Sophie Erhardt

Sophie Erhardt

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Sophie Erhardt

Sophie Erhardt

Publications by authors named "Sophie Erhardt"

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Increased peripheral levels of TARC/CCL17 in first episode psychosis patients.

Schizophr Res 2019 Aug 3;210:221-227. Epub 2019 Jan 3.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.12.033DOI Listing
August 2019

Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.

Eur Arch Psychiatry Clin Neurosci 2019 Jul 13. Epub 2019 Jul 13.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00406-019-01042-9DOI Listing
July 2019

Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls.

Transl Psychiatry 2019 01 29;9(1):37. Epub 2019 Jan 29.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41398-019-0378-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351610PMC
January 2019

Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients.

Schizophr Res 2018 09 4;199:438-441. Epub 2018 Apr 4.

Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.03.029DOI Listing
September 2018

Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: Relevance for schizophrenia.

Neuropharmacology 2018 08 5;138:130-139. Epub 2018 Jun 5.

Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden; Department of Physiology and Pharmacology, Karolinska Institute, Biomedicum 5C, 171 77, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908183027
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http://dx.doi.org/10.1016/j.neuropharm.2018.06.003DOI Listing
August 2018

Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression.

Neurosci Biobehav Rev 2018 07 12;90:212-220. Epub 2018 Apr 12.

Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Deakin University, School of Medicine, 75 Pigdons Road, Waurn Ponds, VIC 3216, Australia; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, United States; Deakin University, School of Psychology, 221 Burwood Highway, Burwood, VIC 3154, Australia; Queensland Brain Institute, The Universty of Queensland, St Lucia, QLD 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2018.04.002DOI Listing
July 2018

First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction.

Schizophr Res 2018 05 23;195:406-408. Epub 2017 Sep 23.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.schres.2017.09.016DOI Listing
May 2018

Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression.

Acta Neuropsychiatr 2017 Feb 13;29(1):54-58. Epub 2016 Jul 13.

2Department of Clinical Neuroscience,Karolinska Institutet,Stockholm,Sweden.

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http://dx.doi.org/10.1017/neu.2016.31DOI Listing
February 2017

The kynurenine pathway in schizophrenia and bipolar disorder.

Neuropharmacology 2017 Jan 28;112(Pt B):297-306. Epub 2016 May 28.

Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S00283908163022
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http://dx.doi.org/10.1016/j.neuropharm.2016.05.020DOI Listing
January 2017

Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes.

Diabetes Metab Res Rev 2016 10 1;32(7):754-761. Epub 2016 May 1.

Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/dmrr.2798DOI Listing
October 2016

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans.

Am J Physiol Cell Physiol 2016 May 30;310(10):C836-40. Epub 2016 Mar 30.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Unit of Cardiology, Karolinska Institutet, Stockholm, Sweden; and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden

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http://dx.doi.org/10.1152/ajpcell.00053.2016DOI Listing
May 2016

Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons.

Neuropharmacology 2016 Mar 24;102:42-7. Epub 2015 Oct 24.

Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2015.10.028DOI Listing
March 2016

Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes.

Diabetes Metab Res Rev 2016 10 1;32(7):754-761. Epub 2016 May 1.

Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/dmrr.2798DOI Listing
October 2016

Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms.

Brain Behav Immun 2016 Jan 17;51:47-55. Epub 2015 Jul 17.

Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbi.2015.07.016DOI Listing
January 2016

Chronic Antipsychotic Treatment in the Rat - Effects on Brain Interleukin-8 and Kynurenic Acid.

Int J Tryptophan Res 2015 20;8:49-52. Epub 2015 Sep 20.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.4137/IJTR.S25915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578548PMC
October 2015

[New findings about schizophrenia can provide new diagnostics and treatment].

Lakartidningen 2015 Oct 13;112. Epub 2015 Oct 13.

Karolinska Institutet - Klinisk Neurovetenskap Stockholm, Sweden Karolinska Institutet - Klinisk Neurovetenskap Stockholm, Sweden.

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October 2015

Imbalanced kynurenine pathway in schizophrenia.

Int J Tryptophan Res 2014 16;7:15-22. Epub 2014 Sep 16.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.4137/IJTR.S16800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179604PMC
October 2014

Kynurenic Acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with lewy bodies.

Int J Tryptophan Res 2014 28;7:1-7. Epub 2014 Apr 28.

Department of Physiology and Pharmacology Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.4137/IJTR.S13958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011721PMC
May 2014

Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder.

