Stefan H E Kaufmann

Stefan H E Kaufmann

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Stefan H E Kaufmann

Stefan H E Kaufmann

Publications by authors named "Stefan H E Kaufmann"

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SiiE prevents an efficient humoral immune memory by interfering with IgG plasma cell persistence in the bone marrow.

Authors:
Christian Männe Akiko Takaya Yuzuru Yamasaki Mathias Mursell Shintaro Hojyo Tsung-Yen Wu Jana Sarkander Mairi A McGrath Rebecca Cornelis Stefanie Hahne Qingyu Cheng Tadafumi Kawamoto Falk Hiepe Stefan H E Kaufmann Tomoko Yamamoto Andreas Radbruch Koji Tokoyoda

Proc Natl Acad Sci U S A 2019 04 25;116(15):7425-7430. Epub 2019 Mar 25.

Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany;

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http://dx.doi.org/10.1073/pnas.1818242116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462062PMC
April 2019

Highly affordable vaccines are critical for our continued efforts to reduce global childhood mortality.

Authors:
Stefan H E Kaufmann

Hum Vaccin Immunother 2019 Apr 11:1-6. Epub 2019 Apr 11.

a Department of Immunology , Max Planck Institute for Infection Biology , Berlin , Germany.

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http://dx.doi.org/10.1080/21645515.2019.1605817DOI Listing
April 2019

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

Authors:
Adam Penn-Nicholson Thomas Hraha Ethan G Thompson David Sterling Stanley Kimbung Mbandi Kirsten M Wall Michelle Fisher Sara Suliman Smitha Shankar Willem A Hanekom Nebojsa Janjic Mark Hatherill Stefan H E Kaufmann Jayne Sutherland Gerhard Walzl Mary Ann De Groote Urs Ochsner Daniel E Zak Thomas J Scriba

PLoS Med 2019 Apr 16;16(4):e1002781. Epub 2019 Apr 16.

South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1371/journal.pmed.1002781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467365PMC
April 2019

Immunology's Coming of Age.

Authors:
Stefan H E Kaufmann

Front Immunol 2019 3;10:684. Epub 2019 Apr 3.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456699PMC
April 2019

Next-Generation Vaccines Based on Bacille Calmette-Guérin.

Authors:
Natalie E Nieuwenhuizen Stefan H E Kaufmann

Front Immunol 2018 5;9:121. Epub 2018 Feb 5.

Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807593PMC
March 2019

Editorial: Reassessing Twenty Years of Vaccine Development against Tuberculosis.

Authors:
Ulrich E Schaible Stefan H E Kaufmann

Front Immunol 2018 7;9:180. Epub 2018 Feb 7.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808321PMC
March 2019

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome.

Authors:
Fergal J Duffy January Weiner Scott Hansen David L Tabb Sara Suliman Ethan Thompson Jeroen Maertzdorf Smitha Shankar Gerard Tromp Shreemanta Parida Drew Dover Michael K Axthelm Jayne S Sutherland Hazel M Dockrell Tom H M Ottenhoff Thomas J Scriba Louis J Picker Gerhard Walzl Stefan H E Kaufmann Daniel E Zak

Front Immunol 2019 22;10:527. Epub 2019 Mar 22.

Center for Infectious Disease Research, Seattle, WA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440524PMC
March 2019

Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for Evaluation of Drug Regimens.

Authors:
Frida Arrey Delia Löwe Stefanie Kuhlmann Peggy Kaiser Pedro Moura-Alves Gopinath Krishnamoorthy Laura Lozza Jeroen Maertzdorf Tatsiana Skrahina Alena Skrahina Martin Gengenbacher Geraldine Nouailles Stefan H E Kaufmann

Front Immunol 2019 31;10:89. Epub 2019 Jan 31.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365439PMC
January 2019

Metabolite changes in blood predict the onset of tuberculosis.

Authors:
January Weiner Jeroen Maertzdorf Jayne S Sutherland Fergal J Duffy Ethan Thompson Sara Suliman Gayle McEwen Bonnie Thiel Shreemanta K Parida Joanna Zyla Willem A Hanekom Robert P Mohney W Henry Boom Harriet Mayanja-Kizza Rawleigh Howe Hazel M Dockrell Tom H M Ottenhoff Thomas J Scriba Daniel E Zak Gerhard Walzl Stefan H E Kaufmann

Nat Commun 2018 12 6;9(1):5208. Epub 2018 Dec 6.

Max Planck Institute for Infection Biology, 10117, Berlin, Germany.

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http://dx.doi.org/10.1038/s41467-018-07635-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283869PMC
December 2018

Phagosomal Copper-Promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis.

Authors:
M Daben J Libardo Cesar de la Fuente-Nuñez Kushi Anand Gopinath Krishnamoorthy Peggy Kaiser Stephanie C Pringle Christopher Dietz Scott Pierce Michael B Smith Amy Barczak Stefan H E Kaufmann Amit Singh Alfredo M Angeles-Boza

ACS Infect Dis 2018 Nov 6;4(11):1623-1634. Epub 2018 Sep 6.

Department of Chemistry , University of Connecticut , 55 N. Eagleville Road , Storrs , Connecticut 06269 , United States.

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http://pubs.acs.org/doi/10.1021/acsinfecdis.8b00171
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http://dx.doi.org/10.1021/acsinfecdis.8b00171DOI Listing
November 2018

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.

Authors:
Haipeng Liu Haiping Zhang Xiangyang Wu Dapeng Ma Juehui Wu Lin Wang Yan Jiang Yiyan Fei Chenggang Zhu Rong Tan Peter Jungblut Gang Pei Anca Dorhoi Qiaoling Yan Fan Zhang Ruijuan Zheng Siyu Liu Haijiao Liang Zhonghua Liu Hua Yang Jianxia Chen Peng Wang Tianqi Tang Wenxia Peng Zhangsen Hu Zhu Xu Xiaochen Huang Jie Wang Haohao Li Yilong Zhou Feng Liu Dapeng Yan Stefan H E Kaufmann Chang Chen Zhiyong Mao Baoxue Ge

Nature 2018 11 24;563(7729):131-136. Epub 2018 Oct 24.

Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

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http://www.nature.com/articles/s41586-018-0629-6
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http://dx.doi.org/10.1038/s41586-018-0629-6DOI Listing
November 2018

The potential of metabolic profiling for vaccine development.

