Stefan Kochanek

Stefan Kochanek

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Stefan Kochanek

Stefan Kochanek

Publications by authors named "Stefan Kochanek"

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Evaluation of life cycle defective adenovirus mutants for production of adeno-associated virus vectors.

J Gene Med 2019 Jun 28;21(6):e3094. Epub 2019 May 28.

Department of Gene Therapy, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1002/jgm.3094DOI Listing
June 2019

Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum.

Neurobiol Aging 2018 06 16;66:97-111. Epub 2018 Feb 16.

CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.02.008DOI Listing
June 2018

Recent advances in gene-enhanced bone tissue engineering.

J Gene Med 2018 06 9;20(6):e3018. Epub 2018 May 9.

Center for Rehabilitation, RKU - University and Rehabilitation Hospitals Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/jgm.3018DOI Listing
June 2018

miR-483 is a self-regulating microRNA and can activate its own expression via USF1 in HeLa cells.

Int J Biochem Cell Biol 2016 11 28;80:81-86. Epub 2016 Sep 28.

Institute of Applied Biotechnology, Biberach University of Applied Sciences, Hubertus-Liebrecht-Strasse 35, 88400 Biberach, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.09.022DOI Listing
November 2016

Temperature-sensitive miR-483 is a conserved regulator of recombinant protein and viral vector production in mammalian cells.

Biotechnol Bioeng 2016 Apr 20;113(4):830-41. Epub 2015 Oct 20.

Institute of Applied Biotechnology, Biberach University of Applied Sciences, Hubertus-Liebrecht-Str. 35, 88400, Biberach, Germany.

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http://dx.doi.org/10.1002/bit.25853DOI Listing
April 2016

Rational plasmid design and bioprocess optimization to enhance recombinant adeno-associated virus (AAV) productivity in mammalian cells.

Biotechnol J 2016 Feb 24;11(2):290-7. Epub 2015 Sep 24.

Development, Rentschler Biotechnologie GmbH, Laupheim, Baden-Württemberg, Germany.

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http://dx.doi.org/10.1002/biot.201500176DOI Listing
February 2016

Human amniocyte-derived cells are a promising cell host for adenoviral vector production under serum-free conditions.

Biotechnol J 2015 May;10(5):760-71

iBET - Instituto de Biologia Experimental e Tecnológica, Animal Cell Technology Unit, Oeiras, Portugal; Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Animal Cell Technology Unit, Oeiras, Portugal.

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http://dx.doi.org/10.1002/biot.201400765DOI Listing
May 2015

CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells.

Proc Natl Acad Sci U S A 2015 Apr 14;112(17):5461-6. Epub 2015 Apr 14.

Institute for Immunology, Ludwig-Maximilian University of Munich, 80336 Munich, Germany and

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http://dx.doi.org/10.1073/pnas.1423356112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418891PMC
April 2015

Pancreatic transduction by helper-dependent adenoviral vectors via intraductal delivery.

Hum Gene Ther 2014 Sep;25(9):824-36

1 Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona , Bellaterra 08193, Spain .

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http://dx.doi.org/10.1089/hum.2013.182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175029PMC
September 2014

The transcription factor serum response factor stimulates axon regeneration through cytoplasmic localization and cofilin interaction.

J Neurosci 2013 Nov;33(48):18836-48

Neuronal Gene Expression Laboratory and Molecular Organ Function Laboratory, Eberhard Karls University Tübingen, Interfaculty Institute for Cell Biology, Department of Molecular Biology, 72076 Tübingen, Germany; Laboratory for NeuroRegeneration and Repair and Laboratory for Molecular Neuro-Oncology, Eberhard Karls University Tübingen, Hertie Institute for Clinical Brain Research, 72076 Tübingen, Germany; and Department of Gene Therapy and Institute for Physiological Chemistry, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.3029-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618710PMC
November 2013

Foamy virus-adenovirus hybrid vectors for gene therapy of the arthritides.

