Stanley Nattel

Stanley Nattel

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Stanley Nattel

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Right Atrial Mechanisms of Atrial Fibrillation in a Rat Model of Right Heart Disease.

J Am Coll Cardiol 2019 Sep;74(10):1332-1347

Montreal Heart Institute (MHI), Department of Medicine, Université de Montréal, Montreal, Quebec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada; IHU Liryc and Fondation Bordeaux Université, Bordeaux, France; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.06.066DOI Listing
September 2019

The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity.

Am J Pathol 2019 Aug 17. Epub 2019 Aug 17.

Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Center, Université de Montréal, Montréal, Québec, Canada; Department of Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Hospital, Université de Montréal, Montréal, Québec, Canada; Department of Ophthalmology, Centre Hospitalier Universitaire Sainte-Justine Hospital, Université de Montréal, Montréal, Québec, Canada; Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Hospital, Université de Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.07.009DOI Listing
August 2019

Role of the lysyl oxidase enzyme family in cardiac function and disease.

Cardiovasc Res 2019 Aug 20. Epub 2019 Aug 20.

Department of Pharmacology and Physiology, Université de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1093/cvr/cvz176DOI Listing
August 2019

Role of autonomic nervous system in atrial fibrillation.

Int J Cardiol 2019 Jul 18;287:181-188. Epub 2018 Nov 18.

Centre for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

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http://dx.doi.org/10.1016/j.ijcard.2018.11.091DOI Listing
July 2019

Clarity and controversy around rate control in AF, the orphan child in AF therapeutics.

Int J Cardiol 2019 Jul 15;287:189-194. Epub 2018 Nov 15.

Research Center, Montreal Heart Institute and Université de Montréal, Canada; Department of Pharmacology and Therapeutics, McGill University, Canada; Institute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-, Essen, Germany; LIRYC Institute, Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.11.024DOI Listing
July 2019

Postoperative atrial fibrillation: mechanisms, manifestations and management.

Nat Rev Cardiol 2019 Jul;16(7):417-436

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/s41569-019-0166-5DOI Listing
July 2019

Editorial Commentary: Obesity, body composition and atrial fibrillation.

Trends Cardiovasc Med 2019 Jun 27. Epub 2019 Jun 27.

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Canada.

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http://dx.doi.org/10.1016/j.tcm.2019.06.008DOI Listing
June 2019

Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics.

Cell Mol Gastroenterol Hepatol 2019 24;7(2):411-431. Epub 2018 Oct 24.

Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine Research Center, Université de Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369230PMC
May 2019

Guideline Implications of Prothrombotic State Assessment in Low-Risk Atrial Fibrillation Patients: Consistency With CHADS-VASc and Support for CHADS-65.

Can J Cardiol 2019 May 8;35(5):547-549. Epub 2019 Mar 8.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom; and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

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http://dx.doi.org/10.1016/j.cjca.2019.03.001DOI Listing
May 2019

Computational models of the atrial fibrillation substrate: can they explain post-ablation recurrences and help to prevent them.

Authors:
Stanley Nattel

Cardiovasc Res 2019 May 14. Epub 2019 May 14.

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.1093/cvr/cvz121DOI Listing
May 2019

An N-/L-Type Calcium Channel Blocker, Cilnidipine, Suppresses Autonomic, Electrical and Structural Remodeling Associated with Atrial Fibrillation.

Cardiovasc Res 2019 May 22. Epub 2019 May 22.

Department of Medicine and Research Center Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1093/cvr/cvz136DOI Listing
May 2019

Natriuretic peptide receptors and atrial-selective fibrosis: potential role in atrial fibrillation.

Authors:
Stanley Nattel

Cardiovasc Res 2019 Feb;115(2):258-260

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.1093/cvr/cvy287DOI Listing
February 2019

The Canadian Journal of Cardiology: Open and Growing.

Authors:
Stanley Nattel

Can J Cardiol 2019 Feb 3;35(2):133-137. Epub 2019 Jan 3.

From the Department of Medicine, Montréal Heart Institute and Université de Montréal, and Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; IHU Liryc and Fondation Bordeaux Université, Bordeaux, France; and Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.037DOI Listing
February 2019

Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling.

