Speranza Rubattu

Speranza Rubattu

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Natriuretic peptides in heart failure: Current achievements and future perspectives.

Int J Cardiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy; IRCCS Neuromed, Pozzilli, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183016
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http://dx.doi.org/10.1016/j.ijcard.2018.04.045DOI Listing
December 2018

Role of oxidative stress in the process of vascular remodeling following coronary revascularization.

Int J Cardiol 2018 Oct 19;268:27-33. Epub 2018 May 19.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy; IRCCS Neuromed, Pozzilli, Isernia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.05.046DOI Listing
October 2018

Effects of dual angiotensin type 1 receptor/neprilysin inhibition vs. angiotensin type 1 receptor inhibition on target organ injury in the stroke-prone spontaneously hypertensive rat.

J Hypertens 2018 Sep;36(9):1902-1914

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Ospedale S.Andrea.

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http://dx.doi.org/10.1097/HJH.0000000000001762DOI Listing
September 2018

Executive Summary of the 2018 Joint Consensus Document on Cardiovascular Disease Prevention in Italy.

High Blood Press Cardiovasc Prev 2018 Sep 20;25(3):327-341. Epub 2018 Sep 20.

Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.

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http://dx.doi.org/10.1007/s40292-018-0278-8DOI Listing
September 2018

The T2238C Human Atrial Natriuretic Peptide Molecular Variant and the Risk of Cardiovascular Diseases.

Int J Mol Sci 2018 Feb 11;19(2). Epub 2018 Feb 11.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, S. Andrea Hospital, via di Grottarossa 1035, 00189 Rome, Italy.

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http://dx.doi.org/10.3390/ijms19020540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855762PMC
February 2018

A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines.

J Hypertens 2017 09;35(9):1857-1871

aIRCCS Neuromed, Pozzilli, Isernia bDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome cDepartment of Pharmacological and Biomolecular Sciences, University of Milan dCentro Cardiologico Monzino IRCCS, Milan eDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.

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http://dx.doi.org/10.1097/HJH.0000000000001374DOI Listing
September 2017

Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease.

Oxid Med Cell Longev 2016 9;2016:1067801. Epub 2016 Aug 9.

IRCCS Neuromed, 86077 Pozzilli, Italy; Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Ospedale S. Andrea, 00189 Rome, Italy.

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http://dx.doi.org/10.1155/2016/1067801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993945PMC
March 2017

NT-proANP and NT-proBNP circulating levels as predictors of cardiovascular outcome following coronary stent implantation.

Cardiovasc Revasc Med 2016 Apr-May;17(3):162-8. Epub 2016 Feb 27.

IRCCS Neuromed, Pozzilli, Italy; Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.carrev.2016.02.012DOI Listing
February 2017

Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells.

Mech Ageing Dev 2016 10 12;159:37-43. Epub 2016 May 12.

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome polo pontino, C.so della Repubblica 79, 04100 Latina, Italy; Department of AngioCardioNeurology, IRCCS NeuroMed, 86077 Pozzilli, IS, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2016.05.004DOI Listing
October 2016

T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients.

J Cardiovasc Med (Hagerstown) 2016 Aug;17(8):601-7

aIRCCS Neuromed, Pozzilli bDept. of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Ospedale S. Andrea, Rome cDept. of Science of Public Health and Infectious Diseases, School of Pharmacy and Medicine, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.2459/JCM.0000000000000195DOI Listing
August 2016

Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art.

Biomed Res Int 2015 4;2015:918069. Epub 2015 Oct 4.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Saint Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy ; IRCCS Neuromed, 86077 Pozzilli, Italy.

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http://www.hindawi.com/journals/bmri/2015/918069/
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http://dx.doi.org/10.1155/2015/918069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609427PMC
August 2016

New therapies for arterial hypertension.

Panminerva Med 2016 Mar 5;58(1):34-47. Epub 2016 Jan 5.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome, Italy -

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March 2016

The C2238/αANP variant is a negative modulator of both viability and function of coronary artery smooth muscle cells.

PLoS One 2014 17;9(11):e113108. Epub 2014 Nov 17.

IRCCS Neuromed, Pozzilli (Isernia), Italy; Department of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113108PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234641PMC
January 2016

Novel Insights Into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation: Proprotein Convertase Subtilisin/Kexin 6 Is the Corin Activating Enzyme.

