Publications by authors named "Stacey M Fernandes"

27Publications

Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses.

Authors:
Jennifer R Brown Sarah R Walker Lisa N Heppler Svitlana Tyekucheva Erik A Nelson Josephine Klitgaard Maria Nicolais Yasmin Kroll Michael Xiang Jennifer E Yeh Mousumi Chaudhury Zachary T Giaccone Stacey M Fernandes Eric D Jacobsen David C Fisher Arnold S Freedman Matthew S Davids Jeffrey G Supko Catherine Wu David A Frank

Am J Hematol 2020 Dec 29. Epub 2020 Dec 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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December 2020

Mechanism of EBV inducing anti-tumour immunity and its therapeutic use.

Authors:
Il-Kyu Choi Zhe Wang Qiang Ke Min Hong Dereck W Paul Stacey M Fernandes Zhuting Hu Jonathan Stevens Indira Guleria Hye-Jung Kim Harvey Cantor Kai W Wucherpfennig Jennifer R Brown Jerome Ritz Baochun Zhang

Nature 2020 Dec 23. Epub 2020 Dec 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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December 2020

miR-29 Modulates CD40 Signaling in Chronic Lymphocytic Leukemia by Targeting TRAF4: an Axis Affected by BCR inhibitors.

Authors:
Sonali Sharma Gabriela Mladonicka Pavlasova Vaclav Seda Katerina Amruz Cerna Eva Vojackova Daniel Filip Laura Ondrisova Veronika Sandova Lenka Kostalova Pedro F Zeni Marek Borsky Jan Oppelt Kvetoslava Liskova Leos Kren Andrea Janikova Sarka Pospisilova Stacey M. Fernandes Medhat Shehata Laura Z Rassenti Ulrich Jaeger Michael Doubek Matthew S Davids Jennifer R Brown Jiri Mayer Thomas J Kipps Marek Mraz

Blood 2020 11 10. Epub 2020 Nov 10.

Central European Institute of Technology, Masaryk University, Brno, Czech Republic

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November 2020

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.

Authors:
Romain Guièze Vivian M Liu Daniel Rosebrock Alexis A Jourdain María Hernández-Sánchez Aina Martinez Zurita Jing Sun Elisa Ten Hacken Kaitlyn Baranowski Philip A Thompson Jin-Mi Heo Zachary Cartun Ozan Aygün J Bryan Iorgulescu Wandi Zhang Giulia Notarangelo Dimitri Livitz Shuqiang Li Matthew S Davids Anat Biran Stacey M Fernandes Jennifer R Brown Ana Lako Zoe B Ciantra Matthew A Lawlor Derin B Keskin Namrata D Udeshi William G Wierda Kenneth J Livak Anthony G Letai Donna Neuberg J Wade Harper Steven A Carr Federica Piccioni Christopher J Ott Ignaty Leshchiner Cory M Johannessen John Doench Vamsi K Mootha Gad Getz Catherine J Wu

Cancer Cell 2019 10 19;36(4):369-384.e13. Epub 2019 Sep 19.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana Building, Room DA-520, Boston MA 02215-02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address:

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October 2019

Growth dynamics in naturally progressing chronic lymphocytic leukaemia.

Authors:
Michaela Gruber Ivana Bozic Ignaty Leshchiner Dimitri Livitz Kristen Stevenson Laura Rassenti Daniel Rosebrock Amaro Taylor-Weiner Oriol Olive Reaha Goyetche Stacey M Fernandes Jing Sun Chip Stewart Alicia Wong Carrie Cibulskis Wandi Zhang Johannes G Reiter Jeffrey M Gerold John G Gribben Kanti R Rai Michael J Keating Jennifer R Brown Donna Neuberg Thomas J Kipps Martin A Nowak Gad Getz Catherine J Wu

Nature 2019 06 29;570(7762):474-479. Epub 2019 May 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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June 2019

Efficacy results of a phase 2 trial of first-line idelalisib plus ofatumumab in chronic lymphocytic leukemia.