Heart Rhythm 2018 11 11;15(11):1708-1716. Epub 2018 Jun 11.

Department of Clinical Pharmacy and Pharmacology, Groningen University Institute for Drug Exploration (GUIDE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.06.014DOI Listing
November 2018

Age as a Critical Determinant of Atrial Fibrillation: A Two-sided Relationship.

Can J Cardiol 2018 11 8;34(11):1396-1406. Epub 2018 Aug 8.

Montreal Heart Institute, Université de Montréal, Montreal, Québec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Québec, Canada; Institute of Pharmacology, University Duisburg-Essen, Essen, Germany; LIRYC Center, Bordeaux, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183100
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http://dx.doi.org/10.1016/j.cjca.2018.08.007DOI Listing
November 2018

Mechanisms and Clinical Significance of Arrhythmia-Induced Cardiomyopathy.

Can J Cardiol 2018 11 1;34(11):1449-1460. Epub 2018 Aug 1.

Research Center, Montréal Heart Institute, Montréal, Québec, Canada; Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada; Cardiovascular Genetics Center, Montréal Heart Institute, Montréal, Québec, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183099
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http://dx.doi.org/10.1016/j.cjca.2018.07.475DOI Listing
November 2018

Taking the Pulse of Atrial Fibrillation: A Practical Approach to Rate Control.

Can J Cardiol 2018 11 23;34(11):1526-1530. Epub 2018 Jul 23.

Research Center, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; Institute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-Essen, North Rhine, Westphaila, Germany; LIRYC Center, Bordeaux, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X183051
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http://dx.doi.org/10.1016/j.cjca.2018.07.015DOI Listing
November 2018

Prof Niels Voigt talks to Prof Stanley Nattel about advances in atrial fibrillation research and career insights.

Cardiovasc Res 2018 07;114(8):e65

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, 5000 Bélanger Street East, Montreal, QC H1T 1C8, Canada.

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http://dx.doi.org/10.1093/cvr/cvy142DOI Listing
July 2018

Associations of Obstructive Sleep Apnea With Atrial Fibrillation and Continuous Positive Airway Pressure Treatment: A Review.

JAMA Cardiol 2018 06;3(6):532-540

Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

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http://dx.doi.org/10.1001/jamacardio.2018.0095DOI Listing
June 2018

Calcium-dependent potassium channels control proliferation of cardiac progenitor cells and bone marrow-derived mesenchymal stem cells.

J Physiol 2018 Jun 5;596(12):2359-2379. Epub 2018 May 5.

Research Center and Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1113/JP275388
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http://dx.doi.org/10.1113/JP275388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002232PMC
June 2018

Catheter ablation of atrial fibrillation and outcomes in heart failure patients: seeking the treasure in the CASTLE.

Authors:
Stanley Nattel

Cardiovasc Res 2018 06;114(7):e50-e52

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, 5000 Bélanger Street East, Montreal, QC H1T 1C8, Canada.

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http://dx.doi.org/10.1093/cvr/cvy101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967463PMC
June 2018

Response by Lau et al to Letters Regarding Article, "Modifiable Risk Factors and Atrial Fibrillation".

Circulation 2018 04;137(14):1534-1535

Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Australia (D.H.L., P.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032205DOI Listing
April 2018

Electrical coupling between cardiomyocytes and fibroblasts: experimental testing of a challenging and important concept.

Authors:
Stanley Nattel

Cardiovasc Res 2018 03;114(3):349-352

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, 5000 Belanger Street E, Montreal, QC H1T 1C8, Canada.

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https://academic.oup.com/cardiovascres/article/114/3/349/481
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http://dx.doi.org/10.1093/cvr/cvy003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018686PMC
March 2018

Translational Challenges in Atrial Fibrillation.

Circ Res 2018 03;122(5):752-773

From the Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, The Netherlands (J.H.); Department of Medicine, Montreal Heart Institute and Université de Montréal, Canada (J.-B.G., S.N.); University Hospital of Saint-Étienne, University Jean Monnet, Saint-Étienne, France (J.-B.G.); Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen (D.D., S.N.); and Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada (S.N.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.31108
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http://dx.doi.org/10.1161/CIRCRESAHA.117.311081DOI Listing
March 2018

Atrial Infarction-Induced Spontaneous Focal Discharges and Atrial Fibrillation in Sheep: Role of Dantrolene-Sensitive Aberrant Ryanodine Receptor Calcium Release.

