Sruti Shiva

Sruti Shiva

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Sruti Shiva

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Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy.

Life Sci 2019 Oct 18;238:116922. Epub 2019 Oct 18.

The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.lfs.2019.116922DOI Listing
October 2019

Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction.

Proc Natl Acad Sci U S A 2019 Sep 26;116(37):18435-18444. Epub 2019 Aug 26.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;

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http://dx.doi.org/10.1073/pnas.1910574116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744920PMC
September 2019

Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane.

Carcinogenesis 2019 Sep 26. Epub 2019 Sep 26.

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh PA.

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http://dx.doi.org/10.1093/carcin/bgz155DOI Listing
September 2019

Platelets: Lone Rangers of Inflammatory Signaling in the Lung.

Am J Respir Cell Mol Biol 2019 Aug;61(2):139-140

2Vascular Medicine Instituteand.

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http://dx.doi.org/10.1165/rcmb.2019-0057EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670034PMC
August 2019

Alterations in platelet bioenergetics in Group 2 PH-HFpEF patients.

PLoS One 2019 31;14(7):e0220490. Epub 2019 Jul 31.

Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220490PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668825PMC
July 2019

Oxidative stress-induced senescence markedly increases disc cell bioenergetics.

Mech Ageing Dev 2019 06 17;180:97-106. Epub 2019 Apr 17.

Department of Orthopedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00476374183019
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http://dx.doi.org/10.1016/j.mad.2019.04.006DOI Listing
June 2019

Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling.

Biochem J 2019 Jun 19;476(12):1713-1724. Epub 2019 Jun 19.

Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, U.S.A.

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http://dx.doi.org/10.1042/BCJ20190302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636327PMC
June 2019

BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Circulation 2019 May;139(19):2238-2255

Center for Pulmonary Vascular Biology and Medicine, Center for Metabolism and Mitochondrial Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (Q.Y., Y.-Y.T., Y.T., J.Z., V.N., M.K.C., J.P., W.S., J.S., M.R., M.S., N.K., T.S., M.Z., N.F., S.S., S.Y.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519484PMC
May 2019

Electrophilic nitro-oleic acid reverses obesity-induced hepatic steatosis.

Redox Biol 2019 04 1;22:101132. Epub 2019 Feb 1.

Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375063PMC
April 2019

Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury.

J Mol Cell Cardiol 2019 Apr 15;129:69-78. Epub 2019 Feb 15.

Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Center for Metabolism and Mitochondrial Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486843PMC
April 2019

Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration.

Redox Biol 2019 04 8;22:101138. Epub 2019 Feb 8.

Vascular Medicine Institute, University of Pittsburgh, 200 Lothrop St., Pittsburgh, PA 15261, United States; Department of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop St., Pittsburgh, PA 15261, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395885PMC
April 2019

Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets.

Redox Biol 2019 04 10;22:101165. Epub 2019 Mar 10.

Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436140PMC
April 2019

Stress-induced autonomic dysregulation of mitochondrial function in the rat urothelium.

Neurourol Urodyn 2019 02 21;38(2):572-581. Epub 2018 Dec 21.

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/nau.23876DOI Listing
February 2019

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Physiol Rev 2019 01;99(1):311-379

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh , Pittsburgh, Pennsylvania ; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania ; Department of Pharmacology and Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Medicine, Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.

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https://www.physiology.org/doi/10.1152/physrev.00036.2017
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http://dx.doi.org/10.1152/physrev.00036.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442925PMC
January 2019

Nocturnal Hypoxia Improves Glucose Disposal, Decreases Mitochondrial Efficiency, and Increases Reactive Oxygen Species in the Muscle and Liver of C57BL/6J Mice Independent of Weight Change.

Oxid Med Cell Longev 2018 4;2018:9649608. Epub 2018 Feb 4.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh, 3459 Fifth Avenue, 628 NW Pittsburgh, PA 15213, USA.

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https://www.hindawi.com/journals/omcl/2018/9649608/
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http://dx.doi.org/10.1155/2018/9649608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817288PMC
September 2018

Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway.

Redox Biol 2018 09 9;18:25-32. Epub 2018 Jun 9.

Division of Cardiology, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, United States; Vascular Medicine Institute, University of Pittsburgh, United States; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008287PMC
September 2018

Moving mitochondria - Breathing new signaling into asthmatic airways.

Redox Biol 2018 09 21;18:244-245. Epub 2018 Jul 21.

Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079482PMC
September 2018

Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis.

