Publications by authors named "Sri Sunarti"

6 Publications

  • Page 1 of 1

Artificial intelligence in healthcare: opportunities and risk for future.

Gac Sanit 2021 ;35 Suppl 1:S67-S70

Department of Nursing, Universitas Muhammadiyah Kalimantan Timur, Indonesia.

Objective: This study aimed to find out the opportunity of artificial intelligence (AI) and the risk in health service.

Method: A comprehensive literature search was collected from three databases (Web of Science, Google Scholar, and EBSCOhost) to identify articles studied Implementing AI in improving in health services. Two reviewers independently assessed the quality of studies using the Joanna Briggs Institute.

Results: The application will improve diagnostics, prevention, and treatment of patients, increasing cost efficiency and equality and equality in health services. For the challenge, there is no AI adoption in public sector, patients' privacy, patient autonomy rights become problems in AI applications.

Conclusions: Implementation of AI is needed in the efficiency of health service management as well as making medical decisions. The challenge is facilitating early adoption and ongoing implementation in the health care system, and we consider some of the ethical problem lists faced by AI clinical application.
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http://dx.doi.org/10.1016/j.gaceta.2020.12.019DOI Listing
January 2021

Frailty state among Indonesian elderly: prevalence, associated factors, and frailty state transition.

BMC Geriatr 2019 07 3;19(1):182. Epub 2019 Jul 3.

Division of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: Information about frailty status and its transition is important to inform clinical decisions. Predicting frailty transition is beneficial for its prevention. While Indonesia is the 4th largest geriatric population in Asia, data about frailty transition is limited. This study aimed to obtain data on prevalence of frailty, its risk factors, frailty state transition and its prognostic factors, as well as to develop prognostic score for frailty state transition.

Methods: Multicenter study on subjects aged ≥60 years old was done to obtain the prevalence of frailty status and to identify risk factors of frailty. Prospective cohort over 12 months was done to obtain data on frailty state transition. Multiple logistic regression analysis was performed to identify its prognostic factors from several clinical data, which then were utilized to develop prognostic score for frailty state worsening.

Results: Cross-sectional data from 448 subjects showed that 25.2% of the subjects were frail based on Frailty index-40 items. Risk factors of frailty were age (OR 2.72; 95% CI 1.58-4.76), functional status (OR 2.89; 95% CI 1.79-4.67), and nutritional status (OR 3.75; 95% CI 2.29-6.13). Data from the 162 subjects who completed the cohort showed 27.2% of the cohort had frailty state worsening. Prognostic factors for frailty state worsening were being 70 years or older (OR 3.9; 95% CI 1.2-12.3, p < 0.05), negative QoL, i.e., fair and poor QoL (OR 2.5; 95% CI 1.1-5.9, p < 0.05), and slow gait speed (OR 2.8; 95% CI 1.3-6.4, p < 0.05). The internal validation of the prognostic score consisted of those three variables showed good performance.

Conclusion: The prevalence of frailty in this study among Indonesian elderly in outpatient setting was 25.2%. The risk factors of frailty were age, functional status and nutritional status. The prognostic factors for frailty state worsening were being 70 years old or older, negative QoL (fair or poor quality of life), and slow gait speed. A prognostic score to predict frailty state worsening in 12 months had been developed.
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http://dx.doi.org/10.1186/s12877-019-1198-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609407PMC
July 2019

The Role of Tomato Genes in Plant Responses to Combined Abiotic and Biotic Stresses.

Front Plant Sci 2018 13;9:801. Epub 2018 Jun 13.

Plant Breeding, Wageningen University & Research, Wageningen, Netherlands.

