Stanley B Prusiner

Stanley B Prusiner

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Stanley B Prusiner

Stanley B Prusiner

Publications by authors named "Stanley B Prusiner"

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Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.

PLoS Pathog 2020 Feb 4;16(2):e1008222. Epub 2020 Feb 4.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1008222DOI Listing
February 2020

Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.

Acta Neuropathol Commun 2019 05 20;7(1):81. Epub 2019 May 20.

Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, Sandler Neurosciences Center, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1186/s40478-019-0703-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526619PMC
May 2019

A long-lived Aβ oligomer resistant to fibrillization.

Biopolymers 2018 Aug 10;109(8):e23096. Epub 2018 Jan 10.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California.

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http://dx.doi.org/10.1002/bip.23096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039285PMC
August 2018

α-Synuclein: Multiple System Atrophy Prions.

Cold Spring Harb Perspect Med 2018 07 2;8(7). Epub 2018 Jul 2.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94158.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a024588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561534PMC
July 2018

β-Amyloid Prions and the Pathobiology of Alzheimer's Disease.

Cold Spring Harb Perspect Med 2018 05 1;8(5). Epub 2018 May 1.

Institute for Neurodegenerative Diseases, Departments of Neurology and of Biochemistry and Biophysics, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94143.

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http://dx.doi.org/10.1101/cshperspect.a023507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554751PMC
May 2018

MSA prions exhibit remarkable stability and resistance to inactivation.

Acta Neuropathol 2018 01 28;135(1):49-63. Epub 2017 Aug 28.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1007/s00401-017-1762-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756500PMC
January 2018

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.

Proc Natl Acad Sci U S A 2018 01 26;115(2):409-414. Epub 2017 Dec 26.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158;

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http://dx.doi.org/10.1073/pnas.1719369115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777081PMC
January 2018

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.

JAMA Neurol 2017 12;74(12):1464-1472

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco.

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http://dx.doi.org/10.1001/jamaneurol.2017.2822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822201PMC
December 2017

Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.

Proc Natl Acad Sci U S A 2017 12 4;114(51):E11029-E11036. Epub 2017 Dec 4.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158;

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http://dx.doi.org/10.1073/pnas.1717193114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754811PMC
December 2017

Experimental Models of Inherited PrP Prion Diseases.

Cold Spring Harb Perspect Med 2017 Nov 1;7(11). Epub 2017 Nov 1.

Institute for Neurodegenerative Diseases, Departments of Neurology and Biochemistry and Biophysics, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94143.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a027151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513788PMC
November 2017

A novel vector for transgenesis in the rat CNS.

Acta Neuropathol Commun 2017 Nov 21;5(1):84. Epub 2017 Nov 21.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, Sandler Neurosciences Center, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1186/s40478-017-0484-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697436PMC
November 2017

Bioassays and Inactivation of Prions.

Cold Spring Harb Perspect Biol 2017 Aug 1;9(8). Epub 2017 Aug 1.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94158.

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http://dx.doi.org/10.1101/cshperspect.a023499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538415PMC
August 2017

Developing Therapeutics for PrP Prion Diseases.

Cold Spring Harb Perspect Med 2017 Apr 3;7(4). Epub 2017 Apr 3.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94143.

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http://dx.doi.org/10.1101/cshperspect.a023747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378016PMC
April 2017

Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.

Proc Natl Acad Sci U S A 2016 12 28;113(50):E8187-E8196. Epub 2016 Nov 28.

Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1616344113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167200PMC
December 2016

Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.

J Virol 2016 11 14;90(21):9558-9569. Epub 2016 Oct 14.

Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA Department of Neurology, University of California, San Francisco, San Francisco, California, USA Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA

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http://dx.doi.org/10.1128/JVI.01106-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068510PMC
November 2016

Towards authentic transgenic mouse models of heritable PrP prion diseases.

Acta Neuropathol 2016 10 28;132(4):593-610. Epub 2016 Jun 28.

Institute for Neurodegenerative Diseases, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA, 94143-0518, USA.

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http://dx.doi.org/10.1007/s00401-016-1585-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152593PMC
October 2016

Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.