Circ Arrhythm Electrophysiol 2018 03;11(3):e005659

From the Division of Cardiovascular Medicine, Department of Internal Medicine, Columbia University, New York, NY (U.M.R.A.); Division of Cardiovascular Medicine, Department of Internal Medicine, Center for Arrhythmia Research (J.J.H., C.R.V., K.K., R.R.-M., J.A., H.H.V.) and Department of Surgery (A.R.-P.), University of Michigan, Ann Arbor; Medical Device Development and Regulation Research Center, The University of Tokyo, Japan (M.Y.); Department of Cardiology, Brown University, Providence, RI (A.C., J.K.); Department of Medicine and Research Center, Montreal Heart Institute, Université de Montréal, Québec (S.N.); Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada (S.N.); and Institute of Pharmacology, West German Heart and Vascular Centre, University Duisburg-Essen (S.N.).

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https://www.ahajournals.org/doi/10.1161/CIRCEP.117.005659
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http://dx.doi.org/10.1161/CIRCEP.117.005659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554725PMC
March 2018

Aging and Protein Kinase Activation: Is It the Missing Link Between Age and Atrial Fibrillation?

Authors:
Stanley Nattel

Circ Res 2018 03;122(6):799-801

From the Department of Medicine and Research Center, Montreal Heart Institute, Université de Montréal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; and Institute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-Essen, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312786DOI Listing
March 2018

Taking Hockey to Heart: Potential Coronary Risks of Watching Exciting Games.

Can J Cardiol 2017 12 5;33(12):1517-1519. Epub 2017 Oct 5.

Department of Medicine, Montréal Heart Institute and Université de Montréal, and Department of Pharmacology, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2017.08.020DOI Listing
December 2017

A Practical Approach to Avoiding Cardiovascular Adverse Effects of Psychoactive Medications.

Can J Cardiol 2017 12 11;33(12):1577-1586. Epub 2017 Sep 11.

Research Centre, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2017.09.001DOI Listing
December 2017

Characterization of Sgo1 expression in developing and adult mouse.

Gene Expr Patterns 2017 11 29;25-26:36-45. Epub 2017 Apr 29.

Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada; Université de Montréal, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.gep.2017.04.004DOI Listing
November 2017

Metabolic Considerations in Atrial Fibrillation - Mechanistic Insights and Therapeutic Opportunities.

Circ J 2017 Nov 24;81(12):1749-1757. Epub 2017 Oct 24.

Department of Medicine and Research Center, Montreal Heart Institute.

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http://dx.doi.org/10.1253/circj.CJ-17-1058DOI Listing
November 2017

Demystifying rotors and their place in clinical translation of atrial fibrillation mechanisms.

Nat Rev Cardiol 2017 Sep 6;14(9):509-520. Epub 2017 Apr 6.

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada.

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http://dx.doi.org/10.1038/nrcardio.2017.37DOI Listing
September 2017

Dataset of expression in cardiac, gastrointestinal, hepatic and neuronal tissue in mouse.

Data Brief 2017 Aug 1;13:731-737. Epub 2017 Jul 1.

Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Canada.

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http://dx.doi.org/10.1016/j.dib.2017.06.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512188PMC
August 2017

Contemporary Atrial Fibrillation Management: A Comparison of the Current AHA/ACC/HRS, CCS, and ESC Guidelines.

Can J Cardiol 2017 08 9;33(8):965-976. Epub 2017 Jun 9.

University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.cjca.2017.06.002DOI Listing
August 2017

Atrial Cardiomyopathy: A Useful Notion in Cardiac Disease Management or a Passing Fad?

J Am Coll Cardiol 2017 Aug;70(6):756-765

Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.06.033DOI Listing
August 2017

Modifiable Risk Factors and Atrial Fibrillation.

