Publications by authors named "Stefan F Lichtenthaler"

100Publications

Role of iRhoms 1 and 2 in Endochondral Ossification.

Int J Mol Sci 2020 Nov 19;21(22). Epub 2020 Nov 19.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Cornell Medicine, New York, NY 10021, USA.

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November 2020

Neuronal Differentiation of LUHMES Cells Induces Substantial Changes of the Proteome.

Proteomics 2021 Jan 8;21(1):e2000174. Epub 2020 Oct 8.

German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen-Straße 17, München, 81377, Germany.

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January 2021

To cut or not to cut: New rules for proteolytic shedding of membrane proteins.

J Biol Chem 2020 08;295(35):12353-12354

Institute of Clinical Neuroimmunology, Biomedical Center and University Hospitals, Ludwig-Maximilians-Universität München, Munich, Germany

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August 2020

Basic Fibroblast Growth Factor 2-Induced Proteome Changes Endorse Lewy Body Pathology in Hippocampal Neurons.

iScience 2020 Aug 9;23(8):101349. Epub 2020 Jul 9.

German Center for Neurodegenerative Diseases (DZNE), 81337 Munich, Germany; Department of Neurology, Ludwig Maximilian University, 81377 Munich, Germany. Electronic address:

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August 2020

The substrate repertoire of γ-secretase/presenilin.

Semin Cell Dev Biol 2020 09 29;105:27-42. Epub 2020 Jun 29.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:

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September 2020

Fibroblast Growth Factor 2-Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons.

Adv Sci (Weinh) 2020 Mar 28;7(6):1902372. Epub 2020 Jan 28.

Department of Translational Neurodegeneration German Centre for Neurodegenerative Diseases Feodor-Lynen-Str. 17 81377 Munich Germany.

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March 2020

Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR.

Bioorg Chem 2019 11 13;92:103253. Epub 2019 Sep 13.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 2A Nan Wei Road, Beijing 100050, PR China. Electronic address:

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November 2019

Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system.

Cell Mol Life Sci 2019 Aug 24;76(16):3055-3081. Epub 2019 Jun 24.

German Center for Neurodegenerative Diseases (DZNE), Feodor-Lynen Strasse 17, 81377, Munich, Germany.

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August 2019

Pathology-linked protease caught in action.

Science 2019 02;363(6428):690-691

German Center for Neurodegenerative Diseases (DZNE), Munich Cluster for Systems Neurology (SyNergy), School of Medicine, Klinikum rechts der Isar, DFG Research Unit FOR 2290 and Institute for Advanced Study, Technical University of Munich, Germany.

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February 2019

BACE2 distribution in major brain cell types and identification of novel substrates.

Life Sci Alliance 2018 Jan 15;1(1):e201800026. Epub 2018 Feb 15.

Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium.

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January 2018

BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines.

Front Aging Neurosci 2018 26;10:229. Epub 2018 Jul 26.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Helmholtz-Gemeinschaft Deutscher Forschungszentren (HZ)-German Center for Neurodegenerative Diseases, Munich, Germany.

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July 2018

Shedding of BAFF/APRIL Receptors Controls B Cells.

Trends Immunol 2018 09 30;39(9):673-676. Epub 2018 Jul 30.

Neuroproteomics, School of Medicine, Klinikum rechts der Isar, and Institute for Advanced Study, Technical University Munich, Munich, Germany; Munich Center for Systems Neurology (SyNergy), Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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September 2018

Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments.

EMBO J 2018 08 5;37(15). Epub 2018 Jul 5.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

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August 2018

CADASIL brain vessels show a HTRA1 loss-of-function profile.

Acta Neuropathol 2018 07 3;136(1):111-125. Epub 2018 May 3.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 17, 81377, Munich, Germany.

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July 2018

PERK activation mitigates tau pathology and .

EMBO Mol Med 2017 03;9(3):371-384

Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

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March 2017

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.

Biol Psychiatry 2018 03 26;83(5):428-437. Epub 2016 Dec 26.

German Center for Neurodegenerative Diseases, Munich, Germany; Center for Neuropathology and Prion Research, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany. Electronic address:

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March 2018

Seizure-6 proteins highlight BACE1 functions in neurobiology.

Oncotarget 2017 Jan;8(5):7214-7215

German Center for Neurodegenerative Diseases, Neuroproteomics, Klinikum rechts der Isar, Technische Universität München, Munich Cluster for Systems Neurology and Institute for Advanced Study, Technische Universität München, Munich, Germany.

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January 2017

An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.

Proteomics 2017 03 31;17(5). Epub 2017 Jan 31.

Institut für Allgemeine Pathologie und pathologische Anatomie, Technische Universität München, München, Germany.

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March 2017

Proteomic Substrate Identification for Membrane Proteases in the Brain.

Front Mol Neurosci 2016 13;9:96. Epub 2016 Oct 13.

German Center for Neurodegenerative Diseases (DZNE)Munich, Germany; Neuroproteomics, Klinikum rechts der Isar, Technische Universität MünchenMunich, Germany; Institute for Advanced Study, Technische Universität MunichGarching, Germany; Munich Cluster for Systems Neurology (SyNergy)Munich, Germany.