J Pharmacol Exp Ther 2016 09 17;358(3):537-47. Epub 2016 Jun 17.

Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., B.N.D., Z.L., A.O., S.B., M.E., S.G., B.M.S., S.H.O., S.B.P.) and Departments of Neurology (K.G., C.C., B.N.D., Z.L., B.M.S., S.H.O., S.B.P.), Pharmaceutical Chemistry (S.G.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco, California

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http://dx.doi.org/10.1124/jpet.116.235556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998675PMC
September 2016

Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study.

J Am Chem Soc 2016 08 28;138(31):9840-52. Epub 2016 Jul 28.

Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/jacs.6b03715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149419PMC
August 2016

FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice.

Proc Natl Acad Sci U S A 2016 07 11;113(30):8514-9. Epub 2016 Jul 11.

Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1607079113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968717PMC
July 2016

Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.

J Pharmacol Exp Ther 2015 Oct 29;355(1):2-12. Epub 2015 Jul 29.

Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco

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http://dx.doi.org/10.1124/jpet.115.224659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576665PMC
October 2015

Propagation of prions causing synucleinopathies in cultured cells.

Proc Natl Acad Sci U S A 2015 Sep 18;112(35):E4949-58. Epub 2015 Aug 18.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143; Department of Neurology, University of California, San Francisco, CA 94143; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143

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http://dx.doi.org/10.1073/pnas.1513426112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568231PMC
September 2015

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.

Proc Natl Acad Sci U S A 2015 Sep 31;112(38):E5308-17. Epub 2015 Aug 31.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143; Department of Neurology, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1514475112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586853PMC
September 2015

Prion Protein-Antibody Complexes Characterized by Chromatography-Coupled Small-Angle X-Ray Scattering.

Biophys J 2015 Aug;109(4):793-805

Department of Bioengineering and Therapeutic Sciences and Department of Pharmaceutical Chemistry and California Institute for Quantitative Biosciences (QB3), University of California San Francisco, San Francisco, California. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.06.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547163PMC
August 2015

Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice.

J Infect Dis 2015 Jul;212 Suppl 1:S17-25

Institute for Neurodegenerative Diseases Department of Neurology, University of California San Francisco.

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http://dx.doi.org/10.1093/infdis/jiu656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551108PMC
July 2015

Mechanism of scrapie prion precipitation with phosphotungstate anions.

ACS Chem Biol 2015 May 19;10(5):1269-77. Epub 2015 Feb 19.

†Department of Chemistry, University of California, Berkeley, 211 Lewis Hall, Berkeley, California 94720, United States.

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http://dx.doi.org/10.1021/cb5006239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437617PMC
May 2015

Structural studies of truncated forms of the prion protein PrP.

Biophys J 2015 Mar;108(6):1548-1554

Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375555PMC
March 2015

Mouse models for studying the formation and propagation of prions.

J Biol Chem 2014 Jul 23;289(29):19841-9. Epub 2014 May 23.

From the Institute for Neurodegenerative Diseases and the Department of Neurology, University of California, San Francisco, California 94143

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http://dx.doi.org/10.1074/jbc.R114.550707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106304PMC
July 2014

Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10329-34. Epub 2014 Jun 30.

Institute for Neurodegenerative Diseases,Departments of Neurology and

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http://dx.doi.org/10.1073/pnas.1408968111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104853PMC
July 2014

Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10323-8. Epub 2014 Jun 30.

Institute for Neurodegenerative Diseases andDepartments of Neurology and

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http://dx.doi.org/10.1073/pnas.1408900111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104857PMC
July 2014

Biology and genetics of prions causing neurodegeneration.

Annu Rev Genet 2013 ;47:601-23

Institute for Neurodegenerative Diseases and Department of Neurology, University of California, San Francisco, California 94143; email:

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http://www.annualreviews.org/doi/10.1146/annurev-genet-11071
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http://dx.doi.org/10.1146/annurev-genet-110711-155524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010318PMC
April 2014

Evidence that bank vole PrP is a universal acceptor for prions.