Stem Cell Res Ther 2018 09 26;9(1):257. Epub 2018 Sep 26.

Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, W1244 BST Tower 200 Lothrop Street, Pittsburgh, PA, 15261, USA.

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http://dx.doi.org/10.1186/s13287-018-0970-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158816PMC
September 2018

Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and Quantum Mechanics and Molecular Mechanics Theoretical Investigations of Preferred Fe -NO Ligand Orientations in Myoglobin Distal Pockets.

Biochemistry 2018 08 27;57(32):4788-4802. Epub 2018 Jul 27.

Price Family Foundation Institute of Structural Biology and Department of Chemistry and Biochemistry , University of Oklahoma , 101 Stephenson Parkway , Norman , Oklahoma 73019 , United States.

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http://dx.doi.org/10.1021/acs.biochem.8b00542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474360PMC
August 2018

Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.

Pulm Circ 2018 Jul-Sep;8(3):2045894018791557. Epub 2018 Jul 13.

1 Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1177/2045894018791557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080084PMC
July 2018

Differential mitochondrial dinitrosyliron complex formation by nitrite and nitric oxide.

Redox Biol 2018 05 23;15:277-283. Epub 2017 Dec 23.

Vascular Medicine Institute, University of Pittsburgh School of Medicine, BST1240E, 200 Lothrop St, Pittsburgh, PA 15261, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Metabolism & Mitochondrial Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317173090
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http://dx.doi.org/10.1016/j.redox.2017.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975210PMC
May 2018

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.

J Mol Cell Cardiol 2018 03 3;116:29-40. Epub 2018 Feb 3.

Department of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2018.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845802PMC
March 2018

IPF lung fibroblasts have a senescent phenotype.

Am J Physiol Lung Cell Mol Physiol 2017 Dec 31;313(6):L1164-L1173. Epub 2017 Aug 31.

The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Pittsburgh, Pennsylvania;

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http://dx.doi.org/10.1152/ajplung.00220.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148001PMC
December 2017

Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Hypertension 2017 09;70(3):634-644

From the Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes (K.S.H.), Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute (K.S.H., S.G.W., M.D.-G., N.H., C.C., S.S., B.A.F., M.T.G.), Department of Pharmacology and Chemical Biology (S.G.W., M.D.-G., S.S., B.A.F.), Department of Medicine, Division of Endocrinology (N.H., B.G.), and Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, PA (M.T.G.); Department of Physics, Wake Forest University, Winston Salem, NC (L.B., D.B.K.-S.); and Pharmaceutical Development Section, Department of Pharmacy, Clinical Center, National Institutes of Health, Bethesda, MD (G.P., G.G.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783786PMC
September 2017

Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.

PLoS One 2016 8;11(8):e0160783. Epub 2016 Aug 8.

Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160783PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976872PMC
August 2017

Biochemical signaling by remote ischemic conditioning of the arm versus thigh: Is one raise of the cuff enough?

Redox Biol 2017 08 18;12:491-498. Epub 2017 Mar 18.

Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Applied Physiology Laboratory, Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362138PMC
August 2017

Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart.

Am J Physiol Heart Circ Physiol 2017 Aug 19;313(2):H265-H274. Epub 2017 May 19.

Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania;

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http://dx.doi.org/10.1152/ajpheart.00752.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582919PMC
August 2017

Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy.

Am J Respir Crit Care Med 2017 03;195(5):596-606

1 Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute.

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http://dx.doi.org/10.1164/rccm.201606-1275CIDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363978PMC
March 2017

Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation.

Mol Carcinog 2017 02 5;56(2):337-348. Epub 2016 May 5.

Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/mc.22497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097706PMC
February 2017

The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney.

PLoS Pathog 2016 Nov 4;12(11):e1005952. Epub 2016 Nov 4.

Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096720PMC
November 2016

Regional Disruptions in Endothelial Nitric Oxide Pathway Associated With Bicuspid Aortic Valve.

Ann Thorac Surg 2016 Oct 7;102(4):1274-81. Epub 2016 Jun 7.

Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2016.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124889PMC
October 2016

AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia.

J Proteome Res 2016 10 27;15(10):3883-3895. Epub 2016 Sep 27.

Altitude Research Center, Department of Emergency Medicine, University of Colorado , Anschutz Medical Campus, Aurora, Colorado, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512539PMC
October 2016

Caveolin-1 controls mitochondrial function through regulation of -AAA mitochondrial protease.

