Stefan France

Stefan France

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Stefan France

Stefan France

Publications by authors named "Stefan France"

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Calcium-Catalyzed Formal [5 + 2] Cycloadditions of Alkylidene β-Ketoesters with Olefins: Chemodivergent Synthesis of Highly Functionalized Cyclohepta[]indole Derivatives.

Org Lett 2019 Sep 12;21(18):7268-7273. Epub 2019 Sep 12.

School of Chemistry and Biochemistry , Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.

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http://dx.doi.org/10.1021/acs.orglett.9b02498DOI Listing
September 2019

Base-Mediated Cascade Aldol Addition and Fragmentation Reactions of Dihydroxyfumaric Acid and Aromatic Aldehydes: Controlling Chemodivergence via Choice of Base, Solvent, and Substituents.

J Org Chem 2018 12 12;83(23):14219-14233. Epub 2018 Oct 12.

School of Chemistry and Biochemistry , Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.

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http://dx.doi.org/10.1021/acs.joc.8b01867DOI Listing
December 2018

α-Alkylidene-γ-butyrolactone Formation via Bi(OTf)-Catalyzed, Dehydrative, Ring-Opening Cyclizations of Cyclopropyl Carbinols: Understanding Substituent Effects and Predicting E/Z Selectivity.

J Org Chem 2017 10 3;82(20):10883-10897. Epub 2017 Oct 3.

School of Chemistry and Biochemistry and ‡Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.

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http://pubs.acs.org/doi/10.1021/acs.joc.7b01706
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http://dx.doi.org/10.1021/acs.joc.7b01706DOI Listing
October 2017

Rh -Catalyzed β-C(sp )-H Alkylation of Enol Ethers, Enamides and Enecarbamates with α-Diazo Dicarbonyl Compounds.

Chemistry 2017 Jan 14;23(5):1129-1135. Epub 2016 Dec 14.

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.

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http://dx.doi.org/10.1002/chem.201604518DOI Listing
January 2017

IMDAF Cascade Approach toward the Synthesis of the Alkaloid (±)-Minfiensine.

J Org Chem 2016 11 1;81(21):10193-10203. Epub 2016 Jun 1.

Department of Chemistry, Emory University , Atlanta, Georgia 30322, United States.

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http://dx.doi.org/10.1021/acs.joc.6b00771DOI Listing
November 2016

Calcium-Catalyzed, Dehydrative, Ring-Opening Cyclizations of Cyclopropyl Carbinols Derived from Donor-Acceptor Cyclopropanes.

Org Lett 2016 09 12;18(17):4218-21. Epub 2016 Aug 12.

School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.

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http://pubs.acs.org/doi/10.1021/acs.orglett.6b01933
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http://dx.doi.org/10.1021/acs.orglett.6b01933DOI Listing
September 2016

Catalytic, Interrupted Formal Homo-Nazarov Cyclization with (Hetero)arenes: Access to α-(Hetero)aryl Cyclohexanones.

J Org Chem 2016 09 30;81(18):8253-67. Epub 2016 Aug 30.

School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.

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http://dx.doi.org/10.1021/acs.joc.6b01312DOI Listing
September 2016

Catalytic, Cascade Ring-Opening Benzannulations of 2,3-Dihydrofuran O,O- and N,O-Acetals.

Chemistry 2016 Jul 15;22(30):10405-9. Epub 2016 Jun 15.

Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.

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http://dx.doi.org/10.1002/chem.201601954DOI Listing
July 2016

A catalytic diastereoselective formal [5+2] cycloaddition approach to azepino[1,2-a]indoles: putative donor-acceptor cyclobutanes as reactive intermediates.

Angew Chem Int Ed Engl 2014 Dec 22;53(50):13907-11. Epub 2014 Oct 22.

School of Chemistry and Biochemistry, Georgia Institute of Technology (USA).

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http://dx.doi.org/10.1002/anie.201408429DOI Listing
December 2014

Catalysis and chemodivergence in the interrupted, formal homo-Nazarov cyclization using allylsilanes.

Org Lett 2014 Dec 11;16(24):6468-71. Epub 2014 Dec 11.

