Stefan K Bohlander

Stefan K Bohlander

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Stefan K Bohlander

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Preface to special issue: Acute myeloid leukemia-Genetics, stem cells, clonal evolution, and new therapies.

Genes Chromosomes Cancer 2019 Dec 2;58(12):827. Epub 2019 Sep 2.

Department of Molecular Medicine and Pathology, Leukaemia and Blood Cancer Research Unit, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1002/gcc.22800DOI Listing
December 2019

The cell of origin and the leukemia stem cell in acute myeloid leukemia.

Genes Chromosomes Cancer 2019 Dec 31;58(12):850-858. Epub 2019 Aug 31.

Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1002/gcc.22805DOI Listing
December 2019

Clinical remission following ascorbate treatment in a case of acute myeloid leukemia with mutations in TET2 and WT1.

Blood Cancer J 2019 Oct 2;9(10):82. Epub 2019 Oct 2.

Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago, Christchurch, Christchurch, New Zealand.

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http://dx.doi.org/10.1038/s41408-019-0242-4DOI Listing
October 2019

Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide.

Mol Pharmacol 2019 Jun 12;95(6):638-651. Epub 2019 Apr 12.

Auckland Cancer Society Research Centre, School of Medical Sciences, Faculty of Medical and Health Sciences (F.W.H., C.R.H., A.K., I.S., W.R.W.), Maurice Wilkins Centre for Molecular Biodiscovery (F.W.H., A.J.R.H., C.G.P., W.R.W.), School of Biological Sciences, Faculty of Science (J.B.L.D., A.J.R.H.), and Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences (P.T., P.M.K., C.G.P., S.K.B.), University of Auckland, Auckland, New Zealand; Threshold Pharmaceuticals, South San Francisco, California (F.M., C.P.H.); Princess Margaret Genomics Centre (T.W.K.) and Princess Margaret Cancer Centre (S.M., Z.S., B.G.W.), University Health Network, and Departments of Radiation Oncology (B.G.W.) and Medical Biophysics (B.G.W.), University of Toronto, Toronto, Ontario, Canada.

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.118
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http://dx.doi.org/10.1124/mol.118.115196DOI Listing
June 2019

Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1.

Exp Hematol 2019 Jun 13;74:42-51.e3. Epub 2019 May 13.

Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2019.04.003DOI Listing
June 2019

Efficient identification of somatic mutations in acute myeloid leukaemia using whole exome sequencing of fingernail derived DNA as germline control.

Sci Rep 2018 09 13;8(1):13751. Epub 2018 Sep 13.

Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand.

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http://www.nature.com/articles/s41598-018-31503-5
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http://dx.doi.org/10.1038/s41598-018-31503-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137150PMC
September 2018

Variable aldehyde dehydrogenase activity and effects on chemosensitivity of primitive human leukemic cells.

Exp Hematol 2017 03 5;47:54-63. Epub 2016 Nov 5.

Department of Medicine III, University of Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.10.012DOI Listing
March 2017

Complement cascade gene expression defines novel prognostic subgroups of acute myeloid leukemia.

Exp Hematol 2016 Nov 26;44(11):1039-1043.e10. Epub 2016 Jul 26.

Research Institute of the McGill University Health Centre and McGill University, Montreal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.07.012DOI Listing
November 2016

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.

Blood 2016 08 10;128(5):686-98. Epub 2016 Jun 10.

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, Ludwig-Maximilans-Universität, Munich, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2016-01-693879DOI Listing
August 2016

Close correlation of copy number aberrations detected by next-generation sequencing with results from routine cytogenetics in acute myeloid leukemia.

Genes Chromosomes Cancer 2016 07 2;55(7):553-67. Epub 2016 May 2.

Experimental Leukemia and Lymphoma Research (ELLF), Department of Internal Medicine III, University Hospital of the Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.

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http://dx.doi.org/10.1002/gcc.22359DOI Listing
July 2016

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.

Blood 2016 Apr 1;127(16):2018-27. Epub 2016 Feb 1.

Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec, Centre de Recherche en Infectiologie du Centre Hospitalier de l'Université de Laval, Quebec City, QC, Canada; CHU de Québec Hôpital Enfant-Jésus, Quebec City, QC, Canada; and Department of Medicine, University Laval, Quebec City, QC, Canada.

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http://dx.doi.org/10.1182/blood-2015-11-683649DOI Listing
April 2016

DNA Repair and Chromosomal Translocations.

Recent Results Cancer Res 2015 ;200:1-37

Faculty of Medical and Health Sciences, Department of Molecular Medicine and Pathology, The University of Auckland, 85 Park Road Grafton, Private Bag 92019, Auckland, 1142, New Zealand.

