Stafford Lightman

Stafford Lightman

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Improving glucocorticoid replacement profiles in adrenal insufficiency.

Clin Endocrinol (Oxf) 2019 Sep 6;91(3):367-371. Epub 2019 May 6.

Department of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/cen.13999DOI Listing
September 2019

The human stress response.

Nat Rev Endocrinol 2019 Sep 27;15(9):525-534. Epub 2019 Jun 27.

Translational Health Sciences, Dorothy Hodgkin Building, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/s41574-019-0228-0DOI Listing
September 2019

Seasonal variation in antidepressant prescriptions, environmental light and web queries for seasonal affective disorder.

Br J Psychiatry 2019 Aug 29;215(2):481-484. Epub 2019 Mar 29.

Professor of Artificial Intelligence,Intelligent Systems Laboratory,University of Bristol,UK.

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http://dx.doi.org/10.1192/bjp.2019.40DOI Listing
August 2019

Utilization of the allen gene expression atlas to gain further insight into glucocorticoid physiology in the adult mouse brain.

Neurosci Lett 2019 07 14;706:194-200. Epub 2019 May 14.

Department of Informatics & Telecommunications, School of Informatics & Telecommunications, University of Ioannina, Arta, Greece.

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http://dx.doi.org/10.1016/j.neulet.2019.05.020DOI Listing
July 2019

Growth hormone secretion, fatigue and quality of life after childhood traumatic brain injury.

Eur J Endocrinol 2019 Jul 1. Epub 2019 Jul 1.

E Crowne, Paediatric Endocrinology, Bristol Royal Hosp Children, Bristol, United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1530/EJE-19-0166DOI Listing
July 2019

Role of the posterodorsal medial amygdala in predator odour stress-induced puberty delay in female rats.

J Neuroendocrinol 2019 Jun 29;31(6):e12719. Epub 2019 Apr 29.

Department of Women and Children's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jne.12719
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http://dx.doi.org/10.1111/jne.12719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563483PMC
June 2019

Mathematical Modelling of Endocrine Systems.

Trends Endocrinol Metab 2019 Apr 21;30(4):244-257. Epub 2019 Feb 21.

Living Systems Institute, University of Exeter, Exeter EX4 4QD, UK; EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter EX4 4QD, UK; Centre for Biomedical Modelling and Analysis, University of Exeter, Exeter EX4 4QD, UK; College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QF, UK.

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http://dx.doi.org/10.1016/j.tem.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425086PMC
April 2019

Thirty years of neuroendocrinology: Technological advances pave the way for molecular discovery.

J Neuroendocrinol 2019 Mar 29;31(3):e12653. Epub 2018 Nov 29.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/jne.12653DOI Listing
March 2019

Dynamics of ACTH-Mediated Regulation of Gene Transcription in ATC1 and ATC7 Adrenal Zona Fasciculata Cell Lines.

Endocrinology 2019 Mar;160(3):587-604

Bristol Medical School: Translational Health Sciences, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1210/en.2018-00840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380881PMC
March 2019

Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity.

Neuropharmacology 2018 11 6;142:30-40. Epub 2018 Jun 6.

Centre for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK; School of Clinical Sciences, University of Bristol, Bristol, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.06.008DOI Listing
November 2018

Diurnal variations of psychometric indicators in Twitter content.

PLoS One 2018 20;13(6):e0197002. Epub 2018 Jun 20.

Intelligent Systems Laboratory, University of Bristol, Bristol, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197002PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010242PMC
November 2018

Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility.

Stress 2018 09 15;21(5):403-416. Epub 2018 May 15.

a Translational Health Sciences, Bristol Medical School , University of Bristol , Bristol , UK.

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http://dx.doi.org/10.1080/10253890.2018.1470238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220752PMC
September 2018

The emerging importance of ultradian glucocorticoid rhythms within metabolic pathology.

