Sophie Langouët

Sophie Langouët

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Sophie Langouët

Sophie Langouët

Publications by authors named "Sophie Langouët"

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36Publications

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In silico prediction of Heterocyclic Aromatic Amines metabolism susceptible to form DNA adducts in humans.

Toxicol Lett 2019 Jan 10;300:18-30. Epub 2018 Oct 10.

Univ Rennes, Inserm, EHESP, Irset - UMR_S1085, F-35043 Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2018.10.011DOI Listing
January 2019

Long term exposure to environmental concentrations of diesel exhaust particles does not impact the phenotype of human bronchial epithelial cells.

Toxicol In Vitro 2018 Oct 19;52:154-160. Epub 2018 Jun 19.

Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2018.06.014DOI Listing
October 2018

Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes.

Chem Res Toxicol 2017 02 15;30(2):657-668. Epub 2016 Dec 15.

Institut National de la Santé et de la Recherche Médicale (Inserm), U1085, Institut de Recherche en Santé Environnement et Travail (IRSET), Université de Rennes 1, UMS 3480 Biosit , F-35043 Rennes, France.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439433PMC
February 2017

Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts.

Environ Mol Mutagen 2016 12 1;57(9):656-667. Epub 2016 Nov 1.

Institut National de la Santé et de la Recherche Médicale (Inserm), U1085, Institut de Recherche en Santé Environnement et Travail (IRSET), Université de Rennes 1, UMS 3480 Biosit, Rennes, F-35043, France.

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http://dx.doi.org/10.1002/em.22059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123841PMC
December 2016

Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment.

J Cell Biochem 2016 Mar 8;117(3):708-20. Epub 2015 Sep 8.

Institut National de la Santé et de la Recherche Médicale (Inserm), UMR1085 Institut de Recherche sur la Santé l'Environnement et le Travail (IRSET); University of Rennes 1, SFR Biosit, F-35043, Rennes, France.

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http://dx.doi.org/10.1002/jcb.25356DOI Listing
March 2016

2-Amino-9H-pyrido[2,3-b]indole (AαC) Adducts and Thiol Oxidation of Serum Albumin as Potential Biomarkers of Tobacco Smoke.

J Biol Chem 2015 Jun 7;290(26):16304-18. Epub 2015 May 7.

From the Masonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455 and

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http://dx.doi.org/10.1074/jbc.M115.646539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481229PMC
June 2015

Mass Spectrometric Characterization of Human Serum Albumin Adducts Formed with N-Oxidized Metabolites of 2-Amino-1-methylphenylimidazo[4,5-b]pyridine in Human Plasma and Hepatocytes.

Chem Res Toxicol 2015 May 10;28(5):1045-59. Epub 2015 Apr 10.

†Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiology Research Building, University of Minnesota, 2231 6th Street, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.5b00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437839PMC
May 2015

MEK1/2 overactivation can promote growth arrest by mediating ERK1/2-dependent phosphorylation of p70S6K.

J Cell Physiol 2014 Jul;229(7):903-15

UMR Inserm U1085 IRSET, Université de Rennes 1, UMS 3480 Biosit, Rennes, France.

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http://dx.doi.org/10.1002/jcp.24521DOI Listing
July 2014

MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells.

Carcinogenesis 2013 Jan 5;34(1):38-47. Epub 2012 Oct 5.

Inserm U1085, Institut de Recherche sur la Santé l'Environnement et le Travail IRSET, Université de Rennes 1, Biosit, F-35043 Rennes, France.

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http://dx.doi.org/10.1093/carcin/bgs317DOI Listing
January 2013

UDP-glucuronosyltransferase-mediated metabolic activation of the tobacco carcinogen 2-amino-9H-pyrido[2,3-b]indole.

J Biol Chem 2012 Apr 5;287(18):14960-72. Epub 2012 Mar 5.

Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA.

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http://dx.doi.org/10.1074/jbc.M111.320093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340249PMC
April 2012

The complexity of ERK1 and ERK2 MAPKs in multiple hepatocyte fate responses.

J Cell Physiol 2012 Jan;227(1):59-69

EA 4427-SeRAIC, IRSET, IFR 140, Campus Biologie-Santé, F-35043 Rennes, France.

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http://dx.doi.org/10.1002/jcp.22742DOI Listing
January 2012

The knock-down of ERCC1 but not of XPF causes multinucleation.

DNA Repair (Amst) 2011 Sep 12;10(9):978-90. Epub 2011 Aug 12.

EA4427 SeRAIC (Signaling and Responses to Infectious and Chemical Agents), Institut de Recherche en Santé, Environnement et Travail, Université de Rennes 1, 2 avenue du Pr L. Bernard, 35043 Rennes Cedex, France.

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https://linkinghub.elsevier.com/retrieve/pii/S15687864110019
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http://dx.doi.org/10.1016/j.dnarep.2011.07.005DOI Listing
September 2011

DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.

Chem Res Toxicol 2011 Jun 19;24(6):913-25. Epub 2011 Apr 19.

Institut de Recherche en Santé Environnement Travail, EA4427 SeRAIC, Université Rennes 1, IFR 140, 2 Avenue du Pr L Bernard, 35043 Rennes, France.

