Pfister Guido Reifenberger David N Louis

Acta Neuropathol 2019 04 8;137(4):683-687. Epub 2019 Mar 8.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00401-019-01987-0DOI Listing
April 2019

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles.

Authors:
Andrey Korshunov Felix Sahm Konstantin Okonechnikov Marina Ryzhova Damian Stichel Daniel Schrimpf Belen Casalini Philipp Sievers Jochen Meyer Olga Zheludkova Andrey Golanov Peter Lichter David T W Jones Stefan M Pfister Marcel Kool Andreas von Deimling

Acta Neuropathol 2019 06 2;137(6):1003-1015. Epub 2019 Mar 2.

Clinical Cooperation Unit Neuropathology (B300), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-01981-6DOI Listing
June 2019

Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype.

Authors:
Christian Koelsche Damian Stichel Klaus G Griewank Daniel Schrimpf David E Reuss Melanie Bewerunge-Hudler Christian Vokuhl Winand N M Dinjens Iver Petersen Michel Mittelbronn Adrian Cuevas-Bourdier Rolf Buslei Stefan M Pfister Uta Flucke Gunhild Mechtersheimer Thomas Mentzel Andreas von Deimling

Clin Sarcoma Res 2019 14;9. Epub 2019 Feb 14.

2Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Baden-Württemberg Germany.

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https://clinicalsarcomaresearch.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s13569-019-0113-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375211PMC
February 2019

Translating genomic medicine to the clinic: challenges and opportunities.

Authors:
Huan Zhang Lars Klareskog Andreas Matussek Stefan M Pfister Mikael Benson

Genome Med 2019 02 22;11(1). Epub 2019 Feb 22.

Centre for Personalised Medicine, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1186/s13073-019-0622-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385380PMC
February 2019

Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre.

Authors:
Zane Jaunmuktane David Capper David T W Jones Daniel Schrimpf Martin Sill Monika Dutt Nirosha Suraweera Stefan M Pfister Andreas von Deimling Sebastian Brandner

Acta Neuropathol Commun 2019 02 20;7(1):24. Epub 2019 Feb 20.

Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK.

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381711PMC
February 2019

Medulloblastoma.

Authors:
Paul A Northcott Giles W Robinson Christian P Kratz Donald J Mabbott Scott L Pomeroy Steven C Clifford Stefan Rutkowski David W Ellison David Malkin Michael D Taylor Amar Gajjar Stefan M Pfister

Nat Rev Dis Primers 2019 02 14;5(1):11. Epub 2019 Feb 14.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41572-019-0063-6DOI Listing
February 2019

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA.

Authors:
Yanghao Hou Jorge Pinheiro Felix Sahm David E Reuss Daniel Schrimpf Damian Stichel Belén Casalini Christian Koelsche Philipp Sievers Annika K Wefers Annekathrin Reinhardt Azadeh Ebrahimi Francisco Fernández-Klett Stefan Pusch Jochen Meier Leonille Schweizer Werner Paulus Marco Prinz Christian Hartmann Karl H Plate Guido Reifenberger Torsten Pietsch Pascale Varlet Mélanie Pagès Ulrich Schüller David Scheie Karin de Stricker Stephan Frank Jürgen Hench Bianca Pollo Sebastian Brandner Andreas Unterberg Stefan M Pfister David T W Jones Andrey Korshunov Wolfgang Wick David Capper Ingmar Blümcke Andreas von Deimling Luca Bertero

Acta Neuropathol 2019 05 13;137(5):837-846. Epub 2019 Feb 13.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-01969-2DOI Listing
May 2019

Challenges to curing primary brain tumours.

Authors:
Kenneth Aldape Kevin M Brindle Louis Chesler Rajesh Chopra Amar Gajjar Mark R Gilbert Nicholas Gottardo David H Gutmann Darren Hargrave Eric C Holland David T W Jones Johanna A Joyce Pamela Kearns Mark W Kieran Ingo K Mellinghoff Melinda Merchant Stefan M Pfister Steven M Pollard Vijay Ramaswamy Jeremy N Rich Giles W Robinson David H Rowitch John H Sampson Michael D Taylor Paul Workman Richard J Gilbertson

Nat Rev Clin Oncol 2019 08;16(8):509-520

CRUK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK.

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http://www.nature.com/articles/s41571-019-0177-5
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650350PMC
August 2019

InTAD: chromosome conformation guided analysis of enhancer target genes.

Authors:
Konstantin Okonechnikov Serap Erkek Jan O Korbel Stefan M Pfister Lukas Chavez

BMC Bioinformatics 2019 Jan 31;20(1):60. Epub 2019 Jan 31.