Circulation 2017 Aug;136(6):583-596

From: Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, (D.H.L., P.S.); Department of Medicine, Université de Montréal, Research Center, Montreal Heart Institute, Quebec, Canada (S.N.); Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Germany (S.N.); and Department of Cardiology, Royal Melbourne Hospital and the Department of Medicine, University of Melbourne, Victoria, Australia (J.M.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023163DOI Listing
August 2017

Allele-Specific Gene Silencing: Another Step in the Inexorable Advance of Gene Therapy for Cardiac Arrhythmia Management.

Authors:
Stanley Nattel

Circ Res 2017 08;121(5):480-482

From the Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal; Departments of Medicine and Pharmacology and Therapeutics, McGill University, Montreal, Canada; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311541DOI Listing
August 2017

T-tubular collagen: a new player in mechanosensing and disease?

Cardiovasc Res 2017 07;113(8):839-840

Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.1093/cvr/cvx091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852544PMC
July 2017

MicroRNA-135a regulates sodium-calcium exchanger gene expression and cardiac electrical activity.

Heart Rhythm 2017 05 8;14(5):739-748. Epub 2017 Feb 8.

Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Canada; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2017.01.045DOI Listing
May 2017

Aortic Vascular Calcification: Cholesterol Lowering Does Not Reduce Progression in Patients With Familial Hypercholesterolemia-or Does It?

Can J Cardiol 2017 05 9;33(5):594-596. Epub 2017 Mar 9.

Department of Medicine, Montreal Heart Institute and Université de Montréal, Montréal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1016/j.cjca.2017.03.001DOI Listing
May 2017

Rate-Dependent Role of I in Human Atrial Repolarization and Atrial Fibrillation Maintenance.

Biophys J 2017 May;112(9):1997-2010

Research Center, Montreal Heart Institute, Université de Montréal, Montreal, Québec, Canada; Department of Medicine, McGill University, Montreal, Québec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Québec, Canada; Department of Medicine, Université de Montréal, Montreal, Québec, Canada; West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495173034
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http://dx.doi.org/10.1016/j.bpj.2017.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425383PMC
May 2017

Atrial Fibrillation and Body Composition: Is it Fat or Lean That Ultimately Determines the Risk?

Authors:
Stanley Nattel

J Am Coll Cardiol 2017 05;69(20):2498-2501

Department of Medicine, Montreal Heart Institute and Université de Montréal, Montréal, Quebec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.03.566DOI Listing
May 2017

Molecular and Cellular Mechanisms of Atrial Fibrosis in Atrial Fibrillation.

Authors:
Stanley Nattel

JACC Clin Electrophysiol 2017 05 15;3(5):425-435. Epub 2017 May 15.

Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacep.2017.03.002DOI Listing
May 2017

Controversies About Atrial Fibrillation Mechanisms: Aiming for Order in Chaos and Whether it Matters.

Circ Res 2017 04;120(9):1396-1398

From the Department of Medicine, Montreal Heart Institute, Université de Montréal, Canada (S.N.); Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada (S.N.); and Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Germany (S.N., D.D.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.310489DOI Listing
April 2017

JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate.

Cardiovasc Res 2017 Mar;113(3):310-320

Department of Medicine and Research Center Montreal Heart Institute and Université de Montréal, 5000 Belanger St. E., Montreal, Quebec, H1T 1C8 Canada.

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https://academic.oup.com/cardiovascres/article/113/3/310/296
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http://dx.doi.org/10.1093/cvr/cvx004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852635PMC
March 2017

Drug Shortages: Patients and Health Care Providers Are All Drawing the Short Straw.

Can J Cardiol 2017 02 17;33(2):283-286. Epub 2016 Aug 17.

Département de pharmacie et Unité de recherche en pratique pharmaceutique, CHU Sainte-Justine, Montréal, Québec, Canada; Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2016.08.010DOI Listing
February 2017

Close connections between contraction and rhythm: a new genetic cause of atrial fibrillation/cardiomyopathy and what it can teach us.

Authors:
Stanley Nattel

Eur Heart J 2017 01 23;38(1):35-37. Epub 2016 Oct 23.

Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, the Department of Pharmacology and Therapeutics, McGill University, Canada; and Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany

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https://academic.oup.com/eurheartj/article-lookup/doi/10.109
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http://dx.doi.org/10.1093/eurheartj/ehw457DOI Listing
January 2017

An Emerging Malignant Arrhythmia Epidemic Due to Loperamide Abuse: Underlying Mechanisms and Clinical Relevance.