PLoS Pathog 2014 Apr 3;10(4):e1003990. Epub 2014 Apr 3.

Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, United States of America; Department of Neurology, University of California, San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974871PMC
April 2014

Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells.

Bioorg Med Chem 2014 Mar 9;22(6):1960-72. Epub 2014 Jan 9.

Institute for Neurodegenerative Diseases, University of California, San Francisco, United States; Department of Neurology, University of California, San Francisco, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984052PMC
March 2014

Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease.

Neurology 2013 Dec 11;81(23):2015-23. Epub 2013 Oct 11.

From the Departments of Neurology (M.D.G., A.L.K., K.S.W., A.H., G.D., B.J.R., D.Y.J., C.C.T.-C., R.F., P.G., J.N.T., H.Q.C., S.A.F., J.L.D., K.L.P., S.B.P., B.L.M.), Biostatistics (J.M.N.), Pathology (S.J.D.), and Clinical Pharmacy (R.F.), and Institute for Neurodegenerative Diseases (S.J.D., S.B.P.), University of California, San Francisco.

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http://www.neurology.org/cgi/doi/10.1212/WNL.0b013e3182a9f3b
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http://dx.doi.org/10.1212/WNL.0b013e3182a9f3b4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211922PMC
December 2013

Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.

Bioorg Med Chem 2013 Dec 18;21(24):7999-8012. Epub 2013 Sep 18.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, United States; Department of Neurology, University of California, San Francisco, CA 94143, United States; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896130080
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http://dx.doi.org/10.1016/j.bmc.2013.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984054PMC
December 2013

Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.

J Pharmacol Exp Ther 2013 Nov 21;347(2):325-38. Epub 2013 Aug 21.

Institute for Neurodegenerative Diseases (D.L., K.G., Z.L., S.R., J.R.G., M.G., M.L.E., S.J.D., B.M.S., S.B.P.), Department of Neurology (K.G., Z.L., S.R., J.R.G., B.M.S., S.B.P.), Department of Pathology (A.O., S.J.D.), Department of Pharmaceutical Chemistry (E.D., C.B., A.R.R., M.P.J.), Department of Bioengineering and Therapeutic Sciences (B.M.S.), and Small Molecule Discovery Center (C.B., A.R.R.), University of California, San Francisco, California.

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http://dx.doi.org/10.1124/jpet.113.205799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807058PMC
November 2013

Transmission of multiple system atrophy prions to transgenic mice.

Proc Natl Acad Sci U S A 2013 Nov 11;110(48):19555-60. Epub 2013 Nov 11.

Institute for Neurodegenerative Diseases, and Departments of Neurology and Pathology, University of California, San Francisco, CA 94143.

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http://dx.doi.org/10.1073/pnas.1318268110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845125PMC
November 2013

Drug resistance confounding prion therapeutics.

Proc Natl Acad Sci U S A 2013 Oct 15;110(44):E4160-9. Epub 2013 Oct 15.

Institute for Neurodegenerative Diseases, Departments of Neurology and Pathology, and Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143.

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http://dx.doi.org/10.1073/pnas.1317164110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816483PMC
October 2013

A high-throughput screening assay for determining cellular levels of total tau protein.

Curr Alzheimer Res 2013 Sep;10(7):679-87

National Center for Advancing Translational Sciences, NIH, 9800 Medical Center Drive, MSC: 3370, Bethesda, MD 20892-3370, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010324PMC
http://dx.doi.org/10.2174/15672050113109990143DOI Listing
September 2013

Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds.

ACS Med Chem Lett 2013 Jul;4(7):647-650

Institute for Neurodegenerative Diseases, University of California, San Francisco, California ; Department of Neurology, University of California, San Francisco, California ; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.

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http://dx.doi.org/10.1021/ml300454kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746989PMC
July 2013

Discovery and Preliminary SAR of Arylpiperazines as Novel, Brainpenetrant Antiprion Compounds.

ACS Med Chem Lett 2013 Apr;4(4):397-401

Institute for Neurodegenerative Diseases, University of California, San Francisco, California ; Department of Neurology, University of California, San Francisco, California.