J Gene Med 2013 Mar-Apr;15(3-4):155-67

University of Würzburg, Department of Virology and Immunobiology, Würzburg, Germany.

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http://dx.doi.org/10.1002/jgm.2705DOI Listing
October 2013

CAP, a new human suspension cell line for influenza virus production.

Appl Microbiol Biotechnol 2013 Jan 21;97(1):111-22. Epub 2012 Jul 21.

Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Sandtorstr. 1, 39106, Magdeburg, Germany.

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http://dx.doi.org/10.1007/s00253-012-4238-2DOI Listing
January 2013

Genomic integration of adenoviral gene transfer vectors following transduction of fertilized mouse oocytes.

Transgenic Res 2011 Feb 13;20(1):123-35. Epub 2010 May 13.

Department of Neurology Friedrich-Baur-Institute, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.1007/s11248-010-9401-xDOI Listing
February 2011

Adenovirus vector production and purification.

Curr Gene Ther 2010 Dec;10(6):437-55

IBET/ITQB-UNL, Apartado 12, P-2781-901, Oeiras, Portugal.

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December 2010

Prostate cancer gene therapy: attempts to innovate.

Hum Gene Ther 2010 Jul;21(7):791

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http://dx.doi.org/10.1089/hum.2010.1216DOI Listing
July 2010

The classical pathway of melanogenesis is not essential for melanin synthesis in the adult retinal pigment epithelium.

Cell Tissue Res 2010 Mar 6;339(3):551-60. Epub 2010 Feb 6.

Department for Experimental Vitreoretinal Surgery, University Eye Hospital Tübingen, Germany.

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http://link.springer.com/10.1007/s00441-009-0920-9
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http://dx.doi.org/10.1007/s00441-009-0920-9DOI Listing
March 2010

Homologous and heterologous recombination between adenovirus vector DNA and chromosomal DNA.

J Gene Med 2008 Nov;10(11):1176-89

Center for Molecular Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/jgm.1246DOI Listing
November 2008

Recombinant complexes of antigen with stress proteins are potent CD8 T-cell-stimulating immunogens.

J Mol Med (Berl) 2008 Sep 13;86(9):1067-79. Epub 2008 Jun 13.

Department of Internal Medicine I, University of Ulm, Robert Koch Strasse 8, 89081 Ulm, Germany.

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http://dx.doi.org/10.1007/s00109-008-0371-xDOI Listing
September 2008

The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigens.

Mol Ther 2008 Sep 8;16(9):1609-16. Epub 2008 Jul 8.

Department for Internal Medicine I, University of Ulm, Ulm, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S152500161632059
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http://dx.doi.org/10.1038/mt.2008.141DOI Listing
September 2008

Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide.

Mol Ther 2008 Jan 2;16(1):16-29. Epub 2007 Oct 2.

Division of Gene Therapy, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1038/sj.mt.6300321DOI Listing
January 2008

Tyrosinase biosynthesis and trafficking in adult human retinal pigment epithelial cells.

Graefes Arch Clin Exp Ophthalmol 2007 Oct 21;245(10):1495-505. Epub 2007 Feb 21.

Section for Experimental Vitreoretinal Surgery, University Eye Hospital Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1007/s00417-007-0543-3DOI Listing
October 2007

High-capacity adenoviral vector-mediated reduction of huntingtin aggregate load in vitro and in vivo.

Hum Gene Ther 2007 Apr;18(4):303-11

Division of Gene Therapy, University of Ulm, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1089/hum.2006.160DOI Listing
April 2007

Increased efficacy and safety in the treatment of experimental liver cancer with a novel adenovirus-alphavirus hybrid vector.

Cancer Res 2006 Feb;66(3):1620-9

Division of Hepatology and Gene Therapy, School of Medicine, Centro de Investigación Médica Aplicada, University of Navarra, 31008 Pamplona, Spain.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-0877DOI Listing
February 2006

Adenovirus vectors based on human adenovirus type 19a have high potential for human muscle-directed gene therapy.