Authors:
January Weiner Robert P Mohney Stefan H E Kaufmann

Semin Immunol 2018 10 19;39:44-51. Epub 2018 Jul 19.

Max Planck Institute for Infection Biology, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2018.07.002DOI Listing
October 2018

Human Monocytic Suppressive Cells Promote Replication of and Alter Stability of Generated Granulomas.

Authors:
Neha Agrawal Ioana Streata Gang Pei January Weiner Leigh Kotze Silke Bandermann Laura Lozza Gerhard Walzl Nelita du Plessis Mihai Ioana Stefan H E Kaufmann Anca Dorhoi

Front Immunol 2018 23;9:2417. Epub 2018 Oct 23.

Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02417
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http://dx.doi.org/10.3389/fimmu.2018.02417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205994PMC
October 2018

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.

Authors:
Andreia C Lino Van Duc Dang Vicky Lampropoulou Anna Welle Jara Joedicke Jelka Pohar Quentin Simon Jessie Thalmensi Aurelia Baures Vinciane Flühler Imme Sakwa Ulrik Stervbo Stefanie Ries Luc Jouneau Pierre Boudinot Takeshi Tsubata Takahiro Adachi Andreas Hutloff Thomas Dörner Ursula Zimber-Strobl Alex F de Vos Katja Dahlke Gunnar Loh Sarantis Korniotis Christian Goosmann Jean-Claude Weill Claude-Agnès Reynaud Stefan H E Kaufmann Jörn Walter Simon Fillatreau

Immunity 2018 07 10;49(1):120-133.e9. Epub 2018 Jul 10.

Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany; Institut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; AP-HP, Hôpital Necker Enfants Malades, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057275PMC
July 2018

Invasion of the Human Lung: First Contact.

Authors:
Jeroen Maertzdorf Mario Tönnies Laura Lozza Sandra Schommer-Leitner Hans Mollenkopf Torsten T Bauer Stefan H E Kaufmann

Front Immunol 2018 12;9:1346. Epub 2018 Jun 12.

Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.01346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022014PMC
June 2018

Hemostasis and Lipoprotein Indices Signify Exacerbated Lung Injury in TB With Diabetes Comorbidity.

Authors:
Zhengwei Dong Jingyun Shi Anca Dorhoi Jie Zhang Adiilah K Soodeen-Lalloo WenLing Tan Hongyun Yin Wei Sha Weitong Li Ruijuan Zheng Zhonghua Liu Hua Yang Lianhua Qin Jie Wang Xiaochen Huang Chunyan Wu Stefan H E Kaufmann Yonghong Feng

Chest 2018 May 7;153(5):1187-1200. Epub 2017 Dec 7.

Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China; Clinic and Research Center of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2017.11.029DOI Listing
May 2018

Indole Propionic Acid: a Small Molecule Links between Gut Microbiota and Tuberculosis.

Authors:
Stefan H E Kaufmann

Antimicrob Agents Chemother 2018 05 26;62(5). Epub 2018 Apr 26.

Max Planck Institute for Infection Biology, Berlin, Germany

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http://dx.doi.org/10.1128/AAC.00389-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923146PMC
May 2018

Mycobacterium tuberculosis-Infected Hematopoietic Stem and Progenitor Cells Unable to Express Inducible Nitric Oxide Synthase Propagate Tuberculosis in Mice.

Authors:
Stephen T Reece Alexis Vogelzang Julia Tornack Wolfgang Bauer Ulrike Zedler Sandra Schommer-Leitner Georg Stingl Fritz Melchers Stefan H E Kaufmann

J Infect Dis 2018 Apr;217(10):1667-1671

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1093/infdis/jiy041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913604PMC
April 2018

A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts.

Authors:
Fergal J Duffy Ethan Thompson Katrina Downing Sara Suliman Harriet Mayanja-Kizza W Henry Boom Bonnie Thiel January Weiner Iii Stefan H E Kaufmann Drew Dover David L Tabb Hazel M Dockrell Tom H M Ottenhoff Gerard Tromp Thomas J Scriba Daniel E Zak Gerhard Walzl

Front Immunol 2018 13;9:661. Epub 2018 Apr 13.

DST/NRF Centre of Excellence for Biomedical TB Research and MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.3389/fimmu.2018.00661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908968PMC
April 2018

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis.

Authors:
Alan Bénard Imme Sakwa Pablo Schierloh André Colom Ingrid Mercier Ludovic Tailleux Luc Jouneau Pierre Boudinot Talal Al-Saati Roland Lang Jan Rehwinkel Andre G Loxton Stefan H E Kaufmann Véronique Anton-Leberre Anne O'Garra Maria Del Carmen Sasiain Brigitte Gicquel Simon Fillatreau Olivier Neyrolles Denis Hudrisier

Am J Respir Crit Care Med 2018 Mar;197(6):801-813

1 Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, Centre National de la Recherche Scientifique (CNRS), Université Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1164/rccm.201707-1475OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855072PMC
March 2018

Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis.

Authors:
Novel N Chegou Jayne S Sutherland Anna-Ritah Namuganga Paul Lam Corstjens Annemieke Geluk Gebremedhin Gebremichael Joseph Mendy Stephanus Malherbe Kim Stanley Gian D van der Spuy Magdalena Kriel Andre G Loxton Belinda Kriel Felanji Simukonda Yonas Bekele Jacob A Sheehama Josefina Nelongo Marieta van der Vyver Atsbeha Gebrexabher Habteyes Hailu Maria M Esterhuyse Ida Rosenkrands Claus Aagard Martin Kidd Desta Kassa Adane Mihret Rawleigh Howe Jacqueline M Cliff Amelia C Crampin Harriet Mayanja-Kizza Stefan H E Kaufmann Hazel M Dockrell Tom H M Ottenhoff Gerhard Walzl

Sci Rep 2018 Feb 8;8(1):2675. Epub 2018 Feb 8.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa.

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http://dx.doi.org/10.1038/s41598-018-20855-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805775PMC
February 2018

Progress and challenges in TB vaccine development.

Authors:
Gerald Voss Danilo Casimiro Olivier Neyrolles Ann Williams Stefan H E Kaufmann Helen McShane Mark Hatherill Helen A Fletcher

F1000Res 2018 16;7:199. Epub 2018 Feb 16.

South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.12688/f1000research.13588.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850090PMC
February 2018

Host-directed therapies for bacterial and viral infections.