Circ Res 2016 Jan;118(2):196-8

From the Department of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome; and IRCCS Neuromed, Angio-Cardio-Neurology Department, Pozzilli, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307875DOI Listing
January 2016

Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis.

J Hypertens 2015 Jul;33(7):1465-79

aIRCCS Neuromed, Pozzilli (Isernia) bDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Ospedale S. Andrea cDepartment of Biology and Biotechnology, Sapienza University dFood and Nutrition Research Center (CRA-NUT), Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Rome eCentro Cardiologico Monzino, IRCCS fDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan gDepartment of Experimental Medicine, Medical Physiopathology, Food Science and Endocrinology Section, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1097/HJH.0000000000000562DOI Listing
July 2015

RyR2 Common Gene Variant G1886S and the Risk of Ventricular Arrhythmias in ICD Patients with Heart Failure.

J Cardiovasc Electrophysiol 2015 Jun 1;26(6):656-61. Epub 2015 May 1.

Department of Clinical and Molecular Medicine, St. Andrea Hospital, Sapienza University, Rome.

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http://dx.doi.org/10.1111/jce.12658DOI Listing
June 2015

New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart.

Oxid Med Cell Longev 2014 15;2014:210934. Epub 2014 Jul 15.

Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, 185 South Orange Avenue, Medical Science Building G-609, Newark, NJ 07103, USA.

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http://dx.doi.org/10.1155/2014/210934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124219PMC
March 2015

Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress.

Int J Mol Sci 2014 Dec 31;16(1):823-39. Epub 2014 Dec 31.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome 00189, Italy.

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http://www.mdpi.com/1422-0067/16/1/823
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http://dx.doi.org/10.3390/ijms16010823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307277PMC
December 2014

High natriuretic peptide levels and low DBP: companion markers of cardiovascular risk?

J Hypertens 2014 Nov;32(11):2142-3

aDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome bIRCCS Neuromed, Pozzilli, Italy.

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http://dx.doi.org/10.1097/HJH.0000000000000365DOI Listing
November 2014

Atrial natriuretic peptide gene variants and circulating levels: implications in cardiovascular diseases.

Clin Sci (Lond) 2014 Jul;127(1):1-13

†IRCCS Neuromed, Pozzilli (Isernia), Italy.

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http://dx.doi.org/10.1042/CS20130427DOI Listing
July 2014

Polypharmacy in heart failure patients.

Curr Heart Fail Rep 2014 Jun;11(2):212-9

Cardiology Department, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Ospedale Sant'Andrea Via di Grottarossa 1035-1039, 00189, Rome, Italy,

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http://dx.doi.org/10.1007/s11897-014-0186-8DOI Listing
June 2014

Natriuretic peptides in cardiovascular diseases: current use and perspectives.

Eur Heart J 2014 Feb 13;35(7):419-25. Epub 2013 Nov 13.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Ospedale S. Andrea, Rome, Italy.

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http://dx.doi.org/10.1093/eurheartj/eht466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023301PMC
February 2014

Common genetic variants in selected Ca²⁺ signaling genes and the risk of appropriate ICD interventions in patients with heart failure.

J Interv Card Electrophysiol 2013 Dec 19;38(3):169-77. Epub 2013 Sep 19.

Division of Cardiology, Department of Clinical and Molecular Medicine, Sapienza University of Rome Sant'Andrea Hospital, Via di Grottarossa, 00189, Rome, Italy,

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http://link.springer.com/content/pdf/10.1007/s10840-013-9827
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http://link.springer.com/10.1007/s10840-013-9827-1
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http://dx.doi.org/10.1007/s10840-013-9827-1DOI Listing
December 2013

Pathogenesis of chronic cardiorenal syndrome: is there a role for oxidative stress?

Int J Mol Sci 2013 Nov 20;14(11):23011-32. Epub 2013 Nov 20.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Ospedale S. Andrea, Rome 00189, Italy.

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http://dx.doi.org/10.3390/ijms141123011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856103PMC
November 2013

The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes.

Clin Sci (Lond) 2013 Aug;125(4):183-9

Division of Cardiology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1042/CS20120395DOI Listing
August 2013

Atrial natriuretic peptide and regulation of vascular function in hypertension and heart failure: implications for novel therapeutic strategies.

