Publications by authors named "Soumendranath Ray"

12 Publications

  • Page 1 of 1

De-Identification of Radiomics Data Retaining Longitudinal Temporal Information.

J Med Syst 2020 Apr 2;44(5):99. Epub 2020 Apr 2.

CSE, IIT Kharagpur, Kharagpur, India.

We propose a de-identification system which runs in a standalone mode. The system takes care of the de-identification of radiation oncology patient's clinical and annotated imaging data including RTSTRUCT, RTPLAN, and RTDOSE. The clinical data consists of diagnosis, stages, outcome, and treatment information of the patient. The imaging data could be the diagnostic, therapy planning, and verification images. Archival of the longitudinal radiation oncology verification images like cone beam CT scans along with the initial imaging and clinical data are preserved in the process. During the de-identification, the system keeps the reference of original data identity in encrypted form. These could be useful for the re-identification if necessary.
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http://dx.doi.org/10.1007/s10916-020-01563-0DOI Listing
April 2020

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties.

J Labelled Comp Radiopharm 2020 Mar 27. Epub 2020 Mar 27.

Division of Nuclear Medicine, Tata Medical Centre, Kolkata, India.

Application of nanotechnology principles in drug delivery has created opportunities for treatment of several diseases. Nanotechnology offers the advantage of overcoming the adverse biopharmaceutics or pharmacokinetic properties of drug molecules, to be determined by the transport properties of the particles themselves. Through the manipulation of size, shape, charge, and type of nanoparticle delivery system, variety of distribution profiles may be obtained. However, there still exists greater need to derive and standardize definitive structure property relationships for the distribution profiles of the delivery system. When applied to radiopharmaceuticals, the delivery systems assume greater significance. For the safety and efficacy of both diagnostics and therapeutic radiopharmaceuticals, selective localization in target tissue is even more important. At the same time, the synthesis and fabrication reactions of radiolabelled nanoparticles need to be completed in much shorter time. Moreover, the extensive understanding of the several interesting optical and magnetic properties of materials in nanoscale provides for achieving multiple objectives in nuclear medicine. This review discusses the various nanoparticle systems, which are applied for radionuclides and analyses the important bottlenecks that are required to be overcome for their more widespread clinical adaptation.
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http://dx.doi.org/10.1002/jlcr.3839DOI Listing
March 2020

Prostate-specific Membrane Antigen-expressing Hepatic Lesion: Metastatic or Hepatocellular Carcinoma.

Indian J Nucl Med 2020 Jan-Mar;35(1):58-60. Epub 2019 Dec 31.

Department of Radiation Oncology, Tata Medical Center, Kolkata, West Bengal, India.

Prostate-specific membrane antigen (PSMA) is a glycosylated type-II transmembrane protein highly expressed in certain tumor cells. It has emerged as a novel radiotracer for evaluation of prostate cancer. Increased PSMA expression in isolated liver lesion is a diagnostic challenge. Solitary liver metastasis from prostate cancer is rare. On the other hand, PSMA avid primary hepatocellular carcinoma (HCC) has been reported in literature. We report a case of PSMA expressing atypical HCC with normal alphafeto protein (AFP) and raised prostate specific antigen (PSA).
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http://dx.doi.org/10.4103/ijnm.IJNM_145_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958946PMC
December 2019

Unusual loco-regional presentation in papillary carcinoma of thyroid: A case series.

Indian J Cancer 2019 Oct-Dec;56(4):325-329

Department of Head and Neck Surgery, Tata Medical Center, Kolkata, West Bengal, India.

Background: Papillary carcinoma of thyroid (PTC) is usually indolent with good prognosis and excellent long-term survival. However, PTC sometimes presents itself in unusual situations, posing diagnostic and therapeutic challenges. Owing to paucity of data, there is lack of consensus as to what treatment should be prescribed in patients with loco-regional spread other than the usual sites.

Materials And Methods: Six patients of PTC presenting with involvement of the aero-digestive tract, retropharyngeal, and para-pharyngeal lymph nodes and great vessels of the neck are included in this case series.

Results And Conclusion: Though rare, unusual loco-regional presentation of PTC poses challenges in diagnosis and treatment. A keen clinical sense is paramount in effectively diagnosing these cases. Aggressive surgical resection and reconstruction results in good functional and aesthetic outcomes. Further studies are required for establishing specific guidelines on the approach to the treatment of these cases.
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http://dx.doi.org/10.4103/ijc.IJC_368_18DOI Listing
February 2020

Axillary Lymph Node Metastasis in Gallbladder Carcinoma with Incidentally Detected Coexistence of Aberrant Right Subclavian Artery with Left-Sided Superior Vena Cava.

