Sophie Uyoga

Sophie Uyoga

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Sophie Uyoga

Sophie Uyoga

Publications by authors named "Sophie Uyoga"

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The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study.

Lancet Glob Health 2019 Oct 23;7(10):e1458-e1466. Epub 2019 Aug 23.

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; London School of Hygiene & Tropical Medicine, London, UK; INDEPTH Network, Accra, Ghana. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X193032
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http://dx.doi.org/10.1016/S2214-109X(19)30328-6DOI Listing
October 2019

Immediate Transfusion in African Children with Uncomplicated Severe Anemia.

N Engl J Med 2019 08;381(5):407-419

From the Department of Pediatrics (K.M., T.N.W.) and Nutrition Research Section (G.F.), Imperial College London, and the Medical Research Council Clinical Trials Unit at University College London (E.C.G., D.M.G., A.S.W.), London, the Centre for Health Economics, University of York, York (P.S.G.), the School of Medicine, Dentistry, and Biomedical Science, Queen's University, Belfast (N.K.), Liverpool School of Tropical Medicine and Hygiene, Liverpool (I.B.), and the Department of Pediatrics, University Hospital of Wales, Cardiff (J.A.E.) - all in the United Kingdom; the Department of Pediatrics, Makerere University and Mulago Hospital (S.K., R.O.O., E.N.), and the Uganda Blood Transfusion Services (BTS), National BTS (D.K.B.), Kampala, Busitema University Faculty of Health Sciences, Mbale Campus and Mbale Regional Referral Hospital (P.O.-O., J.N., C.N.), and Mbale BTS (B.W.), Mbale, and the Soroti Regional Referral Hospital, Soroti (C.E., F.A., M.N.) - all in Uganda; the College of Medicine and Malawi-Liverpool-Wellcome Trust Clinical Research Program (M.M., G.C.). and Malawi BTS (B.M.), Blantyre, Malawi; and the Kenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya (K.M., A.M. S.U., T.N.W.).

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http://dx.doi.org/10.1056/NEJMoa1900105DOI Listing
August 2019

Transfusion Volume for Children with Severe Anemia in Africa.

N Engl J Med 2019 08;381(5):420-431

From the Department of Medicine (K.M., T.N.W.) and Nutrition Research Section (G.F.), Imperial College London, and the Medical Research Council Clinical Trials Unit at University College London (E.C.G., D.M.G., A.S.W.), London, the School of Medicine, Dentistry, and Biomedical Science, Queen's University, Belfast (N.K.), the Liverpool School of Tropical Medicine and Hygiene, Liverpool (I.B.), the Department of Pediatrics, University Hospital of Wales, Cardiff (J.A.E.), and the Centre for Health Economics, University of York, York (P.S.G.) - all in the United Kingdom; Busitema University Faculty of Health Sciences, Mbale Campus, Mbale Regional Referral Hospital (P.O.-O., J.N., C.N.), and the Mbale Blood Transfusion Services (B.W.), Mbale, the Department of Pediatrics, Makerere University and Mulago Hospital (S.K., R.O.O., J.K.), and the Uganda Blood Transfusion Services, National Blood Transfusion Services (D.K.B.), Kampala, and Soroti Regional Referral Hospital, Soroti (F.A., C.E., M.N.) - all in Uganda; the Kenya Medical Research Institute-Wellcome Trust Research Program, Kilifi (K.M., A.M., S.U., T.N.W.); and the College of Medicine and the Malawi-Liverpool-Wellcome Trust Clinical Research Program (G.C., M.M., N.K.) and the Malawi Blood Transfusion Services (B.M.) - all in Blantyre, Malawi.

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http://dx.doi.org/10.1056/NEJMoa1900100DOI Listing
August 2019

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.

Elife 2017 01 9;6. Epub 2017 Jan 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.15085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222559PMC
January 2017

Environmental Correlation Analysis for Genes Associated with Protection against Malaria.

Mol Biol Evol 2016 05 6;33(5):1188-204. Epub 2016 Jan 6.

Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Department of Medicine, Imperial College, London, United Kingdom INDEPTH Network, Kanda, Accra, Ghana.

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http://dx.doi.org/10.1093/molbev/msw004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839215PMC
May 2016

Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya.

EBioMedicine 2015 Oct 8;2(10):1478-86. Epub 2015 Aug 8.

Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Programme (KWTRP), PO Box 230-80108, Kilifi, Kenya ; Department of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.ebiom.2015.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634196PMC
October 2015

Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study.

Lancet Haematol 2015 Oct 22;2(10):e437-44. Epub 2015 Sep 22.

Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Department of Medicine, Imperial College, St Mary's Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(15)00152-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703047PMC
October 2015

Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children.

Blood 2014 May 4;123(21):3221-9. Epub 2014 Mar 4.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford University Hospitals, United Kingdom;

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http://dx.doi.org/10.1182/blood-2013-10-533000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046425PMC
May 2014

Transfer of 4-hydroxynonenal from parasitized to non-parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia.

Br J Haematol 2012 Apr 20;157(1):116-24. Epub 2012 Jan 20.

Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy.

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http://dx.doi.org/10.1111/j.1365-2141.2011.09015.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412292PMC
April 2012

The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya.

Clin Infect Dis 2007 Mar 7;44(6):802-9. Epub 2007 Feb 7.

KEMRI/Wellcome Trust Programme, Centre of Geographic Medicine Research, Kilifi District Hospital, Kilifi, Kenya.

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http://dx.doi.org/10.1086/511868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659731PMC
March 2007

The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya.

PLoS Med 2006 May 18;3(5):e158. Epub 2006 Apr 18.

Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research Coast, Kilifi District Hospital, Kilifi, Kenya.

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http://dx.doi.org/10.1371/journal.pmed.0030158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435778PMC
May 2006

Co-inheritance of alpha+-thalassaemia and sickle trait results in specific effects on haematological parameters.

Br J Haematol 2006 Apr;133(2):206-9

Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi, Kenya.

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http://dx.doi.org/10.1111/j.1365-2141.2006.06006.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394356PMC
April 2006

Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait.

Nat Genet 2005 Nov 16;37(11):1253-7. Epub 2005 Oct 16.

Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi, Kenya.

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http://dx.doi.org/10.1038/ng1660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521056PMC
November 2005

Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya.

Blood 2005 Jul 15;106(1):368-71. Epub 2005 Mar 15.

Wellcome Trust/Kenya Medical Research Institute (KEMRI), Centre for Geographic Medicine Research, Kilifi, Kenya.

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http://dx.doi.org/10.1182/blood-2005-01-0313DOI Listing
July 2005