Dr. Sriram Seshadri, PhD - Institute of Science, Nirma University - Academic Coordinator

Dr. Sriram Seshadri

PhD

Institute of Science, Nirma University

Academic Coordinator

Ahmedabad, Gujarat | India

Main Specialties: Biology, Biotechnology, Endocrinology Diabetes & Metabolism, Gastroenterology, Oncology

Additional Specialties: Gut Microbiota, Probiotics, Metabolic disorder, UTI, Male Reproduction

ORCID logohttps://orcid.org/0000-0003-1547-2193


Top Author

Dr. Sriram Seshadri, PhD - Institute of Science, Nirma University - Academic Coordinator

Dr. Sriram Seshadri

PhD

Introduction

Dr. Sriram Seshadri completed his masters from Sardar Patel University in Zoology/Comparative Endocrinology and his doctorate from University of Rajasthan on Male reproductive Physiology. He has more than 15 years of experience in Teaching and 12 years of experience in research. He is the Institute Coordinator for Internal Quality Assurance Cell and Academic Coordinator.

His research area of interest includes, understanding the role of gut microbiota in diabetes and liver inflammation. His group has successfully developed an animal model for diet induced diabetes and have established that gut dysbiosis is one of the major causes for the induction and progression on insulin resistance resulting in type 2 diabetes and even obesity. His group is currently working on modulation of gut dysbiosis using two strategies. First being the targeted drug delivery using pH specific polymers and secondly targeting the FFAR and GPR receptors in the colon for the treatment of metabolic disorder and liver inflammation. Owing to his expertise in bacteriocin isolation and characterization, he has been appointed in the International Grant Reviewer Panel for reviewing grant proposals on Bacteriocin and Probiotic Research of Czech Science Foundation, Czech Republic.

Primary Affiliation: Institute of Science, Nirma University - Ahmedabad, Gujarat , India

Specialties:

Additional Specialties:

Research Interests:


View Dr. Sriram Seshadri’s Resume / CV

Education

Feb 2000 - Apr 2004
University of Rajasthan
Ph. D. In Science (Male Reproductive Physiology)
Department of Zoology
Jun 1997 - Apr 1999
Sardar Patel University
M. Sc. Zoology (Comparative Endocrinology)
Department of Biosciences
May 1997
South Gujarat University
B. Sc.
Zoology

Experience

Jun 2017
Nirma University
Academic Coordinator
Since May 2007
Aug 2006 - Apr 2007
IET Biotechnology Institute
Assistant Professor
Department of Biotechnology
Jun 2004 - Jul 2006
Madanapalle Institute of Technology and Science
Assistant Professor
Department of Biotechnology
May 2007
Nirma University Institute of Science
Assistant Professor & Programme Coordinator (Biochemistry),
Institute of Science

Publications

102Publications

395Reads

700Profile Views

82PubMed Central Citations

Short Chain Fatty Acids, pancreatic dysfunction and type 2 diabetes.

Pancreatology 2019 Mar 28;19(2):280-284. Epub 2019 Jan 28.

Institute of Science, Nirma University, Ahmedabad, Gujarat, 382481, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14243903193002
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http://dx.doi.org/10.1016/j.pan.2019.01.021DOI Listing
March 2019
29 Reads
2.504 Impact Factor

β-cyclodextrin based dual-responsive multifunctional nanotheranostics for cancer cell targeting and dual drug delivery.

Carbohydr Polym 2019 Feb 20;206:694-705. Epub 2018 Nov 20.

Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2018.11.049DOI Listing
February 2019
10 Reads
4.074 Impact Factor

Correction to: Current scenario and future strategies to fight artemisinin resistance.

Parasitol Res 2019 01;118(1):385

National Institute of Malaria Research, Dwarka Sector 8, New Delhi, 110077, India.

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http://dx.doi.org/10.1007/s00436-018-6175-1DOI Listing
January 2019
2 Reads
2.327 Impact Factor

Current scenario and future strategies to fight artemisinin resistance.