J Hypertens 2013 Jun;31(6):1061-72

Department of Cardiology, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome.

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http://dx.doi.org/10.1097/HJH.0b013e32835ed5ebDOI Listing
June 2013

Association of a single nucleotide polymorphism of the NPR3 gene promoter with early onset ischemic stroke in an Italian cohort.

Eur J Intern Med 2013 Jan 18;24(1):80-2. Epub 2012 Sep 18.

Department of Cardiology, School of Medicine and Psychology, Sapienza University, S. Andrea Hospital, Rome, Italy.

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http://dx.doi.org/10.1016/j.ejim.2012.09.002DOI Listing
January 2013

A survey on blood pressure levels and hypertension control in a sample of the Italian general population.

High Blood Press Cardiovasc Prev 2012 Sep;19(3):129-35

Division of Cardiology, Faculty of Medicine and Psychology, University Sapienza of Rome, Sant'Andrea Hospital, Via di Grottarossa 1039, Rome, Italy.

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http://dx.doi.org/10.2165/11632190-000000000-00000DOI Listing
September 2012

Circulating biomarkers with preventive, diagnostic and prognostic implications in cardiovascular diseases.

Int J Cardiol 2012 May 16;157(2):160-8. Epub 2011 Jul 16.

Dep. Cardiology, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome, Italy.

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http://dx.doi.org/10.1016/j.ijcard.2011.06.066DOI Listing
May 2012

Molecular mechanisms underlying cardiac antihypertrophic and antifibrotic effects of natriuretic peptides.

J Mol Med (Berl) 2012 Jan 9;90(1):5-13. Epub 2011 Aug 9.

Cardiology, Department of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome, Italy.

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http://link.springer.com/10.1007/s00109-011-0801-z
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http://dx.doi.org/10.1007/s00109-011-0801-zDOI Listing
January 2012

Discovering a new role for the atrial natriuretic peptide: A novel risk factor for cardiovascular diseases.

Heart Int 2006 30;2(2):78. Epub 2006 Sep 30.

Division of Cardiology, II Faculty of Medicine, University of Rome "La Sapienza", Sant'Andrea Hospital, Rome - Italy; IRCCS Neuromed, Pozzilli (Is) - Italy.

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www.heart-int.com/article/discovering-a-new-role-for-the-atr
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http://dx.doi.org/10.4081/hi.2006.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184664PMC
November 2011

Prediction of long-term survival in chronic heart failure by multiple biomarker assessment: a 15-year prospective follow-up study.

Clin Cardiol 2010 Nov;33(11):700-7

Cardiology, Department of Clinical and Molecular Medicine, 2nd Faculty of Medicine, Sapienza University, Rome, Italy.

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http://doi.wiley.com/10.1002/clc.20813
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http://dx.doi.org/10.1002/clc.20813DOI Listing
November 2010

NPR-C: a component of the natriuretic peptide family with implications in human diseases.

J Mol Med (Berl) 2010 Sep 19;88(9):889-97. Epub 2010 Jun 19.

Chair and Division of Cardiology, 2nd School of Medicine, University Sapienza, Sant'Andrea Hospital, Via di Grottarossa 1035-9, Rome, Italy.

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http://dx.doi.org/10.1007/s00109-010-0641-2DOI Listing
September 2010

Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.

Thromb Haemost 2010 Aug 10;104(2):231-42. Epub 2010 May 10.

Department of Medical and Surgical Critical Care, University of Florence, Viale Morgagni 85, 50134 Florence, Italy.

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http://www.thieme-connect.de/DOI/DOI?10.1160/TH09-11-0748
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http://dx.doi.org/10.1160/TH09-11-0748DOI Listing
August 2010

Natriuretic peptides and cardiovascular damage in the metabolic syndrome: molecular mechanisms and clinical implications.

Clin Sci (Lond) 2009 Nov 9;118(4):231-40. Epub 2009 Nov 9.

Cardiology Unit, Second Faculty of Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1042/CS20090204DOI Listing
November 2009

Role of the renin-angiotensin-aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction.

Clin Sci (Lond) 2009 Mar;116(6):467-77

Department of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, S. Andrea Hospital, Via di Grottarossa 1035-1039, 00100 Rome, Italy.

