Sotirios Tsimikas

Sotirios Tsimikas

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Sotirios Tsimikas

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Relationship of lipoprotein(a) molar concentrations and mass according to lipoprotein(a) thresholds and apolipoprotein(a) isoform size.

J Clin Lipidol 2018 Sep - Oct;12(5):1313-1323. Epub 2018 Jul 20.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.jacl.2018.07.003DOI Listing
October 2019

Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study.

J Clin Lipidol 2018 Nov - Dec;12(6):1493-1501.e11. Epub 2018 Aug 29.

Vascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2018.08.010DOI Listing
October 2019

The challenges of measuring Lp(a): A fight against Hydra?

Atherosclerosis 2019 Oct 31;289:181-183. Epub 2019 Aug 31.

Vascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiovascular Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.08.019DOI Listing
October 2019

Relationship between "LDL-C", estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide.

J Clin Lipidol 2018 May - Jun;12(3):702-710. Epub 2018 Mar 1.

Ionis Pharmaceuticals, Carlsbad, CA, USA; Division of Cardiovascular Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2018.02.014DOI Listing
September 2019

Lipoprotein Apheresis Acutely Reverses Coronary Microvascular Dysfunction in Patients With Severe Hypercholesterolemia.

JACC Cardiovasc Imaging 2019 Aug 19;12(8 Pt 1):1430-1440. Epub 2018 Jun 19.

Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458098PMC
August 2019

Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome.

N Engl J Med 2019 08;381(6):531-542

From the Department of Medicine, University of California San Diego, La Jolla (J.L.W., S.T.), and Ionis Pharmaceuticals, Carlsbad (V.J.A., Q.Y., S.G.H., R.S.G., S.T.) - both in California; the Department of Medicine, Université de Montréal and ECOGENE 21, Chicoutimi, QC (D.G.), and the Department of Medicine and Laboratory Medicine, Centre Hospitalier Universitaire de Québec-University Laval, Quebec, QC (J.B.) - both in Canada; the Department of Medicine, Beth Israel Deaconess Medical Center (S.D.F.), and the Department of Medicine, Massachusetts General Hospital (L.H.), Boston, and Akcea Therapeutics, Cambridge (A.D., K.R.W., L.O.) - all in Massachusetts; Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome (M.A.); Academic Medical Center, Department of Vascular Medicine, Amsterdam (E.S.G.S.); the Department of Medicine, Manchester University Hospital NHS Foundation Trust, Manchester, United Kingdom (H.S.); the Department of Internal Medicine, Hospital Universitario Miguel Servet, IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain (F.C.); the Division of Lipidology and Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa (D.J.B.); and the Department of Endocrinology and Cardiovascular Disease Prevention, Assistance Publique-Hôpitaux de Paris, La Pitié-Salpêtrière Hospital, Institut de Création et d'Animation Numériques, Paris (E.B.).

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http://dx.doi.org/10.1056/NEJMoa1715944DOI Listing
August 2019

Temporal variability in lipoprotein(a) levels in patients enrolled in the placebo arms of IONIS-APO(a) and IONIS-APO(a)-L antisense oligonucleotide clinical trials.

J Clin Lipidol 2018 Jan - Feb;12(1):122-129.e2. Epub 2017 Nov 2.

Department of Medicine, Ionis Pharmaceuticals, Carlsbad, CA, USA; Department of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19332874173049
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http://dx.doi.org/10.1016/j.jacl.2017.10.024DOI Listing
July 2019

Statin therapy increases lipoprotein(a) levels.

Eur Heart J 2019 May 20. Epub 2019 May 20.

Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0682, USA.

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http://dx.doi.org/10.1093/eurheartj/ehz310DOI Listing
May 2019

Lipoprotein(a) in Patients Undergoing Transcatheter Aortic Valve Replacement.

Angiology 2019 Apr 30;70(4):332-336. Epub 2019 Jan 30.

1 Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Vascular Medicine Program, University of California San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1177/0003319719826461DOI Listing
April 2019

In Search of Patients With Elevated Lp(a): Seek and Ye Shall Find.

J Am Coll Cardiol 2019 Mar;73(9):1040-1042

Division of Cardiovascular Medicine, University of California San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.12.036DOI Listing
March 2019

Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis.

Circ Res 2019 02;124(3):405-415

From the Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361547PMC
February 2019

Lipid-Lowering Agents.

