Publications by authors named "Spiros Denaxas"

81Publications

Emulating a target trial in case-control designs: an application to statins and colorectal cancer.

Int J Epidemiol 2020 Sep 29. Epub 2020 Sep 29.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1093/ije/dyaa144DOI Listing
September 2020

Models for mortality require tailoring in the context of the COVID-19 pandemic - Authors' reply.

Lancet 2020 09;396(10255):883-884

Institute of Health Informatics, University College London, London NW1 1DA, UK; Health Data Research UK, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(20)31966-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515579PMC
September 2020

Using Unsupervised Learning to Identify Clinical Subtypes of Alzheimer's Disease in Electronic Health Records.

Stud Health Technol Inform 2020 Jun;270:499-503

Institute of Health Informatics, University College London, London, UK.

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http://dx.doi.org/10.3233/SHTI200210DOI Listing
June 2020

Trajectories of Disease Accumulation Using Electronic Health Records.

Stud Health Technol Inform 2020 Jun;270:469-473

Centre for Medical Image Computing, University College London.

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http://dx.doi.org/10.3233/SHTI200204DOI Listing
June 2020

Selective recruitment designs for improving observational studies using electronic health records.

Stat Med 2020 Aug 10;39(19):2556-2567. Epub 2020 Jun 10.

UCL Institute of Health Informatics, University College London, London, UK.

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http://dx.doi.org/10.1002/sim.8556DOI Listing
August 2020

Electronic Health Records to Predict Gestational Diabetes Risk.

Trends Pharmacol Sci 2020 May 1;41(5):301-304. Epub 2020 Apr 1.

The Alan Turing Institute, London, UK; Institute of Health Informatics, University College London, London, UK; Health Data Research UK, London, UK; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK; British Heart Foundation Research Accelerator, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2020.03.003DOI Listing
May 2020

Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases.

Hum Mol Genet 2020 May;29(8):1388-1395

Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London NW1 2DA, UK.

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http://dx.doi.org/10.1093/hmg/ddaa052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254844PMC
May 2020

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.

Authors:
Sonia Shah Albert Henry Carolina Roselli Honghuang Lin Garðar Sveinbjörnsson Ghazaleh Fatemifar Åsa K Hedman Jemma B Wilk Michael P Morley Mark D Chaffin Anna Helgadottir Niek Verweij Abbas Dehghan Peter Almgren Charlotte Andersson Krishna G Aragam Johan Ärnlöv Joshua D Backman Mary L Biggs Heather L Bloom Jeffrey Brandimarto Michael R Brown Leonard Buckbinder David J Carey Daniel I Chasman Xing Chen Xu Chen Jonathan Chung William Chutkow James P Cook Graciela E Delgado Spiros Denaxas Alexander S Doney Marcus Dörr Samuel C Dudley Michael E Dunn Gunnar Engström Tõnu Esko Stephan B Felix Chris Finan Ian Ford Mohsen Ghanbari Sahar Ghasemi Vilmantas Giedraitis Franco Giulianini John S Gottdiener Stefan Gross Daníel F Guðbjartsson Rebecca Gutmann Christopher M Haggerty Pim van der Harst Craig L Hyde Erik Ingelsson J Wouter Jukema Maryam Kavousi Kay-Tee Khaw Marcus E Kleber Lars Køber Andrea Koekemoer Claudia Langenberg Lars Lind Cecilia M Lindgren Barry London Luca A Lotta Ruth C Lovering Jian'an Luan Patrik Magnusson Anubha Mahajan Kenneth B Margulies Winfried März Olle Melander Ify R Mordi Thomas Morgan Andrew D Morris Andrew P Morris Alanna C Morrison Michael W Nagle Christopher P Nelson Alexander Niessner Teemu Niiranen Michelle L O'Donoghue Anjali T Owens Colin N A Palmer Helen M Parry Markus Perola Eliana Portilla-Fernandez Bruce M Psaty Kenneth M Rice Paul M Ridker Simon P R Romaine Jerome I Rotter Perttu Salo Veikko Salomaa Jessica van Setten Alaa A Shalaby Diane T Smelser Nicholas L Smith Steen Stender David J Stott Per Svensson Mari-Liis Tammesoo Kent D Taylor Maris Teder-Laving Alexander Teumer Guðmundur Thorgeirsson Unnur Thorsteinsdottir Christian Torp-Pedersen Stella Trompet Benoit Tyl Andre G Uitterlinden Abirami Veluchamy Uwe Völker Adriaan A Voors Xiaosong Wang Nicholas J Wareham Dawn Waterworth Peter E Weeke Raul Weiss Kerri L Wiggins Heming Xing Laura M Yerges-Armstrong Bing Yu Faiez Zannad Jing Hua Zhao Harry Hemingway Nilesh J Samani John J V McMurray Jian Yang Peter M Visscher Christopher Newton-Cheh Anders Malarstig Hilma Holm Steven A Lubitz Naveed Sattar Michael V Holmes Thomas P Cappola Folkert W Asselbergs Aroon D Hingorani Karoline Kuchenbaecker Patrick T Ellinor Chim C Lang Kari Stefansson J Gustav Smith Ramachandran S Vasan Daniel I Swerdlow R Thomas Lumbers

Nat Commun 2020 01 9;11(1):163. Epub 2020 Jan 9.