Ann Endocrinol (Paris) 2018 Jun 5;79(3):112-114. Epub 2018 Apr 5.

Henry Wellcome Laboratories for Integrated Neuroscience and Endocrinology (HW LINE), University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ando.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984398PMC
June 2018

Corticosteroids and Other Anti-Inflammatory Strategies in Pediatric Heart Surgery: A National Survey of Practice.

World J Pediatr Congenit Heart Surg 2018 05;9(3):289-293

5 Department of Congenital Cardiac Surgery, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1177/2150135118762392DOI Listing
May 2018

Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity.

Clin Endocrinol (Oxf) 2018 04 29;88(4):592-600. Epub 2018 Jan 29.

Tommy's Centre for Maternal and Fetal Health, Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1111/cen.13548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887976PMC
April 2018

Corticosteroids in Pediatric Heart Surgery: Myth or Reality.

Front Pediatr 2018 20;6:112. Epub 2018 Apr 20.

Department of Cardiac Surgery, Bristol Heart Institute, Bristol, United Kingdom.

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http://dx.doi.org/10.3389/fped.2018.00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920028PMC
April 2018

Role of amygdala kisspeptin in pubertal timing in female rats.

PLoS One 2017 28;12(8):e0183596. Epub 2017 Aug 28.

Division of Women's Health, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183596PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573137PMC
October 2017

Optimal Sampling Frequency of Serum Cortisol Concentrations After Cardiac Surgery.

Crit Care Med 2017 10;45(10):e1103-e1104

Department of Mathematics, University of Bristol, Bristol, United Kingdom; Department of Cardiac Surgery, Bristol Heart Institute, Bristol, United Kingdom; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom, Department of Cardiac Anesthesia, Bristol Heart Institute, Bristol, United Kingdom.

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http://dx.doi.org/10.1097/CCM.0000000000002534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624499PMC
October 2017

Dysfunctional Skin-Derived Glucocorticoid Synthesis Is a Pathogenic Mechanism of Psoriasis.

J Invest Dermatol 2017 08 28;137(8):1630-1637. Epub 2017 Mar 28.

Centre for Cell Biology and Cutaneous Research, Institute of Cell and Molecular Science, Bart's and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1016/j.jid.2017.02.984DOI Listing
August 2017

Dynamic responses of the adrenal steroidogenic regulatory network.

Proc Natl Acad Sci U S A 2017 08 17;114(31):E6466-E6474. Epub 2017 Jul 17.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1703779114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547620PMC
August 2017

Corticosteroids in septic shock: a systematic review and network meta-analysis.

Crit Care 2017 03 28;21(1):78. Epub 2017 Mar 28.

Medicine: Critical Care Medicine, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris (APHP), Garches, France.

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http://dx.doi.org/10.1186/s13054-017-1659-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371269PMC
March 2017

The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids.

Endocr Rev 2017 02;38(1):3-45

Medical Department I (H.O., V.O.), University of Lübeck, 23562 Lübeck, Germany; Institute for Cellular and Integrative Neuroscience (E.C.), Centre National de la Recherche Scientifique (CNRS) UPR 3212, University of Strasbourg, 67084 Strasbourg, France; Division of Endocrinology, Diabetology and Metabolism (E.A.), Department of Internal Medicine, University of Turin, 10043 Turin, Italy; Department of Endocrinology and Metabolic Disease (E.R.d.K.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Surrey Sleep Research Center (D.-J.D.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XP, United Kingdom; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (S.L.), University of Bristol, Bristol BS8 1TH, United Kingdom; Sleep Research and Treatment Center (A.V.), Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033; and Sleep, Metabolism, and Health Center (E.V.C.), Department of Medicine, University of Chicago, Chicago, Illinois 60637.

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http://dx.doi.org/10.1210/er.2015-1080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563520PMC
February 2017

Ultradian glucocorticoid exposure directs gene-dependent and tissue-specific mRNA expression patterns in vivo.