Authors:
Stefan H E Kaufmann Anca Dorhoi Richard S Hotchkiss Ralf Bartenschlager

Nat Rev Drug Discov 2018 Jan 22;17(1):35-56. Epub 2017 Sep 22.

Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nrd.2017.162DOI Listing
January 2018

The SysteMHC Atlas project.

Authors:
Wenguang Shao Patrick G A Pedrioli Witold Wolski Cristian Scurtescu Emanuel Schmid Juan A Vizcaíno Mathieu Courcelles Heiko Schuster Daniel Kowalewski Fabio Marino Cecilia S L Arlehamn Kerrie Vaughan Bjoern Peters Alessandro Sette Tom H M Ottenhoff Krista E Meijgaarden Natalie Nieuwenhuizen Stefan H E Kaufmann Ralph Schlapbach John C Castle Alexey I Nesvizhskii Morten Nielsen Eric W Deutsch David S Campbell Robert L Moritz Roman A Zubarev Anders Jimmy Ytterberg Anthony W Purcell Miguel Marcilla Alberto Paradela Qi Wang Catherine E Costello Nicola Ternette Peter A van Veelen Cécile A C M van Els Albert J R Heck Gustavo A de Souza Ludvig M Sollid Arie Admon Stefan Stevanovic Hans-Georg Rammensee Pierre Thibault Claude Perreault Michal Bassani-Sternberg Ruedi Aebersold Etienne Caron

Nucleic Acids Res 2018 Jan;46(D1):D1237-D1247

Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich 8093, Switzerland.

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http://dx.doi.org/10.1093/nar/gkx664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753376PMC
January 2018

IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.

Authors:
Fadhil Ahsan Jeroen Maertzdorf Ute Guhlich-Bornhof Stefan H E Kaufmann Pedro Moura-Alves

Sci Rep 2018 01 24;8(1):1520. Epub 2018 Jan 24.

Department of Immunology, Max Planck Institute for Infection Biology, Charitéplatz 1, Berlin, 10117, Germany.

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http://dx.doi.org/10.1038/s41598-018-19476-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784124PMC
January 2018

Pulmonary immune responses to Mycobacterium tuberculosis in exposed individuals.

Authors:
Christian Herzmann Martin Ernst Christoph Lange Steffen Stenger Stefan H E Kaufmann Norbert Reiling Tom Schaberg Lize van der Merwe Jeroen Maertzdorf

PLoS One 2017 10;12(11):e0187882. Epub 2017 Nov 10.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187882PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695274PMC
December 2017

The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.

Authors:
Gang Pei Hellen Buijze Haipeng Liu Pedro Moura-Alves Christian Goosmann Volker Brinkmann Hiroshi Kawabe Anca Dorhoi Stefan H E Kaufmann

Autophagy 2017 17;13(12):2041-2055. Epub 2017 Dec 17.

a Department of Immunology , Max Planck Institute for Infection Biology , Berlin , Germany.

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http://dx.doi.org/10.1080/15548627.2017.1376160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788543PMC
December 2017

Efficacy Testing of H56 cDNA Tattoo Immunization against Tuberculosis in a Mouse Model.

Authors:
Anouk C M Platteel Natalie E Nieuwenhuizen Teresa Domaszewska Stefanie Schürer Ulrike Zedler Volker Brinkmann Alice J A M Sijts Stefan H E Kaufmann

Front Immunol 2017 11;8:1744. Epub 2017 Dec 11.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.01744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732355PMC
December 2017

Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination.

Authors:
Mariëlle C Haks Barbara Bottazzi Valentina Cecchinato Corinne De Gregorio Giuseppe Del Giudice Stefan H E Kaufmann Antonio Lanzavecchia David J M Lewis Jeroen Maertzdorf Alberto Mantovani Federica Sallusto Marina Sironi Mariagrazia Uguccioni Tom H M Ottenhoff

Front Immunol 2017 15;8:1563. Epub 2017 Nov 15.

Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2017.01563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699440PMC
November 2017

Mycobacterium tuberculosis infection modulates adipose tissue biology.

Authors:
Macarena Beigier-Bompadre Georgina N Montagna Anja A Kühl Laura Lozza January Weiner Andreas Kupz Alexis Vogelzang Hans-Joachim Mollenkopf Delia Löwe Silke Bandermann Anca Dorhoi Volker Brinkmann Kai Matuschewski Stefan H E Kaufmann

PLoS Pathog 2017 Oct 17;13(10):e1006676. Epub 2017 Oct 17.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1006676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695609PMC
October 2017

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development.

Authors:
Stefan H E Kaufmann Hazel M Dockrell Nick Drager Mei Mei Ho Helen McShane Olivier Neyrolles Tom H M Ottenhoff Brij Patel Danielle Roordink François Spertini Steffen Stenger Jelle Thole Frank A W Verreck Ann Williams

Front Immunol 2017 4;8:1203. Epub 2017 Oct 4.

Public Health England, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2017.01203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632681PMC
October 2017

Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.

Authors:
Julia Tornack Stephen T Reece Wolfgang M Bauer Alexis Vogelzang Silke Bandermann Ulrike Zedler Georg Stingl Stefan H E Kaufmann Fritz Melchers

PLoS One 2017 3;12(1):e0169119. Epub 2017 Jan 3.

Senior Group on Lymphocyte Development, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169119PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207496PMC
September 2017

Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis.

Authors:
Teresa Domaszewska Lisa Scheuermann Karin Hahnke Hans Mollenkopf Anca Dorhoi Stefan H E Kaufmann January Weiner

Sci Rep 2017 09 21;7(1):12094. Epub 2017 Sep 21.

Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, D-10117, Berlin, Germany.

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http://dx.doi.org/10.1038/s41598-017-11812-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608750PMC
September 2017

The Recombinant Bacille Calmette-Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing.

Authors:
Natalie E Nieuwenhuizen Prasad S Kulkarni Umesh Shaligram Mark F Cotton Cyrill A Rentsch Bernd Eisele Leander Grode Stefan H E Kaufmann

Front Immunol 2017 19;8:1147. Epub 2017 Sep 19.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.01147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610719PMC
September 2017

Accelerating tuberculosis vaccine trials with diagnostic and prognostic biomarkers.

Authors:
Stefan H E Kaufmann January Weiner Jeroen Maertzdorf

Expert Rev Vaccines 2017 08 19;16(8):845-853. Epub 2017 Jun 19.

a Department of Immunology , Max Planck Institute for Infection Biology , Berlin , Germany.