Authors:
Stanley Nattel

JACC Clin Electrophysiol 2016 12 19;2(7):790-792. Epub 2016 Dec 19.

Department of Medicine, Montreal Heart Institute and Université de Montréal, Montréal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacep.2016.10.009DOI Listing
December 2016

Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation.

Nat Rev Cardiol 2016 10 4;13(10):575-90. Epub 2016 Aug 4.

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada.

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http://dx.doi.org/10.1038/nrcardio.2016.118DOI Listing
October 2016

Direct Effects of Activation and Inhibition of the Coagulation System on the Atrial Fibrillation Substrate: Is Anticoagulation Antiarrhythmic?

Authors:
Stanley Nattel

JACC Basic Transl Sci 2016 Aug 13;1(5):340-343. Epub 2016 Jul 13.

Department of Medicine, Montreal Heart Institute and Université de Montréal, Montréal, Canada.

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http://dx.doi.org/10.1016/j.jacbts.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113350PMC
August 2016

How does fibrosis promote atrial fibrillation persistence: in silico findings, clinical observations, and experimental data.

Authors:
Stanley Nattel

Cardiovasc Res 2016 06 30;110(3):295-7. Epub 2016 Apr 30.

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, 5000 Belanger Street E, Montreal, QC, Canada H1T 1C8 Department of Pharmacology and Therapeutics, McGill University Montreal, Montreal, Canada Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany

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http://dx.doi.org/10.1093/cvr/cvw092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872882PMC
June 2016

Potassium Channel Remodeling in Heart Disease.

Card Electrophysiol Clin 2016 06 18;8(2):337-47. Epub 2016 Mar 18.

Department of Medicine, Research Center, Montreal Heart Institute, University of Montreal, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada; Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec H3G 1Y6, Canada; Faculty of Medicine, University Duisburg-Essen, Hufelandstr. 55, Essen 45122, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccep.2016.01.006DOI Listing
June 2016

Dronedarone: Basic Pharmacology and Clinical Use.

Card Electrophysiol Clin 2016 06 19;8(2):453-65. Epub 2016 Mar 19.

Department of Medicine, Université de Montréal and Montreal Heart Institute, 5000 Rue Belanger, Montreal, Québec H1T 1C8, Canada; Heart Rhythm Services, Department of Medicine, University of British Columbia, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccep.2016.02.008DOI Listing
June 2016

Cardiac Potassium Channel Disorders: From Basics to Clinics.

Card Electrophysiol Clin 2016 06;8(2):xv-xvi

Department of Medicine, University of Montreal, Research Center, Montreal Heart Institute, 5000 Belanger Street E., Montreal, Quebec H1T1C8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccep.2016.03.001DOI Listing
June 2016

The pioneering work of George Mines on cardiac arrhythmias: groundbreaking ideas that remain influential in contemporary cardiac electrophysiology.

J Physiol 2016 05 19;594(9):2377-86. Epub 2016 Jan 19.

Research Center, Montreal Heart Institute, Montreal, Canada.

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http://dx.doi.org/10.1113/JP270506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850190PMC
May 2016

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis.

Cardiovasc Res 2016 Apr 23;109(4):467-79. Epub 2015 Dec 23.

Department of Medicine, Montreal Heart Institute and Université de Montréal, 5000 Belanger St. E., Montreal, Canada H1T 1C8 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, Germany

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http://dx.doi.org/10.1093/cvr/cvv275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777910PMC
April 2016

Deciphering the fundamental mechanisms of atrial fibrillation: a quest for over a century.

Cardiovasc Res 2016 Apr 7;109(4):465-6. Epub 2016 Feb 7.

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Hufeland Str. 55, Essen 45122, Germany

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http://dx.doi.org/10.1093/cvr/cvw028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777915PMC
April 2016

Arrhythmias in 2015: Advances in drug, ablation, and device therapy for cardiac arrhythmias.

Nat Rev Cardiol 2016 Mar 29;13(3):179. Epub 2016 Jan 29.

