Publications by authors named "Sridhar Ramaswamy"

100Publications

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.

Mol Cell 2019 08 6;75(4):683-699.e7. Epub 2019 Aug 6.

The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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August 2019

AKT1 quiescent cancer cells in ductal carcinoma in situ of the breast.

NPJ Breast Cancer 2019 21;5:10. Epub 2019 Mar 21.

5Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114 USA.

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March 2019

Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets.

BMC Bioinformatics 2019 Feb 18;20(1):83. Epub 2019 Feb 18.

The Center of Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.

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February 2019

E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression.

Dev Cell 2017 12 7;43(6):689-703.e5. Epub 2017 Dec 7.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA. Electronic address:

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December 2017

AKT1 quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer.

Breast Cancer Res 2017 Aug 1;19(1):88. Epub 2017 Aug 1.

Massachusetts General Hospital Cancer Center, Richard B. Simches Research Building, 185 Cambridge Street, Boston, MA, 02114, USA.

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August 2017

Integrin β1 activation induces an anti-melanoma host response.

PLoS One 2017 27;12(4):e0175300. Epub 2017 Apr 27.

Cancer Center, Massachusetts General Hospital, Boston, MA, United States of America.

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September 2017

Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer.

Oncotarget 2017 Mar;8(13):20572-20587

Department of Molecular Oncology, The Netherlands Cancer Institute, Plesmanlaan, CX, Amsterdam, The Netherlands.

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March 2017

ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.

Cancer Cell 2017 01 29;31(1):35-49. Epub 2016 Dec 29.

Massachusetts General Hospital Cancer Center, GRJ-904, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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January 2017

JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers.

Cancer Res 2016 09 3;76(18):5538-49. Epub 2016 Aug 3.

Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania. The Wistar Institute, Philadelphia, Pennsylvania. VA Medical Center, Philadelphia, Pennsylvania.

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September 2016

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.

Cell 2016 Jun 12;165(6):1401-1415. Epub 2016 May 12.

The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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June 2016

AKT Inhibition Promotes Nonautonomous Cancer Cell Survival.

Mol Cancer Ther 2016 Jan 4;15(1):142-53. Epub 2015 Dec 4.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Broad Institute of Harvard & MIT, Cambridge, Massachusetts. Harvard Stem Cell Institute, Cambridge, Massachusetts. Harvard-Ludwig Center for Cancer Research, Boston, Massachusetts.

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January 2016

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer.

Proc Natl Acad Sci U S A 2015 Dec 2;112(49):15148-53. Epub 2015 Nov 2.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129; Howard Hughes Medical Institute, Chevy Chase, MD 20815; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114;

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December 2015

Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment.

PLoS One 2015 13;10(10):e0140310. Epub 2015 Oct 13.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, United States of America; Dermatology and Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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June 2016

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.

Science 2015 Sep;349(6254):1351-6

Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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September 2015

Mechanisms of Cancer Cell Dormancy--Another Hallmark of Cancer?

Cancer Res 2015 Dec 9;75(23):5014-22. Epub 2015 Sep 9.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Harvard Stem Cell Institute, Cambridge, Massachusetts. Harvard-Ludwig Center for Cancer Research, Boston, Massachusetts.

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December 2015

A microfluidic device for label-free, physical capture of circulating tumor cell clusters.

Nat Methods 2015 Jul 18;12(7):685-91. Epub 2015 May 18.

1] Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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July 2015

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

Nat Cell Biol 2015 May 27;17(5):545-57. Epub 2015 Apr 27.

1] The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA [2] The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA.

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May 2015

The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.

J Biol Chem 2015 Jun 16;290(23):14381-90. Epub 2015 Apr 16.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129 and From the Departments of Medicine and Howard Hughes Medical Institute, Chevy Chase, Maryland 20815

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June 2015

MAPK7 Regulates EMT Features and Modulates the Generation of CTCs.

Mol Cancer Res 2015 May 12;13(5):934-43. Epub 2015 Feb 12.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts. Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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May 2015

A mechanism for asymmetric cell division resulting in proliferative asynchronicity.

Mol Cancer Res 2015 Feb 12;13(2):223-30. Epub 2015 Jan 12.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Harvard Stem Cell Institute, Cambridge, Massachusetts. Harvard-Ludwig Center for Cancer Research, Boston, Massachusetts.

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February 2015

Bioengineered implantable scaffolds as a tool to study stromal-derived factors in metastatic cancer models.