School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.

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http://dx.doi.org/10.1021/ol503305rDOI Listing
December 2014

Catalytic, formal homo-Nazarov-type cyclizations of alkylidene cyclopropane-1,1-ketoesters: access to functionalized arenes and heteroaromatics.

Org Lett 2014 Jul 8;16(14):3788-91. Epub 2014 Jul 8.

School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.

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http://dx.doi.org/10.1021/ol501676qDOI Listing
July 2014

Functionalized 4-carboxy- and 4-keto-2,3-dihydropyrroles via Ni(II)-catalyzed nucleophilic amine ring-opening cyclizations of cyclopropanes.

J Org Chem 2014 Apr 21;79(7):3030-9. Epub 2014 Mar 21.

School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.

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http://dx.doi.org/10.1021/jo5001059DOI Listing
April 2014

Intramolecular donor-acceptor cyclopropane ring-opening cyclizations.

Chem Soc Rev 2014 Feb;43(3):804-18

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

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http://dx.doi.org/10.1039/c3cs60238aDOI Listing
February 2014

Ligands for glaucoma-associated myocilin discovered by a generic binding assay.

ACS Chem Biol 2014 Feb 9;9(2):517-25. Epub 2013 Dec 9.

School of Chemistry & Biochemistry, Georgia Institute of Technology , 901 Atlantic Drive NW, Atlanta, Georgia 30332-0400, United States.

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http://pubs.acs.org/doi/10.1021/cb4007776
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http://dx.doi.org/10.1021/cb4007776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944078PMC
February 2014

A general intramolecular Friedel-Crafts approach to functionalized pyrrolo[3,2,1-ij]quinolin-4-ones.

Chem Commun (Camb) 2012 Oct;48(83):10337-9

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1039/c2cc34650hDOI Listing
October 2012

Indium-catalyzed cycloisomerizations of cyclopropene-3,3-dicarbonyl compounds: efficient access to benzo-fused heteroaromatics and heterobiaryls.

Angew Chem Int Ed Engl 2012 Mar 16;51(13):3198-202. Epub 2012 Feb 16.

School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1002/anie.201107717DOI Listing
March 2012

Diastereoselective intramolecular Friedel-Crafts cyclizations of substituted methyl 2-(1H-indole-1-carbonyl)acrylates: efficient access to functionalized 1H-pyrrolo[1,2-a]indoles.

Org Lett 2011 Nov 11;13(21):5820-3. Epub 2011 Oct 11.

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

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http://dx.doi.org/10.1021/ol202431xDOI Listing
November 2011

An efficient synthesis of hydropyrido[1,2-a]indole-6(7H)-ones via an In(III)-catalyzed tandem cyclopropane ring-opening/Friedel-Crafts alkylation sequence.

Chem Commun (Camb) 2011 Oct 22;47(37):10278-80. Epub 2011 Aug 22.

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

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http://dx.doi.org/10.1039/c1cc14131gDOI Listing
October 2011

Identification of a molecular activator for insulin receptor with potent anti-diabetic effects.

J Biol Chem 2011 Oct 9;286(43):37379-88. Epub 2011 Sep 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M111.247387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199485PMC
October 2011

Bromophycolide A targets heme crystallization in the human malaria parasite Plasmodium falciparum.

ChemMedChem 2011 Sep 5;6(9):1572-7. Epub 2011 Jul 5.

School of Chemistry and Biochemistry and School of Biology, Georgia Institute of Technology, 310 Ferst Drive NW, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1002/cmdc.201100252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381860PMC
September 2011

A catalytic homo-Nazarov cyclization protocol for the synthesis of heteroaromatic ring-fused cyclohexanones.

Org Lett 2011 Apr 18;13(8):1952-5. Epub 2011 Mar 18.

School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, USA.

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http://dx.doi.org/10.1021/ol200305nDOI Listing
April 2011

A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.

J Med Chem 2010 Dec 12;53(23):8274-86. Epub 2010 Nov 12.

