Publications by authors named "Stanley Perlman"

100Publications

Sensitization of Non-permissive Laboratory Mice to SARS-CoV-2 with a Replication-Deficient Adenovirus Expressing Human ACE2.

STAR Protoc 2020 Dec 9;1(3):100169. Epub 2020 Nov 9.

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.

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December 2020

SARS-CoV-2-induced immune activation and death of monocyte-derived human macrophages and dendritic cells.

J Infect Dis 2020 Dec 5. Epub 2020 Dec 5.

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA.

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December 2020

Does common cold coronavirus infection protect against severe SARS-CoV-2 disease?

J Clin Invest 2021 01;131(1)

Department of Microbiology and Immunology, and.

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January 2021

Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice.

J Virol 2021 01 13;95(3). Epub 2021 Jan 13.

Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain

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January 2021

MERS-CoV in Africa-an enigma with relevance to COVID-19.

Lancet Infect Dis 2020 Oct 6. Epub 2020 Oct 6.

Department of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology and National Institute for Health Research Biomedical Research Centre, University College London Hospitals, London, UK.

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October 2020

Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection.

Proc Natl Acad Sci U S A 2020 09 14;117(39):24464-24474. Epub 2020 Sep 14.

Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242;

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September 2020

Coronaviruses: An Updated Overview of Their Replication and Pathogenesis.

Methods Mol Biol 2020 ;2203:1-29

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.

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September 2020

Lessons for COVID-19 Immunity from Other Coronavirus Infections.

Immunity 2020 08 14;53(2):248-263. Epub 2020 Jul 14.

Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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August 2020

Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment.

Cell 2020 08 10;182(3):734-743.e5. Epub 2020 Jun 10.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China; Institute of Infectious Disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510060, China. Electronic address:

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August 2020

Prostaglandin D2 signaling in dendritic cells is critical for the development of EAE.

J Autoimmun 2020 Nov 2;114:102508. Epub 2020 Jul 2.

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA; Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA, USA. Electronic address:

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November 2020

Testing COVID-19 therapies to prevent progression of mild disease.

Lancet Infect Dis 2020 12 6;20(12):1367. Epub 2020 May 6.

Department of Medicine and Department of Microbiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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December 2020

Oligodendrocytes that survive acute coronavirus infection induce prolonged inflammatory responses in the CNS.

Proc Natl Acad Sci U S A 2020 07 22;117(27):15902-15910. Epub 2020 Jun 22.

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242;

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July 2020

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.

Cell 2020 08 10;182(3):744-753.e4. Epub 2020 Jun 10.

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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August 2020

Multiplex Screening Assay for Identifying Cytotoxic CD8 T Cell Epitopes.

Front Immunol 2020 11;11:400. Epub 2020 Mar 11.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

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March 2020

Middle East respiratory syndrome.

Lancet 2020 03 4;395(10229):1063-1077. Epub 2020 Mar 4.

Department of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, UK; National Institute for Health Research Biomedical Research Centre, University College London Hospitals, London, UK. Electronic address:

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March 2020

Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection.

mBio 2020 02 11;11(1). Epub 2020 Feb 11.

Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA

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February 2020

Another Decade, Another Coronavirus.

Authors:
Stanley Perlman

N Engl J Med 2020 02 24;382(8):760-762. Epub 2020 Jan 24.

From the Department of Microbiology and Immunology, University of Iowa, Iowa City.

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February 2020

Evaluation of Activation and Inflammatory Activity of Myeloid Cells During Pathogenic Human Coronavirus Infection.

Methods Mol Biol 2020 ;2099:195-204

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.

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September 2020

Vaccine against Middle East respiratory syndrome coronavirus.

Lancet Infect Dis 2019 10;19(10):1054-1055

Department of Microbiology and Immunology and Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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October 2019

Confronting the persisting threat of the Middle East respiratory syndrome to global health security.

Lancet Infect Dis 2020 02 3;20(2):158-160. Epub 2019 Jul 3.

Division of Infection and Immunity, Center for Clinical Microbiology, University College London, London, UK; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK.