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http://dx.doi.org/10.1080/14760584.2017.1341316DOI Listing
August 2017

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans.

Authors:
Martin Gengenbacher Maria A Duque-Correa Peggy Kaiser Stefanie Schuerer Doris Lazar Ulrike Zedler Stephen T Reece Amit Nayyar Stewart T Cole Vadim Makarov Clifton E Barry Iii Véronique Dartois Stefan H E Kaufmann

Sci Rep 2017 08 18;7(1):8853. Epub 2017 Aug 18.

Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany.

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http://dx.doi.org/10.1038/s41598-017-09177-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562869PMC
August 2017

A Mouse Model of Latent Tuberculosis Infection to Study Intervention Strategies to Prevent Reactivation.

Authors:
Andreas Kupz Ulrike Zedler Manuela Stäber Stefan H E Kaufmann

PLoS One 2016 8;11(7):e0158849. Epub 2016 Jul 8.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158849PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938611PMC
July 2017

Emil von Behring: translational medicine at the dawn of immunology.

Authors:
Stefan H E Kaufmann

Nat Rev Immunol 2017 Jun 10;17(6):341-343. Epub 2017 Apr 10.

Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany.

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http://dx.doi.org/10.1038/nri.2017.37DOI Listing
June 2017

Novel approaches to tuberculosis vaccine development.

Authors:
Stefan H E Kaufmann January Weiner C Fordham von Reyn

Int J Infect Dis 2017 Mar 2;56:263-267. Epub 2016 Nov 2.

Infectious Disease and International Health, Geisel School of Medicine, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1016/j.ijid.2016.10.018DOI Listing
March 2017

High-throughput and computational approaches for diagnostic and prognostic host tuberculosis biomarkers.

Authors:
January Weiner Stefan H E Kaufmann

Int J Infect Dis 2017 Mar 9;56:258-262. Epub 2016 Nov 9.

Max Planck Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany.

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http://dx.doi.org/10.1016/j.ijid.2016.10.017DOI Listing
March 2017

Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa.

Authors:
André G Loxton Julia K Knaul Leander Grode Andrea Gutschmidt Christiane Meller Bernd Eisele Hilary Johnstone Gian van der Spuy Jeroen Maertzdorf Stefan H E Kaufmann Anneke C Hesseling Gerhard Walzl Mark F Cotton

Clin Vaccine Immunol 2017 02 6;24(2). Epub 2017 Feb 6.

Fam-Cru, Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

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http://dx.doi.org/10.1128/CVI.00439-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299117PMC
February 2017

Remembering Emil von Behring: from Tetanus Treatment to Antibody Cooperation with Phagocytes.

Authors:
Stefan H E Kaufmann

MBio 2017 02 28;8(1). Epub 2017 Feb 28.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany

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http://dx.doi.org/10.1128/mBio.00117-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347343PMC
February 2017

Syndecans promote mycobacterial internalization by lung epithelial cells.

Authors:
Natalie Zimmermann Hiroyuki Saiga Erica Houthuys Pedro Moura-Alves Anne Koehler Silke Bandermann Anca Dorhoi Stefan H E Kaufmann

Cell Microbiol 2016 Dec 15;18(12):1846-1856. Epub 2016 Jul 15.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1111/cmi.12627DOI Listing
December 2016

Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants.

Authors:
Thorunn A Olafsdottir Madelene Lindqvist Intawat Nookaew Peter Andersen Jeroen Maertzdorf Josefine Persson Dennis Christensen Yuan Zhang Jenna Anderson Sakda Khoomrung Partho Sen Else Marie Agger Rhea Coler Darrick Carter Andreas Meinke Rino Rappuoli Stefan H E Kaufmann Steven G Reed Ali M Harandi

Sci Rep 2016 12 13;6:39097. Epub 2016 Dec 13.

Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1038/srep39097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153655PMC
December 2016

Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.

Authors:
Ekta Lachmandas Macarena Beigier-Bompadre Shih-Chin Cheng Vinod Kumar Arjan van Laarhoven Xinhui Wang Anne Ammerdorffer Lily Boutens Dirk de Jong Thirumala-Devi Kanneganti Mark S Gresnigt Tom H M Ottenhoff Leo A B Joosten Rinke Stienstra Cisca Wijmenga Stefan H E Kaufmann Reinout van Crevel Mihai G Netea

Eur J Immunol 2016 11 27;46(11):2574-2586. Epub 2016 Sep 27.

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/eji.201546259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129526PMC
November 2016

The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation.

Authors:
Ethel Bayer-Santos Charlotte H Durkin Luciano A Rigano Andreas Kupz Eric Alix Ondrej Cerny Elliott Jennings Mei Liu Aindrias S Ryan Nicolas Lapaque Stefan H E Kaufmann David W Holden

Cell Host Microbe 2016 Nov;20(5):584-595

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104694PMC
November 2016

Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis.

Authors:
Carolina Perdomo Ulrike Zedler Anja A Kühl Laura Lozza Philippe Saikali Leif E Sander Alexis Vogelzang Stefan H E Kaufmann Andreas Kupz

MBio 2016 11 22;7(6). Epub 2016 Nov 22.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1128/mBio.01686-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120139PMC
November 2016

Neonatal Fc Receptor Regulation of Lung Immunoglobulin and CD103+ Dendritic Cells Confers Transient Susceptibility to Tuberculosis.

Authors:
Alexis Vogelzang Laura Lozza Stephen T Reece Carolina Perdomo Ulrike Zedler Karin Hahnke Dagmar Oberbeck-Mueller Anca Dorhoi Stefan H E Kaufmann

Infect Immun 2016 10 19;84(10):2914-21. Epub 2016 Sep 19.

Max Planck Institute for Infection Biology, Berlin, Germany

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http://dx.doi.org/10.1128/IAI.00533-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038074PMC
October 2016

Correction: The CARD9 Polymorphisms rs4077515, rs10870077 and rs10781499 Are Uncoupled from Susceptibility to and Severity of Pulmonary Tuberculosis.

Authors:
Ioana Streata January Weiner Marco Iannaccone Gayle McEwen Marius Sorin Ciontea Marian Olaru Rosanna Capparelli Mihai Ioana Stefan H E Kaufmann Anca Dorhoi

PLoS One 2016;11(10):e0165853. Epub 2016 Oct 26.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165853PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081169PMC
October 2016

Developmental transcriptome of resting cell formation in Mycobacterium smegmatis.