Circ Res 2019 02;124(3):386-404

Sulpizio Cardiovascular Center, Vascular Medicine Program, University of California San Diego, La Jolla (S.T.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313171DOI Listing
February 2019

RNA-targeted therapeutics for lipid disorders.

Curr Opin Lipidol 2018 12;29(6):459-466

Vascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiovascular diseases, University of California San Diego School of Medicine, California, USA.

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http://dx.doi.org/10.1097/MOL.0000000000000549DOI Listing
December 2018

Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials.

Lancet 2018 10 4;392(10155):1311-1320. Epub 2018 Oct 4.

Vascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)31652-0DOI Listing
October 2018

Association of D-dimer with Plaque Characteristics and Plasma Biomarkers of Oxidation-Specific Epitopes in Stable Subjects with Coronary Artery Disease.

J Cardiovasc Transl Res 2018 06 17;11(3):221-229. Epub 2018 Jan 17.

Cardiovascular Research Center, University of Virginia, 415 Lane Road, Bldg MR-5, Rm-G231, Charlottesville, VA, 22908, USA.

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http://link.springer.com/10.1007/s12265-018-9790-4
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http://dx.doi.org/10.1007/s12265-018-9790-4DOI Listing
June 2018

Oxidation-specific epitopes restrain bone formation.

Nat Commun 2018 06 6;9(1):2193. Epub 2018 Jun 6.

Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, 4301W. Markham, Little Rock, AR, 72205, USA.

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http://dx.doi.org/10.1038/s41467-018-04047-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990540PMC
June 2018

In search of a physiological function of lipoprotein(a): causality of elevated Lp(a) levels and reduced incidence of type 2 diabetes.

J Lipid Res 2018 05 2;59(5):741-744. Epub 2018 Apr 2.

Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla, CA

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http://dx.doi.org/10.1194/jlr.C085639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928428PMC
May 2018

Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates.

Circ Cardiovasc Genet 2017 Dec;10(6)

From the King's British Heart Foundation Centre, King's College London, United Kingdom (X.Y., F.B., E.H., H.H., M.M.); Agilent Technologies Ltd, Cheadle, United Kingdom (R.T.B., A.S.); Biognosys AG, Schlieren, Switzerland (T.G., S.M., L.R.); Department of Neurology, Medical University of Innsbruck, Austria (R.P., J.W., S.K.); School of Medicine, University of California San Diego (S.T., J.L.W.); and Department of Laboratory Medicine, Bruneck Hospital, Italy (P.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001808DOI Listing
December 2017

Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a).

J Clin Lipidol 2016 May-Jun;10(3):594-603. Epub 2016 Mar 8.

Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2016.01.005DOI Listing
October 2017

Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia.

J Clin Lipidol 2016 Jul-Aug;10(4):1011-1021. Epub 2016 May 9.

London School of Hygiene & Tropical Medicine, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2016.04.013DOI Listing
October 2017

Lipoprotein(a)-cholesterol levels estimated by vertical auto profile correlate poorly with Lp(a) mass in hyperlipidemic subjects: Implications for clinical practice interpretation of Lp(a)-mediated risk.

J Clin Lipidol 2016 Nov - Dec;10(6):1389-1396. Epub 2016 Sep 28.

Division of Cardiovascular Diseases, Department of Medicine, Sulpizio Cardiovascular Center, University of California, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2016.09.012DOI Listing
October 2017

The Prevalence of Lipoprotein(a) Measurement and Degree of Elevation Among 2710 Patients With Calcific Aortic Valve Stenosis in an Academic Echocardiography Laboratory Setting.

Angiology 2017 Oct 10;68(9):795-798. Epub 2017 Jan 10.

1 Vascular Medicine Program, Sulpizio Cardiovascular Center, University of California, San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1177/0003319716688415DOI Listing
October 2017

Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins.

J Clin Endocrinol Metab 2017 09;102(9):3340-3348

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon 97239.

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http://academic.oup.com/jcem/article/102/9/3340/3869385/Thre
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http://dx.doi.org/10.1210/jc.2016-4043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587068PMC
September 2017

Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease: The Copenhagen General Population Study.

Arterioscler Thromb Vasc Biol 2017 08 1;37(8):1570-1578. Epub 2017 Jun 1.

