Sophie Hambleton

Sophie Hambleton

UNVERIFIED PROFILE

Are you Sophie Hambleton?   Register this Author

Register author
Sophie Hambleton

Sophie Hambleton

Publications by authors named "Sophie Hambleton"

Are you Sophie Hambleton?   Register this Author

89Publications

3246Reads

22Profile Views

Novel Gain-of-Function Mutation in Stat1 Sumoylation Site Leads to CMC/CID Phenotype Responsive to Ruxolitinib.

J Clin Immunol 2019 Sep 11. Epub 2019 Sep 11.

Department of Paediatric Immunology and Infectious Diseases, Children's Health Ireland, Crumlin, Dublin, D12 N512, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10875-019-00687-4DOI Listing
September 2019

New graft manipulation strategies improve the outcome of mismatched stem cell transplantation in children with primary immunodeficiencies.

J Allergy Clin Immunol 2019 Jul 4;144(1):280-293. Epub 2019 Feb 4.

Molecular and Cellular Immunology Unit, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom; Blood and Bone Marrow Transplant Unit, Great Ormond Street Hospital, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.01.030DOI Listing
July 2019

Two decades of excellent transplant survival for chronic granulomatous disease: a supraregional immunology transplant center report.

Blood 2019 Jun 5;133(23):2546-2549. Epub 2019 Apr 5.

Department of Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Great North Children's Hospital, Newcastle upon Tyne Hospital National Health Service (NHS) Foundation Trust, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019000021DOI Listing
June 2019

Life-threatening pulmonary interstitial lung disease complicating pediatric nonhumoral immunodeficiencies.

J Allergy Clin Immunol Pract 2019 Sep - Oct;7(7):2456-2458.e4. Epub 2019 Apr 3.

Department of Paediatric Allergy & Immunology, Lydia Becker Institute of Immunology & Inflammation, University of Manchester, Manchester, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.03.034DOI Listing
April 2019

Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain.

J Allergy Clin Immunol 2019 Jan 8;143(1):413-416.e4. Epub 2018 Sep 8.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749183128
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2018.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320259PMC
January 2019

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.

J Allergy Clin Immunol 2018 12 4;142(6):1932-1946. Epub 2018 May 4.

Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Immunology and Transplantation, Royal Free Hospital, University College London, London, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2018.02.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215742PMC
December 2018

Non-posttransplant lymphoproliferative disorder malignancy after hematopoietic stem cell transplantation in patients with primary immunodeficiency: UK experience.

J Allergy Clin Immunol 2018 06 7;141(6):2319-2321.e1. Epub 2018 Mar 7.

Children's Haemopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2018.02.038DOI Listing
June 2018

Dedicator of cytokinesis 8-deficient CD4 T cells are biased to a T2 effector fate at the expense of T1 and T17 cells.

J Allergy Clin Immunol 2017 Mar 20;139(3):933-949. Epub 2016 Aug 20.

Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Australia; St Vincent's Clinical School, University of New South Wales, Darlinghurst, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.07.016DOI Listing
March 2017

Hematopoietic stem cell transplant in patients with activated PI3K delta syndrome.

J Allergy Clin Immunol 2017 03 12;139(3):1046-1049. Epub 2016 Nov 12.

Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle upon Tyne University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2016.09.040DOI Listing
March 2017

Haploidentical CD3 TCRαβ and CD19-depleted second stem cell transplant for steroid-resistant acute skin graft versus host disease.

J Allergy Clin Immunol 2016 08 23;138(2):603-605.e1. Epub 2016 Mar 23.

Department of Paediatric Immunology, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle upon Tyne University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2015.12.1335DOI Listing
August 2016

When the STATs are against you.

Authors:
Sophie Hambleton

Blood 2016 06;127(25):3109-10

NEWCASTLE UNIVERSITY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-05-715029DOI Listing
June 2016

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.

Brain 2015 Oct 29;138(Pt 10):2834-46. Epub 2015 Jun 29.

1 Mitochondrial Research Group, Genetics and Genomic Medicine, UCL Institute of Child Health, Guilford Street, London, UK 1 Mitochondrial Research Group, Genetics and Genomic Medicine, UCL Institute of Child Health, Guilford Street, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awv182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808733PMC
October 2015

Human IFNAR2 deficiency: Lessons for antiviral immunity.

Sci Transl Med 2015 Sep;7(307):307ra154

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 4LP, UK. Pediatric Immunology Service, Great North Children's Hospital, Newcastle upon Tyne NE1 4LP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aac4227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926955PMC
September 2015

A new case of Fas-associated death domain protein deficiency and update on treatment outcomes.

J Allergy Clin Immunol 2015 Aug 17;136(2):502-5.e4. Epub 2015 Mar 17.

Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2015.02.002DOI Listing
August 2015

Varicella zoster virus infection.

Nat Rev Dis Primers 2015 07 2;1:15016. Epub 2015 Jul 2.

Research Foundation for Microbial Diseases, Osaka University, Suita, Osaka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrdp.2015.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381807PMC
July 2015

Troublesome Thai travels.

Arch Dis Child Educ Pract Ed 2015 Jun 26;100(3):144-5, 166-7. Epub 2014 Nov 26.

Department of Paediatric Immunology, Infectious Disease and Allergy, Great North Children's Hospital, Newcastle-upon-Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/archdischild-2013-305874DOI Listing
June 2015

Varicella zoster virus immunity: A primer.

J Infect 2015 Jun 25;71 Suppl 1:S47-53. Epub 2015 Apr 25.

Primary Immunodeficiency Group, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, Newcastle University, Medical School, Newcastle Upon Tyne, NE2 4HH, UK; Great North Children's Hospital, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinf.2015.04.015DOI Listing
June 2015

Gut immune reconstitution in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome after hematopoietic stem cell transplantation.

