Sridharan Rajamani

Sridharan Rajamani

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Sridharan Rajamani

Sridharan Rajamani

Publications by authors named "Sridharan Rajamani"

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61Publications

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Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy.

Int J Cardiol 2018 07;263:54-62

Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.03.044DOI Listing
July 2018

Pro-arrhythmic effects of low plasma [K] in human ventricle: An illustrated review.

Trends Cardiovasc Med 2018 05 24;28(4):233-242. Epub 2017 Nov 24.

Faculties of Kinesiology and Medicine, University of Calgary, 2500 University Drive, Calgary T2N 1N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2017.11.002DOI Listing
May 2018

Selective inhibition of physiological late Na current stabilizes ventricular repolarization.

Am J Physiol Heart Circ Physiol 2018 02 29;314(2):H236-H245. Epub 2017 Sep 29.

Department of Biology, Gilead Sciences, Fremont, California.

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http://dx.doi.org/10.1152/ajpheart.00071.2017DOI Listing
February 2018

Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.

Cardiovasc Res 2017 Jun;113(7):829-838

Department of Clinical and Experimental Cardiology/Heart Centre, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22660, 1100 DD Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvx077DOI Listing
June 2017

Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model.

Heart Rhythm 2017 03 21;14(3):448-454. Epub 2016 Oct 21.

Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2016.10.021DOI Listing
March 2017

Early somatic mosaicism is a rare cause of long-QT syndrome.

Proc Natl Acad Sci U S A 2016 10 28;113(41):11555-11560. Epub 2016 Sep 28.

Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305; Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1607187113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068256PMC
October 2016

Inhibition of late Na+ current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats.

Am J Physiol Heart Circ Physiol 2016 05 18;310(10):H1313-20. Epub 2016 Mar 18.

Department of Cardiovascular Biology, Gilead Sciences, Fremont, California.

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http://dx.doi.org/10.1152/ajpheart.00863.2015DOI Listing
May 2016

Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin.

Am J Physiol Heart Circ Physiol 2016 Feb 4;310(3):H426-35. Epub 2015 Dec 4.

Department of Biology, Gilead Sciences Inc., Foster City, California.

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http://dx.doi.org/10.1152/ajpheart.00520.2015DOI Listing
February 2016

The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model.

J Cardiovasc Electrophysiol 2015 Dec 30;26(12):1364-9. Epub 2015 Oct 30.

Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/jce.12824DOI Listing
December 2015

Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction.

Heart Rhythm 2015 May 23;12(5):1036-45. Epub 2015 Jan 23.

Department of Biology, Gilead Sciences, Fremont, California. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2015.01.029DOI Listing
May 2015

Combined actions of ivabradine and ranolazine reduce ventricular rate during atrial fibrillation.

J Cardiovasc Electrophysiol 2015 Mar 5;26(3):329-35. Epub 2014 Dec 5.

Department of Medicine, Beth Israel Deaconess Medical Center; Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/jce.12569DOI Listing
March 2015

Cardiac late Na⁺ current: proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress.

Heart Rhythm 2015 Feb 11;12(2):440-8. Epub 2014 Nov 11.

Former Consultant to Gilead Sciences, Foster City, California.

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http://dx.doi.org/10.1016/j.hrthm.2014.11.009DOI Listing
February 2015

Blockade of Na+ channels in pancreatic α-cells has antidiabetic effects.

Diabetes 2014 Oct 8;63(10):3545-56. Epub 2014 May 8.

Department of Biology, Cardiovascular Therapeutic Area, Gilead Sciences, Inc., Fremont, CA.

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http://dx.doi.org/10.2337/db13-1562DOI Listing
October 2014

The role of late I Na in development of cardiac arrhythmias.

Handb Exp Pharmacol 2014 ;221:137-68

Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY, 13501, USA,

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http://dx.doi.org/10.1007/978-3-642-41588-3_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076160PMC
July 2014

Ranolazine reduces neuronal excitability by interacting with inactivated states of brain sodium channels.

Mol Pharmacol 2014 Jan 7;85(1):162-74. Epub 2013 Nov 7.

Department of Biology (Cardiovascular Therapeutic Area), Gilead Sciences, Inc., Foster City and Fremont, California (K.M.K., R.H., L.L., L.B., S.R.); Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (A.L.G.).

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http://dx.doi.org/10.1124/mol.113.088492DOI Listing
January 2014

Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations.

Front Physiol 2013 17;4:282. Epub 2013 Oct 17.

Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano, Universitat Politècnica de València Valencia, Spain.

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http://journal.frontiersin.org/article/10.3389/fphys.2013.00
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http://dx.doi.org/10.3389/fphys.2013.00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797961PMC
October 2013

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

Cardiovasc Res 2013 Sep 10;99(4):600-11. Epub 2013 Jun 10.

Department of Biology, Cardiovascular Therapeutic Area, Gilead Sciences, Foster City, CA, USA.

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http://dx.doi.org/10.1093/cvr/cvt145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841414PMC
September 2013

Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: prolongation of interatrial conduction time and increase in post-repolarization refractoriness.

