Publications by authors named "Soraya Horowitz"

8 Publications

  • Page 1 of 1

Treatment of Radiation Retinopathy with Intravitreal Injection of Ranibizumab (Lucentis).

Int Med Case Rep J 2020 11;13:27-32. Epub 2020 Feb 11.

Department of Ophthalmology, Universidade Federal Fluminense, Niteroi, Brazil.

To report a treatment of radiation retinopathy in a patient exposed to ionizing radiation for a period of 2 years. A 26-year-old female patient with no comorbidities diagnosed with myelodysplasia confirmed by bone marrow biopsy. She presented a complaint of bilateral progressive visual acuity reduction. At the ophthalmologic examination, she presented alterations suggestive of radiation retinopathy as well as macular thickness to optical coherence tomography (OCT) of over 500 µm. The patient underwent intravitreal injection (0.05 mL) of ranibizumab (Lucentis) monthly in both eyes and follow-up through visual acuity and OCT examination. She presented reduction of macular edema as well as a slight improvement of visual acuity. In this case, the treatment of radiation retinopathy with intravitreal injection of ranibizumab (Lucentis) was relatively useful, with a slight improvement of visual acuity, due to the regression of macular edema, not being curative.
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http://dx.doi.org/10.2147/IMCRJ.S191654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023963PMC
February 2020

Diathermy for 23-gauge sclerotomy: a functional and morphologic study to avoid ocular hypotony.

Clin Ophthalmol 2019 4;13:1703-1710. Epub 2019 Sep 4.

Department of Ophthalmology, Universidade Federal Fluminense, Niterói, Brazil.

Purpose: To evaluate diathermy to minimize sclerotomy leakage during small-gauge vitrectomy and prevent ocular hypotony.

Methods: This observational prospective study included 327 patients (327 eyes) who underwent diathermy to close the sclerotomy sites during 23-gauge pars plana vitrectomy (PPV). All patients were operated by a single surgeon (ED) and evaluated at 30 and 60 days postoperatively. Patients with glaucoma, topical/systemic steroids use exceeding 30 days, ocular inflammation, or trauma were excluded. Chi-square, Kruskal-Wallis, Fisher Exact test, and multivariate statistical analyses were performed to evaluate potential risk factors. The primary outcomes were open sclerotomies, leakage, and ocular hypotony.

Results: Sclerotomies remained open in 12 (3.6%) and 2 (0.6%) patients, respectively, at 30 and 60 days postoperatively, revealing no case of ocular hypotony. Leakage only occurred in four patients (1.2%) during week 1 postoperatively. Multivariate analysis indicated that additional vitreoretinal surgeries and longer surgeries were risk factors for persistent sclerotomy opening.

Conclusion: Diathermy was safe and feasible to close sclerotomies. Vitreoretinal surgery reoperations and longer surgeries were the most significant (<0.05) risk factors for persistent sclerotomy opening, which may be functionally closed without evidence of leakage or ocular hypotony.
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http://dx.doi.org/10.2147/OPTH.S209813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732740PMC
September 2019

Prevalence and factors associated with scleral hyaline plaque: clinical study of older adults in southeastern Brazil.

Clin Ophthalmol 2015 30;9:1187-93. Epub 2015 Jun 30.

Department of Ophthalmology, Universidade Federal Fluminense, Niterói, Brazil.

Purpose: To investigate the prevalence of scleral hyaline plaque among older adults in the city of Niterói in southeastern Brazil. A second goal was to assess the correlation between scleral hyaline plaque and several age-related diseases, including eye diseases and systemic diseases.

Methods: The study sample comprised 667 participants who were followed for 15 months. The study had a prospective, longitudinal, observational design that established inclusion and exclusion criteria. The following variables were selected for correlation with scleral hyaline plaque: sex, age, age range, iris color, ethnicity, presence of cataract, moderate to high myopia, age-related macular degeneration (AMD), diabetes mellitus, systemic arterial hypertension, degenerative arthritis, and osteoporosis. These correlations were assessed by means of the χ (2) test and Student's t-test. Multivariate analysis was performed to exclude factors that were potentially associated with aging exclusively but that did not have a direct relationship with hyaline plaque. Binary logistic regression was used to calculate odds ratios, significance, and confidence intervals.