Authors:
Benjamin L Lampson Haesook T Kim Matthew S Davids Jeremy S Abramson Arnold S Freedman Caron A Jacobson Philippe A Armand Robin M Joyce Jon E Arnason Laura Z Rassenti Thomas J Kipps Joshua Fein Stacey M Fernandes John R Hanna David C Fisher Jennifer R Brown

Blood Adv 2019 04;3(7):1167-1174

Division of Hematologic Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.

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April 2019

MYD88 L265P mutations identify a prognostic gene expression signature and a pathway for targeted inhibition in CLL.

Authors:
Ma Reina Improgo Bethany Tesar Josephine L Klitgaard Reuma Magori-Cohen Lijian Yu Siddha Kasar Divya Chaudhary Wenyan Miao Stacey M Fernandes Kevin Hoang William F Westlin Haesook T Kim Jennifer R Brown

Br J Haematol 2019 03 9;184(6):925-936. Epub 2018 Dec 9.

Department of Medical Oncology, Dana-Farber Cancer Institute, Cambridge, MA, USA.

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March 2019

Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia.

Authors:
Christopher J Ott Alexander J Federation Logan S Schwartz Siddha Kasar Josephine L Klitgaard Romina Lenci Qiyuan Li Matthew Lawlor Stacey M Fernandes Amanda Souza Donald Polaski Deepti Gadi Matthew L Freedman Jennifer R Brown James E Bradner

Cancer Cell 2018 12 29;34(6):982-995.e7. Epub 2018 Nov 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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December 2018

Ofatumumab plus high dose methylprednisolone followed by ofatumumab plus alemtuzumab to achieve maximal cytoreduction prior to allogeneic transplantation for 17p deleted or TP53 mutated chronic lymphocytic leukemia

Authors:
Matthew S Davids Haesook T Kim Lijian Yu Guadalupe De Maeyer Mikaela McDonough Alexander R Vartanov Rachael Langey Stacey M Fernandes Jeffrey M Hellman Karen Francoeur Jon Arnason Eric D Jacobsen Ann S LaCasce David C Fisher Jennifer R Brown

Leuk Lymphoma 2019 05 15;60(5):1312-1315. Epub 2018 Oct 15.

a Departments of Medical Oncology , Dana-Farber Cancer Institute, Harvard Medical School , Boston , MA , USA.

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May 2019

Enhanced activation and expansion of T cells using mechanically soft elastomer fibers.

Authors:
Alex Dang Sarah De Leo Danielle R Bogdanowicz Dennis J Yuan Stacey M Fernandes Jennifer R Brown Helen H Lu Lance C Kam

Adv Biosyst 2018 Feb 18;2(2). Epub 2018 Jan 18.

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA,

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February 2018

Minimal residual disease detected by immunoglobulin sequencing predicts CLL relapse more effectively than flow cytometry.

Authors:
Andrew Aw Haesook T Kim Stacey M Fernandes Kevin Hoang Siddha Kasar Malek Faham Jennifer R Brown

Leuk Lymphoma 2018 08 22;59(8):1986-1989. Epub 2017 Nov 22.

e CLL Center and Department of Medical Oncology , Dana-Farber Cancer Institute, Harvard Medical School , Boston , MA , USA.

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August 2018

Analysis of rare germ line variants in chronic lymphocytic leukemia.

Authors:
Grace Tiao M Reina Improgo Eugen Tausch Stacey M Fernandes Jasmin Bahlo Sandra Robrecht Kirsten Fischer Michael Hallek Stephan Stilgenbauer Adam Kiezun Gad Getz Jennifer R Brown

Blood 2017 11 19;130(22):2443-2444. Epub 2017 Oct 19.

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA.

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November 2017

Changes in Bcl-2 Family Protein Profile During Idelalisib Therapy Mimic Those During Duvelisib Therapy in Chronic Lymphocytic Leukemia Lymphocytes.

