Stefan Pfister

Stefan Pfister

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Stefan Pfister

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MYCN amplification drives an aggressive form of spinal ependymoma.

Authors:
David R Ghasemi Martin Sill Konstantin Okonechnikov Andrey Korshunov Stephen Yip Peter W Schutz David Scheie Anders Kruse Patrick N Harter Marina Kastelan Marlies Wagner Christian Hartmann Julia Benzel Kendra K Maass Mustafa Khasraw Ronald Sträter Christian Thomas Werner Paulus Christian P Kratz Hendrik Witt Daisuke Kawauchi Christel Herold-Mende Felix Sahm Sebastian Brandner Marcel Kool David T W Jones Andreas von Deimling Stefan M Pfister David E Reuss Kristian W Pajtler

Acta Neuropathol 2019 Dec 14;138(6):1075-1089. Epub 2019 Aug 14.

Hopp-Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02056-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851394PMC
December 2019

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions.

Authors:
Damian Stichel Daniel Schrimpf Belén Casalini Jochen Meyer Annika K Wefers Philipp Sievers Andrey Korshunov Christian Koelsche David E Reuss Annekathrin Reinhardt Azadeh Ebrahimi Francisco Fernández-Klett Tobias Kessler Dominik Sturm Jonas Ecker Till Milde Christel Herold-Mende Olaf Witt Stefan M Pfister Wolfgang Wick David T W Jones Andreas von Deimling Felix Sahm

Acta Neuropathol 2019 Nov 5;138(5):827-835. Epub 2019 Jul 5.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02039-3DOI Listing
November 2019

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.

Authors:
Hye-Jung E Chun Pascal D Johann Katy Milne Marc Zapatka Annette Buellesbach Naveed Ishaque Murat Iskar Serap Erkek Lisa Wei Basile Tessier-Cloutier Jake Lever Emma Titmuss James T Topham Reanne Bowlby Eric Chuah Karen L Mungall Yussanne Ma Andrew J Mungall Richard A Moore Michael D Taylor Daniela S Gerhard Steven J M Jones Andrey Korshunov Manfred Gessler Kornelius Kerl Martin Hasselblatt Michael C Frühwald Elizabeth J Perlman Brad H Nelson Stefan M Pfister Marco A Marra Marcel Kool

Cell Rep 2019 Nov 7;29(8):2338-2354.e7. Epub 2019 Nov 7.

Hopp Children's Cancer Center, Heidelberg 69120, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.013DOI Listing
November 2019

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation.

Authors:
Philipp Sievers Daniel Schrimpf Damian Stichel David E Reuss Martin Hasselblatt Christian Hagel Ori Staszewski Jürgen Hench Stephan Frank Sebastian Brandner Andrey Korshunov Wolfgang Wick Stefan M Pfister Guido Reifenberger Andreas von Deimling Felix Sahm David T W Jones

Acta Neuropathol 2019 Nov 15. Epub 2019 Nov 15.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02097-7DOI Listing
November 2019

YAP1-fusions in pediatric NF2-wildtype meningioma.

Authors:
Philipp Sievers Jason Chiang Daniel Schrimpf Damian Stichel Nagarajan Paramasivam Martin Sill Tenzin Gayden Belen Casalini David E Reuss James Dalton Kristian W Pajtler Daniel Hänggi Christel Herold-Mende Elisabeth Rushing Andrey Korshunov Christian Mawrin Michael Weller Matthias Schlesner Wolfgang Wick Nada Jabado David T W Jones Stefan M Pfister Andreas von Deimling David W Ellison Felix Sahm

Acta Neuropathol 2019 Nov 16. Epub 2019 Nov 16.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02095-9DOI Listing
November 2019

Genome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients.

Authors:
Matthias Bleeke Pascal Johann Susanne Gröbner Julia Alten Gunnar Cario Hansjörg Schäfer Wolfram Klapper Joseph Khoury Stefan Pfister Ingo Müller

Pediatr Blood Cancer 2019 Nov 18:e28074. Epub 2019 Nov 18.

Division of Pediatric Stem Cell Transplant and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/pbc.28074DOI Listing
November 2019

DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.

Authors:
Felix K F Kommoss Damian Stichel Daniel Schrimpf Mark Kriegsmann Basile Tessier-Cloutier Aline Talhouk Jessica N McAlpine Kenneth T E Chang Dominik Sturm Stefan M Pfister Laura Romero-Pérez Thomas Kirchner Thomas G P Grünewald Rolf Buslei Hans-Peter Sinn Gunhild Mechtersheimer Peter Schirmacher Dietmar Schmidt Hans-Anton Lehr Felix Sahm David G Huntsman C Blake Gilks Friedrich Kommoss Andreas von Deimling Christian Koelsche

J Cancer Res Clin Oncol 2019 Nov 25. Epub 2019 Nov 25.

Department of Pathology, Institute of Pathology, Heidelberg University Hospital, INF 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00432-019-03093-wDOI Listing
November 2019

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.

Authors:
Elke Pfaff Christian Aichmüller Martin Sill Damian Stichel Matija Snuderl Matthias A Karajannis Martin U Schuhmann Jens Schittenhelm Martin Hasselblatt Christian Thomas Andrey Korshunov Marina Rhizova Andrea Wittmann Anna Kaufhold Murat Iskar Petra Ketteler Dietmar Lohmann Brent A Orr David W Ellison Katja von Hoff Martin Mynarek Stefan Rutkowski Felix Sahm Andreas von Deimling Peter Lichter Marcel Kool Marc Zapatka Stefan M Pfister David T W Jones

Acta Neuropathol 2019 Nov 25. Epub 2019 Nov 25.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02101-0DOI Listing
November 2019

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker.

Authors:
Andrey Korshunov Konstantin Okonechnikov Felix Sahm Marina Ryzhova Damian Stichel Daniel Schrimpf David R Ghasemi Kristian W Pajtler Manila Antonelli Vittoria Donofrio Angela Mastronuzzi Sabrina Rossi Francesca Diomedi Camassei Anna Maria Buccoliero Christine Haberler Irene Slavc Sonika Dahiya Belen Casalini Philipp Sievers Jochen Meyer Ella Kumirova Olga Zheludkova Andrey Golanov David T W Jones Stefan M Pfister Marcel Kool Andreas von Deimling

Acta Neuropathol 2019 Nov 28. Epub 2019 Nov 28.

Clinical Cooperation Unit Neuropathology (B300), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02102-zDOI Listing
November 2019

DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study.

Authors:
Jessica C Pickles Amy R Fairchild Thomas J Stone Lorelle Brownlee Ashirwad Merve Shireena A Yasin Aimee Avery Saira W Ahmed Olumide Ogunbiyi Jamie Gonzalez Zapata Abigail F Peary Marie Edwards Lisa Wilkhu Carryl Dryden Dariusz Ladon Mark Kristiansen Catherine Rowe Kathreena M Kurian James A R Nicoll Clare Mitchell Tabitha Bloom David A Hilton Safa Al-Sarraj Lawrence Doey Paul N Johns Leslie R Bridges Aruna Chakrabarty Azzam Ismail Nitika Rathi Khaja Syed G Alistair Lammie Clara Limback-Stanic Colin Smith Antonia Torgersen Frances Rae Rebecca M Hill Steven C Clifford Yura Grabovska Daniel Williamson Matthew Clarke Chris Jones David Capper Martin Sill Andreas von Deimling Stefan M Pfister David T W Jones Darren Hargrave Jane Chalker Thomas S Jacques

Lancet Child Adolesc Health 2019 Nov 27. Epub 2019 Nov 27.

Developmental Biology and Cancer Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(19)30342-6DOI Listing
November 2019

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells.

Authors:
Jonathan P Robson Marc Remke Marcel Kool Elaine Julian Andrey Korshunov Stefan M Pfister Geoffrey W Osborne Michael D Taylor Brandon Wainwright Brent A Reynolds

PLoS One 2019 18;14(1):e0210665. Epub 2019 Jan 18.

Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210665PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338368PMC
October 2019

Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma.

Authors:
Hiromichi Suzuki Sachin A Kumar Shimin Shuai Ander Diaz-Navarro Ana Gutierrez-Fernandez Pasqualino De Antonellis Florence M G Cavalli Kyle Juraschka Hamza Farooq Ichiyo Shibahara Maria C Vladoiu Jiao Zhang Namal Abeysundara David Przelicki Patryk Skowron Nicole Gauer Betty Luu Craig Daniels Xiaochong Wu Antoine Forget Ali Momin Jun Wang Weifan Dong Seung-Ki Kim Wieslawa A Grajkowska Anne Jouvet Michelle Fèvre-Montange Maria Luisa Garrè Amulya A Nageswara Rao Caterina Giannini Johan M Kros Pim J French Nada Jabado Ho-Keung Ng Wai Sang Poon Charles G Eberhart Ian F Pollack James M Olson William A Weiss Toshihiro Kumabe Enrique López-Aguilar Boleslaw Lach Maura Massimino Erwin G Van Meir Joshua B Rubin Rajeev Vibhakar Lola B Chambless Noriyuki Kijima Almos Klekner László Bognár Jennifer A Chan Claudia C Faria Jiannis Ragoussis Stefan M Pfister Anna Goldenberg Robert J Wechsler-Reya Swneke D Bailey Livia Garzia A Sorana Morrissy Marco A Marra Xi Huang David Malkin Olivier Ayrault Vijay Ramaswamy Xose S Puente John A Calarco Lincoln Stein Michael D Taylor

Nature 2019 Oct 9. Epub 2019 Oct 9.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-019-1650-0DOI Listing
October 2019

Germline Mutations Predispose to Pediatric Medulloblastoma.

Authors:
Matthias Begemann Sebastian M Waszak Giles W Robinson Natalie Jäger Tanvi Sharma Cordula Knopp Florian Kraft Olga Moser Martin Mynarek Lea Guerrini-Rousseau Laurence Brugieres Pascale Varlet Torsten Pietsch Daniel C Bowers Murali Chintagumpala Felix Sahm Jan O Korbel Stefan Rutkowski Thomas Eggermann Amar Gajjar Paul Northcott Miriam Elbracht Stefan M Pfister Udo Kontny Ingo Kurth

J Clin Oncol 2019 Oct 14:JCO1900577. Epub 2019 Oct 14.

RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1200/JCO.19.00577DOI Listing
October 2019

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities.