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http://dx.doi.org/10.1007/978-3-319-20291-4_1DOI Listing
January 2016

Inhibition of glutamate regulated calcium entry into leukemic megakaryoblasts reduces cell proliferation and supports differentiation.

Cell Signal 2015 Sep 14;27(9):1860-72. Epub 2015 May 14.

Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand; LabPlus Haematology, Auckland District Health Board, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2015.05.004DOI Listing
September 2015

Disturbing the histone code in leukemia: translocations and mutations affecting histone methyl transferases.

Cancer Genet 2015 May 27;208(5):192-205. Epub 2014 Oct 27.

Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2014.10.005DOI Listing
May 2015

ABCs of genomics.

Hematology Am Soc Hematol Educ Program 2013 ;2013:316-23

1Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1182/asheducation-2013.1.316DOI Listing
December 2014

Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.

PLoS One 2014 7;9(3):e89560. Epub 2014 Mar 7.

Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany; Clinical Cooperative Group Leukemia, Helmholtz Center Munich, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089560PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946485PMC
December 2014

Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.

Sci Rep 2014 Oct 9;4:6565. Epub 2014 Oct 9.

1] Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians-Universität, Munich (LMU), Germany [2] Faculty of Medical and Health Sciences, Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1038/srep06565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190505PMC
October 2014

Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis.

Blood 2014 Aug 12;124(8):1304-11. Epub 2014 Jun 12.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany; Clinical Cooperative Group Leukemia, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2013-12-540716DOI Listing
August 2014

Combined molecular and clinical prognostic index for relapse and survival in cytogenetically normal acute myeloid leukemia.

J Clin Oncol 2014 May 7;32(15):1586-94. Epub 2014 Apr 7.

Friederike Pastore, Annika Dufour, Tobias Benthaus, Klaus H. Metzeler, Stephanie Schneider, Bianka Ksienzyk, Gudrun Mellert, Evelyn Zellmeier, Purvi M. Kakadia, Michael Unterhalt, Wolfgang Hiddemann, Stefan K. Bohlander, Karsten Spiekermann, and Eva Hoster, University Hospital Munich Großhadern; Friederike Pastore, Klaus H. Metzeler, Wolfgang Hiddemann, Stefan K. Bohlander, and Karsten Spiekermann, Helmholtz Center Munich; Eva Hoster, University of Munich, Munich; Purvi M. Kakadia and Stefan K. Bohlander, University Hospital Marburg, Marburg; Michaela Feuring-Buske, University Hospital Ulm; Christian Buske, Comprehensive Cancer Center Ulm, University of Ulm, Ulm; Jan Braess, Klinikum Barmherzige Brüder, Regensburg; Maria Cristina Sauerland and Achim Heinecke, University of Muenster; Utz Krug, Wolfgang E. Berdel, and Thomas Buechner, University Hospital Muenster, Muenster; Bernhard Woermann, German Society of Hematology and Oncology, Berlin, Germany; Kati S. Maharry, Guido Marcucci, and Clara D. Bloomfield, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Kati S. Maharry, Mayo Clinic, Rochester, MN; and Stefan K. Bohlander, University of Auckland, Auckland, New Zealand.

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http://jco.ascopubs.org/content/early/2014/04/03/JCO.2013.52
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.52.3480
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http://dx.doi.org/10.1200/JCO.2013.52.3480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876345PMC
May 2014

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.

Biochem Pharmacol 2014 Mar 13;88(1):36-45. Epub 2014 Jan 13.

Auckland Cancer Society Research Centre, the University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, the University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2013.12.019DOI Listing
March 2014

The radial nuclear positioning of genes correlates with features of megabase-sized chromatin domains.

Chromosome Res 2012 Aug 28;20(6):735-52. Epub 2012 Sep 28.

Department Biologie II, Ludwig-Maximilians-Universität München, Planegg, Martinsried, Germany.

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http://dx.doi.org/10.1007/s10577-012-9309-9DOI Listing
August 2012

Stem cell gene expression programs influence clinical outcome in human leukemia.

Nat Med 2011 Aug 28;17(9):1086-93. Epub 2011 Aug 28.

Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nm.2415
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http://dx.doi.org/10.1038/nm.2415DOI Listing
August 2011

Up a lymphoid blind alley: Does CALM/AF10 disturb Ikaros during leukemogenesis?

