Steen H Hansen

Steen H Hansen

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Steen H Hansen

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A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization.

Mol Biol Cell 2019 Nov 27:mbcE19070375. Epub 2019 Nov 27.

Department of Pediatrics, Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1091/mbc.E19-07-0375DOI Listing
November 2019

INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.

Elife 2018 10 25;7. Epub 2018 Oct 25.

Division of Gastroenterology, Nutrition and Hepatology, Boston Children's Hospital, Boston, United States.

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https://elifesciences.org/articles/38539
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http://dx.doi.org/10.7554/eLife.38539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226287PMC
October 2018

p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity.

J Cell Biol 2018 09 22;217(9):3183-3201. Epub 2018 Jun 22.

GI Cell Biology Research Laboratory, Boston Children's Hospital and Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1083/jcb.201710058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122998PMC
September 2018

The psychoactive drug Escitalopram affects swimming behaviour and increases boldness in zebrafish (Danio rerio).

Ecotoxicology 2018 May 14;27(4):485-497. Epub 2018 Mar 14.

Department of Bioscience, Zoophysiology, Aarhus University, CF Moellersalle 3, building 1131, Aarhus C, Aarhus, DK-8000, Denmark.

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http://dx.doi.org/10.1007/s10646-018-1920-xDOI Listing
May 2018

CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma.

Gastroenterology 2017 12 18;153(6):1662-1673.e10. Epub 2017 Sep 18.

Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801691PMC
December 2017

Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis.

Nat Protoc 2017 03 16;12(3):581-603. Epub 2017 Feb 16.

Biotech Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nprot.2016.165DOI Listing
March 2017

A facility to search for hidden particles at the CERN SPS: the SHiP physics case.

Rep Prog Phys 2016 12 24;79(12):124201. Epub 2016 Oct 24.

Deutsches Elektronensynchrotron DESY, Platanenallee 6, D-15738 Zeuthen, Germany. Institute for High Energy Physics, 142281 Protvino, Moscow region, Russia.

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http://dx.doi.org/10.1088/0034-4885/79/12/124201DOI Listing
December 2016

Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression.

Oncoimmunology 2015 Jun 2;4(6):e1008824. Epub 2015 Mar 2.

Department of Medical Oncology; Dana-Farber Cancer Institute ; Boston, MA, USA ; Department of Medicine; Brigham and Woman's Hospital ; Boston, MA, USA ; Harvard Medical School; Harvard University ; Boston, MA, USA ; Cancer Vaccine Center; Dana-Farber Cancer Institute ; Boston, MA, USA.

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http://dx.doi.org/10.1080/2162402X.2015.1008824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485824PMC
June 2015

Blood-brain barrier permeability and brain uptake mechanism of kainic acid and dihydrokainic acid.

Neurochem Res 2015 Mar 9;40(3):542-9. Epub 2014 Dec 9.

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s11064-014-1499-4DOI Listing
March 2015

The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models.

Int J Pharm 2014 Oct 22;473(1-2):395-7. Epub 2014 Jul 22.

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2014.07.023DOI Listing
October 2014

Detection of follicular transport of lidocaine and metabolism in adipose tissue in pig ear skin by DESI mass spectrometry imaging.

Anal Bioanal Chem 2014 Jun 11;406(15):3735-42. Epub 2014 Apr 11.

Department of Pharmacy, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.

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http://link.springer.com/10.1007/s00216-014-7802-z
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http://dx.doi.org/10.1007/s00216-014-7802-zDOI Listing
June 2014

Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo.

Pharmacol Res Perspect 2014 Apr 24;2(2):e00036. Epub 2014 Mar 24.

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/prp2.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184708PMC
April 2014

Easy peak tracking in CE-UV and CE-UV-ESI-MS by incorporating temperature-correlated mobility scaling.

Electrophoresis 2013 Jun 23;34(12):1787-95. Epub 2013 May 23.

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://doi.wiley.com/10.1002/elps.201200695
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http://dx.doi.org/10.1002/elps.201200695DOI Listing
June 2013

Displaced dual-mode imaging with desorption electrospray ionization for simultaneous mass spectrometry imaging in both polarities and with several scan modes.

J Mass Spectrom 2013 Mar;48(3):361-6

Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1002/jms.3166DOI Listing
March 2013

Transdermal opioid patches for pain treatment in ancient Greece.

Pain Pract 2012 Nov 26;12(8):620-5. Epub 2012 Mar 26.

Department of Animal and Veterinary Basic Sciences (IBHV), Faculty of Health Sciences, Copenhagen University, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/j.1533-2500.2012.00546.xDOI Listing
November 2012

A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis.

Curr Biol 2012 Oct 2;22(19):1747-54. Epub 2012 Aug 2.

GI Cell Biology Research Laboratory, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2012.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470768PMC
October 2012

Topical morphine for oral mucositis in children: dose finding and absorption.

J Pain Symptom Manage 2012 Jul 1;44(1):117-23. Epub 2012 Jun 1.