Authors:
Annekathrin Reinhardt Damian Stichel Daniel Schrimpf Christian Koelsche Annika K Wefers Azadeh Ebrahimi Philipp Sievers Kristin Huang M Belén Casalini Francisco Fernández-Klett Abigail Suwala Michael Weller Dorothee Gramatzki Joerg Felsberg Guido Reifenberger Albert Becker Volkmar H Hans Marco Prinz Ori Staszewski Till Acker Hildegard Dohmen Christian Hartmann Werner Paulus Katharina Heß Benjamin Brokinkel Jens Schittenhelm Rolf Buslei Martina Deckert Christian Mawrin Ekkehard Hewer Ute Pohl Zane Jaunmuktane Sebastian Brandner Andreas Unterberg Daniel Hänggi Michael Platten Stefan M Pfister Wolfgang Wick Christel Herold-Mende Andrey Korshunov David E Reuss Felix Sahm David T W Jones David Capper Andreas von Deimling

Acta Neuropathol Commun 2019 Oct 28;7(1):163. Epub 2019 Oct 28.

Department of Neuropathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s40478-019-0801-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816155PMC
October 2019

Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.

Authors:
Hiromichi Suzuki Sachin A Kumar Shimin Shuai Ander Diaz-Navarro Ana Gutierrez-Fernandez Pasqualino De Antonellis Florence M G Cavalli Kyle Juraschka Hamza Farooq Ichiyo Shibahara Maria C Vladoiu Jiao Zhang Namal Abeysundara David Przelicki Patryk Skowron Nicole Gauer Betty Luu Craig Daniels Xiaochong Wu Antoine Forget Ali Momin Jun Wang Weifan Dong Seung-Ki Kim Wieslawa A Grajkowska Anne Jouvet Michelle Fèvre-Montange Maria Luisa Garrè Amulya A Nageswara Rao Caterina Giannini Johan M Kros Pim J French Nada Jabado Ho-Keung Ng Wai Sang Poon Charles G Eberhart Ian F Pollack James M Olson William A Weiss Toshihiro Kumabe Enrique López-Aguilar Boleslaw Lach Maura Massimino Erwin G Van Meir Joshua B Rubin Rajeev Vibhakar Lola B Chambless Noriyuki Kijima Almos Klekner László Bognár Jennifer A Chan Claudia C Faria Jiannis Ragoussis Stefan M Pfister Anna Goldenberg Robert J Wechsler-Reya Swneke D Bailey Livia Garzia A Sorana Morrissy Marco A Marra Xi Huang David Malkin Olivier Ayrault Vijay Ramaswamy Xose S Puente John A Calarco Lincoln Stein Michael D Taylor

Nature 2019 Oct 9;574(7780):707-711. Epub 2019 Oct 9.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-019-1650-0DOI Listing
October 2019

Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series.

Authors:
Martin Benesch Martin Mynarek Hendrik Witt Monika Warmuth-Metz Torsten Pietsch Brigitte Bison Stefan M Pfister Kristian W Pajtler Marcel Kool Ulrich Schüller Klaus Pietschmann Björn-Ole Juhnke Stephan Tippelt Gudrun Fleischhack Irene Schmid Christof M Kramm Peter Vorwerk Andreas Beilken Carl Friedrich Classen Pablo Hernáiz Driever Gabriele Kropshofer Thomas Imschweiler Andreas Lemmer Rolf-Dieter Kortmann Stefan Rutkowski Katja von Hoff

Oncologist 2019 Sep 8;24(9):e921-e929. Epub 2019 Mar 8.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
Publisher Site
http://dx.doi.org/10.1634/theoncologist.2018-0489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738295PMC
September 2019

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.

Authors:
Miller Huang Jignesh Tailor Qiqi Zhen Aaron H Gillmor Matthew L Miller Holger Weishaupt Justin Chen Tina Zheng Emily K Nash Lauren K McHenry Zhenyi An Fubaiyang Ye Yasuhiro Takashima James Clarke Harold Ayetey Florence M G Cavalli Betty Luu Branden S Moriarity Shirin Ilkhanizadeh Lukas Chavez Chunying Yu Kathreena M Kurian Thierry Magnaldo Nicolas Sevenet Philipp Koch Steven M Pollard Peter Dirks Michael P Snyder David A Largaespada Yoon Jae Cho Joanna J Phillips Fredrik J Swartling A Sorana Morrissy Marcel Kool Stefan M Pfister Michael D Taylor Austin Smith William A Weiss

Cell Stem Cell 2019 Sep 13;25(3):433-446.e7. Epub 2019 Jun 13.

Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Departments of Pediatrics, Neurosurgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731167PMC
September 2019

Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1.

Authors:
Philipp Sievers Romain Appay Daniel Schrimpf Damian Stichel David E Reuss Annika K Wefers Annekathrin Reinhardt Roland Coras Viktoria C Ruf Simone Schmid Karin de Stricker Henning B Boldt Bjarne Winther Kristensen Jeanette Krogh Petersen Benedicte P Ulhøi Maria Gardberg Eleonora Aronica Martin Hasselblatt Wolfgang Brück Franck Bielle Karima Mokhtari Benoît Lhermitte Wolfgang Wick Christel Herold-Mende Daniel Hänggi Sebastian Brandner Felice Giangaspero David Capper Elisabeth Rushing Pieter Wesseling Stefan M Pfister Dominique Figarella-Branger Andreas von Deimling Felix Sahm David T W Jones

Acta Neuropathol 2019 Sep 27;138(3):497-504. Epub 2019 Jun 27.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02038-4DOI Listing
September 2019

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis.

Authors:
Kristian W Pajtler Yiju Wei Konstantin Okonechnikov Patricia B G Silva Mikaella Vouri Lei Zhang Sebastian Brabetz Laura Sieber Melissa Gulley Monika Mauermann Tatjana Wedig Norman Mack Yuka Imamura Kawasawa Tanvi Sharma Marc Zuckermann Felipe Andreiuolo Eric Holland Kendra Maass Huiqin Körkel-Qu Hai-Kun Liu Felix Sahm David Capper Jens Bunt Linda J Richards David T W Jones Andrey Korshunov Lukas Chavez Peter Lichter Mikio Hoshino Stefan M Pfister Marcel Kool Wei Li Daisuke Kawauchi

Nat Commun 2019 Sep 2;10(1):3914. Epub 2019 Sep 2.

Hopp-Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41467-019-11884-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718408PMC
September 2019

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

Authors:
Annika K Wefers Damian Stichel Daniel Schrimpf Roland Coras Mélanie Pages Arnault Tauziède-Espariat Pascale Varlet Daniel Schwarz Figen Söylemezoglu Ute Pohl José Pimentel Jochen Meyer Ekkehard Hewer Anna Japp Abhijit Joshi David E Reuss Annekathrin Reinhardt Philipp Sievers M Belén Casalini Azadeh Ebrahimi Kristin Huang Christian Koelsche Hu Liang Low Olinda Rebelo Dina Marnoto Albert J Becker Ori Staszewski Michel Mittelbronn Martin Hasselblatt Jens Schittenhelm Edmund Cheesman Ricardo Santos de Oliveira Rosane Gomes P Queiroz Elvis Terci Valera Volkmar H Hans Andrey Korshunov Adriana Olar Keith L Ligon Stefan M Pfister Zane Jaunmuktane Sebastian Brandner Ruth G Tatevossian David W Ellison Thomas S Jacques Mrinalini Honavar Eleonora Aronica Maria Thom Felix Sahm Andreas von Deimling David T W Jones Ingmar Blumcke David Capper

Acta Neuropathol 2019 Sep 28. Epub 2019 Sep 28.

Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1007/s00401-019-02078-wDOI Listing
September 2019

Challenges to curing primary brain tumours.

Authors:
Kenneth Aldape Kevin M Brindle Louis Chesler Rajesh Chopra Amar Gajjar Mark R Gilbert Nicholas Gottardo David H Gutmann Darren Hargrave Eric C Holland David T W Jones Johanna A Joyce Pamela Kearns Mark W Kieran Ingo K Mellinghoff Melinda Merchant Stefan M Pfister Steven M Pollard Vijay Ramaswamy Jeremy N Rich Giles W Robinson David H Rowitch John H Sampson Michael D Taylor Paul Workman Richard J Gilbertson

Nat Rev Clin Oncol 2019 08;16(8):509-520

CRUK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK.

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http://www.nature.com/articles/s41571-019-0177-5
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http://dx.doi.org/10.1038/s41571-019-0177-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650350PMC
August 2019

Molecular progression of SHH-activated medulloblastomas.

Authors:
Andrey Korshunov Konstantin Okonechnikov Felix Sahm Marina Ryzhova Damian Stichel Philipp Sievers Jochen Meyer Daniel Schrimpf Olga Zheludkova Andrey Golanov Peter Lichter David T W Jones Stefan M Pfister Andreas von Deimling Marcel Kool

Acta Neuropathol 2019 Aug 27;138(2):327-330. Epub 2019 Apr 27.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02022-yDOI Listing
August 2019

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma.

Authors:
Nagarajan Paramasivam Daniel Hübschmann Umut H Toprak Naveed Ishaque Marian Neidert Daniel Schrimpf Damian Stichel David Reuss Philipp Sievers Annekathrin Reinhardt Annika K Wefers David T W Jones Zuguang Gu Johannes Werner Sebastian Uhrig Hans-Georg Wirsching Matthias Schick Melanie Bewerunge-Hudler Katja Beck Stephanie Brehmer Steffi Urbschat Marcel Seiz-Rosenhagen Daniel Hänggi Christel Herold-Mende Ralf Ketter Roland Eils Zvi Ram Stefan M Pfister Wolfgang Wick Michael Weller Rachel Grossmann Andreas von Deimling Matthias Schlesner Felix Sahm

Acta Neuropathol 2019 Aug 8;138(2):295-308. Epub 2019 May 8.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-02008-wDOI Listing
August 2019

Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes.

Authors:
Tanvi Sharma Edward C Schwalbe Daniel Williamson Martin Sill Volker Hovestadt Martin Mynarek Stefan Rutkowski Giles W Robinson Amar Gajjar Florence Cavalli Vijay Ramaswamy Michael D Taylor Janet C Lindsey Rebecca M Hill Natalie Jäger Andrey Korshunov Debbie Hicks Simon Bailey Marcel Kool Lukas Chavez Paul A Northcott Stefan M Pfister Steven C Clifford

Acta Neuropathol 2019 Aug 10;138(2):309-326. Epub 2019 May 10.

Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00401-019-02020-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660496PMC
August 2019

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.