From the Department of Clinical Biochemistry (P.R.K., B.G.N.) and the Copenhagen General Population Study (P.R.K., B.G.N.), Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark; Department of Medicine, University of California San Diego, La Jolla (M.-Y.H., J.L.W., S.T.); Department of Internal Medicine, School of Medicine, College of Medicine (M.-Y.H.) and Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital (M.-Y.H.), Taipei Medical University, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan (M.-Y.H.); and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (B.G.N.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551411PMC
August 2017

Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis.

Lancet Diabetes Endocrinol 2017 07 10;5(7):524-533. Epub 2017 Apr 10.

Medical Research Council (MRC)/British Heart Foundation (BHF) Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK; National Institute for Health Research Blood and Transplant Research Unit, University of Cambridge, Cambridge, UK; Cambridge British Heart Foundation Centre of Excellence, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(17)30088-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483508PMC
July 2017

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides.

N Engl J Med 2017 07 24;377(3):222-232. Epub 2017 May 24.

From Ionis Pharmaceuticals, Carlsbad (M.J.G., R.G.L., T.A.B., L.-J.T., W.F., R.P., R.Y., E.P., B.W.M., B.F.B., N.C.P., S.G.H., R.S.G., R.M.C., S.T.), and the University of California, San Diego, La Jolla (J.L.W., S.T.) - both in California; and Akcea Therapeutics, Cambridge, MA (E.H., A.D.).

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http://dx.doi.org/10.1056/NEJMoa1701329DOI Listing
July 2017

Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study.

Arterioscler Thromb Vasc Biol 2017 06 4;37(6):1206-1212. Epub 2017 May 4.

From the Department of Vascular Medicine (J.C.v.C., S.J.B.M., J.J.P.K., E.S.G.S., G.K.H.), Department of Clinical Epidemiology and Biostatistics (A.H.Z.), and Department of Cardiology (S.M.B.), Academic Medical Center, Amsterdam, The Netherlands; Vascular Medicine Program, Division of Cardiology (X.Y., S.T.) and Division of Endocrinology and Metabolism (J.L.W.), Department of Medicine, University of California San Diego, La Jolla; Medical Research Council Epidemiology Unit, Cambridge, United Kingdom (N.J.W.); and Department of Public Health and Primary Care, University of Cambridge, United Kingdom (K.-T.K.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484077PMC
June 2017

Relationship of Autoantibodies to MDA-LDL and ApoB-Immune Complexes to Sex, Ethnicity, Subclinical Atherosclerosis, and Cardiovascular Events.

Arterioscler Thromb Vasc Biol 2017 06 4;37(6):1213-1221. Epub 2017 May 4.

From the Division of Cardiology, Department of Medicine, The University of Texas Health Science Center San Antonio (A.P.); Veterans Affairs Medical Center, San Diego, CA (P.C.); Division of Cardiology, University of Texas Southwestern Medical Center at Dallas (C.A., A.K., J.A.d.L.); Division of Endocrinology and Metabolism (J.L.W.) and Department of Medicine (S.T.), University of California San Diego, La Jolla; and Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, La Jolla, CA (S.T.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500201PMC
June 2017

The re-emergence of lipoprotein(a) in a broader clinical arena.

Prog Cardiovasc Dis 2016 Sep - Oct;59(2):135-144. Epub 2016 Aug 3.

Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla, CA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00330620163006
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http://dx.doi.org/10.1016/j.pcad.2016.07.005DOI Listing
May 2017

Lipoprotein(a) Mass Levels Increase Significantly According to Genotype: An Analysis of 431 239 Patients.

Arterioscler Thromb Vasc Biol 2017 Mar 5;37(3):580-588. Epub 2017 Jan 5.

From the Division of Clinical Pharmacology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City (P.M.M.); Salveo Diagnostics, Inc, Richmond, VA (S.A.V., J.P.M.); Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center (P.L.S.M.G.), Department of Medicine, Division of Endocrinology and Metabolism (P.L.S.M.G.), and Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center (S.T.), University of California San Diego, La Jolla.

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http://dx.doi.org/10.1161/ATVBAHA.116.308704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323356PMC
March 2017

Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgR to the List.

Circ Res 2017 03;120(7):1050-1052

From the Department of Medicine, Division of Cardiovascular Medicine (C.Y., S.T.) and Division of Endocrinology and Metabolism (P.L.S.M.G.), University of California San Diego, La Jolla.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470738PMC
March 2017

Elevated Lp(a) and Abdominal Aortic Aneurysm.

