Publications by authors named "Stanley L Hazen"

100Publications

Effects of Smoking and Smoking Cessation on the Intestinal Microbiota.

J Clin Med 2020 Sep 14;9(9). Epub 2020 Sep 14.

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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http://dx.doi.org/10.3390/jcm9092963DOI Listing
September 2020

Gut Microbiota and Cardiovascular Disease.

Circ Res 2020 Jul 30;127(4):553-570. Epub 2020 Jul 30.

From the Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute (M.W., T.L.W., S.L.H.), Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/CIRCRESAHA.120.316242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416843PMC
July 2020

Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.

Circulation 2020 Aug 13;142(6):546-555. Epub 2020 Jul 13.

Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.045526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493828PMC
August 2020

Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism.

Oncotarget 2020 May 12;11(19):1777-1796. Epub 2020 May 12.

Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.18632/oncotarget.27590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233810PMC
May 2020

Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.

J Am Heart Assoc 2020 May 10;9(10):e016223. Epub 2020 May 10.

Cardiovascular Center of Excellence Louisiana State University Health Sciences Center New Orleans LA.

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http://dx.doi.org/10.1161/JAHA.119.016223DOI Listing
May 2020

Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.

Arterioscler Thromb Vasc Biol 2020 05 26;40(5):1239-1255. Epub 2020 Mar 26.

From the Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute (N.G., J.A.B., A.B.R., N.S., S.M.S., L.L., J.A.D., W.H.W.T., S.L.H.), Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/ATVBAHA.120.314139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203662PMC
May 2020

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.

Cell 2020 03;180(5):862-877.e22

Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Center for Microbiome & Human Health, Cleveland Clinic, Cleveland, OH 44106, USA; Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402401PMC
March 2020

Efficient Site-Specific Prokaryotic and Eukaryotic Incorporation of Halotyrosine Amino Acids into Proteins.

ACS Chem Biol 2020 02 10;15(2):562-574. Epub 2020 Feb 10.

Department of Biochemistry and Biophysics , Oregon State University , Corvallis , Oregon 97331 , United States.

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http://dx.doi.org/10.1021/acschembio.9b01026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207724PMC
February 2020

Intestinal Microbiota in Cardiovascular Health and Disease: JACC State-of-the-Art Review.

J Am Coll Cardiol 2019 04;73(16):2089-2105

Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jacc.2019.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518422PMC
April 2019

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.

Authors:
Riyaz S Patel Amand F Schmidt Vinicius Tragante Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Marie-Pierre Dubé Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behlouli Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Line Dufresne Niclas Eriksson Luisa Foco Crystel M Gijsberts Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Natalie Fitzpatrick Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Chris Newton Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Peter Bogaty Gert J de Borst Hermann Brenner Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Julie A Johnson Pim A de Jong J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm Bakhtawar K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Witold Pepinski Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Markus Scholz Agneta Siegbahn Juha Sinisalo J Gustav Smith John A Spertus Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jurriën M Ten Berg George Thanassoulis Joachim Thiery Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Pim Van der Harst Jean-Claude Tardif Naveed Sattar Chim C Lang Guillaume Pare James M Brophy Jeffrey L Anderson Winfried März Lars Wallentin Vicky A Cameron Benjamin D Horne Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 04 21;12(4):e002471. Epub 2019 Mar 21.

Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).

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http://dx.doi.org/10.1161/CIRCGEN.119.002471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625876PMC
April 2019

Subsequent Event Risk in Individuals With Established Coronary Heart Disease.

Authors:
Riyaz S Patel Vinicius Tragante Amand F Schmidt Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behloui Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Marie-Pierre Dubé Line Dufresne Niclas Eriksson Luisa Foco Markus Scholz Crystel M Gijsberts Charlotte Glinge Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Salma Kotti Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica Van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Lawien Al Ali Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Thomas Engstrøm Natalie Fitzpatrick Kim Fox Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Christopher Newton-Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Eric H Boersma Peter Bogaty Michiel L Bots Hermann Brenner Jasper J Brugts Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Nicolas Danchin Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Diederick E Grobbee Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Reza Jabbari Julie A Johnson J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm B K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Anna Niemcunowicz-Janica Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Agneta Siegbahn Tabassome Simon Juha Sinisalo J Gustav Smith John A Spertus Steen Stender Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jean-Claude Tardif Jurriën M Ten Berg Jacob Tfelt-Hansen George Thanassoulis Joachim Thiery Christian Torp-Pedersen Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Peter E Weeke Pim Van der Harst Chim C Lang Naveed Sattar Vicky A Cameron Jeffrey L Anderson James M Brophy Guillaume Pare Benjamin D Horne Winfried März Lars Wallentin Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 04 21;12(4):e002470. Epub 2019 Mar 21.