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http://dx.doi.org/10.1038/nrcardio.2016.11DOI Listing
March 2016

Atrial fibrillation.

Nat Rev Dis Primers 2016 03 31;2:16016. Epub 2016 Mar 31.

University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK.

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http://dx.doi.org/10.1038/nrdp.2016.16DOI Listing
March 2016

Pharmacotherapy for inherited arrhythmia syndromes: mechanistic basis, clinical trial evidence and practical application.

Expert Rev Cardiovasc Ther 2015 20;13(7):769-82. Epub 2015 May 20.

Electrophysiology service and Cardiovascular Genetics Center, Montreal Heart Institute, Université de Montréal, 5000 Bélanger St. E., Montreal, Quebec, H1T 1C8 Canada.

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http://dx.doi.org/10.1586/14779072.2015.1049156DOI Listing
February 2016

Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation.

J Physiol 2016 Feb 28;594(3):537-53. Epub 2015 Dec 28.

Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1113/JP271404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341705PMC
February 2016

Arrhythmias in 2015: Advances in drug, ablation, and device therapy for cardiac arrhythmias.

Nat Rev Cardiol 2016 Feb 4;13(2):67-8. Epub 2016 Jan 4.

Department of Medicine, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada.

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http://dx.doi.org/10.1038/nrcardio.2015.196DOI Listing
February 2016

Caged ligands to study the role of intracellular GPCRs.

Methods 2016 Jan 18;92:72-7. Epub 2015 Jul 18.

Department of Medicine, Université de Montréal, Canada; Montreal Heart Institute, Canada; Department of Pharmacology and Therapeutics, McGill University, Canada; Department of Biochemistry and Molecular Medicine, Université de Montréal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.07.005DOI Listing
January 2016

Potassium Channel Blockade Enhances Atrial Fibrillation-Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade.

Circulation 2015 Dec 23;132(23):2203-11. Epub 2015 Oct 23.

From the Research Center, Montreal Heart Institute and Université de Montréal, Montreal, QC, Canada (M.A., F.X., X.Y.Q., P.C., S.N.); Department of Molecular and Integrative Physiology/Institute of Biomedical Engineering (M.A., P.C.) and Department of Medicine (S.N.), Université de Montréal, Montreal, QC, Canada; and Departments of Medicine (M.A., S.N.) and Pharmacology and Therapeutics (F.X., S.N.), McGill University, Montreal, QC, Canada; and West-German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany (S.N.).

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http://circ.ahajournals.org/content/circulationaha/early/201
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December 2015

Role of inflammation in atrial fibrillation pathophysiology and management.

Circ J 2015 16;79(3):495-502. Epub 2015 Feb 16.

Department of Cardiology, Fujita Health University School of Medicine.

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http://dx.doi.org/10.1253/circj.CJ-15-0138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457364PMC
November 2015

The Past, Present, and Potential Future of Sodium Channel Block as an Atrial Fibrillation Suppressing Strategy.

J Cardiovasc Pharmacol 2015 Nov;66(5):432-40

*Research Center, Montreal Heart Institute, Montreal, Québec, Canada; †Department of Physiology, Université de Montréal, Montreal, Québec, Canada; ‡Department of Medicine, McGill University, Montreal, Québec, Canada; §Department of Medicine, Université de Montréal, Montreal, Québec, Canada; and ¶Department of Pharmacology and Therapeutics, McGill University, Montreal, Québec, Canada.

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http://dx.doi.org/10.1097/FJC.0000000000000271DOI Listing
November 2015

Innovative Therapeutics for Atrial Fibrillation: Imminent Breakthroughs or Much Ado About Nothing?

J Cardiovasc Pharmacol 2015 Nov;66(5):409-11

*Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada; †Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada; and ‡Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1097/FJC.0000000000000319DOI Listing
November 2015

Results-Based Accountability for Cardiovascular Epidemiology Research by the National Heart, Lung, and Blood Institute.

Circulation 2015 Nov 27;132(21):1949-52. Epub 2015 Oct 27.

From Research Center, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (P.K., S.N.); and Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany (S.N.).

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http://circ.ahajournals.org/content/early/2015/10/27/CIRCULA
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http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAH
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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.019564DOI Listing
November 2015

Wavelet analysis of cardiac optical mapping data.