Angiology 2017 02 11;68(2):96-98. Epub 2016 Jul 11.

1 Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/0003319716650960DOI Listing
February 2017

A Test in Context: Lipoprotein(a): Diagnosis, Prognosis, Controversies, and Emerging Therapies.

J Am Coll Cardiol 2017 Feb;69(6):692-711

Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla, California. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07351097163725
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http://dx.doi.org/10.1016/j.jacc.2016.11.042DOI Listing
February 2017

LPA Gene, Ethnicity, and Cardiovascular Events.

Circulation 2017 Jan 9;135(3):251-263. Epub 2016 Nov 9.

From Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California San Diego, La Jolla (S.-R.L., Y.-S.C., S.T.); Division of Cardiology, Chonbuk National University Hospital and Chonbuk School of Medicine, Jeonju, Korea (S.-R.L.); Division of Cardiology, Department of Medicine, The University of Texas Health Science Center San Antonio (A.P.); Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul (Y.-S.C.); Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas (C.X.); Veterans Affairs Medical Center, San Diego, CA (P.C.); and Division of Endocrinology and Metabolism, University of California San Diego, La Jolla (J.L.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241172PMC
January 2017

Oxidized Phospholipids on Apolipoprotein B-100 and Recurrent Ischemic Events Following Stroke or Transient Ischemic Attack.

J Am Coll Cardiol 2017 Jan;69(2):147-158

Division of Cardiovascular Diseases, University of California, San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.10.057DOI Listing
January 2017

JCL Roundtable: Should we treat elevations in Lp(a)?

J Clin Lipidol 2016 Mar-Apr;10(2):215-24. Epub 2016 Mar 5.

Division of Cardiovascular Diseases, Department of Medicine, UCSD Cardiology La Jolla, Perlman Ambulatory Center, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.jacl.2016.02.012DOI Listing
December 2016

Prevalence of Elevated Lp(a) Mass Levels and Patient Thresholds in 532 359 Patients in the United States.

Arterioscler Thromb Vasc Biol 2016 11 22;36(11):2239-2245. Epub 2016 Sep 22.

From the Salveo Diagnostics, LLC, Richmond, VA (S.V., J.P.M.); and Department of Medicine, Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla (S.T.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308011DOI Listing
November 2016

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans.

Circulation 2016 Aug 5;134(8):611-24. Epub 2016 Aug 5.

From Department of Vascular Medicine (F.M.V.d.V., M.N., E.S.G.S.), Department of Molecular Cell Biology, Sanquin Research (J.K., J.D.v.B.), Experimental Vascular Biology, (J.v.d.B.), Department of Radiology (A.J.N.), and Department of Nuclear Medicine (H.J.V.), Academic Medical Center, Amsterdam, the Netherlands; Departments of Internal Medicine (S.B., L.A.B.J., M.G.N., N.P.R.) and Pharmacology-Toxicology (N.P.R.), Radboud UMC, Nijmegen, the Netherlands; Sulpizio Cardiovascular Center, Division of Cardiovascular Medicine (C.Y., S.T.) and Division of Endocrinology and Metabolism, Department of Medicine (J.L.W.), University California, San Diego, La Jolla; St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Canada (A.R.); Department of Chemistry, Biochemistry and Pharmacology, University of Windsor, Windsor, Canada (C.S.); and Robarts Research Institute, Schulich School of Medicine, Western University, London, Canada (M.L.K.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.020838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995139PMC
August 2016

The role of lipoprotein(a) in progression of renal disease: Causality or reverse causality?

J Diabetes Complications 2016 07 7;30(5):755-7. Epub 2016 Apr 7.

Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California, La Jolla, CA. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2016.04.001DOI Listing
July 2016

Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis.

Curr Opin Cardiol 2016 07;31(4):440-50

Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1097/HCO.0000000000000300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956483PMC
July 2016

PCSK9 Association With Lipoprotein(a).

Circ Res 2016 06 27;119(1):29-35. Epub 2016 Apr 27.