Authors:
Mu-Lu Wu Martin Gengenbacher Jade C S Chung Swaine Lin Chen Hans-Joachim Mollenkopf Stefan H E Kaufmann Thomas Dick

BMC Genomics 2016 10 26;17(1):837. Epub 2016 Oct 26.

Antibacterial Drug Discovery Laboratory, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1186/s12864-016-3190-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081680PMC
October 2016

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

Authors:
Novel N Chegou Jayne S Sutherland Stephanus Malherbe Amelia C Crampin Paul L A M Corstjens Annemieke Geluk Harriet Mayanja-Kizza Andre G Loxton Gian van der Spuy Kim Stanley Leigh A Kotzé Marieta van der Vyver Ida Rosenkrands Martin Kidd Paul D van Helden Hazel M Dockrell Tom H M Ottenhoff Stefan H E Kaufmann Gerhard Walzl

Thorax 2016 09 4;71(9):785-94. Epub 2016 May 4.

Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1136/thoraxjnl-2015-207999DOI Listing
September 2016

Vaccination Against Tuberculosis With Whole-Cell Mycobacterial Vaccines.

Authors:
Thomas J Scriba Stefan H E Kaufmann Paul Henri Lambert Melvin Sanicas Carlos Martin Olivier Neyrolles

J Infect Dis 2016 09 30;214(5):659-64. Epub 2016 May 30.

CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale) Université de Toulouse, UPS, IPBS, France.

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http://dx.doi.org/10.1093/infdis/jiw228DOI Listing
September 2016

The CARD9 Polymorphisms rs4077515, rs10870077 and rs10781499 Are Uncoupled from Susceptibility to and Severity of Pulmonary Tuberculosis.

Authors:
Ioana Streata January Weiner Marco Iannaconne Gayle McEwen Marius Sorin Ciontea Marian Olaru Rosanna Capparelli Mihai Ioana Stefan H E Kaufmann Anca Dorhoi

PLoS One 2016;11(9):e0163662. Epub 2016 Sep 29.

Max Planck Institute for Infection Biology, 10117 Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163662PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042433PMC
September 2016

Role of Interleukin 36γ in Host Defense Against Tuberculosis.

Authors:
Fadhil Ahsan Pedro Moura-Alves Ute Guhlich-Bornhof Marion Klemm Stefan H E Kaufmann Jeroen Maertzdorf

J Infect Dis 2016 08 18;214(3):464-74. Epub 2016 Apr 18.

Department of Immunology, Max Planck Institute for Infection Biology, and.

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http://dx.doi.org/10.1093/infdis/jiw152DOI Listing
August 2016

TB biomarkers, TB correlates and human challenge models: New tools for improving assessment of new TB vaccines.

Authors:
Stefan H E Kaufmann Sarah Fortune Ilaria Pepponi Morten Ruhwald Lewis K Schrager Tom H M Ottenhoff

Tuberculosis (Edinb) 2016 08 16;99 Suppl 1:S8-S11. Epub 2016 Jun 16.

Leiden University Medical Center, Leiden, The Netherlands; TuBerculosis Vaccine Initiative (TBVI), Lelystad, The Netherlands.

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http://dx.doi.org/10.1016/j.tube.2016.05.010DOI Listing
August 2016

EFIS lecture. Immune response to tuberculosis: How to control the most successful pathogen on earth.

Authors:
Stefan H E Kaufmann

Immunol Lett 2016 07 12;175:50-7. Epub 2016 May 12.

Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2016.05.006DOI Listing
July 2016

A blood RNA signature for tuberculosis disease risk: a prospective cohort study.

Authors:
Daniel E Zak Adam Penn-Nicholson Thomas J Scriba Ethan Thompson Sara Suliman Lynn M Amon Hassan Mahomed Mzwandile Erasmus Wendy Whatney Gregory D Hussey Deborah Abrahams Fazlin Kafaar Tony Hawkridge Suzanne Verver E Jane Hughes Martin Ota Jayne Sutherland Rawleigh Howe Hazel M Dockrell W Henry Boom Bonnie Thiel Tom H M Ottenhoff Harriet Mayanja-Kizza Amelia C Crampin Katrina Downing Mark Hatherill Joe Valvo Smitha Shankar Shreemanta K Parida Stefan H E Kaufmann Gerhard Walzl Alan Aderem Willem A Hanekom

Lancet 2016 Jun 24;387(10035):2312-2322. Epub 2016 Mar 24.

South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(15)01316-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392204PMC
June 2016

ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo.

Authors:
Andreas Kupz Ulrike Zedler Manuela Stäber Carolina Perdomo Anca Dorhoi Roland Brosch Stefan H E Kaufmann

J Clin Invest 2016 06 25;126(6):2109-22. Epub 2016 Apr 25.

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http://dx.doi.org/10.1172/JCI84978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887189PMC
June 2016

Post-exposure vaccination with the vaccine candidate Bacillus Calmette-Guérin ΔureC::hly induces superior protection in a mouse model of subclinical tuberculosis.

Authors:
Martin Gengenbacher Peggy Kaiser Stefanie Schuerer Doris Lazar Stefan H E Kaufmann

Microbes Infect 2016 05 17;18(5):364-8. Epub 2016 Mar 17.

Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.micinf.2016.03.005DOI Listing
May 2016

Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ΔureC::hly Improves Protection against Tuberculosis.

Authors:
Martin Gengenbacher Natalie Nieuwenhuizen Alexis Vogelzang Haipeng Liu Peggy Kaiser Stefanie Schuerer Doris Lazar Ina Wagner Hans-Joachim Mollenkopf Stefan H E Kaufmann

MBio 2016 05 24;7(3). Epub 2016 May 24.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany

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http://dx.doi.org/10.1128/mBio.00679-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895111PMC
May 2016

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects.

Authors:
Alimuddin Zumla Martin Rao Robert S Wallis Stefan H E Kaufmann Roxana Rustomjee Peter Mwaba Cris Vilaplana Dorothy Yeboah-Manu Jeremiah Chakaya Giuseppe Ippolito Esam Azhar Michael Hoelscher Markus Maeurer

Lancet Infect Dis 2016 Apr;16(4):e47-63

Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(16)00078-5DOI Listing
April 2016

Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis.

Authors:
Anca Dorhoi Stefan H E Kaufmann

Semin Immunopathol 2016 Mar 5;38(2):153-66. Epub 2015 Oct 5.

Department of Immunology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117, Berlin, Germany.

