Stefan A Mann

Stefan A Mann

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Stefan A Mann

Stefan A Mann

Publications by authors named "Stefan A Mann"

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Recording of multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clamp.

J Pharmacol Toxicol Methods 2019 Nov - Dec;100:106599. Epub 2019 Jun 20.

Dept. Biophysics & Physiology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania. Electronic address:

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http://dx.doi.org/10.1016/j.vascn.2019.106599DOI Listing
March 2020

Natural products modulating the hERG channel: heartaches and hope.

Nat Prod Rep 2017 08;34(8):957-980

Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.

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http://dx.doi.org/10.1039/c7np00014fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708533PMC
August 2017

Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes.

J Mol Cell Cardiol 2016 Nov 20;100:25-34. Epub 2016 Sep 20.

Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, University of New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.09.011DOI Listing
November 2016

Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.

J Physiol 2016 07 27;594(14):4031-49. Epub 2016 May 27.

Victor Chang Cardiac Research Institute, Molecular Cardiology and Biophysics Division, Darlinghurst, NSW, 2010, Australia.

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http://dx.doi.org/10.1113/JP271805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945714PMC
July 2016

Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction.

Mol Pharmacol 2016 07 12;90(1):1-11. Epub 2016 May 12.

Computational Cardiology, Victor Chang Cardiac Research Institute, Darlinghurst, Australia (M.J.W., S.A.M., J.I.V., A.P.H.); and St. Vincent's Clinical School, University of New South Wales, Darlinghurst, Australia (S.A.M., J.I.V., A.P.H.)

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http://dx.doi.org/10.1124/mol.115.103127DOI Listing
July 2016

Differential Response to Risperidone in Schizophrenia Patients by KCNH2 Genotype and Drug Metabolizer Status.

Am J Psychiatry 2016 Jan 20;173(1):53-9. Epub 2015 Oct 20.

From the Victor Chang Cardiac Research Institute, Darlinghurst, Australia; St. Vincent's Clinical School, University of New South Wales, Darlinghurst; the Schizophrenia Research Institute, Darlinghurst; the Lieber Institute for Brain Development, Baltimore; the Department of Psychiatry and Behavioral Sciences, the Department of Neurology, the Department of Neuroscience, the Institute of Genetic Medicine, and the Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore; the School of Psychiatry, University of New South Wales, Randwick; the Research Unit for Schizophrenia Epidemiology, University of New South Wales, Darlinghurst; and Neuroscience Research Australia, Randwick.

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http://dx.doi.org/10.1176/appi.ajp.2015.14050653DOI Listing
January 2016

In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS.

Prog Biophys Mol Biol 2016 Jan 20;120(1-3):89-99. Epub 2015 Dec 20.

Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, University of New South Wales, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pbiomolbio.2015.12.005DOI Listing
January 2016

Getting to the heart of hERG K(+) channel gating.

J Physiol 2015 Jun;593(12):2575-85

Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW 2010, Australia.

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http://doi.wiley.com/10.1113/JP270095
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http://dx.doi.org/10.1113/JP270095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500344PMC
June 2015

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.

Nat Commun 2014 Sep 25;5:5069. Epub 2014 Sep 25.

1] Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1038/ncomms6069DOI Listing
September 2014

Kinetics of drug interaction with the Kv11.1 potassium channel.

Mol Pharmacol 2014 May 28;85(5):769-76. Epub 2014 Feb 28.

Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia (A.P.H., J.H., T.J.C., S.A.M., J.I.V.); St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia (A.P.H., J.H., T.J.C., S.A.M., J.I.V.); and Barwon Health, Geelong, Victoria, Australia (M.J.P.).

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http://dx.doi.org/10.1124/mol.114.091835DOI Listing
May 2014

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.

J Mol Cell Cardiol 2014 Feb 27;67:69-76. Epub 2013 Dec 27.

Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia; Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.yjmcc.2013.12.014DOI Listing
February 2014

Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram.

J Physiol 2013 Sep 3;591(17):4207-22. Epub 2013 Apr 3.

A. P. Hill: Victor Chang Cardiac Research Institute, 405, Liverpool Street, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1113/jphysiol.2013.251710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779112PMC
September 2013

Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

Biochem J 2013 Aug;454(1):69-77

Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1042/BJ20130328DOI Listing
August 2013

A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death.

J Mol Cell Cardiol 2013 Aug 19;61:123-32. Epub 2013 Jun 19.

Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1016/j.yjmcc.2013.06.005DOI Listing
August 2013

R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy.

J Am Coll Cardiol 2012 Oct 19;60(16):1566-73. Epub 2012 Sep 19.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.jacc.2012.05.050DOI Listing
October 2012

hERG K(+) channels: structure, function, and clinical significance.

Physiol Rev 2012 Jul;92(3):1393-478

Mark Cowley Lidwill Research Programme in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1152/physrev.00036.2011DOI Listing
July 2012

Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel.

Nat Struct Mol Biol 2011 Jan 19;18(1):35-41. Epub 2010 Dec 19.

Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, New South Wales, Australia.

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http://dx.doi.org/10.1038/nsmb.1966DOI Listing
January 2011