Indian J Nucl Med 2019 Jul-Sep;34(3):244-246

Department of Medical Oncology Tata Medical Center, Kolkata, West Bengal, India.

The sequential development of port site recurrence, followed by recurrence in the axillary lymph node in gallbladder carcinoma is very infrequently reported in the literature. The representing 18F-fluorodeoxyglucose positron emission tomography-computed tomography image shows a metastatic right axillary lymph node in a case of gallbladder cancer developed following surgical removal of port site recurrence and six cycles of chemotherapy. The image also shows coexistence of two incidentally detected vascular anomalies, i.e., aberrant right subclavian artery and left-sided superior vena cava. Coexistence of both the vascular anomalies is rare among the general population and have their own clinical implications as described.
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http://dx.doi.org/10.4103/ijnm.IJNM_62_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593955PMC
July 2019

F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Scan Finding of Portal Venous Tumor Thrombus in a Case of Primary Gastric Malignancy.

Indian J Nucl Med 2017 Jul-Sep;32(3):221-223

Tata Medical Center, Kolkata, West Bengal, India.

Intraluminal portal venous tumor thrombus is an infrequent association with primary gastric malignancy. Ultrasonography features such as low pulsatile flow within the thrombus, expansion of vein, and enhancement of thrombus are nonspecific findings for diagnosis. F-fluorodeoxyglucose positron emission tomography-computed tomography scan can differentiate between the benign and malignant thrombus as well as it helps proper metastatic work up. We report such a case.
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http://dx.doi.org/10.4103/ijnm.IJNM_2_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482021PMC
July 2017

Lymphoscintigraphy combined with single-photon emission computed tomography-computed tomography (SPECT-CT): A very effective imaging approach for identification of the site of leak in postoperative chylothorax.

Indian J Nucl Med 2015 Apr-Jun;30(2):177-9

Department of Nuclear Medicine, Tata Medical Center, Kolkata, West Bengal, India.

Post operative chylothorax is a known complication of various thoracic surgeries. It needs identification of precise site of leak in the thoracic duct. Lymphosicintigraphy can identify chyle leak but cannot delineate exact site of leak. SPECT-CT is precise in anatomic localisation and hence SPECT-CT should be combined with every lymphoscintigraphy in evaluation of clinically suspected case of post operative chylothorax. We report such a case.
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http://dx.doi.org/10.4103/0972-3919.152988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379685PMC
April 2015

Extranodal involvement in lymphoma - A Pictorial Essay and Retrospective Analysis of 281 PET/CT studies.

Asia Ocean J Nucl Med Biol 2014 ;2(1):42-56

Haematology Department, Tata Medical Center, New Town, Kolkata, India.

Objectives: The aim of this study is to evaluate the role of PET-CT in identification of different patterns of extranodal involvement in Hodgkin's disease (HD) and Non-Hodgkin's Lymphoma (NHL) and to enlist the common sites of extranodal involvement in each histological type and compare our results with the existing literature.

Methods: In this retrospective study of 281 cases of lymphomas of various histologies, we illustrate the spectrum of PET/CT features of extranodal lymphoma (ENL) of commonly involved organs and compare our result with the literature.

Result: Extranodal appearance in lymphoma is strikingly varied. Diffuse large B cell lymphoma (DLBCL) is the commonest histological subtype and gastrointestinal tract is the commonest anatomical subsite in NHL. Skeletal system is the commonest site for involvement in HD.

Conclusion: A broad spectrum of extranodal organs is involved in various subtype of lymphoma which can be depicted in PET-CT in the most appropriate manner. Familiarity with the pattern of involvement is essential for comprehensive management.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937711PMC
July 2016

Added value of PET and PET-CT in oesophageal cancer: a review of current practice.

Nucl Med Commun 2008 Jan;29(1):4-10

Nuclear Medicine Department, Royal Liverpool University Hospital, UK.

Oesophageal carcinoma is a relatively rare form of cancer. However, it is also one of the most deadly forms of cancer, with a 5-year survival rate of only 3% for patients with nodal disease, and 42% for those without nodal disease. It is therefore very important to accurately stage the disease at diagnosis and before therapy. In this article, we review the role of commonly used investigative techniques in the diagnosis and staging of oesophageal carcinoma, with special emphasis on PET and PET-CT scanning. The literature is reviewed in the context of our recent experience. A retrospective review of 129 patients with oesophageal carcinoma, who underwent PET or PET-CT scanning over a 24-month period confirmed the incremental value of PET and PET-CT scanning in the staging of oesophageal carcinoma.
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http://dx.doi.org/10.1097/MNM.0b013e3282f1b9c7DOI Listing
January 2008