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http://dx.doi.org/10.1042/CS20080390DOI Listing
March 2009

Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular diseases.

Am J Hypertens 2008 Jul 8;21(7):733-41. Epub 2008 May 8.

Department of Cardiology, II School of Medicine, University La Sapienza, Ospedale Sant'Andrea, Rome, Italy.

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https://academic.oup.com/ajh/article-lookup/doi/10.1038/ajh.
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http://dx.doi.org/10.1038/ajh.2008.174DOI Listing
July 2008

Beta2-adrenergic receptor gene polymorphisms and risk of ischemic stroke.

Am J Hypertens 2007 Jun;20(6):657-62

Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, University La Sapienza, Rome, Italy.

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http://dx.doi.org/10.1016/j.amjhyper.2007.01.006DOI Listing
June 2007

The Pl(A1/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients.

J Hypertens 2007 Mar;25(3):551-6

Department of Clinical Medicine, Cardiovascular & Immunological Sciences, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1097/HJH.0b013e328013cd67DOI Listing
March 2007

Reciprocal congenic lines for a major stroke QTL on rat chromosome 1.

Physiol Genomics 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11.

Istituto di ricovero e cura a carattere scientifico Neuromed, Polo Molisano University La Sapienza, Pozzilli (Isernia), Italy.

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http://dx.doi.org/10.1152/physiolgenomics.00086.2006DOI Listing
October 2006

Assessing the genetic background of arterial baroreflex sensitivity: a complex issue.

J Hypertens 2005 Nov;23(11):1967-9

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November 2005

Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant.

J Hypertens 2004 Nov;22(11):2129-34

IRCCS Neuromed, Pozzilli (Is), Department of Cardiology, IInd School of Medicine, University La Sapienza, Ospedale Sant'Andrea, Rome, Italy.

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November 2004

Role of genetic factors in the etiopathogenesis of cerebrovascular accidents: from an animal model to the human disease.

Cell Mol Neurobiol 2004 Oct;24(5):581-8

Biogem Scacl c/o IGB A. Buzzati-Traverso, Naples, Italy.

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October 2004

In the search for stroke genes: a long and winding road.

Am J Hypertens 2004 Feb;17(2):197-202

IRCCS Neuromed, Località Camerelle, 86077 Pozzilli (Isernia), Italy.

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February 2004

Contribution of genetic factors to renal lesions in the stroke-prone spontaneously hypertensive rat.

Hypertension 2003 Oct 21;42(4):702-6. Epub 2003 Jul 21.

Istituto Neurologico Mediterraneo Neuromed, 86077 Pozzilli, Is, Italy.

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http://dx.doi.org/10.1161/01.HYP.0000084635.01667.8ADOI Listing
October 2003

Altered regulation of endothelin A receptor subtype in the cerebral arterioles in response to a Japanese-style diet, in stroke-prone hypertensive rats.

J Hypertens 2003 Jan;21(1):105-13

Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, University of Padua, via Giustiniani 2, 35126 Padua, Italy.

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http://dx.doi.org/10.1097/01.hjh.0000045532.21915.0fDOI Listing
January 2003

The renin-angiotensin system as a risk factor and therapeutic target for cardiovascular and renal disease.

J Am Soc Nephrol 2002 Nov;13 Suppl 3:S173-8

Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Italy. volpema@uniroma1@it

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November 2002

Cerebrovascular disease in women.

J Hypertens Suppl 2002 May;20(2):S39-43

Dipartimento di Medicina Sperimentale e Patologia, Università degli Studi di Roma La Sapienza, Rome, Italy.

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May 2002

Functional cross-talk between angiotensin II and epidermal growth factor receptors in NIH3T3 fibroblasts.

J Hypertens 2002 Apr;20(4):693-9

IRCSS Istituto Neurologico Mediterraneo Neuromed, Via Atinense 18, Località Camerelle, Pozzilli (Is), Italy.

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April 2002

Effect of a regulatory mutation on the rat atrial natriuretic peptide gene transcription.

Peptides 2002 Mar;23(3):555-60

Istituto Neuromed, Polo Molisano dell'Universita' La Sapienza di Roma, Pozzilli, Italy.

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March 2002