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http://dx.doi.org/10.1021/ml300472nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704178PMC
April 2013

Convergent replication of mouse synthetic prion strains.

Am J Pathol 2013 Mar;182(3):866-74

Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, California 94143-0518, USA.

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http://dx.doi.org/10.1016/j.ajpath.2012.11.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586687PMC
March 2013

Chimeric elk/mouse prion proteins in transgenic mice.

J Gen Virol 2013 Feb 24;94(Pt 2):443-52. Epub 2012 Oct 24.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1099/vir.0.045989-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709613PMC
February 2013

Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter.

PLoS One 2012 2;7(7):e39112. Epub 2012 Jul 2.

Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039112PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388068PMC
November 2012

Salivary prions in sheep and deer.

Prion 2012 Jan-Mar;6(1):52-61

Institute for Neurodegenerative Diseases, Department of Neurology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.4161/pri.6.1.16984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338966PMC
August 2012

Purified and synthetic Alzheimer's amyloid beta (Aβ) prions.

Proc Natl Acad Sci U S A 2012 Jul 18;109(27):11025-30. Epub 2012 Jun 18.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.1206555109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390876PMC
July 2012

Identification of I137M and other mutations that modulate incubation periods for two human prion strains.

J Virol 2012 Jun 21;86(11):6033-41. Epub 2012 Mar 21.

Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, California, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.07027-11
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http://dx.doi.org/10.1128/JVI.07027-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372217PMC
June 2012

Cell biology. A unifying role for prions in neurodegenerative diseases.

Science 2012 Jun;336(6088):1511-3

Institute for Neurodegenerative Diseases and Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/science.1222951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942086PMC
June 2012

Compartment modeling for mammalian protein turnover studies by stable isotope metabolic labeling.

Anal Chem 2012 May 19;84(9):4014-21. Epub 2012 Apr 19.

Department of Pharmaceutical Chemistry and Mass Spectrometry Facility, University of California, San Francisco, California 94158-2517, USA.

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http://dx.doi.org/10.1021/ac203330zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923578PMC
May 2012

Degradation of fungal prion HET-s(218-289) induces formation of a generic amyloid fold.

Biophys J 2012 May 15;102(10):2339-44. Epub 2012 May 15.

Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1016/j.bpj.2012.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353098PMC
May 2012

Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein.

Proc Natl Acad Sci U S A 2012 Feb 13;109(9):3498-503. Epub 2012 Feb 13.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.1121556109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295307PMC
February 2012

A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling.

Mol Cell Proteomics 2011 Dec 21;10(12):M111.010728. Epub 2011 Sep 21.

Department of Pharmaceutical Chemistry and Mass Spectrometry Facility, University of California, San Francisco, CA 94158-2517, USA.

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http://dx.doi.org/10.1074/mcp.M111.010728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237081PMC
December 2011

Spontaneous generation of anchorless prions in transgenic mice.

Proc Natl Acad Sci U S A 2011 Dec 12;108(52):21223-8. Epub 2011 Dec 12.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.1117827108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248514PMC
December 2011

Prion uptake in the gut: identification of the first uptake and replication sites.

PLoS Pathog 2011 Dec 22;7(12):e1002449. Epub 2011 Dec 22.

Section of Cell Biology II, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1002449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245311PMC
December 2011

Protease-resistant prions selectively decrease Shadoo protein.

PLoS Pathog 2011 Nov 17;7(11):e1002382. Epub 2011 Nov 17.

Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219722PMC
November 2011

Conformational transformation and selection of synthetic prion strains.

J Mol Biol 2011 Oct 4;413(3):527-42. Epub 2011 Aug 4.

Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA 94143, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00222836110077
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http://dx.doi.org/10.1016/j.jmb.2011.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195964PMC
October 2011

Conserved properties of human and bovine prion strains on transmission to guinea pigs.

Lab Invest 2011 Sep 4;91(9):1326-36. Epub 2011 Jul 4.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143-0518, USA.

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http://dx.doi.org/10.1038/labinvest.2011.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164925PMC
September 2011

De novo generation of prion strains.