Department of Pharmacology and Pharmacotherapy, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jpainsymman.2011.06.029DOI Listing
July 2012

Improving the reproducibility in capillary electrophoresis by incorporating current drift in mobility and peak area calculations.

Electrophoresis 2012 Mar;33(6):1021-31

Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen, Denmark.

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http://doi.wiley.com/10.1002/elps.201100551
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http://dx.doi.org/10.1002/elps.201100551DOI Listing
March 2012

Characterization of barley leaf tissue using direct and indirect desorption electrospray ionization imaging mass spectrometry.

J Mass Spectrom 2011 Dec;46(12):1241-6

Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/jms.2010DOI Listing
December 2011

A liquid chromatography-electrospray ionization-mass spectrometry method for quantification of cyclotides in plants avoiding sorption during sample preparation.

J Chromatogr A 2011 Nov 8;1218(44):7964-70. Epub 2011 Sep 8.

Department of Basic Sciences and Environment, Faculty of Life Sciences (LIFE), University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S00219673110134
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http://dx.doi.org/10.1016/j.chroma.2011.08.095DOI Listing
November 2011

Versatile flow-injection amperometric ion detector based on an interface between two immiscible electrolyte solutions: numerical and experimental characterization.

Anal Chem 2011 Oct 31;83(19):7388-93. Epub 2011 Aug 31.

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.

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http://pubs.acs.org/doi/abs/10.1021/ac201387r
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http://dx.doi.org/10.1021/ac201387rDOI Listing
October 2011

Gravitational redshift of galaxies in clusters as predicted by general relativity.

Nature 2011 Sep 28;477(7366):567-9. Epub 2011 Sep 28.

Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1038/nature10445DOI Listing
September 2011

Distinct roles of cadherin-6 and E-cadherin in tubulogenesis and lumen formation.

Mol Biol Cell 2011 Jun 20;22(12):2031-41. Epub 2011 Apr 20.

Department of Surgery, Committee on Cancer Biology, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1091/mbc.E11-01-0038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113768PMC
June 2011

Effect of alpha-cyclodextrin on drug distribution studied by electrochemistry at interfaces between immiscible electrolyte solutions.

J Phys Chem B 2009 May;113(20):7263-9

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/jp901247pDOI Listing
May 2009

Identification of reaction products between drug substances and excipients by HPLC-SPE-NMR: ester and amide formation between citric acid and 5-aminosalicylic acid.

J Pharm Biomed Anal 2009 Apr 27;49(3):839-42. Epub 2008 Dec 27.

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jpba.2008.12.028DOI Listing
April 2009

Impact of adult atopic dermatitis on topical drug penetration: assessment by cutaneous microdialysis and tape stripping.

Acta Derm Venereol 2009 ;89(1):33-8

Department of Dermatology and Venereology, University of Copenhagen, Hellerup, Denmark.

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http://dx.doi.org/10.2340/00015555-0562DOI Listing
March 2009

Reaction between drug substances and pharmaceutical excipients: formation of citric acid esters and amides of carvedilol in the solid state.

J Pharm Biomed Anal 2009 Jan 2;49(1):11-7. Epub 2008 Oct 2.

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://linkinghub.elsevier.com/retrieve/pii/S073170850800545
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http://dx.doi.org/10.1016/j.jpba.2008.09.039DOI Listing
January 2009

Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.

Chem Res Toxicol 2008 Oct 13;21(10):2035-41. Epub 2008 Sep 13.

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark.

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http://pubs.acs.org/doi/abs/10.1021/tx8002214
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http://dx.doi.org/10.1021/tx8002214DOI Listing
October 2008

Coordination of Rho and Rac GTPase function via p190B RhoGAP.

Curr Biol 2008 Oct;18(20):1606-11

GI Cell Biology Laboratory, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2008.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084715PMC
October 2008

The PIX-GIT complex: a G protein signaling cassette in control of cell shape.

Semin Cell Dev Biol 2008 Jun 20;19(3):234-44. Epub 2008 Jan 20.

GI Cell Biology Laboratory, The Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.semcdb.2008.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394276PMC
June 2008

Application of the FLIPSY pulse sequence for increased sensitivity in 1H NMR-based metabolic profiling studies.

Anal Chem 2008 May 26;80(9):3365-71. Epub 2008 Mar 26.

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ac702563uDOI Listing
May 2008

Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.

Chem Res Toxicol 2008 May 18;21(5):1107-19. Epub 2008 Apr 18.

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1021/tx700419dDOI Listing
May 2008

Molecular interactions in lipophilic environments studied by electrochemistry at interfaces between immiscible electrolyte solutions.

Anal Chem 2008 Jan 4;80(1):203-8. Epub 2007 Dec 4.

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ac071276tDOI Listing
January 2008

Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice.

J Neurochem 2007 Dec 14;103(5):1907-16. Epub 2007 Sep 14.

Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04892.xDOI Listing
December 2007

Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers.