Authors:
Kenneth Aldape Kevin M Brindle Louis Chesler Rajesh Chopra Amar Gajjar Mark R Gilbert Nicholas Gottardo David H Gutmann Darren Hargrave Eric C Holland David T W Jones Johanna A Joyce Pamela Kearns Mark W Kieran Ingo K Mellinghoff Melinda Merchant Stefan M Pfister Steven M Pollard Vijay Ramaswamy Jeremy N Rich Giles W Robinson David H Rowitch John H Sampson Michael D Taylor Paul Workman Richard J Gilbertson

Nat Rev Clin Oncol 2019 08;16(8):522-523

CRUK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1038/s41571-019-0236-yDOI Listing
August 2019

Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours.

Authors:
David T W Jones Ana Banito Thomas G P Grünewald Michelle Haber Natalie Jäger Marcel Kool Till Milde Jan J Molenaar Arash Nabbi Trevor J Pugh Gudrun Schleiermacher Malcolm A Smith Frank Westermann Stefan M Pfister

Nat Rev Cancer 2019 Aug 12;19(8):420-438. Epub 2019 Jul 12.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41568-019-0169-xDOI Listing
August 2019

Resolving medulloblastoma cellular architecture by single-cell genomics.

Authors:
Volker Hovestadt Kyle S Smith Laure Bihannic Mariella G Filbin McKenzie L Shaw Alicia Baumgartner John C DeWitt Andrew Groves Lisa Mayr Hannah R Weisman Alyssa R Richman Marni E Shore Liliana Goumnerova Celeste Rosencrance Robert A Carter Timothy N Phoenix Jennifer L Hadley Yiai Tong Jim Houston Richard A Ashmun Michael DeCuypere Tanvi Sharma Diane Flasch Antonina Silkov Keith L Ligon Scott L Pomeroy Miguel N Rivera Orit Rozenblatt-Rosen Jessica M Rusert Robert J Wechsler-Reya Xiao-Nan Li Andreas Peyrl Johannes Gojo Dominik Kirchhofer Daniela Lötsch Thomas Czech Christian Dorfer Christine Haberler Rene Geyeregger Angela Halfmann Charles Gawad John Easton Stefan M Pfister Aviv Regev Amar Gajjar Brent A Orr Irene Slavc Giles W Robinson Bradley E Bernstein Mario L Suvà Paul A Northcott

Nature 2019 08 24;572(7767):74-79. Epub 2019 Jul 24.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/s41586-019-1434-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754173PMC
August 2019

RF_Purify: a novel tool for comprehensive analysis of tumor-purity in methylation array data based on random forest regression.

Authors:
Pascal David Johann Natalie Jäger Stefan M Pfister Martin Sill

BMC Bioinformatics 2019 Aug 16;20(1):428. Epub 2019 Aug 16.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12859-019-3014-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697926PMC
August 2019

EORTC SPECTA-AYA: A unique molecular profiling platform for adolescents and young adults with cancer in Europe.

Authors:
Teresa de Rojas Bernd Kasper Winette Van der Graaf Stefan M Pfister Franck Bielle Teresa Ribalta Patrick Shenjere Matthias Preusser Stefan Fröhling Vassilis Golfinopoulos Marie Morfouace Martin G McCabe

Int J Cancer 2019 Aug 29. Epub 2019 Aug 29.

Division of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/ijc.32651DOI Listing
August 2019

Molecular correlates of cerebellar mutism syndrome in medulloblastoma.

Authors:
Rashad Jabarkheel Nisreen Amayiri Derek Yecies Yuhao Huang Sebastian Toescu Liana Nobre Donald J Mabbott Sniya V Sudhakar Prateek Malik Suzanne Laughlin Maisa Swaidan Maysa Al Hussaini Awni Musharbash Geeta Chacko Leni G Mathew Paul G Fisher Darren Hargrave Ute Bartels Uri Tabori Stefan M Pfister Kristian Aquilina Michael D Taylor Gerald A Grant Eric Bouffet Kshitij Mankad Kristen W Yeom Vijay Ramaswamy

Neuro Oncol 2019 Aug 23. Epub 2019 Aug 23.

Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON.

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http://dx.doi.org/10.1093/neuonc/noz158DOI Listing
August 2019

Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.

Authors:
Jason Fangusaro Arzu Onar-Thomas Tina Young Poussaint Shengjie Wu Azra H Ligon Neal Lindeman Anuradha Banerjee Roger J Packer Lindsay B Kilburn Stewart Goldman Ian F Pollack Ibrahim Qaddoumi Regina I Jakacki Paul G Fisher Girish Dhall Patricia Baxter Susan G Kreissman Clinton F Stewart David T W Jones Stefan M Pfister Gilbert Vezina Jessica S Stern Ashok Panigrahy Zoltan Patay Benita Tamrazi Jeremy Y Jones Sofia S Haque David S Enterline Soonmee Cha Michael J Fisher Laurence Austin Doyle Malcolm Smith Ira J Dunkel Maryam Fouladi

Lancet Oncol 2019 Jul 28;20(7):1011-1022. Epub 2019 May 28.

Department of Haematology and Oncology, Cincinnati Children's Hospital, Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/S1470-2045(19)30277-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628202PMC
July 2019

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles.

Authors:
Andrey Korshunov Felix Sahm Konstantin Okonechnikov Marina Ryzhova Damian Stichel Daniel Schrimpf Belen Casalini Philipp Sievers Jochen Meyer Olga Zheludkova Andrey Golanov Peter Lichter David T W Jones Stefan M Pfister Marcel Kool Andreas von Deimling

Acta Neuropathol 2019 Jun 2;137(6):1003-1015. Epub 2019 Mar 2.

Clinical Cooperation Unit Neuropathology (B300), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-01981-6DOI Listing
June 2019

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Authors:
Elke Pfaff Ahmed El Damaty Gnana Prakash Balasubramanian Mirjam Blattner-Johnson Barbara C Worst Sebastian Stark Hendrik Witt Kristian W Pajtler Cornelis M van Tilburg Ruth Witt Till Milde Martin Jakobs Petra Fiesel Michael C Frühwald Pablo Hernáiz Driever Ulrich W Thomale Martin U Schuhmann Markus Metzler Konrad Bochennek Thorsten Simon Matthias Dürken Michael Karremann Stephanie Knirsch Martin Ebinger André O von Bueren Torsten Pietsch Christel Herold-Mende David E Reuss Karl Kiening Peter Lichter Angelika Eggert Christof M Kramm Stefan M Pfister David T W Jones Heidi Bächli Olaf Witt

Eur J Cancer 2019 Jun 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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June 2019

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.

Authors:
Pratiti Bandopadhayay Federica Piccioni Ryan O'Rourke Patricia Ho Elizabeth M Gonzalez Graham Buchan Kenin Qian Gabrielle Gionet Emily Girard Margo Coxon Matthew G Rees Lisa Brenan Frank Dubois Ofer Shapira Noah F Greenwald Melanie Pages Amanda Balboni Iniguez Brenton R Paolella Alice Meng Claire Sinai Giovanni Roti Neekesh V Dharia Amanda Creech Benjamin Tanenbaum Prasidda Khadka Adam Tracy Hong L Tiv Andrew L Hong Shannon Coy Rumana Rashid Jia-Ren Lin Glenn S Cowley Fred C Lam Amy Goodale Yenarae Lee Kathleen Schoolcraft Francisca Vazquez William C Hahn Aviad Tsherniak James E Bradner Michael B Yaffe Till Milde Stefan M Pfister Jun Qi Monica Schenone Steven A Carr Keith L Ligon Mark W Kieran Sandro Santagata James M Olson Prafulla C Gokhale Jacob D Jaffe David E Root Kimberly Stegmaier Cory M Johannessen Rameen Beroukhim

Nat Commun 2019 06 3;10(1):2400. Epub 2019 Jun 3.

Broad Institute of MIT and Harvard, Cambridge, USA.

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http://dx.doi.org/10.1038/s41467-019-10307-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546744PMC
June 2019

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging.

Authors:
Mélanie Pagès Kristian W Pajtler Stéphanie Puget David Castel Nathalie Boddaert Arnault Tauziède-Espariat Stéphanie Picot Marie-Anne Debily Marcel Kool David Capper Christian Sainte-Rose Fabrice Chrétien Stefan M Pfister Torsten Pietsch Jacques Grill Pascale Varlet Felipe Andreiuolo

Brain Pathol 2019 05 28;29(3):325-335. Epub 2018 Nov 28.

Department of Neuropathology, Sainte-Anne Hospital, Paris, France.

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http://dx.doi.org/10.1111/bpa.12664DOI Listing
May 2019

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA.

Authors:
Yanghao Hou Jorge Pinheiro Felix Sahm David E Reuss Daniel Schrimpf Damian Stichel Belén Casalini Christian Koelsche Philipp Sievers Annika K Wefers Annekathrin Reinhardt Azadeh Ebrahimi Francisco Fernández-Klett Stefan Pusch Jochen Meier Leonille Schweizer Werner Paulus Marco Prinz Christian Hartmann Karl H Plate Guido Reifenberger Torsten Pietsch Pascale Varlet Mélanie Pagès Ulrich Schüller David Scheie Karin de Stricker Stephan Frank Jürgen Hench Bianca Pollo Sebastian Brandner Andreas Unterberg Stefan M Pfister David T W Jones Andrey Korshunov Wolfgang Wick David Capper Ingmar Blümcke Andreas von Deimling Luca Bertero

Acta Neuropathol 2019 May 13;137(5):837-846. Epub 2019 Feb 13.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-019-01969-2DOI Listing
May 2019

DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.

Authors:
Christian Koelsche Mark Kriegsmann Felix K F Kommoss Damian Stichel Katharina Kriegsmann Christian Vokuhl Thomas G P Grünewald Laura Romero-Pérez Thomas Kirchner Enrique de Alava Juan Diaz-Martin Wolfgang Hartmann Daniel Baumhoer Cristina R Antonescu Karoly Szuhai Uta Flucke Uta Dirksen Stefan M Pfister David T W Jones Gunhild Mechtersheimer Andreas von Deimling

J Cancer Res Clin Oncol 2019 May 20;145(5):1273-1281. Epub 2019 Mar 20.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00432-019-02895-2DOI Listing
May 2019

Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1.

Authors:
Christian Thomas Friederike Knerlich-Lukoschus Harald Reinhard Pascal D Johann Dominik Sturm Felix Sahm Susanne Bens Julia Vogt Karolina Nemes Florian Oyen Uwe Kordes Reiner Siebert Reinhard Schneppenheim Martina Messing-Jünger Torsten Pietsch Andreas von Deimling Werner Paulus Stefan M Pfister Marcel Kool Michael C Frühwald Martin Hasselblatt

Acta Neuropathol 2019 May 3;137(5):847-850. Epub 2019 Apr 3.

Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany.

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http://dx.doi.org/10.1007/s00401-019-02001-3DOI Listing
May 2019

TelomereHunter - in silico estimation of telomere content and composition from cancer genomes.

Authors:
Lars Feuerbach Lina Sieverling Katharina I Deeg Philip Ginsbach Barbara Hutter Ivo Buchhalter Paul A Northcott Sadaf S Mughal Priya Chudasama Hanno Glimm Claudia Scholl Peter Lichter Stefan Fröhling Stefan M Pfister David T W Jones Karsten Rippe Benedikt Brors

BMC Bioinformatics 2019 May 28;20(1):272. Epub 2019 May 28.

Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12859-019-2851-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540518PMC
May 2019

Prevalence and quantification of contamination of knitted cotton outer gloves during hip and knee arthroplasty surgery.

Authors:
Thorsten Wichmann T Fintan Moriarty Iris Keller Stefan Pfister Vanessa Deggim-Messmer Emanuel Gautier Fabian Kalberer Peter P Koch Peter Wahl

Arch Orthop Trauma Surg 2019 Apr 7;139(4):451-459. Epub 2018 Nov 7.

Division of Orthopaedics and Traumatology, Cantonal Hospital Winterthur, Brauerstrasse 15, P.O. Box 834, 8401, Winterthur, Switzerland.

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http://link.springer.com/10.1007/s00402-018-3061-3
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April 2019

cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF mutation.

Authors:
David W Ellison Cynthia Hawkins David T W Jones Arzu Onar-Thomas Stefan M Pfister Guido Reifenberger David N Louis

Acta Neuropathol 2019 Apr 8;137(4):683-687. Epub 2019 Mar 8.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00401-019-01987-0DOI Listing
April 2019

DECIPHER pooled shRNA library screen identifies PP2A and FGFR signaling as potential therapeutic targets for DIPGs.

Authors:
Kathrin Schramm Murat Iskar Britta Statz Natalie Jäger Daniel Haag Mikołaj Słabicki Stefan M Pfister Marc Zapatka Jan Gronych David T W Jones Peter Lichter

Neuro Oncol 2019 Apr 3. Epub 2019 Apr 3.

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noz057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620639PMC
April 2019

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma.

Authors:
Juliane L Buhl Florian Selt Thomas Hielscher Romain Guiho Jonas Ecker Felix Sahm Johannes Ridinger Dennis Riehl Diren Usta Britta Ismer Alexander C Sommerkamp J P Martinez-Barbera Annika K Wefers Marc Remke Daniel Picard Stefan Pusch Jan Gronych Ina Oehme Cornelis M van Tilburg Marcel Kool Daniela Kuhn David Capper Andreas von Deimling Martin U Schuhmann Christel Herold-Mende Andrey Korshunov Tilman Brummer Stefan M Pfister David T W Jones Olaf Witt Till Milde

Clin Cancer Res 2019 Mar 7;25(6):1851-1866. Epub 2018 Dec 7.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1965DOI Listing
March 2019

Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1.

Authors:
Julieann C Lee Javier E Villanueva-Meyer Sean P Ferris Emily A Sloan Jeffrey W Hofmann Eyas M Hattab Brian J Williams Hua Guo Joseph Torkildson Adriana Florez Jessica Van Ziffle Courtney Onodera James P Grenert Soo-Jin Cho Andrew E Horvai David T W Jones Stefan M Pfister Christian Koelsche Andreas von Deimling Andrey Korshunov Arie Perry David A Solomon

Acta Neuropathol 2019 Mar 16;137(3):521-525. Epub 2019 Jan 16.

Department of Pathology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s00401-019-01960-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408274PMC
March 2019

EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.

Authors:
Jens-Martin Hübner Torsten Müller Dimitris N Papageorgiou Monika Mauermann Jeroen Krijgsveld Robert B Russell David W Ellison Stefan M Pfister Kristian W Pajtler Marcel Kool

Neuro Oncol 2019 Mar 29. Epub 2019 Mar 29.

Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. (J.-M.H., M.M., S.M.P., K.W.P. and M.K.).

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noz058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620627PMC
March 2019

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas.

Authors:
Andrey Korshunov Felix Sahm Olga Zheludkova Andrey Golanov Damian Stichel Daniel Schrimpf Marina Ryzhova Alexander Potapov Antje Habel Jochen Meyer Peter Lichter David T W Jones Andreas von Deimling Stefan M Pfister Marcel Kool

Neuro Oncol 2019 02;21(2):214-221

Hopp Children's Cancer Center at the National Center for Tumor Diseases Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noy155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374763PMC
February 2019

Medulloblastoma.

Authors:
Paul A Northcott Giles W Robinson Christian P Kratz Donald J Mabbott Scott L Pomeroy Steven C Clifford Stefan Rutkowski David W Ellison David Malkin Michael D Taylor Amar Gajjar Stefan M Pfister

Nat Rev Dis Primers 2019 02 14;5(1):11. Epub 2019 Feb 14.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41572-019-0063-6DOI Listing
February 2019

Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre.

Authors:
Zane Jaunmuktane David Capper David T W Jones Daniel Schrimpf Martin Sill Monika Dutt Nirosha Suraweera Stefan M Pfister Andreas von Deimling Sebastian Brandner

Acta Neuropathol Commun 2019 02 20;7(1):24. Epub 2019 Feb 20.

Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK.

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-019-0668-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381711PMC
February 2019

Translating genomic medicine to the clinic: challenges and opportunities.

Authors:
Huan Zhang Lars Klareskog Andreas Matussek Stefan M Pfister Mikael Benson

Genome Med 2019 02 22;11(1). Epub 2019 Feb 22.

Centre for Personalised Medicine, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1186/s13073-019-0622-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385380PMC
February 2019

Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype.

Authors:
Christian Koelsche Damian Stichel Klaus G Griewank Daniel Schrimpf David E Reuss Melanie Bewerunge-Hudler Christian Vokuhl Winand N M Dinjens Iver Petersen Michel Mittelbronn Adrian Cuevas-Bourdier Rolf Buslei Stefan M Pfister Uta Flucke Gunhild Mechtersheimer Thomas Mentzel Andreas von Deimling

Clin Sarcoma Res 2019 14;9. Epub 2019 Feb 14.

2Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Baden-Württemberg Germany.

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https://clinicalsarcomaresearch.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s13569-019-0113-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375211PMC
February 2019

N2M2 (NOA-20) phase I/II trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma.

Authors:
Wolfgang Wick Susan Dettmer Anne Berberich Tobias Kessler Irini Karapanagiotou-Schenkel Antje Wick Frank Winkler Elke Pfaff Benedikt Brors Jürgen Debus Andreas Unterberg Martin Bendszus Christel Herold-Mende Andreas Eisenmenger Andreas von Deimling David T W Jones Stefan M Pfister Felix Sahm Michael Platten

Neuro Oncol 2019 01;21(1):95-105

Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKTK, DKFZ, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noy161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303534PMC
January 2019

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation.

Authors:
Serap Erkek Pascal D Johann Martina A Finetti Yiannis Drosos Hsien-Chao Chou Marc Zapatka Dominik Sturm David T W Jones Andrey Korshunov Marina Rhyzova Stephan Wolf Jan-Philipp Mallm Katja Beck Olaf Witt Andreas E Kulozik Michael C Frühwald Paul A Northcott Jan O Korbel Peter Lichter Roland Eils Amar Gajjar Charles W M Roberts Daniel Williamson Martin Hasselblatt Lukas Chavez Stefan M Pfister Marcel Kool

Cancer Cell 2019 01 27;35(1):95-110.e8. Epub 2018 Dec 27.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183053
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http://dx.doi.org/10.1016/j.ccell.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341227PMC
January 2019

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.

Authors:
Catherine Lee Vasilisa A Rudneva Serap Erkek Marc Zapatka Lianne Q Chau Silvia K Tacheva-Grigorova Alexandra Garancher Jessica M Rusert Ozlem Aksoy Robin Lea Helai P Mohammad Jianxun Wang William A Weiss H Leighton Grimes Stefan M Pfister Paul A Northcott Robert J Wechsler-Reya

Nat Commun 2019 01 18;10(1):332. Epub 2019 Jan 18.

Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.

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http://www.nature.com/articles/s41467-018-08269-5
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http://dx.doi.org/10.1038/s41467-018-08269-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338772PMC
January 2019

InTAD: chromosome conformation guided analysis of enhancer target genes.

Authors:
Konstantin Okonechnikov Serap Erkek Jan O Korbel Stefan M Pfister Lukas Chavez

BMC Bioinformatics 2019 Jan 31;20(1):60. Epub 2019 Jan 31.

Department of Medicine, Division of Medical Genetics, University of California San Diego (UCSD), San Diego, USA.

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-019-2655-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357397PMC
January 2019

Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p.

Authors:
Philipp Sievers Damian Stichel Thomas Hielscher Daniel Schrimpf Annekathrin Reinhardt Annika K Wefers David Reuss David T W Jones Melanie Bewerunge-Hudler Christian Hartmann Peter Baumgarten Hans-Georg Wirsching Bjarne Winther-Kristensen Benjamin Brokinkel Ralf Ketter Miguel Angel Idoate Gastearena Katrin Lamszus Marcel Seiz-Rosenhagen Christian Mawrin Patrick N Harter Jörg Felsberg Daniel Hänggi Christel Herold-Mende Anna Sophie Berghoff Michael Weller Stefan M Pfister Wolfgang Wick Guido Reifenberger Matthias Preusser Andreas von Deimling Felix Sahm

Acta Neuropathol 2018 12 31;136(6):975-978. Epub 2018 Oct 31.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00401-018-1924-x
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December 2018

DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment.

Authors:
Hendrik Witt Dorothee Gramatzki Bettina Hentschel Kristian W Pajtler Jörg Felsberg Gabriele Schackert Markus Löffler David Capper Felix Sahm Martin Sill Andreas von Deimling Marcel Kool Ulrich Herrlinger Manfred Westphal Torsten Pietsch Guido Reifenberger Stefan M Pfister Jörg C Tonn Michael Weller

Neuro Oncol 2018 11;20(12):1616-1624

Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1093/neuonc/noy118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231197PMC
November 2018

Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.

Authors:
Damian Stichel Azadeh Ebrahimi David Reuss Daniel Schrimpf Takahiro Ono Mitsuaki Shirahata Guido Reifenberger Michael Weller Daniel Hänggi Wolfgang Wick Christel Herold-Mende Manfred Westphal Sebastian Brandner Stefan M Pfister David Capper Felix Sahm Andreas von Deimling

Acta Neuropathol 2018 11 5;136(5):793-803. Epub 2018 Sep 5.

Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1905-0DOI Listing
November 2018

A biobank of patient-derived pediatric brain tumor models.

Authors:
Sebastian Brabetz Sarah E S Leary Susanne N Gröbner Madison W Nakamoto Huriye Şeker-Cin Emily J Girard Bonnie Cole Andrew D Strand Karina L Bloom Volker Hovestadt Norman L Mack Fiona Pakiam Benjamin Schwalm Andrey Korshunov Gnana Prakash Balasubramanian Paul A Northcott Kyle D Pedro Joyoti Dey Stacey Hansen Sally Ditzler Peter Lichter Lukas Chavez David T W Jones Jan Koster Stefan M Pfister Marcel Kool James M Olson

Nat Med 2018 11 22;24(11):1752-1761. Epub 2018 Oct 22.

Seattle Children's and University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41591-018-0207-3DOI Listing
November 2018

Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location.

Authors:
David Castel Cathy Philippe Thomas Kergrohen Martin Sill Jane Merlevede Emilie Barret Stéphanie Puget Christian Sainte-Rose Christof M Kramm Chris Jones Pascale Varlet Stefan M Pfister Jacques Grill David T W Jones Marie-Anne Debily

Acta Neuropathol Commun 2018 11 5;6(1):117. Epub 2018 Nov 5.

UMR8203,Vectorologie et Nouvelles Thérapies Anticancéreuses, CNRS, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France.

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http://dx.doi.org/10.1186/s40478-018-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219253PMC
November 2018

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors.

Authors:
Manasi Ratnaparkhe John K L Wong Pei-Chi Wei Mario Hlevnjak Thorsten Kolb Milena Simovic Daniel Haag Yashna Paul Frauke Devens Paul Northcott David T W Jones Marcel Kool Anna Jauch Agata Pastorczak Wojciech Mlynarski Andrey Korshunov Rajiv Kumar Susanna M Downing Stefan M Pfister Marc Zapatka Peter J McKinnon Frederick W Alt Peter Lichter Aurélie Ernst

Nat Commun 2018 11 12;9(1):4760. Epub 2018 Nov 12.

Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.

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http://dx.doi.org/10.1038/s41467-018-06925-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232171PMC
November 2018

Limitations of current models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma.

Authors:
Hazel Anne Rogers Rebecca Chapman Holly Kings Julie Allard Jodie Barron-Hastings Kristian W Pajtler Martin Sill Stefan Pfister Richard Guy Grundy

Oncotarget 2018 Nov 23;9(92):36530-36541. Epub 2018 Nov 23.

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

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http://www.oncotarget.com/fulltext/26370
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http://dx.doi.org/10.18632/oncotarget.26370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284855PMC
November 2018

Molecular Diagnostics in Pediatric Brain Tumors: Impact on Diagnosis and Clinical Decision-Making - A Selected Case Series.

Authors:
Heidi Bächli Jonas Ecker Cornelis van Tilburg Dominik Sturm Florian Selt Felix Sahm Christian Koelsche Kerstin Grund Christian Sutter Torsten Pietsch Hendrik Witt Christel Herold-Mende Andreas von Deimling David Jones Stefan Pfister Olaf Witt Till Milde

Klin Padiatr 2018 Oct 11;230(6):305-313. Epub 2018 Jul 11.

KiTZ Clinical Trial Unit (ZIPO), Hopp-Kindertumorzentrum am NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1055/a-0637-9653DOI Listing
October 2018

Voxel-wise radiogenomic mapping of tumor location with key molecular alterations in patients with glioma.

Authors:
Miguel Angel Tejada Neyra Ulf Neuberger Annekathrin Reinhardt Gianluca Brugnara David Bonekamp Martin Sill Antje Wick David T W Jones Alexander Radbruch Andreas Unterberg Jürgen Debus Sabine Heiland Heinz-Peter Schlemmer Christel Herold-Mende Stefan Pfister Andreas von Deimling Wolfgang Wick David Capper Martin Bendszus Philipp Kickingereder

Neuro Oncol 2018 10;20(11):1517-1524

Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/noy134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176804PMC
October 2018

Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial.

Authors:
Eugene I Hwang Marcel Kool Peter C Burger David Capper Lukas Chavez Sebastian Brabetz Chris Williams-Hughes Catherine Billups Linda Heier Alok Jaju Jeff Michalski Yimei Li Sarah Leary Tianni Zhou Andreas von Deimling David T W Jones Maryam Fouladi Ian F Pollack Amar Gajjar Roger J Packer Stefan M Pfister James M Olson

J Clin Oncol 2018 Oct 17:JCO2017764720. Epub 2018 Oct 17.

Eugene I. Hwang and Roger J. Packer, Children's National Medical Center, Washington, DC; Marcel Kool, Lukas Chavez, Sebastian Brabetz, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; David Capper, Andreas von Deimling, and Stefan M. Pfister, University Hospital Heidelberg; Stefan M. Pfister, National Center for Tumor Diseases, Heidelberg; David Capper, Charité Medical University, Berlin, Germany; Peter C. Burger, Johns Hopkins University, Baltimore, MD; Chris Williams-Hughes, Children's Oncology Group, Littleton, CO; Catherine Billups, Yimei Li, and Amar Gajjar, St Jude Children's Research Hospital, Memphis, TN; Linda Heier, Weill Cornell Medical College, New York, NY; Alok Jaju, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Jeff Michalski, Washington University School of Medicine, St. Louis, MO; Sarah Leary and James M. Olson, Seattle Children's Hospital and Research Institute; Sarah Leary and James M. Olson, Fred Hutchinson Cancer Research Center, Seattle, WA; Tianni Zhou, California State University, Long Beach, Long Beach, CA; Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Ian F. Pollack, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1200/JCO.2017.76.4720DOI Listing
October 2018

EGFL7 enhances surface expression of integrin αβ to promote angiogenesis in malignant brain tumors.

Authors:
Nevenka Dudvarski Stanković Frank Bicker Stefanie Keller David Tw Jones Patrick N Harter Arne Kienzle Clarissa Gillmann Philipp Arnold Anna Golebiewska Olivier Keunen Alf Giese Andreas von Deimling Tobias Bäuerle Simone P Niclou Michel Mittelbronn Weilan Ye Stefan M Pfister Mirko H Schmidt

EMBO Mol Med 2018 09;10(9)

Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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http://dx.doi.org/10.15252/emmm.201708420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127886PMC
September 2018

Correction to: DNA methylation-based reclassification of olfactory neuroblastoma.

Authors:
David Capper Nils W Engel Damian Stichel Matt Lechner Stefanie Glöss Simone Schmid Christian Kölsche Daniel Schrimpf Judith Niesen Annika K Wefers David T W Jones Martin Sill Oliver Weigert Keith L Ligon Adriana Olar Arend Koch Martin Forster Sebastian Moran Oscar M Tirado Miguel Sáinz-Jaspeado Jaume Mora Manel Esteller Javier Alonso Xavier Garcia Del Muro Werner Paulus Jörg Felsberg Guido Reifenberger Markus Glatzel Stephan Frank Camelia M Monoranu Valerie J Lund Andreas von Deimling Stefan Pfister Rolf Buslei Julika Ribbat-Idel Sven Perner Volker Gudziol Matthias Meinhardt Ulrich Schüller

Acta Neuropathol 2018 09;136(3):505

Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-018-1887-yDOI Listing
September 2018

Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling.

Authors:
Antoine Forget Loredana Martignetti Stéphanie Puget Laurence Calzone Sebastian Brabetz Daniel Picard Arnau Montagud Stéphane Liva Alexandre Sta Florent Dingli Guillaume Arras Jaime Rivera Damarys Loew Aurore Besnard Joëlle Lacombe Mélanie Pagès Pascale Varlet Christelle Dufour Hua Yu Audrey L Mercier Emilie Indersie Anaïs Chivet Sophie Leboucher Laura Sieber Kevin Beccaria Michael Gombert Frauke D Meyer Nan Qin Jasmin Bartl Lukas Chavez Konstantin Okonechnikov Tanvi Sharma Venu Thatikonda Franck Bourdeaut Celio Pouponnot Vijay Ramaswamy Andrey Korshunov Arndt Borkhardt Guido Reifenberger Patrick Poullet Michael D Taylor Marcel Kool Stefan M Pfister Daisuke Kawauchi Emmanuel Barillot Marc Remke Olivier Ayrault

Cancer Cell 2018 09;34(3):379-395.e7

Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France; Université Paris Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183035
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http://dx.doi.org/10.1016/j.ccell.2018.08.002DOI Listing
September 2018

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups.

Authors:
Tenley C Archer Tobias Ehrenberger Filip Mundt Maxwell P Gold Karsten Krug Clarence K Mah Elizabeth L Mahoney Colin J Daniel Alexander LeNail Divya Ramamoorthy Philipp Mertins D R Mani Hailei Zhang Michael A Gillette Karl Clauser Michael Noble Lauren C Tang Jessica Pierre-François Jacob Silterra James Jensen Pablo Tamayo Andrey Korshunov Stefan M Pfister Marcel Kool Paul A Northcott Rosalie C Sears Jonathan O Lipton Steven A Carr Jill P Mesirov Scott L Pomeroy Ernest Fraenkel

Cancer Cell 2018 09;34(3):396-410.e8

Eli and Edythe Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372116PMC
September 2018

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations.

Authors:
Annekathrin Reinhardt Damian Stichel Daniel Schrimpf Felix Sahm Andrey Korshunov David E Reuss Christian Koelsche Kristin Huang Annika K Wefers Volker Hovestadt Martin Sill Dorothee Gramatzki Joerg Felsberg Guido Reifenberger Arend Koch Ulrich-W Thomale Albert Becker Volkmar H Hans Marco Prinz Ori Staszewski Till Acker Hildegard Dohmen Christian Hartmann Wolf Mueller Muin S A Tuffaha Werner Paulus Katharina Heß Benjamin Brokinkel Jens Schittenhelm Camelia-Maria Monoranu Almuth Friederike Kessler Mario Loehr Rolf Buslei Martina Deckert Christian Mawrin Patricia Kohlhof Ekkehard Hewer Adriana Olar Fausto J Rodriguez Caterina Giannini Amulya A NageswaraRao Uri Tabori Nuno Miguel Nunes Michael Weller Ute Pohl Zane Jaunmuktane Sebastian Brandner Andreas Unterberg Daniel Hänggi Michael Platten Stefan M Pfister Wolfgang Wick Christel Herold-Mende David T W Jones Andreas von Deimling David Capper

Acta Neuropathol 2018 08 21;136(2):273-291. Epub 2018 Mar 21.

Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1837-8DOI Listing
August 2018

Molecular characterization of medulloblastomas with extensive nodularity (MBEN).

Authors:
Andrey Korshunov Felix Sahm Damian Stichel Daniel Schrimpf Marina Ryzhova Olga Zheludkova Andrey Golanov Peter Lichter David T W Jones Andreas von Deimling Stefan M Pfister Marcel Kool

Acta Neuropathol 2018 08 22;136(2):303-313. Epub 2018 Mar 22.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1840-0DOI Listing
August 2018

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information.

Authors:
Christian Koelsche Wolfgang Hartmann Daniel Schrimpf Damian Stichel Susanne Jabar Andreas Ranft David E Reuss Felix Sahm David T W Jones Melanie Bewerunge-Hudler Marcel Trautmann Thomas Klingebiel Christian Vokuhl Manfred Gessler Eva Wardelmann Iver Petersen Daniel Baumhoer Uta Flucke Cristina Antonescu Manel Esteller Stefan Fröhling Marcel Kool Stefan M Pfister Gunhild Mechtersheimer Uta Dirksen Andreas von Deimling

Mod Pathol 2018 08 23;31(8):1246-1256. Epub 2018 Mar 23.

Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41379-018-0045-3DOI Listing
August 2018

DNA methylation-based reclassification of olfactory neuroblastoma.

Authors:
David Capper Nils W Engel Damian Stichel Matt Lechner Stefanie Glöss Simone Schmid Christian Koelsche Daniel Schrimpf Judith Niesen Annika K Wefers David T W Jones Martin Sill Oliver Weigert Keith L Ligon Adriana Olar Arend Koch Martin Forster Sebastian Moran Oscar M Tirado Miguel Sáinz-Jaspeado Jaume Mora Manel Esteller Javier Alonso Xavier Garcia Del Muro Werner Paulus Jörg Felsberg Guido Reifenberger Markus Glatzel Stephan Frank Camelia M Monoranu Valerie J Lund Andreas von Deimling Stefan Pfister Rolf Buslei Julika Ribbat-Idel Sven Perner Volker Gudziol Matthias Meinhardt Ulrich Schüller

Acta Neuropathol 2018 08 5;136(2):255-271. Epub 2018 May 5.

Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-018-1854-7DOI Listing
August 2018

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features.

Authors:
Maximilian Y Deng Martin Sill Jason Chiang Jens Schittenhelm Martin Ebinger Martin U Schuhmann Camelia-Maria Monoranu Till Milde Andrea Wittmann Christian Hartmann Clemens Sommer Werner Paulus Jutta Gärtner Wolfgang Brück Thomas Rüdiger Alfred Leipold Zane Jaunmuktane Sebastian Brandner Felice Giangaspero Paolo Nozza Jaume Mora Andres Morales la Madrid Ofelia Cruz Martinez Jordan R Hansford Torsten Pietsch Anna Tietze Pablo Hernáiz-Driever Iris Stoler David Capper Andrey Korshunov David W Ellison Andreas von Deimling Stefan M Pfister Felix Sahm David T W Jones

Acta Neuropathol 2018 08 15;136(2):239-253. Epub 2018 May 15.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1865-4DOI Listing
August 2018

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.

Authors:
Christian Koelsche Martin Mynarek Daniel Schrimpf Luca Bertero Jonathan Serrano Felix Sahm David E Reuss Yanghao Hou Daniel Baumhoer Christian Vokuhl Uta Flucke Iver Petersen Wolfgang Brück Stefan Rutkowski Sandro Casavilca Zambrano Juan Luis Garcia Leon Rosdali Yesenia Diaz Coronado Manfred Gessler Oscar M Tirado Jaume Mora Javier Alonso Xavier Garcia Del Muro Manel Esteller Dominik Sturm Jonas Ecker Till Milde Stefan M Pfister Andrey Korshunov Matija Snuderl Gunhild Mechtersheimer Ulrich Schüller David T W Jones Andreas von Deimling

Acta Neuropathol 2018 08 7;136(2):327-337. Epub 2018 Jun 7.

Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1871-6DOI Listing
August 2018

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.

Authors:
Kristian W Pajtler Ji Wen Martin Sill Tong Lin Wilda Orisme Bo Tang Jens-Martin Hübner Vijay Ramaswamy Sujuan Jia James D Dalton Kelly Haupfear Hazel A Rogers Chandanamali Punchihewa Ryan Lee John Easton Gang Wu Timothy A Ritzmann Rebecca Chapman Lukas Chavez Fredrick A Boop Paul Klimo Noah D Sabin Robert Ogg Stephen C Mack Brian D Freibaum Hong Joo Kim Hendrik Witt David T W Jones Baohan Vo Amar Gajjar Stan Pounds Arzu Onar-Thomas Martine F Roussel Jinghui Zhang J Paul Taylor Thomas E Merchant Richard Grundy Ruth G Tatevossian Michael D Taylor Stefan M Pfister Andrey Korshunov Marcel Kool David W Ellison

Acta Neuropathol 2018 08 16;136(2):211-226. Epub 2018 Jun 16.

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00401-018-1877-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105278PMC
August 2018

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

Authors:
David Capper Damian Stichel Felix Sahm David T W Jones Daniel Schrimpf Martin Sill Simone Schmid Volker Hovestadt David E Reuss Christian Koelsche Annekathrin Reinhardt Annika K Wefers Kristin Huang Philipp Sievers Azadeh Ebrahimi Anne Schöler Daniel Teichmann Arend Koch Daniel Hänggi Andreas Unterberg Michael Platten Wolfgang Wick Olaf Witt Till Milde Andrey Korshunov Stefan M Pfister Andreas von Deimling

Acta Neuropathol 2018 08 2;136(2):181-210. Epub 2018 Jul 2.

Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1879-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060790PMC
August 2018

FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.

Authors:
Philipp Sievers Damian Stichel Daniel Schrimpf Felix Sahm Christian Koelsche David E Reuss Annika K Wefers Annekathrin Reinhardt Kristin Huang Azadeh Ebrahimi Yanghao Hou Kristian W Pajtler Stefan M Pfister Martin Hasselblatt Walter Stummer Uta Schick Christian Hartmann Christian Hagel Ori Staszewski Guido Reifenberger Rudi Beschorner Roland Coras Kathy Keyvani Patricia Kohlhof Francesca Diomedi-Camassei Christel Herold-Mende Felice Giangaspero Elisabeth Rushing Caterina Giannini Andrey Korshunov David T W Jones Andreas von Deimling

Acta Neuropathol 2018 08 5;136(2):293-302. Epub 2018 Jul 5.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-018-1882-3DOI Listing
August 2018

Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile.

Authors:
David A Solomon Andrey Korshunov Martin Sill David T W Jones Marcel Kool Stefan M Pfister Xuemo Fan Serguei Bannykh Jethro Hu Moise Danielpour Rong Li James Johnston Elaine Cham Tabitha Cooney Peter P Sun Nancy Ann Oberheim Bush Michael McDermott Jessica Van Ziffle Courtney Onodera James P Grenert Boris C Bastian Javier E Villanueva-Meyer Melike Pekmezci Andrew W Bollen Arie Perry

Acta Neuropathol 2018 08 13;136(2):339-343. Epub 2018 Jul 13.

Department of Pathology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s00401-018-1883-2DOI Listing
August 2018

Heterogeneity within the PF-EPN-B ependymoma subgroup.

Authors:
Florence M G Cavalli Jens-Martin Hübner Tanvi Sharma Betty Luu Martin Sill Michal Zapotocky Stephen C Mack Hendrik Witt Tong Lin David J H Shih Ben Ho Mariarita Santi Lyndsey Emery Juliette Hukin Christopher Dunham Roger E McLendon Eric S Lipp Sridharan Gururangan Andrew Grossbach Pim French Johan M Kros Marie-Lise C van Veelen Amulya A Nageswara Rao Caterina Giannini Sarah Leary Shin Jung Claudia C Faria Jaume Mora Ulrich Schüller Marta M Alonso Jennifer A Chan Almos Klekner Lola B Chambless Eugene I Hwang Maura Massimino Charles G Eberhart Matthias A Karajannis Benjamin Lu Linda M Liau Massimo Zollo Veronica Ferrucci Carlos Carlotti Daniela P C Tirapelli Uri Tabori Eric Bouffet Marina Ryzhova David W Ellison Thomas E Merchant Mark R Gilbert Terri S Armstrong Andrey Korshunov Stefan M Pfister Michael D Taylor Kenneth Aldape Kristian W Pajtler Marcel Kool Vijay Ramaswamy

Acta Neuropathol 2018 08 17;136(2):227-237. Epub 2018 Jul 17.

Programme in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s00401-018-1888-x
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http://dx.doi.org/10.1007/s00401-018-1888-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373486PMC
August 2018

Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group.

Authors:
Stefan Rutkowski Piergiorgio Modena Daniel Williamson Kornelius Kerl Karsten Nysom Barry Pizer Ute Bartels Stephanie Puget François Doz Antony Michalski Katja von Hoff Mathilde Chevignard Shivaram Avula Matthew J Murray Stefan Schönberger Thomas Czech Antoinette Y N Schouten-van Meeteren Uwe Kordes Christof M Kramm Dannis G van Vuurden Esther Hulleman Geert O Janssens Guirish A Solanki Marie-Luise C van Veelen Ulrich Thomale Martin U Schuhmann Chris Jones Felice Giangaspero Dominique Figarella-Branger Torsten Pietsch Steve C Clifford Stefan M Pfister Stefaan W Van Gool

Lancet Oncol 2018 08;19(8):e419-e428

IOZK Immune Oncological Centre Cologne, Cologne, Germany.

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http://dx.doi.org/10.1016/S1470-2045(18)30364-4DOI Listing
August 2018

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.

Authors:
Mitsuaki Shirahata Takahiro Ono Damian Stichel Daniel Schrimpf David E Reuss Felix Sahm Christian Koelsche Annika Wefers Annekathrin Reinhardt Kristin Huang Philipp Sievers Hiroaki Shimizu Hiroshi Nanjo Yusuke Kobayashi Yohei Miyake Tomonari Suzuki Jun-Ichi Adachi Kazuhiko Mishima Atsushi Sasaki Ryo Nishikawa Melanie Bewerunge-Hudler Marina Ryzhova Oksana Absalyamova Andrey Golanov Peter Sinn Michael Platten Christine Jungk Frank Winkler Antje Wick Daniel Hänggi Andreas Unterberg Stefan M Pfister David T W Jones Martin van den Bent Monika Hegi Pim French Brigitta G Baumert Roger Stupp Thierry Gorlia Michael Weller David Capper Andrey Korshunov Christel Herold-Mende Wolfgang Wick David N Louis Andreas von Deimling

Acta Neuropathol 2018 07 23;136(1):153-166. Epub 2018 Apr 23.

Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00401-018-1849-4
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http://dx.doi.org/10.1007/s00401-018-1849-4DOI Listing
July 2018

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

Authors:
Lindsey M Hoffman Sophie E M Veldhuijzen van Zanten Niclas Colditz Joshua Baugh Brooklyn Chaney Marion Hoffmann Adam Lane Christine Fuller Lili Miles Cynthia Hawkins Ute Bartels Eric Bouffet Stewart Goldman Sarah Leary Nicholas K Foreman Roger Packer Katherine E Warren Alberto Broniscer Mark W Kieran Jane Minturn Melanie Comito Emmett Broxson Chie-Schin Shih Soumen Khatua Murali Chintagumpala Anne Sophie Carret Nancy Yanez Escorza Timothy Hassall David S Ziegler Nicholas Gottardo Hetal Dholaria Renee Doughman Martin Benesch Rachid Drissi Javad Nazarian Nada Jabado Nathalie Boddaert Pascale Varlet Géraldine Giraud David Castel Stephanie Puget Chris Jones Esther Hulleman Piergiorgio Modena Marzia Giagnacovo Manila Antonelli Torsten Pietsch Gerrit H Gielen David T W Jones Dominik Sturm Stefan M Pfister Nicolas U Gerber Michael A Grotzer Elke Pfaff André O von Bueren Darren Hargrave Guirish A Solanki Filip Jadrijevic Cvrlje Gertjan J L Kaspers William P Vandertop Jacques Grill Simon Bailey Veronica Biassoni Maura Massimino Raphaël Calmon Esther Sanchez Brigitte Bison Monika Warmuth-Metz James Leach Blaise Jones Dannis G van Vuurden Christof M Kramm Maryam Fouladi

J Clin Oncol 2018 07 10;36(19):1963-1972. Epub 2018 May 10.

Lindsey M. Hoffman and Nicholas K. Foreman, University of Colorado Denver; Lindsey M. Hoffman and Nicholas K. Foreman, Children's Hospital Colorado, Aurora, CO; Sophie E.M. Veldhuijzen van Zanten, Esther Hulleman, Gertjan J.L. Kaspers, Esther Sanchez, and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; William P. Vandertop, Academy of Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Niclas Colditz, Marion Hoffmann, Brigitte Bison, Monika Warmuth-Metz, and Christof M. Kramm, University Medical Center Goettingen, Goettingen; Torsten Pietsch and Gerrit H. Gielen, University of Bonn Medical Center, Bonn; David T.W. Jones, Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, German Cancer Research Center, Hopp-Children's Cancer Center at the Nationale Centrum für Tumorerkrankungen Heidelberg, and German Consortium for Translational Cancer Research; Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, Heidelberg University Hospital, Heidelberg, Germany; Joshua Baugh, Brooklyn Chaney, Adam Lane, Christine Fuller, Nancy Yanez Escorza, Renee Doughman, Rachid Drissi, James Leach, Blaise Jones, and Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati; Emmett Broxson, Wright State University and The Children's Medical Center, Dayton, OH; Lili Miles, Nemours Children's Hospital, Orlando, FL; Cynthia Hawkins, Ute Bartels, and Eric Bouffet, The Hospital for Sick Children, Toronto, Ontario; Anne Sophie Carret, Centre Hospitalier Universitaire Sainte-Justine; Nada Jabado, McGill University, Montreal, Quebec, Canada; Stewart Goldman, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL; Sarah Leary, Seattle Children's Hospital, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA; Roger Packer, Children's National Health System; Javad Nazarian, Children's National Medical Center, Washington, DC; Katherine E. Warren, National Cancer Institute, Bethesda, MD; Alberto Broniscer, St Jude Children's Research Hospital, Memphis, TN; Mark W. Kieran, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA; Jane Minturn, Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia; Melanie Comito, The Pennsylvania State University, Hershey, PA; Chie-Schin Shih, Indiana University, Indianapolis, IN; Soumen Khatua, The University of Texas MD Anderson Cancer Center; Murali Chintagumpala, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX; Timothy Hassall, Lady Cilento Children's Hospital, Brisbane, Queensland; David S. Ziegler, Kids Cancer Centre, Sydney Children's Hospital, Randwick; David S. Ziegler, University of New South Wales, Sydney, New South Wales; Nicholas Gottardo and Hetal Dholaria, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; Martin Benesch, Medical University of Graz, Graz, Austria; Nathalie Boddaert. Stephanie Puget, and Raphaël Calmon, Hôpital Necker Enfants Malades; Pascale Varlet, Hôpital Sainte-Anne, Université Paris V Descartes, Sorbonne Paris Cité, Paris; Géraldine Giraud, David Castel, and Jacques Grill, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, Villejuif, France; Géraldine Giraud, Uppsala University, Uppsala, Sweden; Chris Jones, The Institute of Cancer Research, Sutton; Darren Hargrave, Great Ormond Street Hospital, London; Guirish A. Solanki, Birmingham Women's and Children's Hospital, Birmingham; Simon Bailey, Great North Children's Hospital, Victoria Wing, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom; Piergiorgio Modena and Marzia Giagnacovo, Sant' Anna Como General Hospital, Como; Manila Antonelli, Sapienza University of Rome, Rome; Veronica Biassoni and Maura Massimino, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy; Nicolas U. Gerber and Michael A. Grotzer, University Children's Hospital of Zurich, Zurich; André O. von Bueren, University Hospital of Geneva and University of Geneva, Geneva, Switzerland; and Filip Jadrijevic Cvrlje and Gertjan J.L. Kaspers, Children's Hospital Zagreb, Zagreb, Croatia.

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http://dx.doi.org/10.1200/JCO.2017.75.9308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075859PMC
July 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Authors:
Susanne N Gröbner Barbara C Worst Joachim Weischenfeldt Ivo Buchhalter Kortine Kleinheinz Vasilisa A Rudneva Pascal D Johann Gnana Prakash Balasubramanian Maia Segura-Wang Sebastian Brabetz Sebastian Bender Barbara Hutter Dominik Sturm Elke Pfaff Daniel Hübschmann Gideon Zipprich Michael Heinold Jürgen Eils Christian Lawerenz Serap Erkek Sander Lambo Sebastian Waszak Claudia Blattmann Arndt Borkhardt Michaela Kuhlen Angelika Eggert Simone Fulda Manfred Gessler Jenny Wegert Roland Kappler Daniel Baumhoer Stefan Burdach Renate Kirschner-Schwabe Udo Kontny Andreas E Kulozik Dietmar Lohmann Simone Hettmer Cornelia Eckert Stefan Bielack Michaela Nathrath Charlotte Niemeyer Günther H Richter Johannes Schulte Reiner Siebert Frank Westermann Jan J Molenaar Gilles Vassal Hendrik Witt Birgit Burkhardt Christian P Kratz Olaf Witt Cornelis M van Tilburg Christof M Kramm Gudrun Fleischhack Uta Dirksen Stefan Rutkowski Michael Frühwald Katja von Hoff Stephan Wolf Thomas Klingebiel Ewa Koscielniak Pablo Landgraf Jan Koster Adam C Resnick Jinghui Zhang Yanling Liu Xin Zhou Angela J Waanders Danny A Zwijnenburg Pichai Raman Benedikt Brors Ursula D Weber Paul A Northcott Kristian W Pajtler Marcel Kool Rosario M Piro Jan O Korbel Matthias Schlesner Roland Eils David T W Jones Peter Lichter Lukas Chavez Marc Zapatka Stefan M Pfister

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.

Authors:
Seçkin Akgül Yinghua Li Siyuan Zheng Marcel Kool Daniel M Treisman Chaoyang Li Yuan Wang Susanne Gröbner Tsuneo Ikenoue Yiping Shen Sandra Camelo-Piragua Gerald Tomasek Sebastian Stark Vinay Guduguntla James F Gusella Kun-Liang Guan Stefan M Pfister Roel G W Verhaak Yuan Zhu

Cell Rep 2018 07;24(2):463-478.e5

Cellular and Molecular Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Gilbert Family Neurofibromatosis Institute, Children's National Medical Center, Washington, DC 20010, USA; Center for Cancer and Immunology Research, Children's National Medical Center, Washington, DC 20010, USA; Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116735PMC
July 2018

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.

Authors:
Matija Snuderl Kasthuri Kannan Elke Pfaff Shiyang Wang James M Stafford Jonathan Serrano Adriana Heguy Karina Ray Arline Faustin Olga Aminova Igor Dolgalev Stacie L Stapleton David Zagzag Luis Chiriboga Sharon L Gardner Jeffrey H Wisoff John G Golfinos David Capper Volker Hovestadt Marc K Rosenblum Dimitris G Placantonakis Sarah E LeBoeuf Thales Y Papagiannakopoulos Lukas Chavez Sama Ahsan Charles G Eberhart Stefan M Pfister David T W Jones Matthias A Karajannis

Nat Commun 2018 07 20;9(1):2868. Epub 2018 Jul 20.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, 10065, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-05029-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054684PMC
July 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Authors:
Sebastian M Waszak Paul A Northcott Ivo Buchhalter Giles W Robinson Christian Sutter Susanne Groebner Kerstin B Grund Laurence Brugières David T W Jones Kristian W Pajtler A Sorana Morrissy Marcel Kool Dominik Sturm Lukas Chavez Aurelie Ernst Sebastian Brabetz Michael Hain Thomas Zichner Maia Segura-Wang Joachim Weischenfeldt Tobias Rausch Balca R Mardin Xin Zhou Cristina Baciu Christian Lawerenz Jennifer A Chan Pascale Varlet Lea Guerrini-Rousseau Daniel W Fults Wiesława Grajkowska Peter Hauser Nada Jabado Young-Shin Ra Karel Zitterbart Suyash S Shringarpure Francisco M De La Vega Carlos D Bustamante Ho-Keung Ng Arie Perry Tobey J MacDonald Pablo Hernáiz Driever Anne E Bendel Daniel C Bowers Geoffrey McCowage Murali M Chintagumpala Richard Cohn Timothy Hassall Gudrun Fleischhack Tone Eggen Finn Wesenberg Maria Feychting Birgitta Lannering Joachim Schüz Christoffer Johansen Tina V Andersen Martin Röösli Claudia E Kuehni Michael Grotzer Kristina Kjaerheim Camelia M Monoranu Tenley C Archer Elizabeth Duke Scott L Pomeroy Redmond Shelagh Stephan Frank David Sumerauer Wolfram Scheurlen Marina V Ryzhova Till Milde Christian P Kratz David Samuel Jinghui Zhang David A Solomon Marco Marra Roland Eils Claus R Bartram Katja von Hoff Stefan Rutkowski Vijay Ramaswamy Richard J Gilbertson Andrey Korshunov Michael D Taylor Peter Lichter David Malkin Amar Gajjar Jan O Korbel Stefan M Pfister

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial.