Authors:
Qingshan Yang Prexy Modi Anil Korkut Stacey M Fernandes John Hanna Jennifer R Brown Varsha Gandhi

JCO Precis Oncol 2017 28;1. Epub 2017 Jun 28.

, , , and , The University of Texas MD Anderson Cancer Center, Houston, TX; , , and , Dana-Farber Cancer Institute, Boston, MA.

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June 2017

Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies.

Authors:
Xiaochuan Liu Aoli Wang Xiaofei Liang Juanjuan Liu Fengming Zou Cheng Chen Zheng Zhao Yuanxin Deng Hong Wu Ziping Qi Beilei Wang Li Wang Feiyang Liu Yunhe Xu Wenchao Wang Stacey M Fernandes Richard M Stone Ilene A Galinsky Jennifer R Brown Teckpeng Loh James D Griffin Shanchun Zhang Ellen L Weisberg Xin Zhang Jing Liu Qingsong Liu

Oncotarget 2016 Aug;7(33):53515-53525

High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, 230031, Anhui, P. R. China.

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August 2016

Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia.

Authors:
Rachel Thijssen Johanna Ter Burg Brett Garrick Gregor G W van Bochove Jennifer R Brown Stacey M Fernandes María Solé Rodríguez Jean-Marie Michot Michael Hallek Barbara Eichhorst Hans Christian Reinhardt Johanna Bendell Ingrid A M Derks Roel J W van Kampen Kristen Hege Marie José Kersten Torsten Trowe Ellen H Filvaroff Eric Eldering Arnon P Kater

Blood 2016 07 27;128(4):574-83. Epub 2016 May 27.

Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Lymphoma and Myeloma Center Amsterdam, The Netherlands.

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July 2016

Characterization of selective and potent PI3Kδ inhibitor (PI3KDIN- 015) for B-Cell malignances.

Authors:
Xiaochuan Liu Aoli Wang Xiaofei Liang Cheng Chen Juanjuan Liu Zheng Zhao Hong Wu Yuanxin Deng Li Wang Beilei Wang Jiaxin Wu Feiyang Liu Stacey M Fernandes Sophia Adamia Richard M Stone Ilene A Galinsky Jennifer R Brown James D Griffin Shanchun Zhang Teckpeng Loh Xin Zhang Wenchao Wang Ellen L Weisberg Jing Liu Qingsong Liu

Oncotarget 2016 May;7(22):32641-51

High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China.

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May 2016

Human C1-Inhibitor Suppresses Malaria Parasite Invasion and Cytoadhesion via Binding to Parasite Glycosylphosphatidylinositol and Host Cell Receptors.

Authors:
Pedro Mejia Monica Diez-Silva Faustin Kamena Fengxin Lu Stacey M Fernandes Peter H Seeberger Alvin E Davis James R Mitchell

J Infect Dis 2016 Jan 7;213(1):80-9. Epub 2015 Sep 7.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston.

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January 2016

Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.

Authors:
Dan A Landau Kendell Clement Michael J Ziller Patrick Boyle Jean Fan Hongcang Gu Kristen Stevenson Carrie Sougnez Lili Wang Shuqiang Li Dylan Kotliar Wandi Zhang Mahmoud Ghandi Levi Garraway Stacey M Fernandes Kenneth J Livak Stacey Gabriel Andreas Gnirke Eric S Lander Jennifer R Brown Donna Neuberg Peter V Kharchenko Nir Hacohen Gad Getz Alexander Meissner Catherine J Wu

Cancer Cell 2014 Dec;26(6):813-825

Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA. Electronic address:

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December 2014

A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma.

Authors:
Jennifer R Brown Bradley Messmer Lillian Werner Matthew S Davids Evgeny Mikler Jeffrey G Supko David C Fisher Ann S LaCasce Philippe Armand Eric Jacobsen Virginia Dalton Bethany Tesar Stacey M Fernandes Sean McDonough Jerome Ritz Laura Rassenti Thomas J Kipps Donna Neuberg Arnold S Freedman

Haematologica 2013 Jun 3;98(6):964-70. Epub 2013 May 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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June 2013

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.