Parasitol Res 2019 Jan 26;118(1):29-42. Epub 2018 Nov 26.

National Institute of Malaria Research, Dwarka Sector 8, New Delhi, 110077, India.

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http://link.springer.com/10.1007/s00436-018-6126-x
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http://dx.doi.org/10.1007/s00436-018-6126-xDOI Listing
January 2019
33 Reads
2.327 Impact Factor

Cefdinir Microsphere Modulated Microflora and Liver Immunological Response to Diet Induced Diabetes in Mice.

Endocr Metab Immune Disord Drug Targets 2019 ;19(3):349-357

Institute of Science, Nirma University, S G Highway, Ahmedabad, India.

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http://dx.doi.org/10.2174/1871530319666181224122115DOI Listing
January 2019
5 Reads

Cefdinir Microsphere modulated microflora and liver immunological response to diet induced diabetes in mice

Endocrine, Metabolic & Immune Disorders-Drug Targets

Objective: Gut microbiota is currently targeted for various disease especially metabolic disorders such as diabetes. Our strategy is to alter gut microflora via specific antibiotic to reduce load of inflammation in liver increase of high carbohydrate diet. Th1, Th17 and Treg are important immune cell type which decides type of inflammatory response. Liver is tolerogenic in nature with low Th17/Treg ratio. In diabetic this ratio decreases even more, and can cause liver trauma. Method: The present study tries to find relation between gut flora and immune cells such as Th1/Th17/Treg role in liver metabolism using diet induced diabetic mice model. Result: Upon alteration of flora using Cefdinir in different form, could help to lower the level of Treg cells thus increasing the ratio. Gut flora strongly associated with immunity in liver. Targeted alteration of gut flora helps us to find importance. Conclusion: Colon targeted Cefdinir gives more promising results, opens colonic bacteria as target for improving gut, liver inflammation and insulin sensitivity.

Key words: Diabetes, inflammation, Th1/Th17/Treg cells, gut microflora, cefdinir

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December 2018

Impact Factor 2.013

2 Reads

ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK.

Biochim Biophys Acta Mol Basis Dis 2018 May 27;1864(5 Pt A):1702-1716. Epub 2018 Feb 27.

Department of Biology, Dr. Reddy's Institute of Life Sciences (DRILS), University of Hyderabad Campus, Hyderabad 500046, India. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.02.019DOI Listing
May 2018
25 Reads
4.882 Impact Factor

In Vivo Assessment of Immunogenicity and Toxicity of the Bacteriocin TSU4 in BALB/c Mice.

Probiotics Antimicrob Proteins 2017 09;9(3):345-354

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat, 382481, India.

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http://dx.doi.org/10.1007/s12602-016-9249-3DOI Listing
September 2017
14 Reads

Preparation and Optimization of Moxifloxacin Microspheres for Colon Targeted Delivery Using Quality by Design Approach: In Vitro and In Vivo Study.

Curr Drug Deliv 2016 ;13(7):1021-1033

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Chharodi, Ahmedabad-382481, Gujarat, India.

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February 2017
14 Reads
2.250 Impact Factor

Investigation of Chitosan for Prevention of Diabetic Progression Through Gut Microbiota Alteration in Sugar Rich Diet Induced Diabetic Rats.

Curr Pharm Biotechnol 2015 ;17(2):173-84

Institute of Science, Nirma University, Sarkhej- Gandhinagar Highway, Chharodi, Ahmedabad-382481, Gujarat, India.

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March 2016
6 Reads
3 Citations
2.511 Impact Factor

MicroRNA-16 modulates macrophage polarization leading to improved insulin sensitivity in myoblasts.

Biochimie 2015 Dec 8;119:16-26. Epub 2015 Oct 8.