Mol Cell Endocrinol 2017 01 18;439:46-53. Epub 2016 Oct 18.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131830PMC
January 2017

Circadian mood variations in Twitter content.

Brain Neurosci Adv 2017 Jan 1;1:2398212817744501. Epub 2017 Dec 1.

Intelligent Systems Laboratory, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1177/2398212817744501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736128PMC
January 2017

Cortisol and CBG - Getting cortisol to the right place at the right time.

Pharmacol Ther 2016 10 10;166:128-35. Epub 2016 Jul 10.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.06.020DOI Listing
October 2016

Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light.

PLoS Biol 2016 06 8;14(6):e1002482. Epub 2016 Jun 8.

Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, Oxford Molecular Pathology Institute, Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1002482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898879PMC
June 2016

Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis.

Front Neuroendocrinol 2016 04 24;41:44-58. Epub 2016 May 24.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, United Kingdom.

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http://dx.doi.org/10.1016/j.yfrne.2016.05.001DOI Listing
April 2016

Temporal control of glucocorticoid neurodynamics and its relevance for brain homeostasis, neuropathology and glucocorticoid-based therapeutics.

Neurosci Biobehav Rev 2016 Feb 3;61:12-25. Epub 2015 Dec 3.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol BS1 3NY, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2015.11.009DOI Listing
February 2016

Effects of the pattern of glucocorticoid replacement on neural processing, emotional reactivity and well-being in healthy male individuals: study protocol for a randomised controlled trial.

Trials 2016 Jan 22;17:44. Epub 2016 Jan 22.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK.

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http://dx.doi.org/10.1186/s13063-016-1159-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724084PMC
January 2016

Control of Body Weight by Eating Behavior in Children.

Front Pediatr 2015 19;3:89. Epub 2015 Oct 19.

Section of Applied Neuroendocrinology, Karolinska Institutet, Mandometer Clinic Novum , Huddinge , Sweden.

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http://dx.doi.org/10.3389/fped.2015.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609845PMC
November 2015

60 YEARS OF NEUROENDOCRINOLOGY: Glucocorticoid dynamics: insights from mathematical, experimental and clinical studies.

J Endocrinol 2015 Aug 6;226(2):T55-66. Epub 2015 Jul 6.

Henry Wellcome Laboratories for Integrative Neuroscience and EndocrinologyUniversity of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UKCollege of EngineeringMathematics and Physical Sciences, University of Exeter, Harrison Building, Streatham Campus, North Park Road, Exeter EX4 4QF, UKWellcome Trust Centre for Biomedical Modelling and AnalysisRILD Building, University of Exeter, Exeter, UK

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http://dx.doi.org/10.1530/JOE-15-0132DOI Listing
August 2015

Dynamics of adrenal glucocorticoid steroidogenesis in health and disease.

Mol Cell Endocrinol 2015 Jun 7;408:227-34. Epub 2015 Feb 7.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1016/j.mce.2015.02.005DOI Listing
June 2015

Reversible biological adaptations in obesity.

Lancet Diabetes Endocrinol 2015 May;3(5):314

Departments of Paediatric Endocrinology, Diabetes and Metabolic Endocrinology, School of Clinical Sciences, Department of Medicine, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1016/S2213-8587(15)00090-XDOI Listing
May 2015

Dynamic pituitary-adrenal interactions in response to cardiac surgery.

Crit Care Med 2015 Apr;43(4):791-800

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1097/CCM.0000000000000773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359905PMC
April 2015

Inactivation of corticotropin-releasing hormone-induced insulinotropic role by high-altitude hypoxia.

Diabetes 2015 Mar 2;64(3):785-95. Epub 2014 Oct 2.

Division of Neurobiology and Physiology, Department of Basic Medical Sciences, School of Medicine, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, China

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http://dx.doi.org/10.2337/db14-0500DOI Listing
March 2015

Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort.

