Srilatha Sakamuru

Srilatha Sakamuru

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Srilatha Sakamuru

Srilatha Sakamuru

Publications by authors named "Srilatha Sakamuru"

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35Publications

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Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library.

Environ Health Perspect 2019 Sep 30;127(9):97009. Epub 2019 Sep 30.

National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP5314DOI Listing
September 2019

Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays.

Molecules 2019 Feb 27;24(5). Epub 2019 Feb 27.

National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Bethesda, MD 20814, USA.

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http://dx.doi.org/10.3390/molecules24050841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429183PMC
February 2019

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library.

Toxicol Sci 2019 01;167(1):282-292

Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1093/toxsci/kfy242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657574PMC
January 2019

Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice.

J Med Chem 2019 01 10;62(2):727-741. Epub 2019 Jan 10.

Department of Pharmaceutical Sciences , University of Maryland School of Pharmacy , Baltimore , Maryland 21201 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01408DOI Listing
January 2019

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

ACS Cent Sci 2018 Dec 5;4(12):1727-1741. Epub 2018 Dec 5.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/acscentsci.8b00747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311695PMC
December 2018

Identification of Angiogenesis Inhibitors Using a Co-culture Cell Model in a High-Content and High-Throughput Screening Platform.

SLAS Technol 2018 06 18;23(3):217-225. Epub 2017 Sep 18.

1 Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1177/2472630317729792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032403PMC
June 2018

Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease.

Antiviral Res 2018 02 27;150:217-225. Epub 2017 Dec 27.

Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA; Department of Biomedical Sciences, School of Public Health, University at Albany, PO Box 509, Empire State Plaza, Albany NY 12201, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01663542173045
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http://dx.doi.org/10.1016/j.antiviral.2017.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892443PMC
February 2018

Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles.

Sci Rep 2018 02 28;8(1):3783. Epub 2018 Feb 28.

Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, 20850, USA.

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http://dx.doi.org/10.1038/s41598-018-22046-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830476PMC
February 2018

Mitochondrial Membrane Potential Assay.

Methods Mol Biol 2016 ;1473:17-22

National Center for Advancing Translational Sciences, National Institutes of Health, Building C, MSC: 3375, 9800 Medical Center Drive, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/978-1-4939-6346-1_2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375165PMC
January 2018

Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Signaling Pathway.

Methods Mol Biol 2016 ;1473:23-31

National Center for Advancing Translational Sciences, National Institutes of Health, Building C, MSC: 3375, 9800 Medical Center Drive, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/978-1-4939-6346-1_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375166PMC
January 2018

Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening.

J Appl Toxicol 2017 02 3;37(2):167-180. Epub 2016 May 3.

National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA.

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http://doi.wiley.com/10.1002/jat.3334
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http://dx.doi.org/10.1002/jat.3334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094908PMC
February 2017

A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.

Cancer Res 2016 07 4;76(14):4183-91. Epub 2016 Jun 4.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland. Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea. Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033673PMC
July 2016

Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.

Toxicol In Vitro 2016 Apr 25;32:287-96. Epub 2016 Jan 25.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.tiv.2016.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779714PMC
April 2016

Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.

Nat Commun 2016 Jan 26;7:10425. Epub 2016 Jan 26.

Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.

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http://dx.doi.org/10.1038/ncomms10425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777217PMC
January 2016

Identification of known drugs targeting the endoplasmic reticulum stress response.

Anal Bioanal Chem 2015 Jul 30;407(18):5343-51. Epub 2015 Apr 30.

Life Science Solutions Group, Thermo Fisher Scientific, Rockford, IL, 61105, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs00216-015-86
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http://link.springer.com/10.1007/s00216-015-8694-2
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http://dx.doi.org/10.1007/s00216-015-8694-2DOI Listing
July 2015

Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening.

Chem Res Toxicol 2013 Sep 15;26(9):1323-32. Epub 2013 Aug 15.

National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/tx4001754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154066PMC
September 2013

Identification of repurposed small molecule drugs for chordoma therapy.

Cancer Biol Ther 2013 Jul 10;14(7):638-47. Epub 2013 May 10.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cbt.24596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742493PMC
July 2013

Application of a homogenous membrane potential assay to assess mitochondrial function.

Physiol Genomics 2012 May 20;44(9):495-503. Epub 2012 Mar 20.

NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892-3370, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00161.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426425PMC
May 2012

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

Proc Natl Acad Sci U S A 2012 Apr 19;109(14):5423-8. Epub 2012 Mar 19.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1114278109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325711PMC
April 2012

Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors.

Bioorg Med Chem Lett 2011 Sep 21;21(18):5239-43. Epub 2011 Jul 21.

NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Dr., Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.07.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681418PMC
September 2011

Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Environ Health Perspect 2011 Aug 4;119(8):1142-8. Epub 2011 May 4.

National Institutes of Health Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-3370, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.1002952
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http://dx.doi.org/10.1289/ehp.1002952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237348PMC
August 2011

Identification of clinically used drugs that activate pregnane X receptors.

Drug Metab Dispos 2011 Jan 21;39(1):151-9. Epub 2010 Oct 21.

National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1124/dmd.110.035105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014269PMC
January 2011

Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.

Environ Sci Technol 2010 Aug;44(15):5979-85

National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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http://dx.doi.org/10.1021/es102150zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930403PMC
August 2010

Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action.

Biochem Pharmacol 2010 May 11;79(9):1272-80. Epub 2010 Jan 11.

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bcp.2009.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834878PMC
May 2010

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway.

Mol Cancer 2009 Dec 9;8:117. Epub 2009 Dec 9.

NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892-3370, USA.

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http://dx.doi.org/10.1186/1476-4598-8-117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797767PMC
December 2009

HTS-compatible beta-lactamase transcriptional reporter gene assay for interrogating the heat shock response pathway.

Curr Chem Genomics 2009 Feb 5;3:1-6. Epub 2009 Feb 5.

Invitrogen Corporation, Discovery Assays and Services, 501 Charmany Drive, Madison, WI 53719, USA.

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http://dx.doi.org/10.2174/1875397300903010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793398PMC
February 2009