Cancer Res 2014 Dec 22;74(24):7229-38. Epub 2014 Oct 22.

Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts. Harvard Stem Cell Institute, Boston, Massachusetts.

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December 2014

Small molecules facilitate rapid and synchronous iPSC generation.

Nat Methods 2014 Nov 24;11(11):1170-6. Epub 2014 Sep 24.

1] Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [3] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA. [4] Department of Stem Cell and Regenerative Biology, Cambridge, Massachusetts, USA. [5] Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

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November 2014

dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.

Nucleic Acids Res 2014 Aug 22;42(14):8939-53. Epub 2014 Jul 22.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA

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August 2014

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Nature 2014 Jul 22;511(7511):616-20. Epub 2014 Jun 22.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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July 2014

Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.

Science 2014 Jul;345(6193):216-20

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.

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July 2014

SIRT6 is required for normal retinal function.

PLoS One 2014 4;9(6):e98831. Epub 2014 Jun 4.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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August 2015

Isolation and molecular characterization of circulating melanoma cells.

Cell Rep 2014 May 18;7(3):645-53. Epub 2014 Apr 18.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Howard Hughes Medical Institute, Bethesda, MD 20815, USA. Electronic address:

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May 2014

Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.

J Exp Med 2014 May 7;211(5):909-27. Epub 2014 Apr 7.

Cancer Center, 2 Center for Regenerative Medicine, and 3 Department of Pathology, Massachusetts General Hospital, 4 Harvard Medical School, Boston, MA 02114.

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May 2014

Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1.

Cell Rep 2013 Dec 19;5(6):1679-89. Epub 2013 Dec 19.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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December 2013

mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.

Cancer Discov 2014 Jan 25;4(1):42-52. Epub 2013 Oct 25.

1Massachusetts General Hospital Cancer Center; 2Department of Medicine, Harvard Medical School; 3Division of Gastroenterology, Department of Medicine, Tufts Medical Center; 4Department of Pathology, Massachusetts General Hospital, Boston; and 5Radiation Oncology, Steele Lab for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.

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January 2014

Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.

J Natl Cancer Inst 2012 Nov 20;104(21):1673-9. Epub 2012 Sep 20.

Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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November 2012

RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.

Mol Cell Biol 2012 Nov 27;32(21):4375-87. Epub 2012 Aug 27.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA.

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November 2012

A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity.

PLoS Genet 2012 5;8(4):e1002618. Epub 2012 Apr 5.

Department of Molecular Genetics, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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September 2012

Asymmetric cancer cell division regulated by AKT.

Proc Natl Acad Sci U S A 2011 Aug 14;108(31):12845-50. Epub 2011 Jul 14.

Centers for Cancer Research, Regenerative Medicine, Human Genetics Research, and Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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August 2011

Polo-like kinase 1 is a potential therapeutic target in human melanoma.

J Invest Dermatol 2011 Sep 9;131(9):1886-95. Epub 2011 Jun 9.

Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

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September 2011

MYC and metastasis.

Cancer Res 2011 Mar;71(6):2034-7

Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.

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March 2011

Prognostic signatures, cancer metastasis and MYC.

Cell Cycle 2010 Sep 3;9(18):3639. Epub 2010 Sep 3.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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September 2010

CK1epsilon is required for breast cancers dependent on beta-catenin activity.

PLoS One 2010 Feb 1;5(2):e8979. Epub 2010 Feb 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

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February 2010

Systems-level modeling of cancer-fibroblast interaction.

PLoS One 2009 Sep 3;4(9):e6888. Epub 2009 Sep 3.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America.

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September 2009

A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression.

Genes Dev 2009 Aug;23(15):1737-42

Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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August 2009

Rational design of cancer-drug combinations.

N Engl J Med 2007 Jul;357(3):299-300

Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA.

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July 2007

DNA microarrays in clinical cancer research.

Curr Mol Med 2005 Feb;5(1):111-20

Massachusetts General Hospital Cancer Center & Harvard Medical School, MA, USA.

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February 2005

Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.

Cancer Cell 2004 Dec;6(6):565-76

Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02115, USA.

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December 2004

Translating cancer genomics into clinical oncology.

N Engl J Med 2004 Apr;350(18):1814-6

Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA.

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April 2004

A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.

Cell 2003 Aug;114(3):323-34

Departments of Medical Oncology and Medicine, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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August 2003

MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma.

Am J Pathol 2003 Jul;163(1):333-43

Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Children's Hospital, Harvard Medical School, Boston, USA.

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July 2003