J Clin Endocrinol Metab 2015 Mar 12;100(3):E531-41. Epub 2014 Dec 12.

Department of Endocrinology (J.D., U.S., M.D., P.G., W.M.D., M.K.), Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom; Semmelweis University, School of PhD studies, Doctoral School of Clinical Medicine, Budapest, Hungary (J.D.), Endocrinology Directorate (F.S.), Norfolk and Norwich University Hospital, Norwich NR4 7UZ, United Kingdom; Department of Medical and Molecular Genetics (E.R., E.R.M.), University of Birmingham, Birmingham B15 2TT, United Kingdom; Department of Molecular Genetics (K.S., M.O., S.E.), Royal Devon and Exeter National Health Service Foundation Trust, Exeter EX2 5DW, United Kingdom; University of Exeter Medical School (S.E.), Exeter EX4 4PY, United Kingdom; Oxford Medical Genetics Laboratories (T.C.), Oxford University Hospitals National Health Service Trust, The Churchill Hospital, Oxford OX3 7LJ, United Kingdom; Section on Endocrinology and Genetics (P.X., C.A.S.) and Section on Molecular Dysmorphology (C.W.), Eunice Kennedy Shriver Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; Electron Microscopy Unit (L.M.), Department Histopathology, Charing Cross Hospital, Imperial College Healthcare National Health Service Trust, London W6 8RF, United Kingdom; Department of Clinical Genetics (A.K.), Great Ormond Street Hospital, London WC1N 1LE, United Kingdom; Departments of Oncology (N.F.) and Endocrinology (S.E.B.), University College London Hospitals, London WC1E 6BT, United Kingdom; Department of Diabetes and Endocrinology (D.M.), The Ipswich Hospital National Health Service Trust, Ipswich IP4 5PD, United Kingdom; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (S.L.), University of Bristol, Bristol BS1 3NY, United Kingdom; Department of Endocrinology (A.Ag., C.J.T.), Beaumont Hospital, Dublin 9, Ireland; Institute of Molecular and Experimental Medicine (A.R.), Cardiff University, Cardiff CF10 3US, United Kingd

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http://dx.doi.org/10.1210/jc.2014-3399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333031PMC
March 2015

Can side effects of steroid treatments be minimized by the temporal aspects of delivery method?

Expert Opin Drug Saf 2014 Nov 26;13(11):1501-13. Epub 2014 Sep 26.

University of Bristol, Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology , Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY , UK +44 0117 331 3123 ; +44 0117 331 3169 ;

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http://dx.doi.org/10.1517/14740338.2014.965141DOI Listing
November 2014

A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients.

Hum Reprod Update 2014 Jul-Aug;20(4):594-613. Epub 2014 Mar 27.

School of Community Health Sciences, University of Nottingham, Nottingham NG7 2RD, UK.

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http://dx.doi.org/10.1093/humupd/dmu010DOI Listing
September 2014

Subcutaneous pulsatile glucocorticoid replacement therapy.

Clin Endocrinol (Oxf) 2014 Aug 19;81(2):289-93. Epub 2014 May 19.

Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/cen.12470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231230PMC
August 2014

Effects of 7.5% carbon dioxide inhalation on anxiety and mood in cigarette smokers.

J Psychopharmacol 2014 Aug 24;28(8):763-72. Epub 2014 Apr 24.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK UK Centre for Tobacco and Alcohol Studies, Nottingham, UK School of Experimental Psychology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1177/0269881114529378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986884PMC
August 2014

The importance of dynamic signalling for endocrine regulation and drug development: relevance for glucocorticoid hormones.

Lancet Diabetes Endocrinol 2014 Jul 18;2(7):593-9. Epub 2014 Feb 18.

College of Engineering, Mathematics, and Physical Sciences, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1016/S2213-8587(13)70182-7DOI Listing
July 2014

HPA axis-rhythms.