From the Department of Medicine, Center for Preventive Cardiology, Knight Cardiovascular Institute, Portland, OR (H.T., D.C., D.P., M.D.S., I.G., P.B.D., S.F.); School of Public Health, Oregon Health and Science University, Portland (J.M.); Sulpizio Cardiovascular Center, Vascular Medicine Program, University of California at San Diego, La Jolla (C.Y., S.T.); Inra UMR1280, Université de Nantes, CHU Hôtel-Dieu, Nantes, France (M.C., G.L.); Inserm UMR 1188, Sainte-Clotilde, France (G.L.); Université de la Réunion, Faculté de Médecine, Saint-Denis, France (G.L.); and CHU de la Réunion, Saint-Denis, France (G.L.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920709PMC
June 2016

Lipoprotein(a): novel target and emergence of novel therapies to lower cardiovascular disease risk.

Curr Opin Endocrinol Diabetes Obes 2016 Apr;23(2):157-64

Vascular Medicine Program, Sulpizio Cardiovascular Center, University of California San Diego School of Medicine, La Jolla, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061509PMC
http://dx.doi.org/10.1097/MED.0000000000000237DOI Listing
April 2016

Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results.

J Lipid Res 2016 Apr 4;57(4):706-13. Epub 2016 Feb 4.

Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla, CA Ionis Pharmaceuticals, Carlsbad, CA

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http://dx.doi.org/10.1194/jlr.M066399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808774PMC
April 2016

Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.

Arterioscler Thromb Vasc Biol 2016 Apr 11;36(4):682-91. Epub 2016 Feb 11.

From the Cardiovascular Research Center (D.B.H., P.S., J.L.K., S.N.O., C.M.S., J.C.G., H.M.P., C.A.M.), Department of Biochemistry, Molecular Biology, and Genetics (D.B.H.), Division of Cardiovascular Medicine, Department of Medicine (P.S., A.M.T., C.A.M.), Department of Pathology (J.L.K., H.M.P.), Division of Endocrinology and Metabolism, Department of Medicine (J.L.K.), Department of Surgery (P.H., B.S.), Beirne B. Carter Center for Immunology Research (C.A.M.), Department of Molecular Physiology and Biological Physics (C.A.M.), University of Virginia, Charlottesville; and Department of Medicine, University of California San Diego, La Jolla (T.A.P., A.G., S.T., J.L.W.).

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http://atvb.ahajournals.org/lookup/doi/10.1161/ATVBAHA.116.3
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http://dx.doi.org/10.1161/ATVBAHA.116.307166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808436PMC
April 2016

Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans.

J Lipid Res 2016 Mar 4;57(3):340-51. Epub 2015 Nov 4.

Isis Pharmaceuticals University of California San Diego, La Jolla, CA Division of Cardiovascular Medicine, University of California San Diego, La Jolla, CA

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http://dx.doi.org/10.1194/jlr.R052258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767000PMC
March 2016

Experimental Animal Models Evaluating the Causal Role of Lipoprotein(a) in Atherosclerosis and Aortic Stenosis.

Cardiovasc Drugs Ther 2016 Feb;30(1):75-85

Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California, La Jolla, San Diego, CA, USA.

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http://dx.doi.org/10.1007/s10557-015-6634-1DOI Listing
February 2016

Mechanistic insights into Lp(a)-induced IL-8 expression: a role for oxidized phospholipid modification of apo(a).

J Lipid Res 2015 Dec 16;56(12):2273-85. Epub 2015 Oct 16.

Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada

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http://dx.doi.org/10.1194/jlr.M060210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655984PMC
December 2015

Retrieval of a detached transseptal sheath tip from a right pulmonary artery branch following catheter ablation.

Catheter Cardiovasc Interv 2015 Nov 24;86(6):1131-5. Epub 2015 Apr 24.

Division of Cardiovascular Disease, Vascular Medicine Program, University of California San Diego Medical Center, Sulpizio Family Cardiovascular Center, La Jolla, California.

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http://dx.doi.org/10.1002/ccd.25957DOI Listing
November 2015

Apolipoprotein C-III: From Pathophysiology to Pharmacology.

Trends Pharmacol Sci 2015 Oct;36(10):675-687

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS Multimedica, Milan, Italy.

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http://dx.doi.org/10.1016/j.tips.2015.07.001DOI Listing
October 2015

Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis.