Department of Biology, Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad, Telangana, India. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2015.10.004DOI Listing
December 2015
8 Reads
2 Citations
2.963 Impact Factor

Purification and Molecular Characterization of the Novel Highly Potent Bacteriocin TSU4 Produced by Lactobacillus animalis TSU4.

Appl Biochem Biotechnol 2015 Sep 6;177(1):90-104. Epub 2015 Aug 6.

School of Life Sciences, Sambalpur University, Jyotivihar, Burla, 768019, Sambalpur, Odisha, India.

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http://dx.doi.org/10.1007/s12010-015-1730-zDOI Listing
September 2015
4 Reads
2 Citations
1.740 Impact Factor

In Vitro Evaluation of Probiotic Properties of Lactic Acid Bacteria from the Gut of Labeo rohita and Catla catla.

Probiotics Antimicrob Proteins 2015 Jun;7(2):126-36

School of Life Sciences, Sambalpur University, Jyotivihar, Burla, Sambalpur, 768019, Odisha, India.

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http://dx.doi.org/10.1007/s12602-015-9184-8DOI Listing
June 2015
10 Reads
2 Citations

In vivo evaluation of Eclipta alba extract as anticancer and multidrug resistance reversal agent.

Nutr Cancer 2014 4;66(5):904-13. Epub 2014 Jun 4.

a Institute of Science , Nirma University , Chharodi, Ahmedabad , Gujarat , India.

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http://dx.doi.org/10.1080/01635581.2014.916324DOI Listing
February 2015
6 Reads
1 Citation
2.322 Impact Factor

Understanding the role of heat shock protein isoforms in male fertility, aging and apoptosis.

World J Mens Health 2014 Dec 29;32(3):123-32. Epub 2014 Dec 29.

Institute of Science, Nirma University, Gujarat, India.

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http://dx.doi.org/10.5534/wjmh.2014.32.3.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298814PMC
December 2014
20 Reads
2 Citations

Understanding and modulating the Toll like Receptors (TLRs) and NOD like Receptors (NLRs) cross talk in type 2 diabetes.

Curr Diabetes Rev 2014 May;10(3):190-200

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Chharodi, Ahmedabad-382481, Gujarat, India.

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May 2014
18 Reads
17 Citations

Impact of targeted specific antibiotic delivery for gut microbiota modulation on high-fructose-fed rats.

Appl Biochem Biotechnol 2014 Apr 27;172(8):3810-26. Epub 2014 Feb 27.

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Chandlodia, Ahmedabad, 382481, Gujarat, India.

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http://dx.doi.org/10.1007/s12010-014-0772-yDOI Listing
April 2014
14 Reads
7 Citations
1.740 Impact Factor

Colicin E2 Expression in Lactobacillus brevis DT24, A Vaginal Probiotic Isolate, against Uropathogenic Escherichia coli.

ISRN Urol 2014 4;2014:869610. Epub 2014 Feb 4.

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Chharodi, Ahmedabad, Gujarat 382481, India.

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http://dx.doi.org/10.1155/2014/869610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932652PMC
March 2014
6 Reads

Evaluation of hydro-alcoholic extract of Eclipta alba for its multidrug resistance reversal potential: an in vitro study.

Nutr Cancer 2013 ;65(5):775-80

Institute of Science, Nirma University, Chharodi, Ahmedabad, Gujarat, India.

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http://dx.doi.org/10.1080/01635581.2013.789116DOI Listing
February 2014
37 Reads
3 Citations
2.322 Impact Factor

Partial Purification and Characterization of a Bacteriocin DT24 Produced by Probiotic Vaginal Lactobacillus brevis DT24 and Determination of its Anti-Uropathogenic Escherichia coli Potential.

Probiotics Antimicrob Proteins 2013 Jun;5(2):142-51

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Chharodi, Ahmedabad, 382481, Gujarat, India.

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http://dx.doi.org/10.1007/s12602-013-9132-4DOI Listing
June 2013
6 Reads
1 Citation

Isolation and characterization of probiotic properties of Lactobacilli isolated from rat fecal microbiota.