Compr Physiol 2014 Jul;4(3):1273-98

University of Bristol, Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology, Bristol, United Kingdom.

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http://dx.doi.org/10.1002/cphy.c140003DOI Listing
July 2014

Cardio-metabolic consequences of glucocorticoid replacement: relevance of ultradian signalling.

Clin Endocrinol (Oxf) 2014 May 25;80(5):621-8. Epub 2014 Feb 25.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia; Faculty of Medicine, Dentistry and Health Sciences, School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia.

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http://dx.doi.org/10.1111/cen.12422DOI Listing
May 2014

Steroid hormones in 2013: Glucocorticoids: timing, binding and environment.

Nat Rev Endocrinol 2014 Feb 24;10(2):71-2. Epub 2013 Dec 24.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK.

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http://dx.doi.org/10.1038/nrendo.2013.257DOI Listing
February 2014

The Interface of Stress and the HPA Axis in Behavioural Phenotypes of Mental Illness.

Curr Top Behav Neurosci 2014;18:13-24

Department of Psychological Medicine, Institute of Psychiatry, Kings College London, Room 2-055, The James Black Centre 125 Coldharbour Lane, London, SE5 9NU, UK.

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http://dx.doi.org/10.1007/7854_2014_304DOI Listing
January 2014

The role of mineralocorticoid receptor function in treatment-resistant depression.

J Psychopharmacol 2013 Dec 31;27(12):1169-79. Epub 2013 Jul 31.

1King's College London, Institute of Psychiatry, Section of Neurobiology of Mood Disorders, London, UK.

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http://jop.sagepub.com/content/early/2013/07/29/026988111349
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http://jop.sagepub.com/cgi/doi/10.1177/0269881113499205
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http://dx.doi.org/10.1177/0269881113499205DOI Listing
December 2013

Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.

Brain 2013 Dec 23;136(Pt 12):3753-65. Epub 2013 Nov 23.

1 Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK.

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http://dx.doi.org/10.1093/brain/awt293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859225PMC
December 2013

Psychophysiological responses to pain identify reproducible human clusters.

Pain 2013 Nov 25;154(11):2266-76. Epub 2013 May 25.

Centre for Digestive Diseases, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2013.05.016DOI Listing
November 2013

GHRH receptor-targeted botulinum neurotoxin selectively inhibits pulsatile GH secretion in male rats.

Endocrinology 2013 Sep 3;154(9):3305-18. Epub 2013 Jul 3.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom.

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http://dx.doi.org/10.1210/en.2012-2175DOI Listing
September 2013

Longitudinal measurement of cortisol in association with mental health and experience of domestic violence and abuse: study protocol.

BMC Psychiatry 2013 Jul 13;13:188. Epub 2013 Jul 13.

School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, UK.

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http://dx.doi.org/10.1186/1471-244X-13-188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716999PMC
July 2013

Transcriptional regulation of episodic glucocorticoid secretion.

Mol Cell Endocrinol 2013 May 5;371(1-2):62-70. Epub 2012 Nov 5.

Section on Endocrine Physiology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.mce.2012.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582781PMC
May 2013

Constant light disrupts the circadian rhythm of steroidogenic proteins in the rat adrenal gland.

Mol Cell Endocrinol 2013 May 21;371(1-2):114-23. Epub 2012 Nov 21.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK.

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http://dx.doi.org/10.1016/j.mce.2012.11.010DOI Listing
May 2013

Adaptive changes in basal and stress-induced HPA activity in lactating and post-lactating female rats.

Endocrinology 2013 Feb 7;154(2):749-61. Epub 2013 Jan 7.

University of Nottingham, School of Nursing, Midwifery, and Physiotherapy, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1210/en.2012-1779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724961PMC
February 2013

The origin of glucocorticoid hormone oscillations.

PLoS Biol 2012 5;10(6):e1001341. Epub 2012 Jun 5.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom.

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October 2012

Ultradian corticosterone secretion is maintained in the absence of circadian cues.

