Srinivasa P S Rao

Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom.

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January 2020

Drug Discovery for Kinetoplastid Diseases: Future Directions.

Authors:

Srinivasa P S Rao Michael P Barrett Glenn Dranoff Christopher J Faraday Claudio R Gimpelewicz Asrat Hailu Catherine L Jones John M Kelly Janis K Lazdins-Helds Pascal Mäser Jose Mengel Jeremy C Mottram Charles E Mowbray David L Sacks Phillip Scott Gerald F Späth Rick L Tarleton Jonathan M Spector Thierry T Diagana

ACS Infect Dis 2019 02 13;5(2):152-157. Epub 2018 Dec 13.

Novartis Institute for Tropical Diseases (NITD) , 5300 Chiron Way , Emeryville , California 94608 , United States.

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February 2019

Toward More Drug Like Inhibitors of Trypanosome Alternative Oxidase.

Authors:

Ryan A West Thomas Cunningham Lewis E Pennicott Srinivasa P S Rao Simon E Ward

ACS Infect Dis 2018 04 30;4(4):592-604. Epub 2018 Jan 30.

Sussex Drug Discovery Centre , University of Sussex , Brighton , BN1 9QJ , United Kingdom.

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April 2018

African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase.

Authors:

Ryan A West Oran G O'Doherty Trevor Askwith John Atack Paul Beswick Jamie Laverick Michael Paradowski Lewis E Pennicott Srinivasa P S Rao Gareth Williams Simon E Ward

Eur J Med Chem 2017 Dec 6;141:676-689. Epub 2017 Oct 6.

Sussex Drug Discovery Centre, University of Sussex, Brighton, BN1 9QJ, UK; Medicines Discovery Institute, Cardiff University, Park Place, Cardiff, CF10 3AT, UK. Electronic address:

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December 2017

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.

Nature 2016 09 8;537(7619):229-233. Epub 2016 Aug 8.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.

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September 2016

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.

J Med Chem 2015 Dec 20;58(23):9371-81. Epub 2015 Nov 20.

Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.

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December 2015

Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents.

Authors:

Pearly Shuyi Ng Ujjini H Manjunatha Srinivasa P S Rao Luis R Camacho Ngai Ling Ma Maxime Herve Christian G Noble Anne Goh Stefan Peukert Thierry T Diagana Paul W Smith Ravinder Reddy Kondreddi

Eur J Med Chem 2015 Dec 14;106:144-56. Epub 2015 Oct 14.

Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore 138670, Singapore. Electronic address:

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December 2015

Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents.

Authors:

Suresh B Lakshminarayana Tan Bee Huat Paul C Ho Ujjini H Manjunatha Véronique Dartois Thomas Dick Srinivasa P S Rao

J Antimicrob Chemother 2015 Mar 11;70(3):857-67. Epub 2014 Nov 11.

Novartis Institute for Tropical Diseases, Singapore.

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March 2015

Direct inhibitors of InhA are active against Mycobacterium tuberculosis.

Sci Transl Med 2015 Jan;7(269):269ra3

Novartis Institute for Tropical Diseases, 138670 Singapore, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore, Singapore.

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January 2015

Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.

ACS Med Chem Lett 2013 May 1;4(5):451-5. Epub 2013 Apr 1.

Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore.

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May 2013

Targeting Lipid Esterases in Mycobacteria Grown Under Different Physiological Conditions Using Activity-based Profiling with Tetrahydrolipstatin (THL).

Authors:

Madhu Sudhan Ravindran Srinivasa P S Rao Xiamin Cheng Ankit Shukla Amaury Cazenave-Gassiot Shao Q Yao Markus R Wenk

Mol Cell Proteomics 2014 Feb 1;13(2):435-448. Epub 2020 Oct 1.

NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456;; Department of Biochemistry, Yong Loo Lin School of Medicine, NUS, Singapore 117456;; Department of Biological Sciences, National University of Singapore, Singapore 117456;; Swiss Tropical and Public Health Institute, University of Basel, 4051 Basel, Switzerland. Electronic address:

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February 2014

Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity-based profiling with tetrahydrolipstatin (THL).

Authors:

Madhu Sudhan Ravindran Srinivasa P S Rao Xiamin Cheng Ankit Shukla Amaury Cazenave-Gassiot Shao Q Yao Markus R Wenk

Mol Cell Proteomics 2014 Feb 17;13(2):435-48. Epub 2013 Dec 17.

NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456;

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February 2014

Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis.

Sci Transl Med 2013 Dec;5(214):214ra168

Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.

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December 2013

Design, synthesis, and biological evaluation of indole-2-carboxamides: a promising class of antituberculosis agents.

Authors:

Ravinder Reddy Kondreddi Jan Jiricek Srinivasa P S Rao Suresh B Lakshminarayana Luis R Camacho Ranga Rao Maxime Herve Pablo Bifani Ngai Ling Ma Kelli Kuhen Anne Goh Arnab K Chatterjee Thomas Dick Thierry T Diagana Ujjini H Manjunatha Paul W Smith

J Med Chem 2013 Nov 22;56(21):8849-59. Epub 2013 Oct 22.

Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, Singapore 138670.

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November 2013

Structural basis of mycobacterial inhibition by cyclomarin A.

Authors:

Dileep Vasudevan Srinivasa P S Rao Christian G Noble

J Biol Chem 2013 Oct 10;288(43):30883-91. Epub 2013 Sep 10.

From the Novartis Institute for Tropical Diseases, 05-01 Chromos, Singapore 138670.

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October 2013

Exploring the mode of action of bioactive compounds by microfluidic transcriptional profiling in mycobacteria.

Authors:

Paul Murima Paola Florez de Sessions Vivian Lim Ahmad Nazri Mohamed Naim Pablo Bifani Helena I M Boshoff Vasan K Sambandamurthy Thomas Dick Martin L Hibberd Mark Schreiber Srinivasa P S Rao

PLoS One 2013 31;8(7):e69191. Epub 2013 Jul 31.

Novartis Institute for Tropical Diseases, Singapore, Singapore.

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April 2014

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.

Nat Med 2013 Sep 4;19(9):1157-60. Epub 2013 Aug 4.

1] Institut Pasteur Korea, Sampyeong-dong, Seongnam-si, Gyeonggi-do, Korea. [2].

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September 2013

Characterization of phosphofructokinase activity in Mycobacterium tuberculosis reveals that a functional glycolytic carbon flow is necessary to limit the accumulation of toxic metabolic intermediates under hypoxia.

Authors:

Wai Yee Phong Wenwei Lin Srinivasa P S Rao Thomas Dick Sylvie Alonso Kevin Pethe

PLoS One 2013 7;8(2):e56037. Epub 2013 Feb 7.

Novartis Institute for Tropical Diseases, Singapore, Singapore.

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August 2013

A novel F(420) -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents.

Authors:

Meera Gurumurthy Martin Rao Tathagata Mukherjee Srinivasa P S Rao Helena I Boshoff Thomas Dick Clifton E Barry Ujjini H Manjunatha

Mol Microbiol 2013 Feb 28;87(4):744-55. Epub 2012 Dec 28.

Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01, Singapore 138670, Singapore.

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February 2013

Solution structure of subunit γ (γ(1-204)) of the Mycobacterium tuberculosis F-ATP synthase and the unique loop of γ(165-178), representing a novel TB drug target.

Authors:

Ragunathan Priya Goran Biuković Malathy Sony Subramanian Manimekalai Jackwee Lim Srinivasa P S Rao Gerhard Grüber

J Bioenerg Biomembr 2013 Feb 27;45(1-2):121-9. Epub 2012 Oct 27.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Republic of Singapore.

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February 2013

Variations of subunit {varepsilon} of the Mycobacterium tuberculosis F1Fo ATP synthase and a novel model for mechanism of action of the tuberculosis drug TMC207.

Authors:

Goran Biukovic Sandip Basak Malathy Sony Subramanian Manimekalai Sankaranarayanan Rishikesan Manfred Roessle Thomas Dick Srinivasa P S Rao Cornelia Hunke Gerhard Grüber

Antimicrob Agents Chemother 2013 Jan 22;57(1):168-76. Epub 2012 Oct 22.

School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore.

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January 2013

A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis.

ACS Chem Biol 2012 Jul 25;7(7):1190-7. Epub 2012 Apr 25.

Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, United States.

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July 2012

The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease.

Authors:

Esther K Schmitt Meliana Riwanto Vasan Sambandamurthy Silvio Roggo Charlotte Miault Christian Zwingelstein Philipp Krastel Christian Noble David Beer Srinivasa P S Rao Melvin Au Pornwaratt Niyomrattanakit Viviam Lim Jun Zheng Douglas Jeffery Kevin Pethe Luis R Camacho

Angew Chem Int Ed Engl 2011 Jun 11;50(26):5889-91. Epub 2011 May 11.

Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.

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June 2011

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.

Nat Commun 2010 Aug 24;1:57. Epub 2010 Aug 24.

Novartis Institute for Tropical Diseases, #05-01 Chromos, Singapore 138670, Singapore.

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August 2010

Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin.

Authors:

Kai Leng Low Guanghou Shui Klaus Natter Wee Kiang Yeo Sepp D Kohlwein Thomas Dick Srinivasa P S Rao Markus R Wenk

J Biol Chem 2010 Jul 6;285(28):21662-70. Epub 2010 May 6.

NUS Graduate School for Integrative Sciences and Engineering, Yong Loo Lin Schoolof Medicine, Singapore.

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July 2010

Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability.

Authors:

Martin Gengenbacher Srinivasa P S Rao Kevin Pethe Thomas Dick

Microbiology (Reading) 2010 Jan 1;156(Pt 1):81-87. Epub 2009 Oct 1.

Novartis Institute for Tropical Diseases Pte Ltd, 10 Biopolis Road, #05-01 Chromos, 138670, Singapore.

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January 2010

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