Institute of Health Informatics (N.F., A. Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCGEN.119.002470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629546PMC
April 2019

Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data.

Anal Chem 2019 03 19;91(5):3590-3596. Epub 2019 Feb 19.

West Coast Metabolomics Center, UC Davis Genome Center , University of California, Davis , 451 Health Sciences Drive , Davis , California 95616 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b05592DOI Listing
March 2019

Gut Microbiota Involvement in Ventricular Remodeling Post-Myocardial Infarction.

Circulation 2019 01;139(5):660-662

Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute (A.M., S.L.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355251PMC
January 2019

Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults.

Nutrients 2019 Jan 16;11(1). Epub 2019 Jan 16.

Integrative Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.

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http://dx.doi.org/10.3390/nu11010179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356515PMC
January 2019

Dietary metabolism, the gut microbiome, and heart failure.

Nat Rev Cardiol 2019 03;16(3):137-154

Center for Microbiome & Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://www.nature.com/articles/s41569-018-0108-7
Publisher Site
http://dx.doi.org/10.1038/s41569-018-0108-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377322PMC
March 2019

Omalizumab can inhibit respiratory reaction during aspirin desensitization.

Ann Allergy Asthma Immunol 2018 07 16;121(1):98-104. Epub 2018 May 16.

Lerner Research Institute, Department of Cellular and Molecular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.anai.2018.05.007DOI Listing
July 2018

Microbial modulation of cardiovascular disease.

Nat Rev Microbiol 2018 03 8;16(3):171-181. Epub 2018 Jan 8.

Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, NC-10, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nrmicro.2017.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885760PMC
March 2018

Novel Risk Stratification Assays for Acute Coronary Syndrome.

Curr Cardiol Rep 2017 08;19(8):69

Preventive Cardiology and Rehabilitation, Cleveland Clinic, Heart and Vascular Institute, 9500 Euclid Ave, Desk JB1, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1007/s11886-017-0880-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998330PMC
August 2017

NMR quantification of trimethylamine-N-oxide in human serum and plasma in the clinical laboratory setting.

Clin Biochem 2017 Nov 15;50(16-17):947-955. Epub 2017 Jun 15.

LipoScience, Laboratory Corporation of America® Holdings, Raleigh, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632584PMC
November 2017

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

Authors:
Stephen Zewinger Marcus E Kleber Vinicius Tragante Raymond O McCubrey Amand F Schmidt Kenan Direk Ulrich Laufs Christian Werner Wolfgang Koenig Dietrich Rothenbacher Ute Mons Lutz P Breitling Herrmann Brenner Richard T Jennings Ioannis Petrakis Sarah Triem Mira Klug Alexandra Filips Stefan Blankenberg Christoph Waldeyer Christoph Sinning Renate B Schnabel Karl J Lackner Efthymia Vlachopoulou Ottar Nygård Gard Frodahl Tveitevåg Svingen Eva Ringdal Pedersen Grethe S Tell Juha Sinisalo Markku S Nieminen Reijo Laaksonen Stella Trompet Roelof A J Smit Naveed Sattar J Wouter Jukema Heinrich V Groesdonk Graciela Delgado Tatjana Stojakovic Anna P Pilbrow Vicky A Cameron A Mark Richards Robert N Doughty Yan Gong Rhonda Cooper-DeHoff Julie Johnson Markus Scholz Frank Beutner Joachim Thiery J Gustav Smith Ragnar O Vilmundarson Ruth McPherson Alexandre F R Stewart Sharon Cresci Petra A Lenzini John A Spertus Oliviero Olivieri Domenico Girelli Nicola I Martinelli Andreas Leiherer Christoph H Saely Heinz Drexel Axel Mündlein Peter S Braund Christopher P Nelson Nilesh J Samani Daniel Kofink Imo E Hoefer Gerard Pasterkamp Arshed A Quyyumi Yi-An Ko Jaana A Hartiala Hooman Allayee W H Wilson Tang Stanley L Hazen Niclas Eriksson Claes Held Emil Hagström Lars Wallentin Axel Åkerblom Agneta Siegbahn Igor Karp Christopher Labos Louise Pilote James C Engert James M Brophy George Thanassoulis Peter Bogaty Wojciech Szczeklik Marcin Kaczor Marek Sanak Salim S Virani Christie M Ballantyne Vei-Vei Lee Eric Boerwinkle Michael V Holmes Benjamin D Horne Aroon Hingorani Folkert W Asselbergs Riyaz S Patel Bernhard K Krämer Hubert Scharnagl Danilo Fliser Winfried März Thimoteus Speer

Lancet Diabetes Endocrinol 2017 07 26;5(7):534-543. Epub 2017 May 26.