Microbiol Immunol 2013 Jun;57(6):407-16

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Chharodi, Ahmedabad 382481, Gujarat.

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http://dx.doi.org/10.1111/1348-0421.12054DOI Listing
June 2013
6 Reads
5 Citations
1.310 Impact Factor

Bacteriocin PJ4 active against enteric pathogen produced by Lactobacillus helveticus PJ4 isolated from gut microflora of wistar rat (Rattus norvegicus): partial purification and characterization of bacteriocin.

Appl Biochem Biotechnol 2013 Apr 1;169(7):2088-100. Epub 2013 Feb 1.

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Chharodi, Ahmedabad 382481 Gujarat, India.

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http://link.springer.com/content/pdf/10.1007/s12010-012-0044
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http://link.springer.com/10.1007/s12010-012-0044-7
Publisher Site
http://dx.doi.org/10.1007/s12010-012-0044-7DOI Listing
April 2013
8 Reads
3 Citations
1.740 Impact Factor

Plant Extracts as Anti-cancer Agents.

LAP Lambert Academic Publishing GmbH & Co. KG (Germany)

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2012
2 Reads

The ART Industry – The Legal, Ethical and Health Issues in Surrogacy and ART.

In: A.B. Prasad and M. Rao (Eds): Law, Science & Society: Dynamics, Dilemmas, Disparities

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March 2012
3 Reads

Cathepsin D: A Novel Target for Apoptotic Induction, as a Future Anti-Cancer Therapy.

Journal of Physiology and Pharmacology Advances

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March 2012
3 Reads

Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: an in vitro study.

J Ethnopharmacol 2011 Jun 6;136(2):363-7. Epub 2011 May 6.

Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Village - Chharodi, Ahmedabad, Gujarat 382481, India.

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http://dx.doi.org/10.1016/j.jep.2011.04.066DOI Listing
June 2011
6 Reads
4 Citations
3.000 Impact Factor

In vitro antibacterial activity in seed extracts of Manilkara zapota, Anona squamosa, and Tamarindus indica.

Biol Res 2010 24;43(2):165-8. Epub 2010 Sep 24.

Department of Biochemistry & Biotechnology, Institute of Science Nirma, University of Science & Technology, Gujarat, India.

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http://dx.doi.org//S0716-97602010000200003DOI Listing
May 2011
6 Reads
1 Citation
1.480 Impact Factor

Combinational system for the treatment of textile waste water: a future perspective

Asian Journal of Water and Environmental Pollution

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March 2011
3 Reads

Antimicrobial Peptides and its Role in Gastro-Intestinal Diseases: a Review.

Journal of Animal Sciences Advances

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January 2011
2 Reads

Reversal of Pseudomonas infections by plant extracts.

LAP Lambert Academic Publishing GmbH & Co. KG (Germany),

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2010
3 Reads

In vitro antibacterial activity in seed extracts of Manilkara zapota, Anona squamosa, and Tamarindus indica

Vijay Kothari, Sriram Seshadri, 2010, 'In vitro antibacterial activity in seed extracts of Manilkara zapota, Anona squamosa, and Tamarindus indica', Biological Research, vol. 43, no. 2

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2010
2 Reads

Intrinsically unstructured proteins: Potential targets for drug discovery

Pathan Salma, Chintan Chhatbar, Sriram Seshadri, 2009, 'Intrinsically Unstructured Proteins: Potential Targets for Drug Discovery', American Journal of Infectious Diseases, vol. 5, no. 2, pp. 133-141

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2009
3 Reads

Pathogenesis-Related Proteins for the Plant Protection

Asian Journal of Experimental Sciences

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March 2008
3 Reads

Pathogenic Plant Toxins as an Agent for Bioterrorism.

In: A.L. Bhatia and S.K. Kulshrestha (Eds): Bioterrorism and Biological Warfare

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January 2008
2 Reads

Efficacy trial on the purified compounds of the seeds of Carica papaya for male contraception in albino rat.