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http://dx.doi.org/10.1007/s00281-015-0531-3DOI Listing
March 2016

Immunopathology of mycobacterial diseases.

Authors:
Stefan H E Kaufmann

Semin Immunopathol 2016 Mar 2;38(2):135-8. Epub 2016 Feb 2.

Department of Immunology, Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117, Berlin, Germany.

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http://dx.doi.org/10.1007/s00281-015-0547-8DOI Listing
March 2016

Molecular Determinants in Phagocyte-Bacteria Interactions.

Authors:
Stefan H E Kaufmann Anca Dorhoi

Immunity 2016 Mar;44(3):476-491

Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.02.014DOI Listing
March 2016

Dysregulation of Apoptosis Is a Risk Factor for Tuberculosis Disease Progression.

Authors:
Thomas O J P Elliott Olumuyiwa Owolabi Simon Donkor Beate Kampmann Philip C Hill Tom H M Ottenhoff Marielle C Haks Stefan H E Kaufmann Jeroen Maertzdorf Jayne S Sutherland

J Infect Dis 2015 Nov 20;212(9):1469-79. Epub 2015 Apr 20.

Vaccines & Immunity, Medical Research Council Unit, Fajara, The Gambia.

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http://dx.doi.org/10.1093/infdis/jiv238DOI Listing
November 2015

TRANSVAC research infrastructure - Results and lessons learned from the European network of vaccine research and development.

Authors:
Mark J Geels Regitze L Thøgersen Carlos A Guzman Mei Mei Ho Frank Verreck Nicolas Collin James S Robertson Samuel J McConkey Stefan H E Kaufmann Odile Leroy

Vaccine 2015 Oct 8;33(41):5481-5487. Epub 2015 Feb 8.

European Vaccine Initiative, UniversitätsKlinikum Heidelberg, Im Neuenheimer Feld 326 - 3.OG, 69120, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.01.079DOI Listing
October 2015

Reply to Crawford.

Authors:
Anca Dorhoi Yonghong Feng Stefan H E Kaufmann

J Infect Dis 2015 Oct 23;212(7):1173-4. Epub 2015 Mar 23.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1093/infdis/jiv156DOI Listing
October 2015

Big Data in Vaccinology: Introduction and section summaries.

Authors:
Stefan H E Kaufmann Helen A Fletcher Carlos A Guzmán Tom H M Ottenhoff

Vaccine 2015 Sep 2;33(40):5237-40. Epub 2015 May 2.

Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.vaccine.2015.04.078DOI Listing
September 2015

High-throughput data analysis and data integration for vaccine trials.

Authors:
January Weiner Stefan H E Kaufmann Jeroen Maertzdorf

Vaccine 2015 Sep 11;33(40):5249-55. Epub 2015 May 11.

Department of Immunology, Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117, Berlin, Germany.

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http://dx.doi.org/10.1016/j.vaccine.2015.04.096DOI Listing
September 2015

Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers.

Authors:
Maria M Esterhuyse January Weiner Etienne Caron Andre G Loxton Marco Iannaccone Chandre Wagman Philippe Saikali Kim Stanley Witold E Wolski Hans-Joachim Mollenkopf Matthias Schick Ruedi Aebersold Heinz Linhart Gerhard Walzl Stefan H E Kaufmann

MBio 2015 Sep 15;6(5):e01187-15. Epub 2015 Sep 15.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany

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http://dx.doi.org/10.1128/mBio.01187-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600108PMC
September 2015

Versatile myeloid cell subsets contribute to tuberculosis-associated inflammation.

Authors:
Anca Dorhoi Stefan H E Kaufmann

Eur J Immunol 2015 Aug;45(8):2191-202

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201545493DOI Listing
August 2015

Towards host-directed therapies for tuberculosis.

Authors:
Alimuddin Zumla Markus Maeurer Jeremiah Chakaya Michael Hoelscher Francine Ntoumi Roxana Rustomjee Cristina Vilaplana Dorothy Yeboah-Manu Voahangy Rasolof Paula Munderi Nalini Singh Eleni Aklillu Nesri Padayatchi Eusebio Macete Nathan Kapata Modest Mulenga Gibson Kibiki Sayoki Mfinanga Thomas Nyirenda Leonard Maboko Alberto Garcia-Basteiro Niaina Rakotosamimanana Matthew Bates Peter Mwaba Klaus Reither Sebastien Gagneux Sarah Edwards Elirehema Mfinanga Salim Abdulla Pere-Joan Cardona James B W Russell Vanya Gant Mahdad Noursadeghi Paul Elkington Maryline Bonnet Clara Menendez Tandakha N Dieye Bassirou Diarra Almoustapha Maiga Abraham Aseffa Shreemanta Parida Christian Wejse Eskild Petersen Pontiano Kaleebu Matt Oliver Gill Craig Tumena Corrah Leopold Tientcheu Martin Antonio Martin Rao Timothy D McHugh Aziz Sheikh Giuseppe Ippolito Gita Ramjee Stefan H E Kaufmann Gavin Churchyard Andrie Steyn Martin Grobusch Ian Sanne Neil Martinson Rajhmun Madansein Robert J Wilkinson Bongani Mayosi Marco Schito Robert S Wallis

Nat Rev Drug Discov 2015 Aug 17;14(8):511-2. Epub 2015 Jul 17.

Aurum Institute, Johannesburg, South Africa.

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http://dx.doi.org/10.1038/nrd4696DOI Listing
August 2015

Absolute Proteome Composition and Dynamics during Dormancy and Resuscitation of Mycobacterium tuberculosis.

Authors:
Olga T Schubert Christina Ludwig Maria Kogadeeva Michael Zimmermann George Rosenberger Martin Gengenbacher Ludovic C Gillet Ben C Collins Hannes L Röst Stefan H E Kaufmann Uwe Sauer Ruedi Aebersold

Cell Host Microbe 2015 Jul 18;18(1):96-108. Epub 2015 Jun 18.

Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, CH-8093, Switzerland; Faculty of Science, University of Zurich, Zurich CH-8057, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.06.001DOI Listing
July 2015

The Recombinant BCG ΔureC::hly Vaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation.

Authors:
Hiroyuki Saiga Natalie Nieuwenhuizen Martin Gengenbacher Anne-Britta Koehler Stefanie Schuerer Pedro Moura-Alves Ina Wagner Hans-Joachim Mollenkopf Anca Dorhoi Stefan H E Kaufmann

J Infect Dis 2015 Jun 11;211(11):1831-41. Epub 2014 Dec 11.