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http://dx.doi.org/10.1021/tx200091yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118939PMC
June 2011

Xenobiotic-metabolizing cytochromes p450 in human white adipose tissue: expression and induction.

Drug Metab Dispos 2010 Apr 24;38(4):679-86. Epub 2009 Dec 24.

Institut National de la Santé et de la Recherche Médicale, Université Paris Descartes, Interdisciplinary Institute of Life Sciences des Saints Péres, Paris, France.

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http://dx.doi.org/10.1124/dmd.109.029249DOI Listing
April 2010

RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo.

Int J Cancer 2010 Mar;126(6):1367-77

EA 4427-SeRAIC, IFR 140, Université de Rennes 1, F-35043 Rennes, France.

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http://dx.doi.org/10.1002/ijc.24950DOI Listing
March 2010

Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes.

Toxicol In Vitro 2010 Mar 12;24(2):452-9. Epub 2009 Oct 12.

INSERM U620, Université de Rennes 1, F-35043, France.

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http://dx.doi.org/10.1016/j.tiv.2009.09.025DOI Listing
March 2010

Screening for DNA adducts by data-dependent constant neutral loss-triple stage mass spectrometry with a linear quadrupole ion trap mass spectrometer.

Anal Chem 2009 Jan;81(2):809-19

Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA.

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http://dx.doi.org/10.1021/ac802096pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646368PMC
January 2009

Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).

Drug Metab Dispos 2008 Dec 28;36(12):2556-63. Epub 2008 Aug 28.

Unité Propre de Recherche et de l'Enseignement Supérieur SeRAIC/Institut National de la Santé et de la Recherche Médicale U620, Université de Rennes 1, Faculté de Pharmacie, IFR140, Rennes, France.

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http://dx.doi.org/10.1124/dmd.108.023333DOI Listing
December 2008

Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.

Toxicol In Vitro 2008 Apr 25;22(3):632-42. Epub 2008 Jan 25.

INSERM U620, Université de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France.

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http://dx.doi.org/10.1016/j.tiv.2007.12.004DOI Listing
April 2008

GATA-1 is essential in EGF-mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells.

Cancer Res 2007 Mar;67(5):2114-23

Institut National de la Santé et de la Recherche Médicale U620, Université de Rennes I, Hôpital Pontchaillou, IFR 140, 2 avenue du Pr Léon Bernard, 35043 Rennes Cedex, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3821DOI Listing
March 2007

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.

Drug Metab Dispos 2006 Jan 4;34(1):75-83. Epub 2005 Oct 4.

Institut National de la Santé et de la Recherche Médicale (INSERM) U620, Université de Rennes 1, France.

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http://dx.doi.org/10.1124/dmd.105.006759DOI Listing
January 2006

Overexpression of the two nucleotide excision repair genes ERCC1 and XPC in human hepatocellular carcinoma.

J Hepatol 2005 Aug 25;43(2):288-93. Epub 2005 Apr 25.

INSERM U620, Détoxication et Reparation Tissulaire, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, 35043 Rennes Cedex, France.

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http://dx.doi.org/10.1016/j.jhep.2005.02.020DOI Listing
August 2005

Oltipraz regulates different categories of genes relevant to chemoprevention in human hepatocytes.

Carcinogenesis 2005 Feb 21;26(2):343-51. Epub 2004 Oct 21.

INSERM U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, 35043 Rennes, France.

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http://dx.doi.org/10.1093/carcin/bgh316DOI Listing
February 2005

Upregulation of DNA repair genes in active cirrhosis associated with hepatocellular carcinoma.

FEBS Lett 2005 Jan;579(1):95-9

INSERM U620, Détoxication et Réparation Tissulaire, Facultés de Médecine et Pharmacie, Université de Rennes I, 2 Av. Léon Bernard, 35043 Rennes Cedex, France.

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http://dx.doi.org/10.1016/j.febslet.2004.09.092DOI Listing
January 2005

Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2.

Mutat Res 2002 Sep;506-507:187-95

National Center for Toxicological Research, 3900 NCTR DR, HFT 100 Jefferson, AR 72079-9502, USA.

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http://dx.doi.org/10.1016/s0027-5107(02)00165-3DOI Listing
September 2002

1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase.

J Biol Chem 2002 Jul 16;277(30):26987-93. Epub 2002 May 16.

Groupe Réparation de l'ADN, Unité Mixte de Recherche 8532 CNRS, Laboratoire de Biotechnologies et Pharmacologie Génétique Appliquée-Ecole Normale Supérieure Cachan, Institut Gustave Roussy, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1074/jbc.M111100200DOI Listing
July 2002

Investigations on the effects of oltipraz on the nucleotide excision repair in the liver.

Biochem Pharmacol 2002 Feb;63(4):745-9

INSERM U456, Détoxication et Réparation Tissulaire, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, 2 avenue Léon Bernard, 35043 cédex, Rennes, France.

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http://dx.doi.org/10.1016/s0006-2952(01)00906-6DOI Listing
February 2002

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes.

Carcinogenesis 2002 Jan;23(1):115-22

INSERM U456, Faculté de Pharmacie, Université de Rennes I, 35043 Rennes, France.

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http://dx.doi.org/10.1093/carcin/23.1.115DOI Listing
January 2002