Eur J Neurosci 2012 Oct 23;36(8):3142-50. Epub 2012 Jul 23.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK.

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October 2012

Circadian and ultradian rhythms of free glucocorticoid hormone are highly synchronized between the blood, the subcutaneous tissue, and the brain.

Endocrinology 2012 Sep 20;153(9):4346-53. Epub 2012 Jul 20.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom.

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http://dx.doi.org/10.1210/en.2012-1484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480985PMC
September 2012

Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia.

Neuropsychopharmacology 2012 Jul 28;37(8):1911-22. Epub 2012 Mar 28.

Institute of Psychiatric Research in the Department of Psychiatry, Indianapolis, IN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376323PMC
July 2012

Dynamic regulation of glucocorticoid signalling in health and disease.

Rheumatology (Oxford) 2012 Mar 3;51(3):403-12. Epub 2011 Sep 3.

University of Bristol, Bristol BS1 3NY, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281495PMC
March 2012

NFκB and glucocorticoid receptor activity in steroid resistance.

J Recept Signal Transduct Res 2012 Feb 20;32(1):29-35. Epub 2011 Dec 20.

Department of Clinical Biochemistry, Bristol Royal Infirmary, Bristol, UK.

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February 2012

G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis.

Front Neuroendocrinol 2012 Jan 23;33(1):45-66. Epub 2011 Jul 23.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, School of Clinical Sciences, University of Bristol, Whitson Street, Bristol BS1 3NY, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336209PMC
January 2012

Molecular dynamics of ultradian glucocorticoid receptor action.

Mol Cell Endocrinol 2012 Jan 22;348(2):383-93. Epub 2011 Aug 22.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, UK.

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January 2012

Acute glucocorticoid administration rapidly suppresses basal and stress-induced hypothalamo-pituitary-adrenal axis activity.

Endocrinology 2012 Jan 15;153(1):200-11. Epub 2011 Nov 15.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, United Kingdom.

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http://dx.doi.org/10.1210/en.2011-1434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279736PMC
January 2012

The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat.

Endocrinology 2012 Jan 22;153(1):307-15. Epub 2011 Nov 22.

Division of Women's Health, School of Medicine, King's College London, Guy's Campus, London SE1 1UL, United Kingdom.

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January 2012

Desipramine treatment has minimal effects on the brain accumulation of glucocorticoids in P-gp-deficient and wild-type mice.

Psychoneuroendocrinology 2011 Oct 11;36(9):1351-60. Epub 2011 Apr 11.

Institute of Pharmaceutical Science, King's College London, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179986PMC
October 2011

Transcription factor interactions in genomic nuclear receptor function.

Epigenomics 2011 Aug;3(4):471-85

Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology, Faculty of Medicine & Dentistry, University of Bristol, Bristol, BS1 3NY, UK.

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August 2011

Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding.

Mol Cell 2011 Jul;43(1):145-55

Laboratory of Receptor Biology and Gene Expression, B602, Building 41, 41 Library Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138120PMC
July 2011

The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its coregulatory molecules CBP/p300 during ultradian ligand treatment.

Mol Endocrinol 2011 Jun 21;25(6):944-54. Epub 2011 Apr 21.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom.

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http://dx.doi.org/10.1210/me.2010-0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163797PMC
June 2011

ACTH-dependent ultradian rhythm of corticosterone secretion.

Endocrinology 2011 Apr 8;152(4):1448-57. Epub 2011 Feb 8.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060625PMC
April 2011

Attentional processing of infant emotion during late pregnancy and mother-infant relations after birth.

Arch Womens Ment Health 2011 Feb 22;14(1):23-31. Epub 2010 Sep 22.

Academic Unit of Psychiatry, Cotham House, Cotham Hill, Bristol, UK.

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February 2011

Epigenetics: a lasting impression?

