Publications by authors named "Stanley R Riddell"

99Publications

Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors.

Clin Cancer Res 2019 12 23;25(24):7506-7516. Epub 2019 Sep 23.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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December 2019

Tinkering in the garage - tuning CARs for safety.

Nat Rev Clin Oncol 2019 09;16(9):530-532

Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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September 2019

Endogenous CD4 T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic and () Driver Mutations.

Cancer Immunol Res 2019 06 1;7(6):910-922. Epub 2019 May 1.

Immunotherapy Integrated Research Center, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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June 2019

Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting.

Cancer Cell 2019 03;35(3):489-503.e8

Program in Immunology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D3-100, Seattle, WA 98109-1024, USA; Department of Immunology, University of Washington, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA 98109, USA.

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March 2019

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity.

J Immunol 2019 01 12;202(2):476-483. Epub 2018 Dec 12.

Herbold Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;

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January 2019

Dormant tumour cells, their niches and the influence of immunity.

Nat Cell Biol 2018 11 25;20(11):1240-1249. Epub 2018 Oct 25.

Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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November 2018

Chimeric antigen receptor-modified T cells: CD19 and the road beyond.

Blood 2018 06 4;131(24):2621-2629. Epub 2018 May 4.

Immunotherapy Integrated Research Center, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and.

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June 2018

Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy.

J Immunol 2018 01;200(2):459-468

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109

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January 2018

Graft-Derived Reconstitution of Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation.

Biol Blood Marrow Transplant 2018 02 9;24(2):242-251. Epub 2017 Oct 9.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington.

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February 2018

Durable Molecular Remissions in Chronic Lymphocytic Leukemia Treated With CD19-Specific Chimeric Antigen Receptor-Modified T Cells After Failure of Ibrutinib.

J Clin Oncol 2017 Sep 17;35(26):3010-3020. Epub 2017 Jul 17.

Cameron J. Turtle, Kevin A. Hay, Laïla-Aïcha Hanafi, Shelly Heimfeld, Stanley R. Riddell, and David G. Maloney, Fred Hutchinson Cancer Research Center; Cameron J. Turtle, Sindhu Cherian, Xueyan Chen, Brent Wood, Stanley R. Riddell, and David G. Maloney, University of Washington; Daniel Li, Juno Therapeutics, Seattle, WA; and Arletta Lozanski and John C. Byrd, The Ohio State University, Columbus, OH.

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September 2017

Preserved Activity of CD20-Specific Chimeric Antigen Receptor-Expressing T Cells in the Presence of Rituximab.

Cancer Immunol Res 2016 06 21;4(6):509-19. Epub 2016 Apr 21.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington.

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June 2016

Role of memory T cell subsets for adoptive immunotherapy.

Semin Immunol 2016 02 11;28(1):28-34. Epub 2016 Mar 11.

Focus Group "Clinical Cell Processing and Purification", Institute for Advanced Study, TUM, Munich 81675, Germany; Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address:

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February 2016

Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy.

Blood 2016 05 23;127(20):2406-10. Epub 2016 Feb 23.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and Department of Medicine, University of Washington, Seattle, WA.

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May 2016

Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy.

Nat Biotechnol 2016 Apr 22;34(4):430-4. Epub 2016 Feb 22.

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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April 2016

TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells.

Blood 2015 Dec 27;126(26):2781-9. Epub 2015 Oct 27.

Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, United Kingdom;

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December 2015

A BiTE from cancer's intracellular menu.

Nat Biotechnol 2015 Oct;33(10):1040-1

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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October 2015

Engineering CAR-T cells: Design concepts.

Trends Immunol 2015 Aug 11;36(8):494-502. Epub 2015 Jul 11.

Program in Immunology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, WA 98109, USA. Electronic address:

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August 2015

Adoptive cellular therapy: a race to the finish line.

Sci Transl Med 2015 Mar;7(280):280ps7

Division of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

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March 2015

Designing chimeric antigen receptors to effectively and safely target tumors.

Curr Opin Immunol 2015 Apr 23;33:9-15. Epub 2015 Jan 23.

University of Washington, Seattle, WA, United States; Fred Hutchinson Cancer Research Institute, Seattle, WA, United States; Institute for Advanced Study, Technical University of Munich, Munich, Germany.

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April 2015

Cytotoxic T-cell cytokines put cancer under arrest.

Cancer Immunol Res 2015 Jan 17;3(1):23-5. Epub 2014 Dec 17.

Fred Hutchinson Cancer Research Center, Seattle, Washington.

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January 2015

Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells.

Cancer Immunol Res 2015 Feb 29;3(2):206-16. Epub 2014 Oct 29.

Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Medicine, University of Washington, Seattle, Washington. Institute for Advanced Study, Technical University of Munich, Germany.

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February 2015

Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8(+) T cells.

J Immunother Cancer 2014 14;2(1):36. Epub 2014 Oct 14.

Clinical Research Division, D3-100 Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109 USA ; Department of Medicine, University of Washington, Seattle, WA USA ; Department of Melanoma Medical Oncology, UT MD Anderson Cancer Center, 7455 Fannin St, Unit 904, Houston, TX 77054 USA.

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October 2014

The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

Cancer Immunol Res 2015 Feb 11;3(2):125-35. Epub 2014 Sep 11.

Fred Hutchinson Cancer Research Center, Clinical Research Division, Program in Immunology, Seattle, Washington. Department of Medicine, University of Washington, Seattle, Washington. Technical University of Munich, Institute for Advanced Study, Munich, Germany.