Comput Biol Med 2015 Oct 2;65:243-55. Epub 2015 Jul 2.

Research Center, Montreal Heart Institute and Université de Montréal, 5000 Belanger Street East, Montreal, Que., Canada H1T 1C8; Department of Molecular and Integrative Physiology/Institute of Biomedical Engineering, Université de Montréal, Montreal, Que., Canada. Electronic address:

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http://dx.doi.org/10.1016/j.compbiomed.2015.06.022DOI Listing
October 2015

The interaction between delayed rectifier channel alpha-subunits does not involve hetero-tetramer formation.

Naunyn Schmiedebergs Arch Pharmacol 2015 Sep 20;388(9):973-81. Epub 2015 Mar 20.

Division of Cardiology, Goethe-University, Theodor Stern Kai 7, 60590, Frankfurt, Germany.

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http://link.springer.com/10.1007/s00210-015-1108-3
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September 2015

Loss of cardiomyocyte integrin-linked kinase produces an arrhythmogenic cardiomyopathy in mice.

Circ Arrhythm Electrophysiol 2015 Aug 12;8(4):921-32. Epub 2015 Jun 12.

From the Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (K.L.Q., A.M., X.-Y.Q., P.N., F.X., A.T., Y.-F.S., D.C., C.T., S.N.); Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada (F.X., S.N.); and Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (D.D.).

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http://dx.doi.org/10.1161/CIRCEP.115.001668DOI Listing
August 2015

A Systematic Review on the Progression of Paroxysmal to Persistent Atrial Fibrillation: Shedding New Light on the Effects of Catheter Ablation.

JACC Clin Electrophysiol 2015 Jun 13;1(3):105-115. Epub 2015 May 13.

McGill University Health Center, Montreal, Quebec, Canada; Hôpital Sacré-Coeur de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jacep.2015.04.010DOI Listing
June 2015

Pulmonary vein exit block despite recovery of entry conduction during redo-ablation for atrial fibrillation.

Europace 2015 May 16;17(5):752. Epub 2015 Mar 16.

Electrophysiology Service, Montreal Heart Institute,Université de Montréal, 5000 Belanger St. E., Montreal, QC, Canada H1T 1C8

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https://academic.oup.com/europace/article-lookup/doi/10.1093
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http://dx.doi.org/10.1093/europace/euv033DOI Listing
May 2015

Targeting MicroRNA-208a to Suppress Adverse Postmyocardial Infarction Remodelling Related to RNA Activation of Endoglin Gene Expression.

Authors:
Stanley Nattel

Can J Cardiol 2015 May 12;31(5):591-2. Epub 2015 Mar 12.

Department of Medicine, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X150020
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http://dx.doi.org/10.1016/j.cjca.2015.03.013DOI Listing
May 2015

Modeling the aging heart: from local respiratory defects to global rhythm disturbances.

Cell Metab 2015 May;21(5):662-3

Department of Medicine, Montreal Heart Institute and Université de Montréal, Montréal, QC H1T 1C8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816650PMC
May 2015

Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling.

Circ Res 2015 Feb 21;116(5):836-45. Epub 2015 Jan 21.

From the Research Center and Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (X.-Y.Q., H.H., B.O., X.L., P.N., Y.S., C.-T.W., K.D., A.T., Y.C., M.H., S.N.); Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada (K.D., Y.C.); Department of Cardiology, Chang-Gung Memorial Hospital and University, Taoyuan, Taiwan, Republic of China (C.T.W., S.N.); Department of Cardiology, Fujita Health University School of Medicine, Toyoake, Japan (M.H.); and Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany (D.D.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.30532
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http://dx.doi.org/10.1161/CIRCRESAHA.116.305326DOI Listing
February 2015

Changes in the atrial transcriptome and atrial fibrillation: susceptibility, persistence, causes, and consequences.

Authors:
Stanley Nattel

Circ Arrhythm Electrophysiol 2015 Feb;8(1):5-7

From the Department of Medicine and Research Center, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.

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https://www.ahajournals.org/doi/10.1161/CIRCEP.115.002673
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http://dx.doi.org/10.1161/CIRCEP.115.002673DOI Listing
February 2015