Publications by authors named "Soroush Maazinezhad"

3 Publications

  • Page 1 of 1

Treatment of chronic insomnia with atypical antipsychotics: results from a follow-up study.

Sleep Sci 2021 Jan-Mar;14(1):27-32

Sleep disorders research center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Objective: Second generation (atypical) antipsychotics are increasingly being used for treatment of insomnia, but there is little evidence to show long-term efficacy of these medication. This follow-up study was designed to assess patients with chronic insomnia who were treated with atypical antipsychotics.

Material And Methods: In this follow-up study, forty patients with chronic insomnia were evaluated between 2016 and 2018 following after one year of treatment with two atypical antipsychotic drugs of olanzapine and quetiapine in two groups in the sleep disorders research center of Kermanshah University of Medical Science in Iran. The Pittsburgh Sleep Quality Questionnaire (PSQI) and 5 consecutive nights of Actigraphy were utilized to evaluate both subjective and objective measures of sleep quality. Lastly, sleep quality before and after treatment and comparisons of sleep quality between the two groups were performed.

Results: Nine male participants comprised olanzapine group (n=22) and six male participants comprised the quetiapine group (n=18). The average age in the olanzapine group was 45.23±10.18 and the average age in the quetiapine group was 46.33±7.99. Results showed total PSQI score improved significantly in both groups (p<0.05), while the actigraphy results showed only significant improvement in sleep quality parameters in the quetiapine group (p<0.05).

Conclusion: Two atypical antipsychotics drugs of olanzapine and quetiapine have long-term efficacy in managing chronic insomnia. More improvements in objective sleep quality with quetiapine is promising for patients with chronic insomnia. Further research to evaluate long-term adverse effects of atypical antipsychotic drugs is recommended.
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June 2021

Compared to Individuals with Mild to Moderate Obstructive Sleep Apnea (OSA), Individuals with Severe OSA Had Higher BMI and Respiratory-Disturbance Scores.

Life (Basel) 2021 Apr 21;11(5). Epub 2021 Apr 21.

Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 67146, Iran.

Objective: Individuals with obstructive sleep apnea (OSA) are at increased risk to suffer from further somatic and sleep-related complaints. To assess OSA, demographic, anthropometric, and subjective/objective sleep parameters are taken into consideration, but often separately. Here, we entered demographic, anthropometric, subjective, and objective sleep- and breathing-related dimensions in one model.

Methods: We reviewed the demographic, anthropometric, subjective and objective sleep- and breathing-related data, and polysomnographic records of 251 individuals with diagnosed OSA. OSA was considered as a continuous and as categorical variable (mild, moderate, and severe OSA). A series of correlational computations, X-tests, F-tests, and a multiple regression model were performed to investigate which demographic, anthropometric, and subjective and objective sleep dimensions were associated with and predicted dimensions of OSA.

Results: Higher apnea/hypopnea index (AHI) scores were associated with higher BMI, higher daytime sleepiness, a higher respiratory disturbance index, and higher snoring. Compared to individuals with mild to moderate OSA, individuals with severe OSA had a higher BMI, a higher respiratory disturbance index (RDI) and a higher snoring index, while subjective sleep quality and daytime sleepiness did not differ. Results from the multiple regression analysis showed that an objectively shorter sleep duration, more N2 sleep, and a higher RDI predicted AHI scores.

Conclusion: The pattern of results suggests that blending demographic, anthropometric, and subjective/objective sleep- and breathing-related data enabled more effective discrimination of individuals at higher risk for OSA. The results are of practical and clinical importance: demographic, anthropometric, and breathing-related issues derived from self-rating scales provide a quick and reliable identification of individuals at risk of OSA; objective assessments provide further certainty and reliability.
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April 2021

Respiration data on sleep state misperception, psychophysiological insomnia and normal individuals from a cross sectional study.

Data Brief 2019 Oct 22;26:104428. Epub 2019 Aug 22.

Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

The data prepared here had been originally collected for a study project entitled 'Breathing pattern analysis in insomnia suffers'. This data describes the information of 82 individuals; participating 41 normal individuals and 41 insomnia suffers with tow phenotype included 30 sleep state misperception and 11 psychophysiological suffers. The data presents 8 hours of respiratory signals included flow pressure, flow temperature, Oxygen saturation, Thorax and Abdomen signal in frequency sampling 256, 32, 32, 32, 4 Hz respectively. It includes breathing features and sleep profiles in segments of 30s for each individuals. In addition, the full demographic and objective specifications was attached.
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October 2019