Department of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/S2213-8587(17)30096-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651679PMC
July 2017

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Nat Genet 2017 Jul 22;49(7):1113-1119. Epub 2017 May 22.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555387PMC
July 2017

Gut Microbe-Generated Trimethylamine -Oxide From Dietary Choline Is Prothrombotic in Subjects.

Circulation 2017 04;135(17):1671-1673

From Department of Cellular and Molecular Medicine, Lerner Research Institute (W.Z., Z.W., W.H.W.T., S.L.H.), Center for Microbiome & Human Health (W.Z., Z.W., W.H.W.T., S.L.H.), and Heart and Vascular Institute (W.H.W.T., S.L.H.), Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460631PMC
April 2017

Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling.

Circ Res 2017 Jun 12;121(1):56-70. Epub 2017 Apr 12.

From the Cardiology, Heart Center (M.M., K.F., M.L., J.G., L.R., C.K., J.S., T.R., M.M., M.H., G.P., D.M., M.A., K.M., T.K.R., S.B., A.K., V.R.), Center for Molecular Medicine Cologne (M.M., K.F., M.L., J.G., L.R., C.K., J.S., T.R., M.M., M.H., G.P., D.M., M.A., K.M., T.K.R., S.B., A.K., V.R.), and Center for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty (T.S.), University of Cologne, Germany; University Heart Center Hamburg, Germany (J.K., D.L.); General and Interventional Cardiology (F.G.D.) and Experimental Pharmacology and Toxicology (B.G., T.E.), University Heart Center Hamburg, University Hospital Hamburg-Eppendorf (UKE), Germany; Institute of Biophysics, Czech Academy of Sciences, Brno (L.K.); International Clinical Research Center, St. Anne's University Hospital Brno, Czech Republic (L.K., A.K.); Mathematics, Cleveland State University, OH (Y.W.); and Cellular and Molecular Medicine and Cardiovascular Medicine, Cleveland Clinic, OH (W.H.W.T., S.L.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482785PMC
June 2017

Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery.

J Biol Chem 2017 05 7;292(21):8560-8568. Epub 2017 Apr 7.

From the Departments of Cellular and Molecular Medicine and

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http://dx.doi.org/10.1074/jbc.R116.765388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448085PMC
May 2017

Gut Microbiota in Cardiovascular Health and Disease.

Circ Res 2017 Mar;120(7):1183-1196

From the Department of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.); Department of Cardiovascular Medicine, Heart and Vascular Institute (W.H.W.T., T.K.); and Center for Clinical Genomics, Cleveland Clinic, Cleveland OH (W.H.W.T.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.309715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390330PMC
March 2017

The Gut Microbiome and Its Role in Cardiovascular Diseases.

Circulation 2017 03;135(11):1008-1010

From Department of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.); Department of Cardiovascular Medicine, Heart and Vascular Institute (W.H.W.T., S.L.H.); Center for Microbiome and Human Health (W.H.W.T., S.L.H.), and Center for Clinical Genomics (W.H.W.T.), Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354081PMC
March 2017

Relation of Red Cell Distribution Width to Left Ventricular End-Diastolic Pressure and Mortality in Patients With and Without Heart Failure.

Am J Cardiol 2017 05 10;119(9):1421-1427. Epub 2017 Feb 10.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Ohio; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2017.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392141PMC
May 2017

High-density lipoprotein-associated paraoxonase-1 activity for prediction of adverse outcomes in outpatients with chronic heart failure.

Eur J Heart Fail 2017 06 7;19(6):748-755. Epub 2017 Feb 7.

Department of Cellular & Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1002/ejhf.777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461194PMC
June 2017

Atherosclerosis in 2016: Advances in new therapeutic targets for atherosclerosis.

Nat Rev Cardiol 2017 01;14(2):71-72

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nrcardio.2016.216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880294PMC
January 2017

Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo.

Free Radic Biol Med 2017 03 6;104:20-31. Epub 2017 Jan 6.

Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, United States; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, United States; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, United States. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353359PMC
March 2017

Reply: Trimethylamine N-Oxide in Seafood: Rotten or Forgotten?

J Am Coll Cardiol 2016 12;68(25):2917-2918

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http://dx.doi.org/10.1016/j.jacc.2016.09.969DOI Listing
December 2016

Microbial Modulation of a Uremic Toxin.

Cell Host Microbe 2016 Dec;20(6):691-692

Department of Cellular & Molecular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA; Preventive Cardiology & Rehabilitation, Center for Microbiome and Human Health, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.11.005DOI Listing
December 2016

Predicting long-term prognosis in stable peripheral artery disease with baseline functional capacity estimated by the Duke Activity Status Index.