J Allergy Clin Immunol 2015 Jan 25;135(1):260-2. Epub 2014 Oct 25.

Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, United Kingdom; Department of Pediatric Immunology, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2014.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282727PMC
January 2015

Host genetic factors in susceptibility to mycobacterial disease.

Clin Med (Lond) 2014 Dec;14 Suppl 6:s17-21

Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK, and Department of Infection and Tropical Medicine Royal Victoria Infirmary, Newcastle-upon-Tyne, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7861/clinmedicine.14-6-s17DOI Listing
December 2014

Dual proteolytic pathways govern glycolysis and immune competence.

Cell 2014 Dec;159(7):1578-90

Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297473PMC
December 2014

Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency.

Blood 2014 Aug 3;124(6):851-60. Epub 2014 Jun 3.

Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany; Center for Paediatrics and Adolescent Medicine, University Medical Center, University of Freiburg, Freiburg, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-03-564286DOI Listing
August 2014

Low-dose serotherapy improves early immune reconstitution after cord blood transplantation for primary immunodeficiencies.

Biol Blood Marrow Transplant 2014 Feb 10;20(2):243-9. Epub 2013 Nov 10.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2013.11.005DOI Listing
February 2014

STAT2 deficiency and susceptibility to viral illness in humans.

Proc Natl Acad Sci U S A 2013 Feb 7;110(8):3053-8. Epub 2013 Feb 7.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1220098110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581986PMC
February 2013

Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands.

Leuk Lymphoma 2013 Jan 8;54(1):167-73. Epub 2012 Sep 8.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/10428194.2012.708026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588533PMC
January 2013

PEPtalk: postexposure prophylaxis against varicella in children with cancer.

Arch Dis Child 2011 Sep 28;96(9):841-5. Epub 2011 Jun 28.

Division of Clinical Sciences, St George's, University of London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/adc.2010.209650DOI Listing
September 2011

Human dendritic cell deficiency: the missing ID?

Nat Rev Immunol 2011 Aug 19;11(9):575-83. Epub 2011 Aug 19.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri3046DOI Listing
August 2011

Preventing varicella in children with malignancies: what is the evidence?

Curr Opin Infect Dis 2011 Jun;24(3):203-11

Northern Institute of Cancer Research, Newcastle University, Newcastle Upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QCO.0b013e328345d666DOI Listing
June 2011

Editorial commentary: a better grip: T cells strengthen our hand against influenza.

Authors:
Sophie Hambleton

Clin Infect Dis 2011 Jan;52(1):8-9

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciq018DOI Listing
January 2011

Low-strength T-cell activation promotes Th17 responses.

Blood 2010 Dec 16;116(23):4829-37. Epub 2010 Aug 16.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-03-272153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223073PMC
December 2010

The role of vaccination in prevention of VZV disease in the immunocompromised child.

Authors:
Sophie Hambleton

Clin Adv Hematol Oncol 2009 Mar;7(3):159-61

Paediatric Immunology and Infectious Diseases, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, NE1 7RU, United Kingdom.

View Article

Download full-text PDF

Source
March 2009

Prevention of varicella in children with cancer: Is it time to reconsider our strategy?

Pediatr Blood Cancer 2008 Oct;51(4):451-2

Department of Paediatric and Adolescent Oncology, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.21680DOI Listing
October 2008

Biliary cirrhosis in a child with inherited interleukin-12 deficiency.

J Trop Pediatr 2008 Aug 19;54(4):269-71. Epub 2008 Jan 19.

Department of Paediatrics, University of Oxford, CCVTM, Churchill Hospital, Oxford OX3 7LJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/tropej/fmm119DOI Listing
August 2008

Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity.

J Biol Chem 2008 Apr 22;283(17):11785-93. Epub 2008 Feb 22.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M708424200DOI Listing
April 2008

Risk of herpes zoster in adults immunized with varicella vaccine.

J Infect Dis 2008 Mar;197 Suppl 2:S196-9

Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/522131DOI Listing
March 2008

Prevention of varicella and zoster by live attenuated VZV vaccine.

Authors:
Sophie Hambleton

Front Biosci 2008 Jan 1;13:2696-704. Epub 2008 Jan 1.

Children's Bone Marrow Transplant Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2741/2876DOI Listing
January 2008

Chickenpox party or varicella vaccine?

Adv Exp Med Biol 2005 ;568:11-24

Columbia University, Department of Pediatrics, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/0-387-25342-4_2DOI Listing
September 2005

Chickenpox.

Authors:
Sophie Hambleton

Curr Opin Infect Dis 2005 Jun;18(3):235-40

Department of pediatrics, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
June 2005

Preventing varicella-zoster disease.

Clin Microbiol Rev 2005 Jan;18(1):70-80

Columbia University College of Physicians and Surgeons, 650 W. 168th Street, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/CMR.18.1.70-80.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544176PMC
January 2005

The impact of varicella vaccination in the United States.

Semin Pediatr Infect Dis 2005 Jan;16(1):38-43

Department of Pediatrics, Columbia University, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.spid.2004.09.010DOI Listing
January 2005

Structural and functional properties of the human notch-1 ligand binding region.

Structure 2004 Dec;12(12):2173-83

Division of Molecular and Cellular Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2004.09.012DOI Listing
December 2004

Varicella vaccine for susceptible adults: do it today.

Clin Infect Dis 2004 Dec 9;39(11):1640-1. Epub 2004 Nov 9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/425618DOI Listing
December 2004

Bone and joint infections in children.

Adv Exp Med Biol 2004 ;549:47-62

Department of Pediatrics, John Radcliffe Hospital, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4419-8993-2_9DOI Listing
August 2004