J Am Coll Cardiol 2015 Sep;66(11):1236-1246

Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.07.020DOI Listing
September 2015

Invasive Cardiologists Are Exposed to Greater Left Sided Cranial Radiation: The BRAIN Study (Brain Radiation Exposure and Attenuation During Invasive Cardiology Procedures).

JACC Cardiovasc Interv 2015 Aug;8(9):1197-1206

Division of Cardiovascular Medicine, University of California, San Diego Sulpizio Cardiovascular Center, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2015.03.027DOI Listing
August 2015

Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study.

Arterioscler Thromb Vasc Biol 2015 Jul 7;35(7):1704-11. Epub 2015 May 7.

From the Departments of Medicine (F.R., A.J.S., E.R.M., J.L.W., D.T.O., S.T.) and Psychiatry (A.X.M., C.M.N.), University of California, La Jolla; and University of Washington, Seattle (S.M.M.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483152PMC
July 2015

HDL-C, ABCA1-mediated cholesterol efflux, and lipoprotein(a): insights into a potential novel physiologic role of lipoprotein(a).

J Lipid Res 2015 Jul 26;56(7):1241-4. Epub 2015 May 26.

Division of Cardiovascular Medicine, University of California San Diego, Sulpizio Cardiovascular Center, La Jolla, CA.

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http://dx.doi.org/10.1194/jlr.E060947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479328PMC
July 2015

B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis.

Circ Res 2015 Jul 16;117(3):e28-39. Epub 2015 Jun 16.

From the Cardiovascular Research Center (S.M.R., H.M.P., P.S., S.G., D.D., C.M., C.A.M.), Department of Pathology (S.M.R., H.M.P.), Department of Medicine, Division of Cardiovascular Medicine (A.M.T., C.A.M.), and Beirne B. Carter Center for Immunology Research (T.P.B., C.A.M.), University of Virginia, Charlottesville; and Department of Medicine, Division of Endocrinology and Metabolism (A.G., T.A.P., J.L.W.) and Department of Medicine, Division of Cardiology (S.T.), University of California San Diego, La Jolla.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.306044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527334PMC
July 2015

Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials.

Arterioscler Thromb Vasc Biol 2015 Mar 22;35(3):689-99. Epub 2015 Jan 22.

From the Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil (R.D.S.); Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (F.J.R.); Department of Pharmacological and Biomolecular Sciences, University of Milan, IRCCS Multimedica, Milan, Italy (A.L.C.); Lipid Ambulatory Clinic, Charite-Universitaetsmedizin Berlin, Berlin, Germany (E.S.-T.); and University of California San Diego, La Jolla (J.L.W., S.T.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344404PMC
March 2015

Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies.

J Lipid Res 2015 Feb 18;56(2):440-8. Epub 2014 Dec 18.

Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Krems, Austria.

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http://dx.doi.org/10.1194/jlr.P054569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306697PMC
February 2015

Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.

Arterioscler Thromb Vasc Biol 2015 Jan 30;35(1):229-36. Epub 2014 Oct 30.

From the Department of Neurology (R.P., P.W., K.W., J.W., S.K.) and Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Genetic Epidemiology (M.S., F.K., M.H.), Medical University of Innsbruck, Innsbruck, Austria; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (P.W.); Departments of Laboratory Medicine (P.S.) and Internal Medicine (G.E.), Hospital of Bruneck, Bruneck, Italy; Department of Internal Medicine VI, Medical University of Innsbruck, Innsbruck, Austria (E.D., G.W.); Department of Medicine, University of California San Diego, La Jolla (S.T., J.L.W.); Department of Geriatric Medicine (B.I.) and First Department of Internal Medicine (B.P., L.K.), Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria; Institute of Epidemiology II (C.M., A.P.), Institute of Genetic Epidemiology (C.G., M.M.-N.), Research Unit of Molecular Epidemiology (C.G.), Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany (M.M.-N.); and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany (M.M.-N., A.P.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317265PMC
January 2015

Prevalence of coronary artery spasm after stent placement and its association with inflammation.

Int J Cardiol 2015 Jan 6;179:252-5. Epub 2014 Nov 6.

Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2014.11.025DOI Listing
January 2015

What is the ultimate test that lowering lipoprotein(a) is beneficial for cardiovascular disease and aortic stenosis?

Curr Opin Lipidol 2014 Dec;25(6):423-30

aDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City bDepartment of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan cSchool of Medicine, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1097/MOL.0000000000000131DOI Listing
December 2014