Results: Scleral hyaline plaques were found in 177 patients (17.54%). There was a statistically significant association between the presence of hyaline plaques and sex (female), age range (≥70 years old), ethnicity (Caucasian), cataract, moderate to high myopia, systemic arterial hypertension, degenerative arthritis, and osteoporosis (P<0.05). On multivariate binary logistic regression analysis, only female sex, age range (≥70 years), moderate to high myopia, and degenerative arthritis exhibited significant correlation.

Conclusion: The prevalence of scleral hyaline plaque in the present study was higher than in previous reports in the medical literature. Several age-related diseases exhibited a correlation with scleral hyaline plaque. The most significant factors associated with scleral hyaline plaque were advanced age, female sex, moderate to high myopia, and degenerative arthritis.
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http://dx.doi.org/10.2147/OPTH.S82421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494614PMC
July 2015

Leuconostoc as a Cause of Endophthalmitis Post-intravitreal Injection of Ranibizumab.

Ocul Immunol Inflamm 2016 21;24(1):118-9. Epub 2014 Apr 21.

b Department of Ophthalmology School of Medicine - Universidade Federal Fluminense , Niteroi , Brazil.

Purpose: The authors report a case of endophthalmitis after intravitreal injection of ranibizumab.

Methods: After searching for extensive laboratory tests to isolate the etiologic agent Results: The agent was determined as Leuconostoc mesenteroides, gram-positive cocci, vancomycin resistant.

Discussion: Considerations regarding this bacterium were done by calling attention to its rarity, difficulty of isolation, and action on secondary comorbidities as opportunistic pathogen.
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http://dx.doi.org/10.3109/09273948.2014.898073DOI Listing
November 2016

Emphysema following vitrectomy with fluid-gas exchange: description of a rare complication.

Clin Ophthalmol 2014 11;8:401-3. Epub 2014 Feb 11.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Purpose: To report a case of subcutaneous emphysema involving the orbit, mediastinum, and face after pars plana vitrectomy with fluid-gas exchange.

Methods: Case report of a 55-year-old man who presented with bilateral eyelid and face edema and dysphagia in the immediate postoperative period after pars plana vitrectomy. Orbital and chest computed tomographies were performed, revealing emphysema of the orbit and soft tissue of the face, extending from the neck to the upper chest.

Results: The patient with a retinal detachment in the right eye underwent 23-gauge vitrectomy surgery with fluid-gas exchange and an implantation of silicone oil. The patient had a previous history of facial trauma for more than 20 years with an orbital fracture. After surgery, the patient developed emphysema of the orbit, soft tissue of the face and upper chest. Systemic prophylactic antibiotics associated with antibiotics and steroid drops performed a satisfactory evolution.

Conclusion: The fluid-gas exchange during pars plana vitrectomy in patients with orbital fracture can lead to emphysema of the face, chest, and soft tissue.
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http://dx.doi.org/10.2147/OPTH.S56083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929265PMC
March 2014

Anterior uveitis after treatment of age-related macular degeneration with ranibizumab and bevacizumab: uncommon complication.

Clin Ophthalmol 2012 31;6:1201-5. Epub 2012 Jul 31.

Ophthalmology Department, Hospital Naval Marcilio Dias, Rio de Janeiro, Brazil.

The authors describe one case of anterior uveitis after treatment of age-related macular degeneration with both antiangiogenic drugs: ranibizumab and bevacizumab. The case is described as a complication of ranibizumab and bevacizumab due to an inflammatory process. Several reasons are suggested to explain this possibility, and the authors conclude that the main cause remains unknown.
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http://dx.doi.org/10.2147/OPTH.S31239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422141PMC
October 2012

Pyogenic granuloma after retinal detachment surgery with scleral buckle: case report.

Arq Bras Oftalmol 2009 Jul-Aug;72(4):543-4

Departamento de Oftalmologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

The authors relate an uncommon case of pyogenic granuloma restricted to tarsal conjunctiva post retinopexy with scleral buckle.
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http://dx.doi.org/10.1590/s0004-27492009000400021DOI Listing
March 2010