Nat Rev Microbiol 2011 Sep 26;9(11):771-7. Epub 2011 Sep 26.

Department of Chemical Engineering, University of Delaware, Newark, Delaware 19716, USA.

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http://dx.doi.org/10.1038/nrmicro2650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924856PMC
September 2011

A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.

J Biol Chem 2011 Aug 24;286(31):27718-28. Epub 2011 May 24.

Department of Neurology, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1074/jbc.M111.234393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149362PMC
August 2011

2-Aminothiazoles as therapeutic leads for prion diseases.

J Med Chem 2011 Feb 19;54(4):1010-21. Epub 2011 Jan 19.

The Small Molecule Discovery Center, San Francisco, California 94158, United States.

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http://pubs.acs.org/doi/abs/10.1021/jm101250y
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041857PMC
February 2011

Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease.

Proc Natl Acad Sci U S A 2011 Feb 24;108(6):2528-33. Epub 2011 Jan 24.

Department of Neurology and Pathology, Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.1019034108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038719PMC
February 2011

Prions.

Cold Spring Harb Perspect Biol 2011 Jan 1;3(1):a006833. Epub 2011 Jan 1.

Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California 94143, USA.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003464PMC
January 2011

Generation of antisera to purified prions in lipid rafts.

Prion 2010 Apr-Jun;4(2):94-104. Epub 2010 Apr 9.

USDA Agricultural Research Service, Foodborne Contaminants Research Unit, Albany, CA, USA.

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http://dx.doi.org/10.4161/pri.4.2.12622DOI Listing
December 2010

Human prion strain selection in transgenic mice.

Ann Neurol 2010 Aug;68(2):151-61

Institute for Neurodegenerative Diseases, University of California at San Francisco, 94143-0518, USA.

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http://dx.doi.org/10.1002/ana.22104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935907PMC
August 2010

Analysis of proteome dynamics in the mouse brain.

Proc Natl Acad Sci U S A 2010 Aug;107(32):14508-13

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.1006551107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922600PMC
August 2010

Conformation-dependent high-affinity monoclonal antibodies to prion proteins.

J Immunol 2010 Jul 7;185(1):729-37. Epub 2010 Jun 7.

Foodborne Contaminants Research Unit, U.S. Department of Agriculture Agricultural Research Service, Albany, CA 94710, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0902930
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957185PMC
July 2010

Colloid formation by drugs in simulated intestinal fluid.

J Med Chem 2010 May;53(10):4259-65

Department of Pharmaceutical Chemistry, University of California-San Francisco, San Francisco, California 94158-2550, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm100254w
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874266PMC
May 2010

Chemical induction of misfolded prion protein conformers in cell culture.

J Biol Chem 2010 Apr 2;285(14):10415-23. Epub 2009 Dec 2.

Institute for Neurodegenerative Diseases, University of California, San Francisco, California 94143, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.045112
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856248PMC
April 2010

Discovery of 2-aminothiazoles as potent antiprion compounds.

J Virol 2010 Apr 23;84(7):3408-12. Epub 2009 Dec 23.

Institute for Neurodegenerative Diseases, San Francisco, CA 94143-0518, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02145-09
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838138PMC
April 2010

Protease-sensitive synthetic prions.

PLoS Pathog 2010 Jan 22;6(1):e1000736. Epub 2010 Jan 22.

Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1000736
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809756PMC
January 2010

Design and construction of diverse mammalian prion strains.

Proc Natl Acad Sci U S A 2009 Dec 13;106(48):20417-22. Epub 2009 Nov 13.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0910350106
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787151PMC
December 2009

Continuous quinacrine treatment results in the formation of drug-resistant prions.

PLoS Pathog 2009 Nov 26;5(11):e1000673. Epub 2009 Nov 26.

Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1000673
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777304PMC
November 2009

Natural and synthetic prion structure from X-ray fiber diffraction.

Proc Natl Acad Sci U S A 2009 Oct 28;106(40):16990-5. Epub 2009 Sep 28.

Institute for Neurodegenerative Diseases, Departments of Neurology and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.0909006106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761340PMC
October 2009

Prion proteins with pathogenic and protective mutations show similar structure and dynamics.