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February 2015

Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells.

Immunity 2014 Jul;41(1):116-26

Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich 81675, Germany; Focus Group "Clinical Cell Processing and Purification," Institute for Advanced Study, TUM, Munich 81675, Germany; Clinical Cooperation Groups "Antigen-specific Immunotherapy" and "Immune-Monitoring," Helmholtz Center Munich (Neuherberg), TUM, Munich 81675, Germany; German Center for Infection Research (DZIF), Munich 81675, Germany. Electronic address:

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July 2014

Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells.

Immunol Rev 2014 Jan;257(1):127-44

Seattle Children's Research Institute, University of Washington, Seattle, WA, USA.

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January 2014

HLA-F and MHC-I open conformers cooperate in a MHC-I antigen cross-presentation pathway.

J Immunol 2013 Aug 12;191(4):1567-77. Epub 2013 Jul 12.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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August 2013

CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia.

Blood 2013 Aug 6;122(7):1316-24. Epub 2013 Jun 6.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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August 2013

HLA engineering of human pluripotent stem cells.

Mol Ther 2013 Jun 30;21(6):1232-41. Epub 2013 Apr 30.

Department of Medicine, University of Washington, Seattle, Washington 98195, USA.

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June 2013

Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells.

Clin Cancer Res 2013 Jun 25;19(12):3153-64. Epub 2013 Apr 25.

Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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June 2013

Proliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaques.

PLoS One 2013 13;8(2):e56268. Epub 2013 Feb 13.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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August 2013

Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale.

J Immunother 2012 Nov-Dec;35(9):689-701

Departments of Cancer Immunotherapeutics & Tumor Immunology, and Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.

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March 2013

Chimeric antigen receptor--modified T cells: clinical translation in stem cell transplantation and beyond.

Biol Blood Marrow Transplant 2013 Jan 17;19(1 Suppl):S2-5. Epub 2012 Oct 17.

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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January 2013

Augmentation of anti-tumor immunity by adoptive T-cell transfer after allogeneic hematopoietic stem cell transplantation.

Expert Rev Hematol 2012 Aug;5(4):409-25

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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August 2012

Engineered T cells for anti-cancer therapy.

Curr Opin Immunol 2012 Oct 18;24(5):633-9. Epub 2012 Jul 18.

Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.

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October 2012

Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells.

Blood 2012 Jan 26;119(1):72-82. Epub 2011 Oct 26.

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

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January 2012

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1.

Nat Immunol 2011 Sep 4;12(10):984-91. Epub 2011 Sep 4.

National Creative Research Initiative Center for Antigen Presentation, Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea.

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September 2011

A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells.

Blood 2011 Aug 7;118(5):1255-63. Epub 2011 Jun 7.

Department of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.

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August 2011

Identification of MAGE-C1 (CT-7) epitopes for T-cell therapy of multiple myeloma.

Cancer Immunol Immunother 2011 Jul 3;60(7):985-97. Epub 2011 Apr 3.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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July 2011

Double unit cord blood transplantation: Who wins-and why do we care?

Chimerism 2010 Jul-Sep;1(1):21-2

Division of Medical Oncology; University of Colorado; Aurora, CO USA.

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August 2017

Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia.

Immunol Cell Biol 2011 Mar 8;89(3):396-407. Epub 2011 Feb 8.

Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-981024, USA.

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March 2011

Genetically retargeting CD8+ lymphocyte subsets for cancer immunotherapy.

Curr Opin Immunol 2011 Apr 14;23(2):299-305. Epub 2011 Jan 14.

Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.

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April 2011

Engraftment of human central memory-derived effector CD8+ T cells in immunodeficient mice.

Blood 2011 Feb 1;117(6):1888-98. Epub 2010 Dec 1.

Department of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.

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February 2011

Adoptive T-cell therapy for B-cell malignancies.

Expert Rev Hematol 2009 Oct;2(5):517-32

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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October 2009

Overlap and effective size of the human CD8+ T cell receptor repertoire.

Sci Transl Med 2010 Sep;2(47):47ra64

Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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September 2010

Artificial antigen-presenting cells for use in adoptive immunotherapy.

Cancer J 2010 Jul-Aug;16(4):374-81

Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.

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December 2010

Immune responses to AAV in canine muscle monitored by cellular assays and noninvasive imaging.

Mol Ther 2010 Mar 29;18(3):617-24. Epub 2009 Dec 29.

Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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March 2010

Recognition and killing of brain tumor stem-like initiating cells by CD8+ cytolytic T cells.

Cancer Res 2009 Dec 10;69(23):8886-93. Epub 2009 Nov 10.

Department of Cancer Immunotherapeutics, Division of Neurosurgery, City of Hope National Medical Center, Duarte, California 91010, USA.

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December 2009

A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy.

Immunity 2009 Nov 29;31(5):834-44. Epub 2009 Oct 29.

Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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November 2009

Safety and immunologic effects of IL-15 administration in nonhuman primates.

Blood 2009 Sep 15;114(12):2417-26. Epub 2009 Jul 15.

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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September 2009

Development of tumor-reactive T cells after nonmyeloablative allogeneic hematopoietic stem cell transplant for chronic lymphocytic leukemia.

Clin Cancer Res 2009 Jul 30;15(14):4759-68. Epub 2009 Jun 30.

Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA.

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July 2009

Adoptive transfer of virus-specific and tumor-specific T cell immunity.

Curr Opin Immunol 2009 Apr 21;21(2):224-32. Epub 2009 Mar 21.

Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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April 2009