Authors:
Giles W Robinson Vasilisa A Rudneva Ivo Buchhalter Catherine A Billups Sebastian M Waszak Kyle S Smith Daniel C Bowers Anne Bendel Paul G Fisher Sonia Partap John R Crawford Tim Hassall Daniel J Indelicato Frederick Boop Paul Klimo Noah D Sabin Zoltan Patay Thomas E Merchant Clinton F Stewart Brent A Orr Jan O Korbel David T W Jones Tanvi Sharma Peter Lichter Marcel Kool Andrey Korshunov Stefan M Pfister Richard J Gilbertson Robert P Sanders Arzu Onar-Thomas David W Ellison Amar Gajjar Paul A Northcott

Lancet Oncol 2018 06 16;19(6):768-784. Epub 2018 May 16.

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1016/S1470-2045(18)30204-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078206PMC
June 2018

Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.

Authors:
Samuel Rivero-Hinojosa Ling San Lau Mojca Stampar Jerome Staal Huizhen Zhang Heather Gordish-Dressman Paul A Northcott Stefan M Pfister Michael D Taylor Kristy J Brown Brian R Rood

Acta Neuropathol Commun 2018 06 7;6(1):48. Epub 2018 Jun 7.

Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.

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http://dx.doi.org/10.1186/s40478-018-0548-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992829PMC
June 2018

Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

Authors:
Jenny Wegert Christian Vokuhl Grace Collord Martin Del Castillo Velasco-Herrera Sarah J Farndon Charlotte Guzzo Mette Jorgensen John Anderson Olga Slater Catriona Duncan Sabrina Bausenwein Heike Streitenberger Barbara Ziegler Rhoikos Furtwängler Norbert Graf Michael R Stratton Peter J Campbell David Tw Jones Christian Koelsche Stefan M Pfister William Mifsud Neil Sebire Monika Sparber-Sauer Ewa Koscielniak Andreas Rosenwald Manfred Gessler Sam Behjati

Nat Commun 2018 06 18;9(1):2378. Epub 2018 Jun 18.

Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.

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http://dx.doi.org/10.1038/s41467-018-04650-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006309PMC
June 2018

CRISPR-mediated Loss of Function Analysis in Cerebellar Granule Cells Using In Utero Electroporation-based Gene Transfer.

Authors:
Weijun Feng Lena Herbst Peter Lichter Stefan M Pfister Hai-Kun Liu Daisuke Kawauchi

J Vis Exp 2018 06 9(136). Epub 2018 Jun 9.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ); Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK);

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http://dx.doi.org/10.3791/57311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101645PMC
June 2018

A Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation.

Authors:
Kristian W Pajtler Stefan M Pfister

Cell Rep 2018 06;23(13):3699-3700

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.062DOI Listing
June 2018

Key Implications of Data Sharing in Pediatric Genomics.

Authors:
Vasiliki Rahimzadeh Christoph Schickhardt Bartha M Knoppers Karine Sénécal Danya F Vears Conrad V Fernandez Stefan Pfister Sharon Plon Sharon Terry Janet Williams Marc S Williams Martina Cornel Jan M Friedman

JAMA Pediatr 2018 05;172(5):476-481

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1001/jamapediatrics.2017.5500DOI Listing
May 2018

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.

Authors:
Alan Mackay Anna Burford Valeria Molinari David T W Jones Elisa Izquierdo Jurriaan Brouwer-Visser Felice Giangaspero Christine Haberler Torsten Pietsch Thomas S Jacques Dominique Figarella-Branger Daniel Rodriguez Paul S Morgan Pichai Raman Angela J Waanders Adam C Resnick Maura Massimino Maria Luisa Garrè Helen Smith David Capper Stefan M Pfister Thomas Würdinger Rachel Tam Josep Garcia Meghna Das Thakur Gilles Vassal Jacques Grill Tim Jaspan Pascale Varlet Chris Jones

Cancer Cell 2018 05;33(5):829-842.e5

Division of Molecular Pathology, The Institute of Cancer Research, 15 Cotswold Road, Sutton, London, Surrey SM2 5NG, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, London, Surrey SM2 5NG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956280PMC
May 2018

Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.

Authors:
J Bryan Iorgulescu Jessica Van Ziffle Meredith Stevers James P Grenert Boris C Bastian Lukas Chavez Damian Stichel Ivo Buchhalter David Samuel Theodore Nicolaides Anuradha Banerjee Sabine Mueller Nalin Gupta Tarik Tihan Andrew W Bollen Paul A Northcott Marcel Kool Stefan Pfister Andrey Korshunov Arie Perry David A Solomon

Acta Neuropathol 2018 04 12;135(4):635-638. Epub 2018 Feb 12.

Department of Pathology, University of California, San Francisco, 513 Parnassus Ave, Health Sciences West 451, San Francisco, CA, 94143, USA.

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http://dx.doi.org/10.1007/s00401-018-1819-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078208PMC
April 2018

Systematic identification of suspected anthelmintic benzimidazole metabolites using LC-MS/MS.

Authors:
Marius Majewsky David Castel Ludivine Le Dret Pascal Johann David T Jones Stefan M Pfister Walter E Haefeli Jürgen Burhenne

J Pharm Biomed Anal 2018 Mar 28;151:151-158. Epub 2017 Dec 28.

Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, University Hospital Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jpba.2017.12.056DOI Listing
March 2018

A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma.

Authors:
Soledad Gómez Alícia Garrido-Garcia Laura Garcia-Gerique Isadora Lemos Mariona Suñol Carmen de Torres Marta Kulis Sara Pérez-Jaume Ángel M Carcaboso Betty Luu Mark W Kieran Nada Jabado Alexey Kozlenkov Stella Dracheva Vijay Ramaswamy Volker Hovestadt Pascal Johann David T W Jones Stefan M Pfister Andrés Morales La Madrid Ofelia Cruz Michael D Taylor Jose-Ignacio Martin-Subero Jaume Mora Cinzia Lavarino

Clin Cancer Res 2018 03 19;24(6):1355-1363. Epub 2018 Jan 19.

Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundació Sant Joan de Déu, Sant Joan de Déu, Barcelona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2243DOI Listing
March 2018

The landscape of genomic alterations across childhood cancers.

Authors:
Susanne N Gröbner Barbara C Worst Joachim Weischenfeldt Ivo Buchhalter Kortine Kleinheinz Vasilisa A Rudneva Pascal D Johann Gnana Prakash Balasubramanian Maia Segura-Wang Sebastian Brabetz Sebastian Bender Barbara Hutter Dominik Sturm Elke Pfaff Daniel Hübschmann Gideon Zipprich Michael Heinold Jürgen Eils Christian Lawerenz Serap Erkek Sander Lambo Sebastian Waszak Claudia Blattmann Arndt Borkhardt Michaela Kuhlen Angelika Eggert Simone Fulda Manfred Gessler Jenny Wegert Roland Kappler Daniel Baumhoer Stefan Burdach Renate Kirschner-Schwabe Udo Kontny Andreas E Kulozik Dietmar Lohmann Simone Hettmer Cornelia Eckert Stefan Bielack Michaela Nathrath Charlotte Niemeyer Günther H Richter Johannes Schulte Reiner Siebert Frank Westermann Jan J Molenaar Gilles Vassal Hendrik Witt Birgit Burkhardt Christian P Kratz Olaf Witt Cornelis M van Tilburg Christof M Kramm Gudrun Fleischhack Uta Dirksen Stefan Rutkowski Michael Frühwald Katja von Hoff Stephan Wolf Thomas Klingebiel Ewa Koscielniak Pablo Landgraf Jan Koster Adam C Resnick Jinghui Zhang Yanling Liu Xin Zhou Angela J Waanders Danny A Zwijnenburg Pichai Raman Benedikt Brors Ursula D Weber Paul A Northcott Kristian W Pajtler Marcel Kool Rosario M Piro Jan O Korbel Matthias Schlesner Roland Eils David T W Jones Peter Lichter Lukas Chavez Marc Zapatka Stefan M Pfister

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

Authors:
Paola Infante Roberta Faedda Flavia Bernardi Francesca Bufalieri Ludovica Lospinoso Severini Romina Alfonsi Daniela Mazzà Mariangela Siler Sonia Coni Agnese Po Marialaura Petroni Elisabetta Ferretti Mattia Mori Enrico De Smaele Gianluca Canettieri Carlo Capalbo Marella Maroder Isabella Screpanti Marcel Kool Stefan M Pfister Daniele Guardavaccaro Alberto Gulino Lucia Di Marcotullio

Nat Commun 2018 03 7;9(1):976. Epub 2018 Mar 7.

Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.

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http://dx.doi.org/10.1038/s41467-018-03339-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841288PMC
March 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.

Authors:
Daniel J Merk Jasmin Ohli Natalie D Merk Venu Thatikonda Sorana Morrissy Melanie Schoof Susanne N Schmid Luke Harrison Severin Filser Julia Ahlfeld Serap Erkek Kaamini Raithatha Thomas Andreska Marc Weißhaar Michael Launspach Julia E Neumann Mehdi Shakarami Dennis Plenker Marco A Marra Yisu Li Andrew J Mungall Richard A Moore Yussanne Ma Steven J M Jones Beat Lutz Birgit Ertl-Wagner Andrea Rossi Rabea Wagener Reiner Siebert Andreas Jung Charles G Eberhart Boleslaw Lach Michael Sendtner Stefan M Pfister Michael D Taylor Lukas Chavez Marcel Kool Ulrich Schüller

Dev Cell 2018 03 15;44(6):709-724.e6. Epub 2018 Mar 15.

Center for Neuropathology, Ludwig-Maximilians-University, 81377 Munich, Germany; Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, N63 (HPI), Hamburg 20251, Germany; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.02.012DOI Listing
March 2018