Hum Gene Ther 2006 Feb;17(2):193-205

Gene Center, Friedrich Baur Institute, and Department of Neurology, Ludwig-Maximilians-University, Munich 81377, Germany.

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http://dx.doi.org/10.1089/hum.2006.17.193DOI Listing
February 2006

Combined genetic and chemical capsid modifications enable flexible and efficient de- and retargeting of adenovirus vectors.

Mol Ther 2005 Jul;12(1):107-17

Division of Gene Therapy, University of Ulm, Helmholtzstrasse 8/1, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.ymthe.2005.03.006DOI Listing
July 2005

Adenovirus-mediated silencing of huntingtin expression by shRNA.

Hum Gene Ther 2005 May;16(5):618-26

Division of Gene Therapy, University of Ulm, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1089/hum.2005.16.618DOI Listing
May 2005

Adenoviral vectors for gene transfer and therapy.

J Gene Med 2004 Feb;6 Suppl 1:S164-71

Center for Molecular Medicine (ZMMK) and Institute for Genetics, University of Cologne, Kerpener Str. 34, 50931 Cologne, Germany.

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http://dx.doi.org/10.1002/jgm.496DOI Listing
February 2004

Long-term transgene expression in proliferating cells mediated by episomally maintained high-capacity adenovirus vectors.

J Virol 2004 Jan;78(1):9-22

Center for Molecular Medicine Cologne, University of Cologne, D-50931 Cologne, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC303378PMC
http://dx.doi.org/10.1128/jvi.78.1.9-22.2004DOI Listing
January 2004

Strategies for muscle-specific targeting of adenoviral gene transfer vectors.

Neuromuscul Disord 2002 Oct;12 Suppl 1:S30-9

Gene Center, Ludwig-Maximilians-University, Munich, Germany.

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October 2002

Autologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye.

Proc Natl Acad Sci U S A 2002 Oct 18;99(20):13090-5. Epub 2002 Sep 18.

Center for Molecular Medicine Cologne (ZMMK), Center of Ophthalmology, Department of Retinal Surgery, Institute for Anatomy, University of Cologne, Kerpener Strasse 34, D-50931 Cologne, Germany.

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http://dx.doi.org/10.1073/pnas.202486199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130591PMC
October 2002

Immune response to full-length dystrophin delivered to Dmd muscle by a high-capacity adenoviral vector.

Mol Ther 2002 Sep;6(3):359-68

Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1006/mthe.2002.0675DOI Listing
September 2002

Systemic delivery of a high-capacity adenoviral vector expressing mouse CTLA4Ig improves skeletal muscle gene therapy.

Mol Ther 2002 Sep;6(3):369-76

Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1006/mthe.2002.0676DOI Listing
September 2002

Efficient in vitro and in vivo excision of floxed sequences with a high-capacity adenoviral vector expressing Cre recombinase.

Genesis 2002 Jul;33(3):119-24

Center for Molecular Medicine (ZMMK), University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/gene.10099DOI Listing
July 2002

A DNA-based method to assay total and infectious particle contents and helper virus contamination in high-capacity adenoviral vector preparations.

Hum Gene Ther 2002 Jul;13(10):1151-6

Center for Molecular Medicine (ZMMK), University of Cologne, 50931 Cologne, Germany.

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http://dx.doi.org/10.1089/104303402320138934DOI Listing
July 2002

Long-term transgene expression in the RPE after gene transfer with a high-capacity adenoviral vector.

Invest Ophthalmol Vis Sci 2002 Jun;43(6):1965-70

University Eye Hospital, Laboratory of Experimental Ophthalmology, Cologne, Germany.

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June 2002

Variables affecting in vivo performance of high-capacity adenovirus vectors.

J Virol 2002 Feb;76(4):1600-9

Center for Molecular Medicine (ZMMK), University of Cologne, D-50931 Cologne, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135880PMC
http://dx.doi.org/10.1128/jvi.76.4.1600-1609.2002DOI Listing
February 2002