Department of Medicine, Division of Medical Genetics, University of California San Diego (UCSD), San Diego, USA.

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357397PMC
January 2019

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.

Authors:
Catherine Lee Vasilisa A Rudneva Serap Erkek Marc Zapatka Lianne Q Chau Silvia K Tacheva-Grigorova Alexandra Garancher Jessica M Rusert Ozlem Aksoy Robin Lea Helai P Mohammad Jianxun Wang William A Weiss H Leighton Grimes Stefan M Pfister Paul A Northcott Robert J Wechsler-Reya

Nat Commun 2019 01 18;10(1):332. Epub 2019 Jan 18.

Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.

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http://www.nature.com/articles/s41467-018-08269-5
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338772PMC
January 2019

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells.

Authors:
Jonathan P Robson Marc Remke Marcel Kool Elaine Julian Andrey Korshunov Stefan M Pfister Geoffrey W Osborne Michael D Taylor Brandon Wainwright Brent A Reynolds

PLoS One 2019 18;14(1):e0210665. Epub 2019 Jan 18.

Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338368PMC
October 2019

Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1.

Authors:
Julieann C Lee Javier E Villanueva-Meyer Sean P Ferris Emily A Sloan Jeffrey W Hofmann Eyas M Hattab Brian J Williams Hua Guo Joseph Torkildson Adriana Florez Jessica Van Ziffle Courtney Onodera James P Grenert Soo-Jin Cho Andrew E Horvai David T W Jones Stefan M Pfister Christian Koelsche Andreas von Deimling Andrey Korshunov Arie Perry David A Solomon

Acta Neuropathol 2019 03 16;137(3):521-525. Epub 2019 Jan 16.

Department of Pathology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s00401-019-01960-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408274PMC
March 2019

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation.

Authors:
Serap Erkek Pascal D Johann Martina A Finetti Yiannis Drosos Hsien-Chao Chou Marc Zapatka Dominik Sturm David T W Jones Andrey Korshunov Marina Rhyzova Stephan Wolf Jan-Philipp Mallm Katja Beck Olaf Witt Andreas E Kulozik Michael C Frühwald Paul A Northcott Jan O Korbel Peter Lichter Roland Eils Amar Gajjar Charles W M Roberts Daniel Williamson Martin Hasselblatt Lukas Chavez Stefan M Pfister Marcel Kool

Cancer Cell 2019 01 27;35(1):95-110.e8. Epub 2018 Dec 27.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183053
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http://dx.doi.org/10.1016/j.ccell.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341227PMC
January 2019

Limitations of current models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma.

Authors:
Hazel Anne Rogers Rebecca Chapman Holly Kings Julie Allard Jodie Barron-Hastings Kristian W Pajtler Martin Sill Stefan Pfister Richard Guy Grundy

Oncotarget 2018 Nov 23;9(92):36530-36541. Epub 2018 Nov 23.

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

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http://www.oncotarget.com/fulltext/26370
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http://dx.doi.org/10.18632/oncotarget.26370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284855PMC
November 2018

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma.

Authors:
Juliane L Buhl Florian Selt Thomas Hielscher Romain Guiho Jonas Ecker Felix Sahm Johannes Ridinger Dennis Riehl Diren Usta Britta Ismer Alexander C Sommerkamp J P Martinez-Barbera Annika K Wefers Marc Remke Daniel Picard Stefan Pusch Jan Gronych Ina Oehme Cornelis M van Tilburg Marcel Kool Daniela Kuhn David Capper Andreas von Deimling Martin U Schuhmann Christel Herold-Mende Andrey Korshunov Tilman Brummer Stefan M Pfister David T W Jones Olaf Witt Till Milde

Clin Cancer Res 2019 03 7;25(6):1851-1866. Epub 2018 Dec 7.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1965DOI Listing
March 2019

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors.

Authors:
Manasi Ratnaparkhe John K L Wong Pei-Chi Wei Mario Hlevnjak Thorsten Kolb Milena Simovic Daniel Haag Yashna Paul Frauke Devens Paul Northcott David T W Jones Marcel Kool Anna Jauch Agata Pastorczak Wojciech Mlynarski Andrey Korshunov Rajiv Kumar Susanna M Downing Stefan M Pfister Marc Zapatka Peter J McKinnon Frederick W Alt Peter Lichter Aurélie Ernst

Nat Commun 2018 11 12;9(1):4760. Epub 2018 Nov 12.

Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.