Biochemistry 2009 Sep;48(34):8120-8

Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 90237, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi900923b
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762478PMC
September 2009

Measuring prions by bioluminescence imaging.

Proc Natl Acad Sci U S A 2009 Sep 17;106(35):15002-6. Epub 2009 Aug 17.

Institute for Neurodegenerative Diseases and Department of Neurology, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.0907339106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736416PMC
September 2009

Asymptomatic deer excrete infectious prions in faeces.

Nature 2009 Sep 9;461(7263):529-32. Epub 2009 Sep 9.

Institute for Neurodegenerative Diseases, University of California, San Francisco, California 94143 USA.

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http://www.nature.com/articles/nature08289
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186440PMC
September 2009

Is Parkinson's disease a prion disorder?

Proc Natl Acad Sci U S A 2009 Aug 28;106(31):12571-2. Epub 2009 Jul 28.

Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.0906759106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722298PMC
August 2009

Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein.

J Gen Virol 2009 Apr 4;90(Pt 4):1035-47. Epub 2009 Mar 4.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143-0518, USA.

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http://dx.doi.org/10.1099/vir.0.007500-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804060PMC
April 2009

Development of antibody fragments for immunotherapy of prion diseases.

Biochem J 2009 Mar;418(3):507-15

Unité de Trafic Membranaire et Pathogénèse, Institut Pasteur, 25 Rue du Docteur Roux, Paris Cedex 15, France.

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http://biochemj.org/lookup/doi/10.1042/BJ20081541
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March 2009

Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein.

Proc Natl Acad Sci U S A 2009 Mar 17;106(10):3740-5. Epub 2009 Feb 17.

Institute for Neurodegenerative Diseases and Department of Neurology, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.0812770106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656150PMC
March 2009

Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation.

PLoS Pathog 2008 Nov 14;4(11):e1000206. Epub 2008 Nov 14.

Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576443PMC
November 2008

Transmission and detection of prions in feces.

J Infect Dis 2008 Jul;198(1):81-9

Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, USA.

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http://dx.doi.org/10.1086/588193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803675PMC
July 2008

A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.

Proc Natl Acad Sci U S A 2008 Jul 22;105(30):10595-600. Epub 2008 Jul 22.

Departments of Pathology and Neurology and Institute for Neurodegenerative Disease, University of California, San Francisco, CA 94143, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0803671105
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http://dx.doi.org/10.1073/pnas.0803671105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492499PMC
July 2008

Small-molecule aggregates inhibit amyloid polymerization.

Nat Chem Biol 2008 Mar 27;4(3):197-9. Epub 2008 Jan 27.

Department of Pharmaceutical Chemistry and Graduate Group in Chemistry and Chemical Biology, University of California San Francisco, 1700 4th Street, San Francisco, California 94158-2330, USA.

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http://dx.doi.org/10.1038/nchembio.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730835PMC
March 2008

Mechanisms of prion protein assembly into amyloid.

Proc Natl Acad Sci U S A 2008 Feb 11;105(7):2409-14. Epub 2008 Feb 11.

Institut fuer Physikalische Biologie and Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universitaet Duesseldorf, 40225 Duesseldorf, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0712036105
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http://dx.doi.org/10.1073/pnas.0712036105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268150PMC
February 2008

Prion detection by an amyloid seeding assay.

Proc Natl Acad Sci U S A 2007 Dec 20;104(52):20914-9. Epub 2007 Dec 20.

Institute for Neurodegenerative Diseases [corrected], University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.0710152105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409241PMC
December 2007

Electron crystallography of the scrapie prion protein complexed with heavy metals.

Arch Biochem Biophys 2007 Nov 23;467(2):239-48. Epub 2007 Aug 23.

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.abb.2007.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557509PMC
November 2007

Cell division modulates prion accumulation in cultured cells.

Proc Natl Acad Sci U S A 2007 Nov 7;104(46):17971-6. Epub 2007 Nov 7.

Institute for Neurodegenerative Diseases and Department of Neurology, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.0708372104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2084281PMC
November 2007