Reprod Toxicol 2005 May-Jun;20(1):135-48

Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302004, India.

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http://dx.doi.org/10.1016/j.reprotox.2004.11.015DOI Listing
July 2005
11 Reads
3 Citations
3.230 Impact Factor

Safety evaluation of long-term vas occlusion with styrene maleic anhydride and its non-invasive reversal on accessory reproductive organs in langurs.

Asian J Androl 2005 Jun;7(2):195-204

Department of Zoology, University of Rajasthan, Jaipur-302 004, India.

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http://dx.doi.org/10.1111/j.1745-7262.2005.00011.xDOI Listing
June 2005
5 Reads
3 Citations
2.530 Impact Factor

Preclinical evaluation for noninvasive reversal following long-term vas occlusion with styrene maleic anhydride in langur monkeys.

Contraception 2005 Mar;71(3):214-26

Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur-302 004, India.

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http://dx.doi.org/10.1016/j.contraception.2004.08.016DOI Listing
March 2005
7 Reads
6 Citations
2.340 Impact Factor

Ultrastructural changes in the testis and epididymis of rats following treatment with the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya.

Phytother Res 2004 Apr;18(4):285-9

Reproductive Physiology Section, Department of Zoology University of Rajasthan, Jaipur-302 004, India.

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http://dx.doi.org/10.1002/ptr.1386DOI Listing
April 2004
5 Reads
2 Citations
2.400 Impact Factor

Status of spermatogenesis and sperm parameters in langur monkeys following long-term vas occlusion with styrene maleic anhydride.

J Androl 2003 Jul-Aug;24(4):501-9

Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur, India.

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December 2003
32 Reads
2 Citations
2.473 Impact Factor

Current advances in male contraception.

Reproductive Biology and Comparative Endocrinology

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March 2002
3 Reads

Chloroform extract of Carica papaya seeds induces long-term reversible azoospermia in langur monkey.

Asian J Androl 2002 Mar;4(1):17-26

Department of Zoology, University of Rajasthan, Jaipur, India.

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March 2002
22 Reads
8 Citations
2.530 Impact Factor

Preclinical evaluation for noninvasive reversal following long-term vas occlusion with styrene maleic anhydride in langur monkeys

Nirmal K. Lohiya, Boomi Manivannan, Pradyumma K. Mishra, Seshadri Sriram, Satish S. Bhande, Subbarayalu Panneerdoss, 2005, 'Preclinical evaluation for noninvasive reversal following long-term vas occlusion with styrene maleic anhydride in langur monkeys', Contraception, vol. 71, no. 3, pp. 21

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1969
3 Reads

Hydroalcoholic Extracts of Eclipta Alba as a Reversal Agent in Boric Acid Induced Male Reproductive Toxicity

Pooja Nair, Nidhi Vora, Kaveri Purandhar, Vishal Kamle, Sriram Seshadri, 2012, 'Hydroalcoholic Extracts of Eclipta Alba as a Reversal Agent in Boric Acid Induced Male Reproductive Toxicity', Zoologica Poloniae, vol. 57, no. 1-4

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1969
3 Reads

Top co-authors

Prasant Kumar Jena
Prasant Kumar Jena

Institute of Science

14
Bhumika Prajapati
Bhumika Prajapati

Nirma University

9
S Sriram
S Sriram

RMIT University

5
Harshita Chaudhary
Harshita Chaudhary

Nirma University

5
Parimal Misra
Parimal Misra

Dr. Reddy's Institute of Life Sciences

4
Disha Trivedi
Disha Trivedi

Institute of Science

4
Tapasa Kumar Sahoo
Tapasa Kumar Sahoo

School of Life Sciences

4
Parth Rajput
Parth Rajput

Institute of Science

4
Sireesh T Kumar
Sireesh T Kumar

School of Life Sciences

3