Sowmya Iyer

Sowmya Iyer

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Sowmya Iyer

Sowmya Iyer

Publications by authors named "Sowmya Iyer"

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13Publications

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CRISPR DNA base editors with reduced RNA off-target and self-editing activities.

Nat Biotechnol 2019 09 2;37(9):1041-1048. Epub 2019 Sep 2.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0236-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730565PMC
September 2019

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors.

Nature 2019 05 17;569(7756):433-437. Epub 2019 Apr 17.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1161-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657343PMC
May 2019

A (fire)cloud-based DNA methylation data preprocessing and quality control platform.

BMC Bioinformatics 2019 Mar 29;20(1):160. Epub 2019 Mar 29.

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12859-019-2750-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440105PMC
March 2019

Molecularly distinct models of zebrafish Myc-induced B cell leukemia.

Leukemia 2019 02 20;33(2):559-562. Epub 2018 Dec 20.

Section of Pediatric Hematology-Oncology, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1038/s41375-018-0328-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365381PMC
February 2019

Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia.

Leukemia 2018 08 18;32(8):1860-1865. Epub 2018 Apr 18.

Department of Pathology, Massachusetts General Hospital Research Institute, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41375-018-0130-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620784PMC
August 2018

Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies.

Genes Dev 2018 08 24;32(15-16):1008-1019. Epub 2018 Jul 24.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.315192.118
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http://dx.doi.org/10.1101/gad.315192.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075149PMC
August 2018

Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.

Cell Stem Cell 2018 03;22(3):414-427.e6

Molecular Pathology, Cancer Center, and Regenerative Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02129, USA; Harvard Stem Cell Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354590PMC
March 2018

Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain.

Cell 2017 Sep 24;171(1):163-178.e19. Epub 2017 Aug 24.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791823PMC
September 2017

Factorbook.org: a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium.

Nucleic Acids Res 2013 Jan 29;41(Database issue):D171-6. Epub 2012 Nov 29.

Program in Bioinformatics and Integrative Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1093/nar/gks1221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531197PMC
January 2013

Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors.

Genome Res 2012 Sep;22(9):1798-812

Program in Bioinformatics and Integrative Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1101/gr.139105.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431495PMC
September 2012