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http://dx.doi.org/10.1038/s41467-018-06925-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232171PMC
November 2018

Prevalence and quantification of contamination of knitted cotton outer gloves during hip and knee arthroplasty surgery.

Authors:
Thorsten Wichmann T Fintan Moriarty Iris Keller Stefan Pfister Vanessa Deggim-Messmer Emanuel Gautier Fabian Kalberer Peter P Koch Peter Wahl

Arch Orthop Trauma Surg 2019 Apr 7;139(4):451-459. Epub 2018 Nov 7.

Division of Orthopaedics and Traumatology, Cantonal Hospital Winterthur, Brauerstrasse 15, P.O. Box 834, 8401, Winterthur, Switzerland.

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http://link.springer.com/10.1007/s00402-018-3061-3
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April 2019

Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location.

Authors:
David Castel Cathy Philippe Thomas Kergrohen Martin Sill Jane Merlevede Emilie Barret Stéphanie Puget Christian Sainte-Rose Christof M Kramm Chris Jones Pascale Varlet Stefan M Pfister Jacques Grill David T W Jones Marie-Anne Debily

Acta Neuropathol Commun 2018 11 5;6(1):117. Epub 2018 Nov 5.

UMR8203,Vectorologie et Nouvelles Thérapies Anticancéreuses, CNRS, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France.

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http://dx.doi.org/10.1186/s40478-018-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219253PMC
November 2018

Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p.

Authors:
Philipp Sievers Damian Stichel Thomas Hielscher Daniel Schrimpf Annekathrin Reinhardt Annika K Wefers David Reuss David T W Jones Melanie Bewerunge-Hudler Christian Hartmann Peter Baumgarten Hans-Georg Wirsching Bjarne Winther-Kristensen Benjamin Brokinkel Ralf Ketter Miguel Angel Idoate Gastearena Katrin Lamszus Marcel Seiz-Rosenhagen Christian Mawrin Patrick N Harter Jörg Felsberg Daniel Hänggi Christel Herold-Mende Anna Sophie Berghoff Michael Weller Stefan M Pfister Wolfgang Wick Guido Reifenberger Matthias Preusser Andreas von Deimling Felix Sahm

Acta Neuropathol 2018 12 31;136(6):975-978. Epub 2018 Oct 31.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00401-018-1924-x
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December 2018

A biobank of patient-derived pediatric brain tumor models.

Authors:
Sebastian Brabetz Sarah E S Leary Susanne N Gröbner Madison W Nakamoto Huriye Şeker-Cin Emily J Girard Bonnie Cole Andrew D Strand Karina L Bloom Volker Hovestadt Norman L Mack Fiona Pakiam Benjamin Schwalm Andrey Korshunov Gnana Prakash Balasubramanian Paul A Northcott Kyle D Pedro Joyoti Dey Stacey Hansen Sally Ditzler Peter Lichter Lukas Chavez David T W Jones Jan Koster Stefan M Pfister Marcel Kool James M Olson

Nat Med 2018 11 22;24(11):1752-1761. Epub 2018 Oct 22.

Seattle Children's and University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41591-018-0207-3DOI Listing
November 2018

Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial.

Authors:
Eugene I Hwang Marcel Kool Peter C Burger David Capper Lukas Chavez Sebastian Brabetz Chris Williams-Hughes Catherine Billups Linda Heier Alok Jaju Jeff Michalski Yimei Li Sarah Leary Tianni Zhou Andreas von Deimling David T W Jones Maryam Fouladi Ian F Pollack Amar Gajjar Roger J Packer Stefan M Pfister James M Olson

J Clin Oncol 2018 Oct 17:JCO2017764720. Epub 2018 Oct 17.

Eugene I. Hwang and Roger J. Packer, Children's National Medical Center, Washington, DC; Marcel Kool, Lukas Chavez, Sebastian Brabetz, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; David Capper, Andreas von Deimling, and Stefan M. Pfister, University Hospital Heidelberg; Stefan M. Pfister, National Center for Tumor Diseases, Heidelberg; David Capper, Charité Medical University, Berlin, Germany; Peter C. Burger, Johns Hopkins University, Baltimore, MD; Chris Williams-Hughes, Children's Oncology Group, Littleton, CO; Catherine Billups, Yimei Li, and Amar Gajjar, St Jude Children's Research Hospital, Memphis, TN; Linda Heier, Weill Cornell Medical College, New York, NY; Alok Jaju, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Jeff Michalski, Washington University School of Medicine, St. Louis, MO; Sarah Leary and James M. Olson, Seattle Children's Hospital and Research Institute; Sarah Leary and James M. Olson, Fred Hutchinson Cancer Research Center, Seattle, WA; Tianni Zhou, California State University, Long Beach, Long Beach, CA; Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Ian F. Pollack, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1200/JCO.2017.76.4720DOI Listing
October 2018

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging.