Department of Pathology and Laboratory Medicine Emory University School of Medicine, Room 141 Whitehead Building, 615 Michael Street, Atlanta, Georgia 30322, United States.

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http://dx.doi.org/10.1021/jm101206pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150605PMC
December 2010

Indium-catalyzed homo-Nazarov cyclizations of alkenyl cyclopropyl ketones.

Org Lett 2010 Dec 23;12(24):5684-7. Epub 2010 Nov 23.

School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, USA.

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http://dx.doi.org/10.1021/ol102497wDOI Listing
December 2010

Deoxygedunin, a natural product with potent neurotrophic activity in mice.

PLoS One 2010 Jul 13;5(7):e11528. Epub 2010 Jul 13.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011528PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903477PMC
July 2010

Cycloaddition across the benzofuran ring as an approach to the morphine alkaloids.

J Org Chem 2008 Oct 13;73(20):8120-3. Epub 2008 Sep 13.

Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1021/jo8016956DOI Listing
October 2008

A Dipolar Cycloaddition Approach Toward the Kopsifoline Alkaloid Framework.

Tetrahedron 2007 Jun;63(26):5962-5976

Department of Chemistry, Emory University, Atlanta, GA 30322, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S004040200700140
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http://dx.doi.org/10.1016/j.tet.2007.01.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948834PMC
June 2007

Scalable methodology for the catalytic, asymmetric alpha-bromination of acid chlorides.

J Org Chem 2006 Nov;71(23):8946-9

Department of Chemistry, New Chemistry Building, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/jo061522lDOI Listing
November 2006

Performing the synthesis of a complex molecule on sequentially linked columns: toward the development of a "synthesis machine".

Org Lett 2005 Jul;7(14):3009-12

Department of Chemistry, New Chemistry Building, Johns Hopkins University, Baltimore, Maryland 21218, USA.

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http://pubs.acs.org/doi/abs/10.1021/ol050980y
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http://dx.doi.org/10.1021/ol050980yDOI Listing
July 2005

Bifunctional Lewis acid-nucleophile-based asymmetric catalysis: mechanistic evidence for imine activation working in tandem with chiral enolate formation in the synthesis of beta-lactams.

J Am Chem Soc 2005 Feb;127(4):1206-15

Department of Chemistry, New Chemistry Building, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/ja044179fDOI Listing
February 2005

Advances in the catalytic, asymmetric synthesis of beta-lactams.

Acc Chem Res 2004 Aug;37(8):592-600

Department of Chemistry, New Chemistry Building, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://pubs.acs.org/doi/abs/10.1021/ar030055g
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http://dx.doi.org/10.1021/ar030055gDOI Listing
August 2004

Development of a new dimeric cyclophane ligand: application to enhanced diastereo- and enantioselectivity in the catalytic synthesis of beta-lactams.

J Org Chem 2004 Jun;69(13):4531-3

Department of Chemistry, New Chemistry Building, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://pubs.acs.org/doi/abs/10.1021/jo049804d
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http://dx.doi.org/10.1021/jo049804dDOI Listing
June 2004

Catalytic, asymmetric alpha-chlorination of acid halides.

J Am Chem Soc 2004 Apr;126(13):4245-55

Department of Chemistry, New Chemistry Building, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1021/ja039046tDOI Listing
April 2004

Nucleophilic chiral amines as catalysts in asymmetric synthesis.

Chem Rev 2003 Aug;103(8):2985-3012

Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.

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http://pubs.acs.org/doi/abs/10.1021/cr020061a
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http://dx.doi.org/10.1021/cr020061aDOI Listing
August 2003

Bifunctional asymmetric catalysis: a tandem nucleophile/Lewis acid promoted synthesis of beta-lactams.

Org Lett 2002 May;4(9):1603-5

Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/ol025805lDOI Listing
May 2002

Generation of ketenes from acid chlorides using NaH/crown ether shuttle-deprotonation for use in asymmetric catalysis.

Org Lett 2002 Feb;4(4):627-9

Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://pages.jh.edu/~chem/lectka/Pubs/supporting/orglett_4su
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http://dx.doi.org/10.1021/ol0172525DOI Listing
February 2002