British Heart Foundation Research Accelerator, University College London, London, UK.

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http://dx.doi.org/10.1038/s41467-019-13690-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952380PMC
January 2020

Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma: A United Kingdom nationwide case-control study.

J Allergy Clin Immunol 2020 Mar 12;145(3):868-876. Epub 2019 Nov 12.

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2019.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057259PMC
March 2020

Natural language processing for disease phenotyping in UK primary care records for research: a pilot study in myocardial infarction and death.

J Biomed Semantics 2019 11 12;10(Suppl 1):20. Epub 2019 Nov 12.

Health Data Research UK London, University College London, 222 Euston Road, London, NW1 2DA, UK.

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http://dx.doi.org/10.1186/s13326-019-0214-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849160PMC
November 2019

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.

Authors:
Amand F Schmidt Michael V Holmes David Preiss Daniel I Swerdlow Spiros Denaxas Ghazaleh Fatemifar Rupert Faraway Chris Finan Dennis Valentine Zammy Fairhurst-Hunter Fernando Pires Hartwig Bernardo Lessa Horta Elina Hypponen Christine Power Max Moldovan Erik van Iperen Kees Hovingh Ilja Demuth Kristina Norman Elisabeth Steinhagen-Thiessen Juri Demuth Lars Bertram Christina M Lill Stefan Coassin Johann Willeit Stefan Kiechl Karin Willeit Dan Mason John Wright Richard Morris Goya Wanamethee Peter Whincup Yoav Ben-Shlomo Stela McLachlan Jackie F Price Mika Kivimaki Catherine Welch Adelaida Sanchez-Galvez Pedro Marques-Vidal Andrew Nicolaides Andrie G Panayiotou N Charlotte Onland-Moret Yvonne T van der Schouw Giuseppe Matullo Giovanni Fiorito Simonetta Guarrera Carlotta Sacerdote Nicholas J Wareham Claudia Langenberg Robert A Scott Jian'an Luan Martin Bobak Sofia Malyutina Andrzej Pająk Ruzena Kubinova Abdonas Tamosiunas Hynek Pikhart Niels Grarup Oluf Pedersen Torben Hansen Allan Linneberg Tine Jess Jackie Cooper Steve E Humphries Murray Brilliant Terrie Kitchner Hakon Hakonarson David S Carrell Catherine A McCarty Kirchner H Lester Eric B Larson David R Crosslin Mariza de Andrade Dan M Roden Joshua C Denny Cara Carty Stephen Hancock John Attia Elizabeth Holliday Rodney Scott Peter Schofield Martin O'Donnell Salim Yusuf Michael Chong Guillaume Pare Pim van der Harst M Abdullah Said Ruben N Eppinga Niek Verweij Harold Snieder Tim Christen D O Mook-Kanamori Stefan Gustafsson Lars Lind Erik Ingelsson Raha Pazoki Oscar Franco Albert Hofman Andre Uitterlinden Abbas Dehghan Alexander Teumer Sebastian Baumeister Marcus Dörr Markus M Lerch Uwe Völker Henry Völzke Joey Ward Jill P Pell Tom Meade Ingrid E Christophersen Anke H Maitland-van der Zee Ekaterina V Baranova Robin Young Ian Ford Archie Campbell Sandosh Padmanabhan Michiel L Bots Diederick E Grobbee Philippe Froguel Dorothée Thuillier Ronan Roussel Amélie Bonnefond Bertrand Cariou Melissa Smart Yanchun Bao Meena Kumari Anubha Mahajan Jemma C Hopewell Sudha Seshadri Caroline Dale Rui Providencia E Costa Paul M Ridker Daniel I Chasman Alex P Reiner Marylyn D Ritchie Leslie A Lange Alex J Cornish Sara E Dobbins Kari Hemminki Ben Kinnersley Marc Sanson Karim Labreche Matthias Simon Melissa Bondy Philip Law Helen Speedy James Allan Ni Li Molly Went Niels Weinhold Gareth Morgan Pieter Sonneveld Björn Nilsson Hartmut Goldschmidt Amit Sud Andreas Engert Markus Hansson Harry Hemingway Folkert W Asselbergs Riyaz S Patel Brendan J Keating Naveed Sattar Richard Houlston Juan P Casas Aroon D Hingorani

BMC Cardiovasc Disord 2019 10 29;19(1):240. Epub 2019 Oct 29.

Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.

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http://dx.doi.org/10.1186/s12872-019-1187-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820948PMC
October 2019

Avoidable flaws in observational analyses: an application to statins and cancer.

Nat Med 2019 10 7;25(10):1601-1606. Epub 2019 Oct 7.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41591-019-0597-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076561PMC
October 2019

Phenotyping UK Electronic Health Records from 15 Million Individuals for Precision Medicine: The CALIBER Resource.

Stud Health Technol Inform 2019 Jul;262:220-223

Institute of Health Informatics, University College London, United Kingdom.

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http://dx.doi.org/10.3233/SHTI190058DOI Listing
July 2019

Identifying clinically important COPD sub-types using data-driven approaches in primary care population based electronic health records.

BMC Med Inform Decis Mak 2019 04 18;19(1):86. Epub 2019 Apr 18.

Institute of Health Informatics, University College London, 222 Euston Road, London, NW1 2DA, UK.

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http://dx.doi.org/10.1186/s12911-019-0805-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472089PMC
April 2019

Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records.

Eur J Heart Fail 2019 10 7;21(10):1197-1206. Epub 2019 Jan 7.

Farr Institute of Health Informatics Research, Institute of Health Informatics, University College London, London, UK.

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http://doi.wiley.com/10.1002/ejhf.1350
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http://dx.doi.org/10.1002/ejhf.1350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074015PMC
October 2019

Evaluation of Semantic Web Technologies for Storing Computable Definitions of Electronic Health Records Phenotyping Algorithms.

AMIA Annu Symp Proc 2017 16;2017:1352-1361. Epub 2018 Apr 16.

Institute of Health Informatics, University College London, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977586PMC
April 2019

A novel metadata management model to capture consent for record linkage in longitudinal research studies.

Inform Health Soc Care 2019 6;44(2):176-188. Epub 2017 Nov 6.

a University College London, Institute of Health Informatics , London , United Kingdom.

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http://dx.doi.org/10.1080/17538157.2017.1364251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484449PMC
September 2019

Serotonin reuptake inhibitors and mortality in epilepsy: A linked primary-care cohort study.

Epilepsia 2017 11 24;58(11):2002-2009. Epub 2017 Sep 24.

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1111/epi.13904DOI Listing
November 2017

Methods for enhancing the reproducibility of biomedical research findings using electronic health records.

BioData Min 2017 11;10:31. Epub 2017 Sep 11.

EHR Research Group, Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Streeet, London, WC1E 7HT UK.

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http://dx.doi.org/10.1186/s13040-017-0151-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594436PMC
September 2017

Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients.

PLoS One 2017 9;12(6):e0178945. Epub 2017 Jun 9.

The Farr Institute of Health Informatics Research and the National Institute for Health Research, Biomedical Research Centre, University College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178945PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466321PMC
September 2017

Evaluation of Machine Learning Methods to Predict Coronary Artery Disease Using Metabolomic Data.

Stud Health Technol Inform 2017 ;235:111-115

Institute of Health Informatics, UCL.

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October 2017

Prognosis of undiagnosed chest pain: linked electronic health record cohort study.

BMJ 2017 Apr 3;357:j1194. Epub 2017 Apr 3.

Farr Institute of Health Informatics Research London, Institute of Health Informatics, University College London, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482346PMC
http://dx.doi.org/10.1136/bmj.j1194DOI Listing
April 2017

Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study.

J Am Coll Cardiol 2017 Mar;69(9):1160-1169

Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2016.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332591PMC
March 2017

Integrating Bio-ontologies and Controlled Clinical Terminologies: From Base Pairs to Bedside Phenotypes.

Authors:
Spiros C Denaxas

Methods Mol Biol 2017 ;1446:275-287

Farr Institute of Health Informatics Research, University College London, London, UK.

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http://dx.doi.org/10.1007/978-1-4939-3743-1_20DOI Listing
December 2017

The tip of the iceberg: challenges of accessing hospital electronic health record data for biological data mining.

BioData Min 2016 22;9:29. Epub 2016 Sep 22.

Institute for Biomedical Informatics, Department of Biostatistics and Epidemiology, Perelman School or Medicine, University of Pennsylvania, Philadelphia, PA 19104-6116 USA.