Department of Immunology.

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http://dx.doi.org/10.1093/infdis/jiu675DOI Listing
June 2015

Aeras-sponsored meeting reports: Aerosol TB vaccines, whole mycobacteria cell TB vaccines, and prevention of sustained Mycobacterium tuberculosis infection.

Authors:
Stefan H E Kaufmann

Vaccine 2015 Jun 8;33(26):3035-7. Epub 2015 Apr 8.

Max Planck Institute for Infection Biology, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.04.001DOI Listing
June 2015

The human immune response to tuberculosis and its treatment: a view from the blood.

Authors:
Jacqueline M Cliff Stefan H E Kaufmann Helen McShane Paul van Helden Anne O'Garra

Immunol Rev 2015 Mar;264(1):88-102

TB Centre and Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK.

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http://dx.doi.org/10.1111/imr.12269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368415PMC
March 2015

Mycobacterium genotypes in pulmonary tuberculosis infections and their detection by trained African giant pouched rats.

Authors:
Georgies F Mgode Stéphan Cohen-Bacrie Marielle Bedotto Bart J Weetjens Christophe Cox Maureen Jubitana Dian Kuipers Robert S Machang'u Rudovick Kazwala Sayoki G Mfinanga Stefan H E Kaufmann Michel Drancourt

Curr Microbiol 2015 Feb 2;70(2):212-8. Epub 2014 Oct 2.

Department of Immunology, Max Planck Institute for Infection Biology, Charitéplatz 1, Campus Charité Mitte, 10117, Berlin, Germany.

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http://link.springer.com/10.1007/s00284-014-0705-6
Publisher Site
http://dx.doi.org/10.1007/s00284-014-0705-6DOI Listing
February 2015

Tuberculosis vaccines: time for a global strategy.

Authors:
Stefan H E Kaufmann Thomas G Evans Willem A Hanekom

Sci Transl Med 2015 Feb;7(276):276fs8

Bill & Melinda Gates Foundation, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa4730DOI Listing
February 2015

CXCL5 drives neutrophil recruitment in TH17-mediated GN.

Authors:
Erik M Disteldorf Christian F Krebs Hans-Joachim Paust Jan-Eric Turner Geraldine Nouailles André Tittel Catherine Meyer-Schwesinger Gesa Stege Silke Brix Joachim Velden Thorsten Wiech Udo Helmchen Oliver M Steinmetz Anett Peters Sabrina B Bennstein Anna Kaffke Chrystel Llanto Sergio A Lira Hans-Willi Mittrücker Rolf A K Stahl Christian Kurts Stefan H E Kaufmann Ulf Panzer

J Am Soc Nephrol 2015 Jan 5;26(1):55-66. Epub 2014 Jun 5.

III. Medical Clinic and

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http://dx.doi.org/10.1681/ASN.2013101061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279732PMC
January 2015

Central memory CD4+ T cells are responsible for the recombinant Bacillus Calmette-Guérin ΔureC::hly vaccine's superior protection against tuberculosis.

Authors:
Alexis Vogelzang Carolina Perdomo Ulrike Zedler Stefanie Kuhlmann Robert Hurwitz Martin Gengenbacher Stefan H E Kaufmann

J Infect Dis 2014 Dec 18;210(12):1928-37. Epub 2014 Jun 18.

Department of Immunology.

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http://dx.doi.org/10.1093/infdis/jiu347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241943PMC
December 2014

Serologic diagnosis of tuberculosis by combining Ig classes against selected mycobacterial targets.

Authors:
Ralf Baumann Susanne Kaempfer Novel N Chegou Wulf Oehlmann André G Loxton Stefan H E Kaufmann Paul D van Helden Gillian F Black Mahavir Singh Gerhard Walzl

J Infect 2014 Dec 23;69(6):581-9. Epub 2014 Jun 23.

DST/NRF Centre of Excellence for Biomedical TB Research and MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg 7505, South Africa.

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http://dx.doi.org/10.1016/j.jinf.2014.05.014DOI Listing
December 2014

Platelets direct monocyte differentiation into epithelioid-like multinucleated giant foam cells with suppressive capacity upon mycobacterial stimulation.

Authors:
Yonghong Feng Anca Dorhoi Hans-Joachim Mollenkopf Hongyun Yin Zhengwei Dong Ling Mao Jun Zhou Aixiao Bi Stephan Weber Jeroen Maertzdorf Gang Chen Yang Chen Stefan H E Kaufmann

J Infect Dis 2014 Dec 1;210(11):1700-10. Epub 2014 Jul 1.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1093/infdis/jiu355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224136PMC
December 2014

Perspectives on host adaptation in response to Mycobacterium tuberculosis: modulation of inflammation.

Authors:
Anca Dorhoi Stefan H E Kaufmann

Semin Immunol 2014 Dec 25;26(6):533-42. Epub 2014 Oct 25.

Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2014.10.002DOI Listing
December 2014

Introduction.

Authors:
Stefan H E Kaufmann

Semin Immunol 2014 Dec 16;26(6):429-30. Epub 2014 Oct 16.

Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2014.09.007DOI Listing
December 2014

Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis.

Authors:
Julia K Knaul Sabine Jörg Dagmar Oberbeck-Mueller Ellen Heinemann Lisa Scheuermann Volker Brinkmann Hans-Joachim Mollenkopf Vladimir Yeremeev Stefan H E Kaufmann Anca Dorhoi

Am J Respir Crit Care Med 2014 Nov;190(9):1053-66

1 Department of Immunology.

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http://dx.doi.org/10.1164/rccm.201405-0828OCDOI Listing
November 2014

Toward a unified biosignature for tuberculosis.

Authors:
Jeroen Maertzdorf Stefan H E Kaufmann January Weiner

Cold Spring Harb Perspect Med 2014 Oct 23;5(1):a018531. Epub 2014 Oct 23.

Max Planck Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany.

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http://dx.doi.org/10.1101/cshperspect.a018531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292082PMC
October 2014

Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas.

Authors:
María A Duque-Correa Anja A Kühl Paulo C Rodriguez Ulrike Zedler Sandra Schommer-Leitner Martin Rao January Weiner Robert Hurwitz Joseph E Qualls George A Kosmiadi Peter J Murray Stefan H E Kaufmann Stephen T Reece

Proc Natl Acad Sci U S A 2014 Sep 8;111(38):E4024-32. Epub 2014 Sep 8.