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February 2020

Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection.

Emerg Microbes Infect 2019 ;8(1):760-772

a Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences , School of Medicine, Tsinghua University , Beijing , People's Republic of China.

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August 2019

Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection.

JCI Insight 2019 02 21;4(4). Epub 2019 Feb 21.

AIDS Institute and Department of Microbiology, State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

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February 2019

Not your usual tRNA synthetase: hWARS serves as an enterovirus entry factor.

J Clin Invest 2018 11 15;128(11):4767-4769. Epub 2018 Oct 15.

Department of Microbiology and Immunology, Loyola University, Chicago, Illinois, USA.

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November 2018

Microglia are required for protection against lethal coronavirus encephalitis in mice.

J Clin Invest 2018 03 29;128(3):931-943. Epub 2018 Jan 29.

Interdisciplinary Graduate Program in Immunology.

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March 2018

Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis.

Trends Microbiol 2018 07;26(7):598-610

University of Iowa, Department of Microbiology and Immunology, Iowa City, IA 52242, USA. Electronic address:

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July 2018

The coronavirus nucleocapsid protein is ADP-ribosylated.

Virology 2018 04 1;517:62-68. Epub 2017 Dec 1.

Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, IA 52242, United States. Electronic address:

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April 2018

Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host.

Curr Opin Virol 2018 02 21;28:43-52. Epub 2017 Nov 21.

Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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February 2018

Murine Olfactory Bulb Interneurons Survive Infection with a Neurotropic Coronavirus.

J Virol 2017 Nov 27;91(22). Epub 2017 Oct 27.

Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USA

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November 2017

The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases.

PLoS Pathog 2017 Jul 31;13(7):e1006546. Epub 2017 Jul 31.

Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL, United States of America.

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July 2017

Simultaneous Intranasal/Intravascular Antibody Labeling of CD4 T Cells in Mouse Lungs.

Bio Protoc 2017 Jan;7(1)

State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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January 2017

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology.

Semin Immunopathol 2017 07 2;39(5):529-539. Epub 2017 May 2.

Department of Microbiology, University of Iowa, BSB 3-712, Iowa City, IA, 52242, USA.

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July 2017

DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice.

Vaccine 2017 04 14;35(16):2069-2075. Epub 2017 Mar 14.

Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Science, Changchun, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China. Electronic address:

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April 2017

Roles of regulatory T cells and IL-10 in virus-induced demyelination.

J Neuroimmunol 2017 07 4;308:6-11. Epub 2017 Jan 4.

State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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July 2017

Passive immunotherapy for Middle East Respiratory Syndrome coronavirus infection with equine immunoglobulin or immunoglobulin fragments in a mouse model.

Antiviral Res 2017 01 24;137:125-130. Epub 2016 Nov 24.

Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China. Electronic address:

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January 2017

Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines.

Nat Commun 2016 11 22;7:13473. Epub 2016 Nov 22.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.

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November 2016

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model.

Virus Res 2017 01 10;228:7-13. Epub 2016 Nov 10.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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January 2017

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism.

Proc Natl Acad Sci U S A 2016 10 10;113(43):12262-12267. Epub 2016 Oct 10.

Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153;

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October 2016

Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus.

Annu Rev Med 2017 01 26;68:387-399. Epub 2016 Aug 26.

Department of Microbiology, University of Iowa, Iowa City, Iowa 52242; email:

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January 2017

MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and Pathogenesis.

J Virol 2016 Aug 27;90(16):7098-7108. Epub 2016 Jul 27.

Department of Microbiology, University of Iowa, Iowa City, Iowa, USA

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August 2016

Middle East respiratory syndrome vaccines.

Int J Infect Dis 2016 Jun 7;47:23-8. Epub 2016 Apr 7.

Department of Microbiology, BSB 3-712, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA.

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June 2016

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice.

Cell Host Microbe 2016 Feb;19(2):181-93

Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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February 2016

Middle East respiratory syndrome and severe acute respiratory syndrome.

Curr Opin Virol 2016 Feb 12;16:70-76. Epub 2016 Feb 12.

Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, United States; Department of Microbiology, University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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February 2016

Efficacy of an Automated Multiple Emitter Whole-Room Ultraviolet-C Disinfection System Against Coronaviruses MHV and MERS-CoV.

Infect Control Hosp Epidemiol 2016 May 28;37(5):598-9. Epub 2016 Jan 28.

1University of Iowa,Department of Microbiology,Iowa City,Iowa.

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May 2016

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine.

PLoS Pathog 2015 Oct 29;11(10):e1005215. Epub 2015 Oct 29.

Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain.

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October 2015

Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.

J Exp Med 2015 Oct 21;212(11):1851-68. Epub 2015 Sep 21.

Interdisciplinary Program in Immunology and Department of Otolaryngology, Department of Pathology, and Department of Microbiology, University of Iowa, Iowa City, IA 52242 Interdisciplinary Program in Immunology and Department of Otolaryngology, Department of Pathology, and Department of Microbiology, University of Iowa, Iowa City, IA 52242

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October 2015

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.

Cell Res 2015 Nov 22;25(11):1237-49. Epub 2015 Sep 22.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Academy of Sciences, Beijing 100101, China.

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November 2015

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus.

Proc Natl Acad Sci U S A 2015 Aug 27;112(33):10473-8. Epub 2015 Jul 27.

Immune Regulation Unit, Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; Institute of Microbiology, Eidgenössische Technische Hochschule Zurich, 8093 Zurich, Switzerland

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August 2015

Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses.

Authors:
Stanley Perlman

PLoS Pathog 2015 Jul 14;11(7):e1005023. Epub 2015 Jul 14.

Departments of Microbiology and Pediatrics, University of Iowa, Iowa City, Iowa, United States of America.

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July 2015

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection.

J Infect Dis 2015 Dec 8;212(12):1894-903. Epub 2015 Jun 8.

Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, China Lindsley F. Kimball Research Institute, New York Blood Center, New York.

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December 2015

Middle East Respiratory Syndrome - advancing the public health and research agenda on MERS - lessons from the South Korea outbreak.

Int J Infect Dis 2015 Jul 10;36:54-5. Epub 2015 Jun 10.

Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom. Electronic address:

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July 2015

Spread of MERS to South Korea and China.

Lancet Respir Med 2015 Jul 4;3(7):509-10. Epub 2015 Jun 4.

Division of Infection and Immunity, University College London, London NW3 2PF, UK; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK. Electronic address:

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July 2015

Middle East respiratory syndrome.

Lancet 2015 Sep 3;386(9997):995-1007. Epub 2015 Jun 3.

Department of Microbiology, University of Iowa, Iowa City, IA, USA; Department of Pediatrics, University of Iowa, Iowa City, IA, USA. Electronic address:

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September 2015

Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection.

J Virol 2015 Jun 18;89(11):6117-20. Epub 2015 Mar 18.

The School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China

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June 2015

Coronaviruses: an overview of their replication and pathogenesis.

Methods Mol Biol 2015 ;1282:1-23

Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.

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November 2015

Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.

J Virol 2015 May 18;89(9):4907-17. Epub 2015 Feb 18.

Department of Microbiology & Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA

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May 2015

Severe acute respiratory syndrome coronaviruses with mutations in the E protein are attenuated and promising vaccine candidates.

J Virol 2015 Apr 21;89(7):3870-87. Epub 2015 Jan 21.

Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, Madrid, Spain.

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April 2015

Middle East respiratory syndrome in the shadow of Ebola.

Lancet Respir Med 2015 Feb 13;3(2):100-102. Epub 2015 Jan 13.

Division of Respiratory Medicine and Stanley Ho Center for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong.

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February 2015

The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis.

J Virol 2015 Feb 26;89(3):1523-36. Epub 2014 Nov 26.

Department of Microbiology, University of Iowa, Iowa City, Iowa, USA

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February 2015

The cellular redox environment alters antigen presentation.

J Biol Chem 2014 Oct 18;289(40):27979-91. Epub 2014 Aug 18.

the Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia, the Department of Biochemistry and Molecular Biology and

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October 2014