Eur J Clin Pharmacol 2007 Dec 16;63(12):1153-9. Epub 2007 Sep 16.

Department of Pharmacology and Pharmacotherapy, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

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http://link.springer.com/10.1007/s00228-007-0377-2
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http://dx.doi.org/10.1007/s00228-007-0377-2DOI Listing
December 2007

Searching for decaying axionlike dark matter from clusters of galaxies.

Phys Rev Lett 2007 Sep 28;99(13):131301. Epub 2007 Sep 28.

Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1103/PhysRevLett.99.131301DOI Listing
September 2007

Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers.

Eur J Clin Pharmacol 2007 Aug 31;63(8):761-7. Epub 2007 May 31.

Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00228-007-0306-4DOI Listing
August 2007

CE frontal analysis employing contactless conductivity detection for determination of CMCs of non-UV absorbing charged surfactants.

Electrophoresis 2007 Aug;28(17):2975-80

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/elps.200700236DOI Listing
August 2007

Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.

Chem Res Toxicol 2007 May 21;20(5):821-31. Epub 2007 Apr 21.

Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1021/tx700029uDOI Listing
May 2007

Simultaneous determination of loratadine and desloratadine in pharmaceutical preparations using liquid chromatography with a microemulsion as eluent.

J Pharm Biomed Anal 2007 Mar 28;43(4):1236-42. Epub 2006 Nov 28.

Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

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http://dx.doi.org/10.1016/j.jpba.2006.10.027DOI Listing
March 2007

CE frontal analysis based on simultaneous UV and contactless conductivity detection: a general setup for studying noncovalent interactions.

Electrophoresis 2007 Feb;28(3):322-7

Department of Pharmaceutics and Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark.

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http://doi.wiley.com/10.1002/elps.200600365
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http://dx.doi.org/10.1002/elps.200600365DOI Listing
February 2007

Human urine as test material in 1H NMR-based metabonomics: recommendations for sample preparation and storage.

Anal Chem 2007 Feb;79(3):1181-6

Department of Pharmaceutics and Analytical Chemistry and Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ac061354xDOI Listing
February 2007

Bioequivalence of topical formulations in humans: evaluation by dermal microdialysis sampling and the dermatopharmacokinetic method.

J Invest Dermatol 2007 Jan 27;127(1):170-8. Epub 2006 Jul 27.

Department of Dermatology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.

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http://dx.doi.org/10.1038/sj.jid.5700495DOI Listing
January 2007

GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover.

EMBO J 2006 May 20;25(9):1848-59. Epub 2006 Apr 20.

Boston Biomedical Research Institute, Watertown, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456948PMC
May 2006

Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors.

Biochim Biophys Acta 2006 Feb 26;1761(2):143-50; discussion 141-2. Epub 2006 Jan 26.

Department of Pharmacology and Pharmacotherapy, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.bbalip.2005.12.011DOI Listing
February 2006

Pre-equilibrium capillary zone electrophoresis or frontal analysis: advantages of plateau peak conditions in affinity capillary electrophoresis.

Electrophoresis 2005 Nov;26(21):4050-4

Department of Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/elps.200500287DOI Listing
November 2005

Rnd3/RhoE induces tight junction formation in mammary epithelial tumor cells.

Exp Cell Res 2005 Apr 27;305(1):74-82. Epub 2005 Jan 27.

Department of Molecular and Cell Biology and The Cancer Research Laboratory, University of California, Berkeley, CA 94720-3200, USA.

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http://dx.doi.org/10.1016/j.yexcr.2004.12.010DOI Listing
April 2005

Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis.

Org Lett 2005 Apr;7(9):1703-6

Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ol050305oDOI Listing
April 2005

Separation of isomers of acyl glucuronides using micellar electrokinetic capillary chromatography in dynamically coated capillaries.

Electrophoresis 2004 Oct;25(18-19):3277-81

Department of Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/elps.200406036DOI Listing
October 2004

Reference methods for the measurement of free thyroid hormones in blood: evaluation of potential reference methods for free thyroxine.

Clin Biochem 2004 Feb;37(2):85-93

Department of Clinical Biochemistry, Holbaek Hospital, 4300 Holbaek, Denmark.

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http://dx.doi.org/10.1016/j.clinbiochem.2003.09.009DOI Listing
February 2004

Pak1 and PIX regulate contact inhibition during epithelial wound healing.

EMBO J 2003 Aug;22(16):4155-65

Department of Anatomy and Biochemistry and Biophysics, University of California San Francisco, Box 2140, 600 16th Street, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1093/emboj/cdg398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC175788PMC
August 2003

Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.

Curr Biol 2003 Jul;13(13):1106-15

Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/s0960-9822(03)00418-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918695PMC
July 2003

Influence of adsorption and deproteination on potential free thyroxine reference methods.

Clin Chem 2002 Jan;48(1):108-14

Department of Clinical Biochemistry, Holbaek Hospital, 4300 Holbaek, Denmark.

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January 2002