Europace 2013 May 1;15(5):761-9. Epub 2013 Feb 1.

Division of Electrophysiology, Department of Cardiovascular Medicine, University Hospital of Münster, Albert-Schweitzer Campus 1, Münster, Germany.

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http://dx.doi.org/10.1093/europace/eus399DOI Listing
May 2013

Effect of ranolazine on ventricular repolarization in class III antiarrhythmic drug-treated rabbits.

Heart Rhythm 2012 Dec 28;9(12):2051-8. Epub 2012 Aug 28.

Division of Electrophysiology, Department of Cardiovascular Medicine, University of Münster, Münster, Germany

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http://dx.doi.org/10.1016/j.hrthm.2012.08.029DOI Listing
December 2012

Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure.

PLoS One 2012 12;7(3):e32659. Epub 2012 Mar 12.

Instituto de Investigación Interuniversitario en Bioingeniería y Tecnología Orientada al Ser Humano, Universitat Politècnica de València, Valencia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032659PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299678PMC
August 2012

Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine.

Neuropharmacology 2012 Jun 2;62(7):2251-60. Epub 2012 Feb 2.

Department of Biology, Gilead Sciences Inc., 1651 Page Mill Road, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2012.01.021DOI Listing
June 2012

Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.

Am J Physiol Cell Physiol 2011 Sep 15;301(3):C577-86. Epub 2011 Jun 15.

Department of Biology, Gilead Sciences, Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1152/ajpcell.00125.2011DOI Listing
September 2011

Ranolazine block of human Na v 1.4 sodium channels and paramyotonia congenita mutants.

Channels (Austin) 2011 Mar-Apr;5(2):161-72. Epub 2011 Mar 1.

Department of Biology,Gilead Sciences, Palo Alto, CA, USA.

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http://dx.doi.org/10.4161/chan.5.2.14851DOI Listing
July 2011

Use-dependent block of cardiac late Na(+) current by ranolazine.

Heart Rhythm 2009 Nov 28;6(11):1625-31. Epub 2009 Jul 28.

Department of Biology, Gilead Sciences, Inc., Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1016/j.hrthm.2009.07.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879577PMC
November 2009

Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart.

Am J Physiol Heart Circ Physiol 2009 Sep 10;297(3):H1048-57. Epub 2009 Jul 10.

Pharmacological Sciences, Gilead Sciences, Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1152/ajpheart.00467.2009DOI Listing
September 2009

Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine.

Channels (Austin) 2008 Nov-Dec;2(6):449-60. Epub 2008 Nov 7.

Department of Pharmacological Sciences, CV Therapeutics, Inc., Palo Alto, California 94304, USA.

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http://dx.doi.org/10.4161/chan.2.6.7362DOI Listing
April 2009

Rapid kinetic interactions of ranolazine with HERG K+ current.

J Cardiovasc Pharmacol 2008 Jun;51(6):581-9

Department of Pharmacological Sciences, CV Therapeutics, Inc., Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1097/FJC.0b013e3181799690DOI Listing
June 2008

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

Cardiovasc Res 2008 Feb 13;77(3):481-8. Epub 2007 Nov 13.

Department of Pharmacological Sciences, CV Therapeutics, Inc. 3172 Porter Drive, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1093/cvr/cvm069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365898PMC
February 2008

Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr).

Am J Physiol Heart Circ Physiol 2006 Mar 14;290(3):H1278-88. Epub 2005 Oct 14.

Department of Medicine (Cardiology), University of Wisconsin, Madison 53792, USA.

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http://dx.doi.org/10.1152/ajpheart.00777.2005DOI Listing
March 2006

Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome.

Br J Pharmacol 2005 May;145(1):3-4

Department of Medicine (Cardiology), University of Wisconsin, Madison, WI 53792, USA.

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http://dx.doi.org/10.1038/sj.bjp.0706143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576114PMC
May 2005

Biology of cardiac arrhythmias: ion channel protein trafficking.

Circ Res 2004 Jun;94(11):1418-28

Section of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, USA.

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http://dx.doi.org/10.1161/01.RES.0000128561.28701.eaDOI Listing
June 2004

Genetic basis for the origin of cardiac arrhythmias: implications for therapy.

Curr Cardiol Rep 2002 Sep;4(5):411-7

University of Wisconsin Hospitals and Clinics, Section of Cardiovascular Medicine, Room H6/354 CSC (3248), 600 Highland Avenue, Madison, WI 53792, USA.

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September 2002

The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.

Cardiovasc Res 2002 Sep;55(4):799-805

Department of Medicine, Section of Cardiovascular Medicine, Room H6/354 CSC (3248), University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI 53792, USA.

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http://dx.doi.org/10.1016/s0008-6363(02)00448-0DOI Listing
September 2002

Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block.

Circulation 2002 Jun;105(24):2830-5

Department of Medicine, University of Wisconsin, Madison, USA.

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http://dx.doi.org/10.1161/01.cir.0000019513.50928.74DOI Listing
June 2002