Department of Immunology and.

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http://www.pnas.org/content/111/38/E4024.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1408839111
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http://dx.doi.org/10.1073/pnas.1408839111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183271PMC
September 2014

Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics.

Authors:
Anca Dorhoi Vladimir Yeremeev Geraldine Nouailles January Weiner Sabine Jörg Ellen Heinemann Dagmar Oberbeck-Müller Julia K Knaul Alexis Vogelzang Stephen T Reece Karin Hahnke Hans-Joachim Mollenkopf Volker Brinkmann Stefan H E Kaufmann

Eur J Immunol 2014 Aug 24;44(8):2380-93. Epub 2014 Jun 24.

Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201344219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298793PMC
August 2014

AhR sensing of bacterial pigments regulates antibacterial defence.

Authors:
Pedro Moura-Alves Kellen Faé Erica Houthuys Anca Dorhoi Annika Kreuchwig Jens Furkert Nicola Barison Anne Diehl Antje Munder Patricia Constant Tatsiana Skrahina Ute Guhlich-Bornhof Marion Klemm Anne-Britta Koehler Silke Bandermann Christian Goosmann Hans-Joachim Mollenkopf Robert Hurwitz Volker Brinkmann Simon Fillatreau Mamadou Daffe Burkhard Tümmler Michael Kolbe Hartmut Oschkinat Gerd Krause Stefan H E Kaufmann

Nature 2014 Aug 13;512(7515):387-92. Epub 2014 Aug 13.

Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany.

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http://dx.doi.org/10.1038/nature13684DOI Listing
August 2014

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.

Authors:
Céline Dutruel Jelle Thole Mark Geels Hans-Joachim Mollenkopf Tom Ottenhoff Carlos A Guzman Helen A Fletcher Odile Leroy Stefan H E Kaufmann

Vaccine 2014 Jul 17;32(35):4365-8. Epub 2014 Jun 17.

Department of Immunology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.06.014DOI Listing
July 2014

Communication between Human Dendritic Cell Subsets in Tuberculosis: Requirements for Naive CD4(+) T Cell Stimulation.

Authors:
Laura Lozza Maura Farinacci Marina Bechtle Manuela Stäber Ulrike Zedler Andrea Baiocchini Franca Del Nonno Stefan H E Kaufmann

Front Immunol 2014 14;5:324. Epub 2014 Jul 14.

Department of Immunology, Max Planck Institute for Infection Biology , Berlin , Germany.

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http://journal.frontiersin.org/article/10.3389/fimmu.2014.00
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http://dx.doi.org/10.3389/fimmu.2014.00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094910PMC
July 2014

Antigen export during liver infection of the malaria parasite augments protective immunity.

Authors:
Georgina N Montagna Macarena Beigier-Bompadre Martina Becker Richard A Kroczek Stefan H E Kaufmann Kai Matuschewski

MBio 2014 Jul 29;5(4):e01321-14. Epub 2014 Jul 29.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1128/mBio.01321-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128355PMC
July 2014

Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection.

Authors:
Hans-Willi Mittrücker Daniel Seidel Paul W Bland Agnieszka Zarzycka Stefan H E Kaufmann Alexander Visekruna Ulrich Steinhoff

Eur J Immunol 2014 Jun 20;44(6):1710-5. Epub 2014 Mar 20.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany; Institute for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/eji.201343927DOI Listing
June 2014

Tumor necrosis factor alpha in mycobacterial infection.

Authors:
Anca Dorhoi Stefan H E Kaufmann

Semin Immunol 2014 Jun 10;26(3):203-9. Epub 2014 May 10.

Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2014.04.003DOI Listing
June 2014

Novel vaccination strategies against tuberculosis.

Authors:
Peter Andersen Stefan H E Kaufmann

Cold Spring Harb Perspect Med 2014 Jun 2;4(6). Epub 2014 Jun 2.

Max Planck Institute for Infection Biology, 10117 Berlin, Germany.

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http://dx.doi.org/10.1101/cshperspect.a018523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031959PMC
June 2014

Dietary pyridoxine controls efficacy of vitamin B6-auxotrophic tuberculosis vaccine bacillus Calmette-Guérin ΔureC::hly Δpdx1 in mice.

Authors:
Martin Gengenbacher Alexis Vogelzang Stefanie Schuerer Doris Lazar Peggy Kaiser Stefan H E Kaufmann

MBio 2014 Jun 3;5(3):e01262-14. Epub 2014 Jun 3.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany

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http://dx.doi.org/10.1128/mBio.01262-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049106PMC
June 2014

NKT cells determine titer and subtype profile of virus-specific IgG antibodies during herpes simplex virus Infection.

Authors:
Martin J Raftery Eike Wolter Simon Fillatreau Helga Meisel Stefan H E Kaufmann Günther Schönrich

J Immunol 2014 May 28;192(9):4294-302. Epub 2014 Mar 28.

Institut für Virologie, Helmut-Ruska-Haus, Charité - Universitätsmedizin Berlin, 10117 Berlin, Gemany;

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1300148
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http://dx.doi.org/10.4049/jimmunol.1300148DOI Listing
May 2014

Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states.

Authors:
Adane Mihret Andre G Loxton Yonas Bekele Stefan H E Kaufmann Martin Kidd Mariëlle C Haks Tom H M Ottenhoff Abraham Aseffa Rawleigh Howe Gerhard Walzl

BMC Infect Dis 2014 May 13;14:257. Epub 2014 May 13.

Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

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http://dx.doi.org/10.1186/1471-2334-14-257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041060PMC
May 2014

Mycobacterium tuberculosis in the Proteomics Era.

Authors:
Martin Gengenbacher Jeppe Mouritsen Olga T Schubert Ruedi Aebersold Stefan H E Kaufmann

Microbiol Spectr 2014 Apr;2(2)

Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany.

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http://dx.doi.org/10.1128/microbiolspec.MGM2-0020-2013DOI Listing
April 2014

Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review.

Authors:
Stefan H E Kaufmann Christoph Lange Martin Rao Kithiganahalli N Balaji Michael Lotze Marco Schito Alimuddin I Zumla Markus Maeurer

Lancet Respir Med 2014 Apr 24;2(4):301-20. Epub 2014 Mar 24.

Center for Allogeneic Stem Cell Transplantation (CAST), Therapeutic Immunology (TIM), Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(14)70033-5DOI Listing
April 2014