World J Biol Chem 2011 Jun;2(6):115-8

Philipp A Greif, Stefan K Bohlander, Clinical Cooperative Group "Leukemia", Helmholtz Zentrum München, German Research Center for Environmental Health, 81377 Munich, Germany.

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http://dx.doi.org/10.4331/wjbc.v2.i6.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159521PMC
June 2011

Genetic instability in inherited and sporadic leukemias.

Genes Chromosomes Cancer 2010 Dec;49(12):1071-81

Department of Internal Medicine III, Laboratory of Leukemia Diagnostics, Ludwig-Maximilians-University-Campus Grosshadern, Marchioninistrasse 15, Munich, Germany.

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http://dx.doi.org/10.1002/gcc.20823DOI Listing
December 2010

Age-specific differences in oncogenic pathway dysregulation and anthracycline sensitivity in patients with acute myeloid leukemia.

J Clin Oncol 2009 Nov 26;27(33):5580-6. Epub 2009 Oct 26.

Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC 27708, USA.

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http://dx.doi.org/10.1200/JCO.2009.22.2547DOI Listing
November 2009

Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias.

Blood 2009 Jul 14;114(3):651-8. Epub 2009 May 14.

State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, China.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-03-20
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http://dx.doi.org/10.1182/blood-2009-03-209395DOI Listing
July 2009

Monitoring minimal residual disease in acute myeloid leukaemia with NPM1 mutations by quantitative PCR: clonal evolution is a limiting factor.

Br J Haematol 2009 Feb 26;144(4):517-23. Epub 2008 Nov 26.

Laboratory for Leukaemia Diagnostics and Department of Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07488.xDOI Listing
February 2009

Rapid and sensitive screening for CEBPA mutations in acute myeloid leukaemia.

Br J Haematol 2008 Oct 24;143(2):230-9. Epub 2008 Aug 24.

Laboratory for Leukaemia Diagnostics, Department of Medicine III, University of Munich-Grosshadern, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07328.xDOI Listing
October 2008

Association between a prognostic gene signature and functional gene sets.

Bioinform Biol Insights 2008 Sep 22;2:329-41. Epub 2008 Sep 22.

Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735947PMC
September 2008

The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60.

Biochim Biophys Acta 2007 Dec 13;1772(11-12):1211-24. Epub 2007 Oct 13.

Institute of Human Genetics, Heinrich-Düker-Weg 12, 37037 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.bbadis.2007.09.006DOI Listing
December 2007

Defining the heterochromatin localization and repression domains of SALL1.

Biochim Biophys Acta 2006 Mar 6;1762(3):386-91. Epub 2006 Jan 6.

Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 53111 Bonn, Germany.

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http://dx.doi.org/10.1016/j.bbadis.2005.12.005DOI Listing
March 2006

A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia.

Genes Chromosomes Cancer 2005 Nov;44(3):329-33

Department of Hematology and Oncology, University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany.

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http://dx.doi.org/10.1002/gcc.20235DOI Listing
November 2005

ETV6: a versatile player in leukemogenesis.

Semin Cancer Biol 2005 Jun;15(3):162-74

Department of Medicine III, University Hospital Grosshadern, Marchioninistr. 15, D-81377 Munich, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S1044579X0500009
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http://dx.doi.org/10.1016/j.semcancer.2005.01.008DOI Listing
June 2005

A t(1;9)(q23.3 approximately q25;q34) affecting the ABL1 gene in a biphenotypic leukemia.

Cancer Genet Cytogenet 2004 Jul;152(1):81-3

Laboratorio de Citogenética, Centro de Investigación Biomédica de Occidente, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (CIBO-IMSS), Colonia Independencia, Guadalajara, Jalisco, Mexico.

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http://dx.doi.org/10.1016/j.cancergencyto.2003.10.014DOI Listing
July 2004

Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.

Proc Natl Acad Sci U S A 2004 Jan 12;101(3):817-22. Epub 2004 Jan 12.

GSF-Clinical Cooperative Group Leukemia and Department of Medicine III, Grosshadern, Ludwig Maximilians University, 81377 Munich, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0305555101
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http://dx.doi.org/10.1073/pnas.0305555101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321764PMC
January 2004

Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line.

Br J Haematol 2002 Nov;119(2):454-8

Division of Haematology and Oncology, and Department of Internal Medicine, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03850.xDOI Listing
November 2002

Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1.

Biochem Biophys Res Commun 2002 Aug;296(4):870-6

Institute of Human Genetics, University of Göttingen, Heinrich-Düker-Weg 12, 37073 Göttingen, Germany.

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http://dx.doi.org/10.1016/s0006-291x(02)02003-xDOI Listing
August 2002