Am Heart J 2017 02 20;184:17-25. Epub 2016 Oct 20.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

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http://dx.doi.org/10.1016/j.ahj.2016.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322238PMC
February 2017

Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus.

Clin Chem 2017 Jan 18;63(1):297-306. Epub 2016 Nov 18.

Center for Cardiovascular Diagnostics & Prevention, Department of Cellular & Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH;

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http://dx.doi.org/10.1373/clinchem.2016.263640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659115PMC
January 2017

Trimethylamine N-Oxide and Mortality Risk in Patients With Peripheral Artery Disease.

J Am Heart Assoc 2016 10 19;5(10). Epub 2016 Oct 19.

Cleveland Clinic, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland, OH Cleveland Clinic, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, OH

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http://dx.doi.org/10.1161/JAHA.116.004237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121520PMC
October 2016

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.

Sci Rep 2016 10 12;6:35278. Epub 2016 Oct 12.

Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1038/srep35278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059659PMC
October 2016

Carbamylated Low-Density Lipoprotein and Thrombotic Risk in Chronic Kidney Disease.

J Am Coll Cardiol 2016 10;68(15):1677-1679

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jacc.2016.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659112PMC
October 2016

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma.

J Biol Chem 2016 Oct 1;291(42):22118-22135. Epub 2016 Sep 1.

From the Departments of Cellular and Molecular Medicine, Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195,

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http://dx.doi.org/10.1074/jbc.M116.750034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063994PMC
October 2016

PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly.

Circ Res 2016 Sep 11;119(7):827-38. Epub 2016 Aug 11.

From the Department of Cellular and Molecular Medicine (K.G., G.B., H.C., S.W., R.Z., S.L.H., J.D.S.) and Department of Cardiovascular Medicine (S.L.H., J.D.S.), Cleveland Clinic, OH.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026623PMC
September 2016

Microbiome, trimethylamine N-oxide, and cardiometabolic disease.

Transl Res 2017 01 18;179:108-115. Epub 2016 Jul 18.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.trsl.2016.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164964PMC
January 2017

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation.

J Am Heart Assoc 2016 07 28;5(8). Epub 2016 Jul 28.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA

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http://dx.doi.org/10.1161/JAHA.116.003947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015312PMC
July 2016

Intestinal Microbiota-Generated Metabolite Trimethylamine-N-Oxide and 5-Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE-Like Patient Cohort.

J Am Heart Assoc 2016 06 10;5(6). Epub 2016 Jun 10.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

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http://dx.doi.org/10.1161/JAHA.115.002816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937244PMC
June 2016

Plasma Trimethylamine N-Oxide, a Gut Microbe-Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden.

J Am Coll Cardiol 2016 06;67(22):2620-8

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.03.546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893167PMC
June 2016

Effect of Continuous Positive Airway Pressure on Cardiovascular Biomarkers: The Sleep Apnea Stress Randomized Controlled Trial.

Chest 2016 Jul 18;150(1):80-90. Epub 2016 Mar 18.

Sleep Disorders Center, Neurological Institute, Cleveland Clinic, Cleveland, OH; Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2016.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980547PMC
July 2016

Dietary metabolism, gut microbiota and acute heart failure.

Heart 2016 06 15;102(11):813-4. Epub 2016 Mar 15.

Department of Cardiovascular Disease, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1136/heartjnl-2016-309268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659351PMC
June 2016

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.

Cell 2016 Mar 10;165(1):111-124. Epub 2016 Mar 10.

Department of Cellular & Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862743PMC
March 2016

Usefulness of Relative Hypochromia in Risk Stratification for Nonanemic Patients With Chronic Heart Failure.

Am J Cardiol 2016 Apr 28;117(8):1299-304. Epub 2016 Jan 28.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2016.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811711PMC
April 2016

Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus.

J Acquir Immune Defic Syndr 2016 May;72(1):114-8

*Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Departments of †Epidemiology; ‡Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; §Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; ‖Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrence, CA; ¶Department of Medicine, Northwestern University, Chicago, IL; and #Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1097/QAI.0000000000000937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836953PMC
May 2016

Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.

Circ Heart Fail 2016 Jan 23;9(1):e002314. Epub 2015 Dec 23.

From the Department of Pharmacology, Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans (C.L.O., H.O., S.B., J.B., R.T., D.J.P., D.J.L.); Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, OH (Z.W., W.H.W.T., S.L.H.); and Department of Mathematics, Cleveland State University, OH (Y.W.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943035PMC
January 2016

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains.

PLoS Genet 2015 Dec 22;11(12):e1005711. Epub 2015 Dec 22.

Departments of Medicine, Human Genetics, and Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687930PMC
December 2015