Sriram Sankararaman

Sriram Sankararaman

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Sriram Sankararaman

Sriram Sankararaman

Publications by authors named "Sriram Sankararaman"

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37Publications

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An automated machine learning-based model predicts postoperative mortality using readily-extractable preoperative electronic health record data.

Br J Anaesth 2019 12 15;123(6):877-886. Epub 2019 Oct 15.

Department of Computer Science, University of California, Los Angeles, CA, USA; Department of Anaesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, CA, USA; Department of Biomathematics, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.bja.2019.07.030DOI Listing
December 2019

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture.

Nat Genet 2019 Aug 29;51(8):1244-1251. Epub 2019 Jul 29.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41588-019-0465-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686906PMC
August 2019

Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology.

Nat Commun 2019 07 31;10(1):3417. Epub 2019 Jul 31.

Department of Computer Science, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1038/s41467-019-11052-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668473PMC
July 2019

A statistical model for reference-free inference of archaic local ancestry.

PLoS Genet 2019 05 28;15(5):e1008175. Epub 2019 May 28.

Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

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http://dx.plos.org/10.1371/journal.pgen.1008175
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http://dx.doi.org/10.1371/journal.pgen.1008175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555542PMC
May 2019

A Comprehensive Map of Genetic Variation in the World's Largest Ethnic Group-Han Chinese.

Mol Biol Evol 2018 11;35(11):2736-2750

Department of Computer Science, University of California Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1093/molbev/msy170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693441PMC
November 2018

A unifying framework for joint trait analysis under a non-infinitesimal model.

Bioinformatics 2018 07;34(13):i195-i201

Department of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022541PMC
July 2018

A scalable estimator of SNP heritability for biobank-scale data.

Bioinformatics 2018 07;34(13):i187-i194

Department of Computer Science, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022682PMC
July 2018

Widespread Allelic Heterogeneity in Complex Traits.

Am J Hum Genet 2017 May;100(5):789-802

Department of Computer Science, University of California, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420356PMC
May 2017

Colocalization of GWAS and eQTL Signals Detects Target Genes.

Am J Hum Genet 2016 Dec 17;99(6):1245-1260. Epub 2016 Nov 17.

Department of Computer Science, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30439-6.pdf
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http://biorxiv.org/content/biorxiv/early/2016/08/29/065037.f
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http://dx.doi.org/10.1016/j.ajhg.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142122PMC
December 2016

The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.

Nature 2016 Oct 21;538(7624):201-206. Epub 2016 Sep 21.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature18964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161557PMC
October 2016

The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans.

Curr Biol 2016 05 28;26(9):1241-7. Epub 2016 Mar 28.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/current-biology/pdf/S0960-9822(16)30247-
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http://dx.doi.org/10.1016/j.cub.2016.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864120PMC
May 2016

A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years.

Proc Natl Acad Sci U S A 2016 May 2;113(20):5652-7. Epub 2016 May 2.

Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142; Department of Genetics, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1514696113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878468PMC
May 2016

Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates.

Am J Hum Genet 2015 Dec 12;97(6):775-89. Epub 2015 Nov 12.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2015.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678427PMC
December 2015

Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns.

Proc Natl Acad Sci U S A 2015 Nov 19;112(44):13621-6. Epub 2015 Oct 19.

Department of Medicine, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1501741112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640764PMC
November 2015

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes.

PLoS Genet 2015 Nov 12;11(11):e1005550. Epub 2015 Nov 12.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642934PMC
November 2015

Evidence for archaic adaptive introgression in humans.

Nat Rev Genet 2015 Jun 12;16(6):359-71. Epub 2015 May 12.

Molecular and Cell Biology Unit, School of Natural Sciences, University of California, Merced, Merced, California 95343, USA.

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http://dx.doi.org/10.1038/nrg3936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478293PMC
June 2015

Inferring parental genomic ancestries using pooled semi-Markov processes.

Bioinformatics 2015 Jun;31(12):i190-6

Microsoft Research, One Memorial Drive, Cambridge, MA 02142, USA, Blavatnik School of Computer Science, Tel Aviv University, Tel-Aviv 69978, Israel, Department of Bioengineering and Therapeutic Sciences and Department of Medicine, University of California, San Francisco, CA 94158 and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/bioinformatics/btv239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765873PMC
June 2015

The genomic landscape of Neanderthal ancestry in present-day humans.

Nature 2014 Mar 29;507(7492):354-7. Epub 2014 Jan 29.

1] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA [3] Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature12961
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http://dx.doi.org/10.1038/nature12961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072735PMC
March 2014

Estimating and interpreting FST: the impact of rare variants.

Genome Res 2013 Sep 16;23(9):1514-21. Epub 2013 Jul 16.

Harvard-Massachusetts Institute of Technology (MIT), Division of Health, Science, and Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gr.154831.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759727PMC
September 2013

The date of interbreeding between Neandertals and modern humans.

PLoS Genet 2012 4;8(10):e1002947. Epub 2012 Oct 4.

Department of Genetics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464203PMC
March 2013

Phylogenetic inference via sequential Monte Carlo.

Syst Biol 2012 Jul 4;61(4):579-93. Epub 2012 Jan 4.

Department of Statistics, University of British Columbia, Vancouver, BC V6T 1Z2, Canada.

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http://dx.doi.org/10.1093/sysbio/syr131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376373PMC
July 2012

Active site prediction using evolutionary and structural information.

Bioinformatics 2010 Mar 14;26(5):617-24. Epub 2010 Jan 14.

Computer Science Division, University of California, Berkeley, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btq008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828116PMC
March 2010

Genomic privacy and limits of individual detection in a pool.

Nat Genet 2009 Sep 23;41(9):965-7. Epub 2009 Aug 23.

Computer Science Division, University of California, Berkeley, Berkeley, California, USA.

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http://dx.doi.org/10.1038/ng.436DOI Listing
September 2009

INTREPID: a web server for prediction of functionally important residues by evolutionary analysis.

Nucleic Acids Res 2009 Jul 13;37(Web Server issue):W390-5. Epub 2009 May 13.

Department of Computer Science, University of California, Berkeley, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkp339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703888PMC
July 2009

Inference of locus-specific ancestry in closely related populations.

Bioinformatics 2009 Jun;25(12):i213-21

International Computer Science Institute, Computer Science Division, University of California, Berkeley, CA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btp197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687951PMC
June 2009

ResBoost: characterizing and predicting catalytic residues in enzymes.

BMC Bioinformatics 2009 Jun 27;10:197. Epub 2009 Jun 27.

Department of Computer Science, University of North Carolina at Chapel Hill, USA.

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http://dx.doi.org/10.1186/1471-2105-10-197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713229PMC
June 2009

INTREPID--INformation-theoretic TREe traversal for Protein functional site IDentification.

Bioinformatics 2008 Nov 6;24(21):2445-52. Epub 2008 Sep 6.

Department of Electrical Engineering & Computer Science and Department of Bioengineering, University of California, Berkeley, USA.

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http://dx.doi.org/10.1093/bioinformatics/btn474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572704PMC
November 2008

On the inference of ancestries in admixed populations.

Genome Res 2008 Apr 18;18(4):668-75. Epub 2008 Mar 18.

Computer Science Division, University of California Berkeley, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1101/gr.072751.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279254PMC
April 2008

Estimating local ancestry in admixed populations.

Am J Hum Genet 2008 Feb;82(2):290-303

Computer Science Deptartment, University of California, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1016/j.ajhg.2007.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664993PMC
February 2008