Aging (Albany NY) 2016 10;8(10):2355-2369

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.18632/aging.101051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115893PMC
October 2016

Inhaled Carbon Monoxide Protects against the Development of Shock and Mitochondrial Injury following Hemorrhage and Resuscitation.

PLoS One 2015 14;10(9):e0135032. Epub 2015 Sep 14.

VA Pittsburgh Healthcare System, Pittsburgh, PA, United States of America; The Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA, United States of America; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135032PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569171PMC
June 2016

Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation.

Cell Rep 2016 05 12;15(8):1700-14. Epub 2016 May 12.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Western Michigan University Homer Stryker School of Medicine, Kalamazoo, MI 49008, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.04.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880515PMC
May 2016

Platelets from Asthmatic Individuals Show Less Reliance on Glycolysis.

PLoS One 2015 6;10(7):e0132007. Epub 2015 Jul 6.

Vascular Medicine Institute, Dept of Pharmacology & Chemical Biology, Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132007PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492492PMC
April 2016

LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1.

J Cell Sci 2016 Jan 24;129(1):51-64. Epub 2015 Nov 24.

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA Department of Cell Biology and Physiology and Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA Medical Specialty Service Line, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA

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http://dx.doi.org/10.1242/jcs.176701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732295PMC
January 2016

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes.

Free Radic Biol Med 2015 Dec 16;89:333-41. Epub 2015 Sep 16.

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh PA, 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.07.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684780PMC
December 2015

Inhaled, nebulized sodium nitrite protects in murine and porcine experimental models of hemorrhagic shock and resuscitation by limiting mitochondrial injury.

Nitric Oxide 2015 Dec 26;51:7-18. Epub 2015 Sep 26.

VA Pittsburgh Healthcare System, USA; Department of Surgery, USA; The Center for Critical Care Nephrology, USA; Vascular Medicine Institute, University of Pittsburgh, USA. Electronic address:

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http://dx.doi.org/10.1016/j.niox.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884699PMC
December 2015

Sirtuin 1 Agonist Minimizes Injury and Improves the Immune Response Following Traumatic Shock.

Shock 2015 Aug;44 Suppl 1:149-55

*Department of Surgery, University of Pittsburgh; †VA Pittsburgh Healthcare System; Departments of ‡Critical Care Medicine and §Pharmacology & Chemical Biology, ∥Vascular Medicine Institute, and ¶The Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/SHK.0000000000000412DOI Listing
August 2015

Nitrite Confers Preconditioning and Cytoprotection After Ischemia/Reperfusion Injury Through the Modulation of Mitochondrial Function.

Antioxid Redox Signal 2015 Aug;23(4):307-27

1 Vascular Medicine Institute, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/ars.2015.6260DOI Listing
August 2015

Inorganic nitrite improves components of the metabolic syndrome independent of weight change in a murine model of obesity and insulin resistance.

J Physiol 2015 Jul 25;593(14):3135-45. Epub 2015 Jun 25.

Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, University of Pittsburgh, 3459 Fifth Avenue 628 NW, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1113/JP270386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532532PMC
July 2015

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.

J Biol Chem 2015 May 16;290(19):11843-52. Epub 2015 Mar 16.

From the Department of Medicine, Acute Lung Injury Center of Excellence and the Medical Specialty Service Line, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240

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http://dx.doi.org/10.1074/jbc.M114.629931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424325PMC
May 2015

Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells.

Free Radic Biol Med 2014 Dec 16;77:307-16. Epub 2014 Sep 16.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278422PMC
December 2014

β-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice.

Am J Pathol 2014 Dec 7;184(12):3284-98. Epub 2014 Oct 7.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1016/j.ajpath.2014.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258504PMC
December 2014

Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury.

Am J Physiol Lung Cell Mol Physiol 2014 Dec 17;307(12):L987-97. Epub 2014 Oct 17.

University of Pittsburgh School of Medicine Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine, Pittsburgh, Pennsylvania; University of Pittsburgh Vascular Medicine Institute, Pittsburgh, Pennsylvania;

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http://ajplung.physiology.org/content/ajplung/307/12/L987.fu
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http://ajplung.physiology.org/cgi/doi/10.1152/ajplung.00063.
Publisher Site
http://dx.doi.org/10.1152/ajplung.00063.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269687PMC
December 2014

T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.

Sci Signal 2014 Jun 10;7(329):ra55. Epub 2014 Jun 10.