In the field, plants constantly face a plethora of abiotic and biotic stresses that can impart detrimental effects on plants. In response to multiple stresses, plants can rapidly reprogram their transcriptome through a tightly regulated and highly dynamic regulatory network where WRKY transcription factors can act as activators or repressors. WRKY transcription factors have diverse biological functions in plants, but most notably are key players in plant responses to biotic and abiotic stresses. In tomato there are 83 genes identified. Here we review recent progress on functions of these tomato genes and their homologs in other plant species, such as Arabidopsis and rice, with a special focus on their involvement in responses to abiotic and biotic stresses. In particular, we highlight genes that play a role in plant responses to a combination of abiotic and biotic stresses.
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http://dx.doi.org/10.3389/fpls.2018.00801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008426PMC
June 2018

Responses to combined abiotic and biotic stress in tomato are governed by stress intensity and resistance mechanism.

J Exp Bot 2016 09 19;67(17):5119-32. Epub 2016 Jul 19.

Wageningen UR Plant Breeding, Wageningen University & Research Centre, PO Box 386, 6700AJ, Wageningen, The Netherlands

Stress conditions in agricultural ecosystems can occur at variable intensities. Different resistance mechanisms against abiotic stress and pathogens are deployed by plants. Thus, it is important to examine plant responses to stress combinations under different scenarios. Here, we evaluated the effect of different levels of salt stress ranging from mild to severe (50, 100, and 150mM NaCl) on powdery mildew resistance and overall performance of tomato introgression lines with contrasting levels of partial resistance, as well as near-isogenic lines (NILs) carrying the resistance gene Ol-1 (associated with a slow hypersensitivity response; HR), ol-2 (an mlo mutant associated with papilla formation), and Ol-4 (an R gene associated with a fast HR). Powdery mildew resistance was affected by salt stress in a genotype- and stress intensity-dependent manner. In susceptible and partial resistant lines, increased susceptibility was observed under mild salt stress (50mM) which was accompanied by accelerated cell death-like senescence. In contrast, severe salt stress (150mM) reduced disease symptoms. Na(+) and Cl(-) accumulation in the leaves was linearly related to the decreased pathogen symptoms under severe stress. In contrast, complete resistance mediated by ol-2 and Ol-4 was unaffected under all treatment combinations, and was associated with a decreased growth penalty. Increased susceptibility and senescence under combined stress in NIL-Ol-1 was associated with the induction of ethylene and jasmonic acid pathway genes and the cell wall invertase gene LIN6. These results highlight the significance of stress severity and resistance type on the plant's performance under the combination of abiotic and biotic stress.
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http://dx.doi.org/10.1093/jxb/erw285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014164PMC
September 2016

Successful Treatment of Unstageable Pressure Ulcer by Using Advanced Wound Dressing.

Authors:
Sri Sunarti

Acta Med Indones 2015 Jul;47(3):251-2

Department of Internal Medicine, Faculty of Medicine, Brawijaya University - Saiful Anwar Hospital, Malang, Indonesia.

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July 2015

Profile of food and nutrient intake among Indonesian elderly population and factors associated with energy intake: a multi-centre study.

Acta Med Indones 2013 Oct;45(4):265-74

Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Aim: to obtain profile of food and nutrient intake in Indonesian elderly population and factors associated with energy intake.

Methods: multi-center cross sectional study in 13 hospitals across Indonesia was conducted among 387 elderly who had attended geriatric clinics. Data collected including demographic characteristics, functional status, cognitive status, mental status, nutritional status, food intake, present activities, and data on chronic diseases. Chi square and logistic regression tests were performed to analyze the data.

Results: most of subjects (58.4%) were women and had educational background senior high school or higher degree (61.1%). The average of energy intake was 1266.74 (336.51) kilocalories. Calcium and protein intake were below the recommended of dietary allowance. female sex (OR 0.23; 95% CI 0.139-0.390) and osteoporotic subjects (OR 0.48; 95% CI 0.25-0.93) have lower risk for having <80% RDA daily energy intake, while lower educational level (OR 1.96; 95% CI 1.21-3.18) has higher risk for having <80% RDA daily energy intake.

Conclusion: total energy intake were inadequate in the elderly. Female sex and osteoporotic subjects have lower risk for having <80% RDA daily energy intake, while lower educational level has higher risk for having <80% RDA daily energy intake.
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October 2013