J Neuroendocrinol 2011 Feb;23(2):194-5

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1111/j.1365-2826.2010.02082.xDOI Listing
February 2011

Neonatal programming by immunological challenge: effects on ovarian function in the adult rat.

Reproduction 2011 Feb 17;141(2):241-8. Epub 2010 Nov 17.

Division of Women's Health, School of Medicine, King's College London, Guy's Campus, 2.95W, Hodgkin Building, London SE1 1UL, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021912PMC
February 2011

Induction of c-Fos in 'panic/defence'-related brain circuits following brief hypercarbic gas exposure.

J Psychopharmacol 2011 Jan 15;25(1):26-36. Epub 2010 Jan 15.

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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January 2011

The prednisolone suppression test in depression: dose-response and changes with antidepressant treatment.

Psychoneuroendocrinology 2010 Nov 16;35(10):1486-91. Epub 2010 Jun 16.

Section of Perinatal Psychiatry & Stress, Psychiatry and Immunology, Institute of Psychiatry, King's College London, Department of Psychological Medicine, London, UK.

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http://dx.doi.org/10.1016/j.psyneuen.2010.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513406PMC
November 2010

Stress responsiveness varies over the ultradian glucocorticoid cycle in a brain-region-specific manner.

Endocrinology 2010 Nov 22;151(11):5369-79. Epub 2010 Sep 22.

Division of Medical Pharmacology, Leiden/Amsterdam Centre for Drug Research/Leiden University Medical Centre, University of Leiden, Einsteinweg 55, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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November 2010

Temperature-responsive release of cortisol from its binding globulin: a protein thermocouple.

J Clin Endocrinol Metab 2010 Oct 14;95(10):4689-95. Epub 2010 Jul 14.

Department of Biochemistry, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1210/jc.2010-0942DOI Listing
October 2010

Reduced stress responsiveness in pregnancy: relationship with pattern of forebrain c-fos mRNA expression.

Brain Res 2010 Oct 21;1358:102-9. Epub 2010 Aug 21.

University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK.

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http://dx.doi.org/10.1016/j.brainres.2010.08.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994639PMC
October 2010

The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration.

Nat Rev Neurosci 2010 10 15;11(10):710-8. Epub 2010 Sep 15.

University of Bristol, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK.

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http://dx.doi.org/10.1038/nrn2914DOI Listing
October 2010

Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic.

Endocrinology 2010 Aug 9;151(8):3720-7. Epub 2010 Jun 9.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1210/en.2010-0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964781PMC
August 2010

Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis.

Proc Biol Sci 2010 Jun 3;277(1688):1627-33. Epub 2010 Feb 3.

Department of Engineering Mathematics, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1098/rspb.2009.2148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871854PMC
June 2010

Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression.

Brain Res 2009 Dec 23;1305:47-63. Epub 2009 Sep 23.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1016/j.brainres.2009.09.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788613PMC
December 2009

Characterization of conserved tandem donor sites and intronic motifs required for alternative splicing in corticosteroid receptor genes.

Endocrinology 2009 Nov 9;150(11):4958-4967. Epub 2009 Oct 9.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (C.R., A.F., X.Q., S.L., M.N.), University of Bristol, Bristol BS1 3NY, United Kingdom; and Endocrine Sciences Research Group (L.M., D.R.), University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 PT, United Kingdom.

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http://dx.doi.org/10.1210/en.2009-0346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455001PMC
November 2009

Hypothalamic-pituitary-adrenal axis activation in obstructive sleep apnea: the effect of continuous positive airway pressure therapy.

J Clin Endocrinol Metab 2009 Nov 9;94(11):4234-42. Epub 2009 Oct 9.

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, United Kingdom.

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http://dx.doi.org/10.1210/jc.2009-1174DOI Listing
November 2009

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription.

Nat Cell Biol 2009 Sep 16;11(9):1093-102. Epub 2009 Aug 16.

Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-5055, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711162PMC
September 2009