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http://biodatamining.biomedcentral.com/articles/10.1186/s130
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034453PMC
http://dx.doi.org/10.1186/s13040-016-0109-1DOI Listing
September 2016

Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study.

Open Heart 2016 5;3(2):e000477. Epub 2016 Sep 5.

Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London , London , UK.

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http://dx.doi.org/10.1136/openhrt-2016-000477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013342PMC
September 2016

A novel framework for assessing metadata quality in epidemiological and public health research settings.

AMIA Jt Summits Transl Sci Proc 2016 20;2016:199-208. Epub 2016 Jul 20.

Farr Institute of Health Informatics Research; Institute of Health Informatics, University College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001774PMC
August 2016

How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People.

Circulation 2015 Oct 1;132(14):1320-8. Epub 2015 Sep 1.

From Farr Institute of Health Informatics Research (London), University College London, United Kingdom (J.G., M.P.-R., A.D.S., S.D., H.H.); Worldwide Clinical Trials, Nottingham, United Kingdom (E.R.); Farr Institute of Health Informatics Research (London), London School of Hygiene & Tropical Medicine, United Kingdom (E.H., L.S.); and Farr Institute of Health Informatics Research (London) and Barts National Institute for Health Research Cardiovascular Biomedical Research Unit, Queen Mary University of London, United Kingdom (A.T.).

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http://circ.ahajournals.org/content/early/2015/09/01/CIRCULA
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http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAH
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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.013797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590518PMC
October 2015

Big biomedical data and cardiovascular disease research: opportunities and challenges.

Eur Heart J Qual Care Clin Outcomes 2015 Jul;1(1):9-16

Farr Institute of Health Informatics Research, University College London, 222 Euston Road, London NW1 2DA, UK.

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http://dx.doi.org/10.1093/ehjqcco/qcv005DOI Listing
July 2015

Use of electronic health records to ascertain, validate and phenotype acute myocardial infarction: A systematic review and recommendations.

Int J Cardiol 2015 5;187:705-11. Epub 2015 Mar 5.

Farr Institute of Health Informatics Research, University College London, UK.

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http://dx.doi.org/10.1016/j.ijcard.2015.03.075DOI Listing
February 2016

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people.

Lancet Diabetes Endocrinol 2015 Feb 11;3(2):105-13. Epub 2014 Nov 11.

Farr Institute of Health Informatics Research at London, London, UK; Department of Epidemiology and Public Health, University College London, London, UK.

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http://www.thelancet.com/pdfs/journals/landia/PIIS2213858714
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http://linkinghub.elsevier.com/retrieve/pii/S221385871470219
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http://dx.doi.org/10.1016/S2213-8587(14)70219-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303913PMC
February 2015

Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction.

Int J Epidemiol 2015 Feb 20;44(1):129-41. Epub 2014 Nov 20.

Farr Institute of Health Informatics Research, University College London, London, UK, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK and National Institute for Health Research, Biomedical Research Unit, Barts Health NHS Trust, London, UK.

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http://dx.doi.org/10.1093/ije/dyu218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339760PMC
February 2015

Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation.

PLoS One 2014 4;9(11):e110900. Epub 2014 Nov 4.

Farr Institute of Health Informatics Research, University College London, London, United Kingdom, and Clinical Epidemiology, Department of Epidemiology and Public Health, University College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110900PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219705PMC
July 2015

Association between clinical presentations before myocardial infarction and coronary mortality: a prospective population-based study using linked electronic records.

Eur Heart J 2014 Sep 19;35(35):2363-71. Epub 2014 Jul 19.

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK Farr Institute of Health Informatics Research, London, UK.

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http://dx.doi.org/10.1093/eurheartj/ehu286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163194PMC
September 2014

Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study.

Eur Heart J 2015 Apr 8;36(16):984-92. Epub 2014 Jul 8.

Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1093/eurheartj/ehu263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404491PMC
April 2015

Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER).

Int J Epidemiol 2012 Dec 5;41(6):1625-38. Epub 2012 Dec 5.

Department of Epidemiology and Public Health, Clinical Epidemiology, University College London, London, UK.

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http://dx.doi.org/10.1093/ije/dys188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535749PMC
December 2012

Influenza infection and risk of acute myocardial infarction in England and Wales: a CALIBER self-controlled case series study.

J Infect Dis 2012 Dec 9;206(11):1652-9. Epub 2012 Oct 9.

Centre for Infectious Disease Epidemiology, Research Department of Infection & Population Health, University College London, Royal Free Hospital, Rowland Hill St, London NW3 2PF, United Kingdom.

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http://dx.doi.org/10.1093/infdis/jis597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488196PMC
December 2012