Authors:
Mélanie Pagès Kristian W Pajtler Stéphanie Puget David Castel Nathalie Boddaert Arnault Tauziède-Espariat Stéphanie Picot Marie-Anne Debily Marcel Kool David Capper Christian Sainte-Rose Fabrice Chrétien Stefan M Pfister Torsten Pietsch Jacques Grill Pascale Varlet Felipe Andreiuolo

Brain Pathol 2019 05 28;29(3):325-335. Epub 2018 Nov 28.

Department of Neuropathology, Sainte-Anne Hospital, Paris, France.

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http://dx.doi.org/10.1111/bpa.12664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379587PMC
May 2019

N2M2 (NOA-20) phase I/II trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma.

Authors:
Wolfgang Wick Susan Dettmer Anne Berberich Tobias Kessler Irini Karapanagiotou-Schenkel Antje Wick Frank Winkler Elke Pfaff Benedikt Brors Jürgen Debus Andreas Unterberg Martin Bendszus Christel Herold-Mende Andreas Eisenmenger Andreas von Deimling David T W Jones Stefan M Pfister Felix Sahm Michael Platten

Neuro Oncol 2019 01;21(1):95-105

Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKTK, DKFZ, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noy161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303534PMC
January 2019

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas.

Authors:
Andrey Korshunov Felix Sahm Olga Zheludkova Andrey Golanov Damian Stichel Daniel Schrimpf Marina Ryzhova Alexander Potapov Antje Habel Jochen Meyer Peter Lichter David T W Jones Andreas von Deimling Stefan M Pfister Marcel Kool

Neuro Oncol 2019 02;21(2):214-221

Hopp Children's Cancer Center at the National Center for Tumor Diseases Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noy155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374763PMC
February 2019

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups.

Authors:
Tenley C Archer Tobias Ehrenberger Filip Mundt Maxwell P Gold Karsten Krug Clarence K Mah Elizabeth L Mahoney Colin J Daniel Alexander LeNail Divya Ramamoorthy Philipp Mertins D R Mani Hailei Zhang Michael A Gillette Karl Clauser Michael Noble Lauren C Tang Jessica Pierre-François Jacob Silterra James Jensen Pablo Tamayo Andrey Korshunov Stefan M Pfister Marcel Kool Paul A Northcott Rosalie C Sears Jonathan O Lipton Steven A Carr Jill P Mesirov Scott L Pomeroy Ernest Fraenkel

Cancer Cell 2018 09;34(3):396-410.e8

Eli and Edythe Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372116PMC
September 2018

Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling.

Authors:
Antoine Forget Loredana Martignetti Stéphanie Puget Laurence Calzone Sebastian Brabetz Daniel Picard Arnau Montagud Stéphane Liva Alexandre Sta Florent Dingli Guillaume Arras Jaime Rivera Damarys Loew Aurore Besnard Joëlle Lacombe Mélanie Pagès Pascale Varlet Christelle Dufour Hua Yu Audrey L Mercier Emilie Indersie Anaïs Chivet Sophie Leboucher Laura Sieber Kevin Beccaria Michael Gombert Frauke D Meyer Nan Qin Jasmin Bartl Lukas Chavez Konstantin Okonechnikov Tanvi Sharma Venu Thatikonda Franck Bourdeaut Celio Pouponnot Vijay Ramaswamy Andrey Korshunov Arndt Borkhardt Guido Reifenberger Patrick Poullet Michael D Taylor Marcel Kool Stefan M Pfister Daisuke Kawauchi Emmanuel Barillot Marc Remke Olivier Ayrault

Cancer Cell 2018 09;34(3):379-395.e7

Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France; Université Paris Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183035
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http://dx.doi.org/10.1016/j.ccell.2018.08.002DOI Listing
September 2018

Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.

Authors:
Damian Stichel Azadeh Ebrahimi David Reuss Daniel Schrimpf Takahiro Ono Mitsuaki Shirahata Guido Reifenberger Michael Weller Daniel Hänggi Wolfgang Wick Christel Herold-Mende Manfred Westphal Sebastian Brandner Stefan M Pfister David Capper Felix Sahm Andreas von Deimling

Acta Neuropathol 2018 11 5;136(5):793-803. Epub 2018 Sep 5.

Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1905-0DOI Listing
November 2018