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October 2016

Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.

J Mol Neurosci 2016 Nov 25;60(3):305-315. Epub 2016 Jul 25.

Department of Anatomy and Neuroscience, School of Biomedical Sciences, The University of Melbourne, Parkville, Melbourne, Australia.

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November 2016

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.

EMBO Mol Med 2016 05 2;8(5):458-65. Epub 2016 May 2.

Biomedical Center, Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany

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May 2016

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Trends Neurosci 2016 Mar 30;39(3):158-169. Epub 2016 Jan 30.

VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics, Universitaire Ziekenhuizen and LIND, KU Leuven, 3000 Leuven, Belgium; Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. Electronic address:

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March 2016

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.

Prog Neurobiol 2015 Dec 29;135:1-20. Epub 2015 Oct 29.

German Center for Neurodegenerative Diseases (DZNE), and Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Strasse 17, D-81377 München, Germany; Neuroproteomics, Klinikum rechts der Isar, and Institute for Advanced Study, Technische Universität München, 81675 Munich, Germany. Electronic address:

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December 2015

Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA.

J Immunol 2015 Nov 25;195(9):4244-56. Epub 2015 Sep 25.

Institute for Immunology, Ludwig-Maximilians-University, 80336 Munich, Germany;

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November 2015

iRhoms in the brain - a new frontier?

Cell Cycle 2015 ;14(19):3003-4

d Institute for Advanced Study; Technische Universität München ; Munich , Germany.

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August 2016

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.

Mol Cell Proteomics 2015 Oct 2;14(10):2550-63. Epub 2015 Jul 2.

From the ‡German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; §Neuroproteomics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; **Institute for Advanced Study, Technische Universität München, Garching, Germany; ‡‡Munich Center for Systems Neurology (SyNergy), Munich, Germany

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October 2015

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.

Mol Cell Proteomics 2015 Jun 31;14(6):1584-98. Epub 2015 Mar 31.

From the DZNE - German Center for Neurodegenerative Diseases, Munich, Germany; Institute for Metabolic Biochemistry, Ludwig-Maximilians University Munich, Munich, Germany;

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June 2015

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.

EMBO J 2014 Dec 29;33(24):2890-905. Epub 2014 Oct 29.

Adolf Butenandt Institute for Biochemistry, Ludwig-Maximilians University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany

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December 2014

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

J Neurochem 2014 Jul 19;130(1):4-28. Epub 2014 Apr 19.

Department of Cell and Molecular Biology, Feinberg University School of Medicine, Northwestern University, Chicago, Illinois, USA.

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July 2014

A new sandwich immunoassay for detection of the α-secretase cleaved, soluble amyloid-β protein precursor in cerebrospinal fluid and serum.

J Alzheimers Dis 2013 ;37(4):667-78

DZNE - German Center for Neurodegenerative Diseases, Munich, Germany Neuroproteomics, Klinikum rechts der Isar Technische Universität München, Munich, Germany.

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July 2014

QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis.

Nucleic Acids Res 2013 Jul 31;41(Web Server issue):W459-64. Epub 2013 May 31.

Department of Genome Oriented Bioinformatics, Technische Universität München, Wissenschaftszentrum Weihenstephan, Maximus-von-Imhof Forum 3, 85354 Freising, Germany.

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July 2013

Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.

Neurobiol Aging 2013 Jul 6;34(7):1779-89. Epub 2013 Mar 6.

Center for Human Genetics, Leuven Research Institute for Neuroscience and Disease (LIND), University of Leuven, Leuven, Belgium

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July 2013

iRHOM2 takes control of rheumatoid arthritis.

J Clin Invest 2013 Feb 25;123(2):560-2. Epub 2013 Jan 25.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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February 2013

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Neurobiol Dis 2013 Jan 24;49:137-47. Epub 2012 Aug 24.

German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany; Adolf Butenandt Institute, LMU Munich, Munich, Germany; Technical University Munich, Munich, Germany. Electronic address:

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January 2013

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.

BMC Med Genet 2012 May 17;13:35. Epub 2012 May 17.

Helmholtz Centre Munich, German Research Centre for Environmental Health (GmbH) and Technical University Munich, Institute of Developmental Genetics, Ingolstädter Landstraße, 1, 85764, Munich-Neuherberg, Germany.

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May 2012

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond.

Front Physiol 2012 17;3. Epub 2012 Feb 17.

German Center for Neurodegenerative Diseases (DZNE) Munich, Germany.

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October 2012

Cell biology. Sheddase gets guidance.

Science 2012 Jan;335(6065):179-80

DZNE-German Center for Neurodegenerative Diseases Munich, 80336 Munich, Germany.

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January 2012

Alpha-secretase cleavage of the amyloid precursor protein: proteolysis regulated by signaling pathways and protein trafficking.

Curr Alzheimer Res 2012 Feb;9(2):165-77

DZNE - German Center for Neurodegenerative Diseases, 80336 Munich, Germany.

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February 2012