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1126/scisignal.2005169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405131PMC
June 2014

Nitrite augments glucose uptake in adipocytes through the protein kinase A-dependent stimulation of mitochondrial fusion.

Free Radic Biol Med 2014 May 17;70:45-53. Epub 2014 Feb 17.

Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006287PMC
May 2014

Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning.

Circ Res 2014 May 18;114(10):1601-10. Epub 2014 Mar 18.

From the Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Hospital Duesseldorf, Duesseldorf, Germany (T.R., M.T., U.B.H.-C., M.K.); Department of Pharmacology and Chemical Biology, University of Pittsburgh, PA (S.S.); Institute for Pathophysiology, University of Essen, Essen, Germany (G.H.); and Cardiovascular Research Institute Duesseldorf, Duesseldorf, Germany (M.K.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.114.30382
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http://dx.doi.org/10.1161/CIRCRESAHA.114.303822DOI Listing
May 2014

E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia.

Cell Rep 2014 Apr 3;7(2):476-487. Epub 2014 Apr 3.

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Medical Specialty Service Line, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.02.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085683PMC
April 2014

Nox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4.

Am J Physiol Heart Circ Physiol 2014 Jan 8;306(2):H197-205. Epub 2013 Nov 8.

Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania;

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http://dx.doi.org/10.1152/ajpheart.00977.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920131PMC
January 2014

Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation.

J Immunol 2013 Nov 2;191(10):5230-8. Epub 2013 Oct 2.

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261;

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http://dx.doi.org/10.4049/jimmunol.1301490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833073PMC
November 2013

Mechanisms for cellular NO oxidation and nitrite formation in lung epithelial cells.

Free Radic Biol Med 2013 Aug 30;61:428-37. Epub 2013 Apr 30.

Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883890PMC
August 2013

Metabolic alterations in mammary cancer prevention by withaferin A in a clinically relevant mouse model.

J Natl Cancer Inst 2013 Aug 2;105(15):1111-22. Epub 2013 Jul 2.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1093/jnci/djt153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735460PMC
August 2013

Ceruloplasmin is an endogenous inhibitor of myeloperoxidase.

J Biol Chem 2013 Mar 10;288(9):6465-77. Epub 2013 Jan 10.

Centre for Free Radical Research, Department of Pathology, University of Otago, Christchurch, Christchurch 8140, New Zealand.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.418970
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585080PMC
March 2013

Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma.

Antioxid Redox Signal 2013 Feb 7;18(4):412-23. Epub 2012 Sep 7.

Department of Pathobiology, Lerner Research Institute, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1089/ars.2012.4566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526896PMC
February 2013

Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease.

Biochem Soc Trans 2013 Feb;41(1):118-23

Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1042/BST20120327DOI Listing
February 2013

Nitrite: A Physiological Store of Nitric Oxide and Modulator of Mitochondrial Function.

Authors:
Sruti Shiva

Redox Biol 2013 ;1(1):40-44

Vascular Medicine Institute and Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261.

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http://dx.doi.org/10.1016/j.redox.2012.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661298PMC
January 2013

Oxygen regulates tissue nitrite metabolism.

Antioxid Redox Signal 2012 Oct 7;17(7):951-61. Epub 2012 Feb 7.

Critical Care Medicine, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1089/ars.2011.4242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411351PMC
October 2012

Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase.

Free Radic Biol Med 2012 Oct 4;53(7):1440-50. Epub 2012 Aug 4.

Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.07.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477807PMC
October 2012

Chronic hypoxia induces right heart failure in caveolin-1-/- mice.

Am J Physiol Heart Circ Physiol 2012 Jun 13;302(12):H2518-27. Epub 2012 Apr 13.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://www.physiology.org/doi/10.1152/ajpheart.01140.2011
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http://dx.doi.org/10.1152/ajpheart.01140.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378264PMC
June 2012

Myoglobin and mitochondria: a relationship bound by oxygen and nitric oxide.

Nitric Oxide 2012 May 29;26(4):251-8. Epub 2012 Mar 29.

Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, United States.

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http://dx.doi.org/10.1016/j.niox.2012.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391710PMC
May 2012

Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species.

PLoS One 2011 10;6(8):e23354. Epub 2011 Aug 10.

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023354PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154436PMC
December 2011

Nitrite as a mediator of ischemic preconditioning and cytoprotection.

Nitric Oxide 2011 Aug 26;25(2):70-80. Epub 2011 Jan 26.

Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.niox.2011.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118399PMC
August 2011