Authors:
Dan A Landau Scott L Carter Petar Stojanov Aaron McKenna Kristen Stevenson Michael S Lawrence Carrie Sougnez Chip Stewart Andrey Sivachenko Lili Wang Youzhong Wan Wandi Zhang Sachet A Shukla Alexander Vartanov Stacey M Fernandes Gordon Saksena Kristian Cibulskis Bethany Tesar Stacey Gabriel Nir Hacohen Matthew Meyerson Eric S Lander Donna Neuberg Jennifer R Brown Gad Getz Catherine J Wu

Cell 2013 Feb;152(4):714-26

Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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February 2013

LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas.

Authors:
Yong Zhang Aldo M Roccaro Christopher Rombaoa Ludmilla Flores Susanna Obad Stacey M Fernandes Antonio Sacco Yang Liu Hai Ngo Phong Quang Abdel Kareem Azab Feda Azab Patricia Maiso Michaela Reagan Jennifer R Brown To-Ha Thai Sakari Kauppinen Irene M Ghobrial

Blood 2012 Aug 13;120(8):1678-86. Epub 2012 Jul 13.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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August 2012

The effect of C1 inhibitor on myocardial ischemia and reperfusion injury.

Authors:
Fengxin Lu Stacey M Fernandes Alvin E Davis

Cardiovasc Pathol 2013 Jan-Feb;22(1):75-80. Epub 2012 Jun 16.

Immune Disease Institute, Harvard Medical School, 3 Blackfan Circle, Boston, MA 02115, USA.

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May 2013

Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemia.

Authors:
Jennifer R Brown Megan Hanna Bethany Tesar Lillian Werner Nathalie Pochet John M Asara Yaoyu E Wang Paola Dal Cin Stacey M Fernandes Christina Thompson Laura Macconaill Catherine J Wu Yves Van de Peer Mick Correll Aviv Regev Donna Neuberg Arnold S Freedman

Clin Cancer Res 2012 Jul 23;18(14):3791-802. Epub 2012 May 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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July 2012

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.

Authors:
Lili Wang Michael S Lawrence Youzhong Wan Petar Stojanov Carrie Sougnez Kristen Stevenson Lillian Werner Andrey Sivachenko David S DeLuca Li Zhang Wandi Zhang Alexander R Vartanov Stacey M Fernandes Natalie R Goldstein Eric G Folco Kristian Cibulskis Bethany Tesar Quinlan L Sievers Erica Shefler Stacey Gabriel Nir Hacohen Robin Reed Matthew Meyerson Todd R Golub Eric S Lander Donna Neuberg Jennifer R Brown Gad Getz Catherine J Wu

N Engl J Med 2011 Dec 12;365(26):2497-506. Epub 2011 Dec 12.

Cancer Vaccine Center and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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December 2011

The role of the complement and contact systems in the dextran sulfate sodium-induced colitis model: the effect of C1 inhibitor in inflammatory bowel disease.

Authors:
Fengxin Lu Stacey M Fernandes Alvin E Davis

Am J Physiol Gastrointest Liver Physiol 2010 Jun 25;298(6):G878-83. Epub 2010 Mar 25.

Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, USA.

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June 2010

The effect of C1 inhibitor on intestinal ischemia and reperfusion injury.

Authors:
Fengxin Lu Anil K Chauhan Stacey M Fernandes Meghan T Walsh Denisa D Wagner Alvin E Davis

Am J Physiol Gastrointest Liver Physiol 2008 Nov 11;295(5):G1042-9. Epub 2008 Sep 11.

Immune Disease Inst., Harvard Medical School, Boston, Massachusetts, USA.

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November 2008

C1 inhibitor-mediated protection from sepsis.

Authors:
Dongxu Liu Fengxin Lu Gangjian Qin Stacey M Fernandes Jinan Li Alvin E Davis

J Immunol 2007 Sep;179(6):3966-72

CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA.

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September 2007