Bipolar Disord 2012 Nov 3;14(7):719-26. Epub 2012 Oct 3.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bdi.12009DOI Listing
November 2012

Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder.

Bipolar Disord 2012 Nov 3;14(7):719-26. Epub 2012 Oct 3.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bdi.12009DOI Listing
November 2012

Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia.

Schizophr Bull 2012 May 20;38(3):426-32. Epub 2010 Aug 20.

Department of Physiology and Pharmacology, Nanna Svartz väg 2, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1093/schbul/sbq086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329991PMC
May 2012

Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice.

J Neural Transm (Vienna) 2012 Feb 9;119(2):155-63. Epub 2011 Sep 9.

Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz väg 2, 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00702-011-0706-6DOI Listing
February 2012

Role of the NMDA-receptor in Prepulse Inhibition in the Rat.

Int J Tryptophan Res 2010 12;3:1-12. Epub 2010 Feb 12.

Dept. of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195246PMC
November 2011

Elevation of cerebrospinal fluid interleukin-1ß in bipolar disorder.

J Psychiatry Neurosci 2011 Mar;36(2):114-8

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1503/jpn.100080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044194PMC
March 2011

Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct.

J Neuroinflammation 2010 Aug 6;7:44. Epub 2010 Aug 6.

Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/1742-2094-7-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925358PMC
August 2010

Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder.

J Psychiatry Neurosci 2010 May;35(3):195-9

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861136PMC
May 2010

Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia.

Int J Neuropsychopharmacol 2009 May 17;12(4):501-12. Epub 2008 Sep 17.

Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1017/S1461145708009383DOI Listing
May 2009

Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.

CNS Drugs 2009 ;23(2):91-101

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2165/00023210-200923020-00001DOI Listing
April 2009

Prenatal dexamethasone impairs behavior and the activation of the BDNF exon IV promoter in the paraventricular nucleus in adult offspring.

Endocrinology 2008 Dec 28;149(12):6356-65. Epub 2008 Aug 28.

Department of Physiology & Pharmacology Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1210/en.2008-0388DOI Listing
December 2008

Clozapine interacts with the glycine site of the NMDA receptor: electrophysiological studies of dopamine neurons in the rat ventral tegmental area.

Life Sci 2008 Aug 10;83(5-6):170-5. Epub 2008 Jun 10.

Department of Physiology and Pharmacology, Karolinska Institute, SE 171 77 Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S002432050800231
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http://dx.doi.org/10.1016/j.lfs.2008.05.014DOI Listing
August 2008

Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: a pharmacological analysis.

Neuropharmacology 2007 Dec 20;53(8):918-24. Epub 2007 Sep 20.

Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuropharm.2007.09.003DOI Listing
December 2007

The kynurenic acid hypothesis of schizophrenia.

Physiol Behav 2007 Sep 21;92(1-2):203-9. Epub 2007 May 21.

Karolinska Institutet, Department of Physiology and Pharmacology, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.physbeh.2007.05.025DOI Listing
September 2007

Cerebrospinal fluid kynurenic acid in male and female controls - correlation with monoamine metabolites and influences of confounding factors.

J Psychiatr Res 2007 Jan-Feb;41(1-2):144-51. Epub 2006 Jan 24.

Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jpsychires.2005.12.001DOI Listing
February 2007

Cerebrospinal fluid kynurenic acid in male patients with schizophrenia - correlation with monoamine metabolites.

Acta Neuropsychiatr 2007 Feb;19(1):45-52

1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1601-5215.2006.00170.xDOI Listing
February 2007

Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons--possible involvement of endogenous kynurenic acid.

Synapse 2006 Apr;59(5):290-8

Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1002/syn.20241DOI Listing
April 2006

Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms.

Int J Neuropsychopharmacol 2005 Sep 18;8(3):329-39. Epub 2005 Feb 18.

Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1017/S1461145705005080DOI Listing
September 2005

Kynurenic acid and schizophrenia.

Adv Exp Med Biol 2003 ;527:155-65

Dept. of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1007/978-1-4615-0135-0_18DOI Listing
September 2004

Endogenous kynurenic acid disrupts prepulse inhibition.

Biol Psychiatry 2004 Aug;56(4):255-60

Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S000632230400659
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http://dx.doi.org/10.1016/j.biopsych.2004.06.006DOI Listing
August 2004

Clozapine modulates midbrain dopamine neuron firing via interaction with the NMDA receptor complex.

Synapse 2004 May;52(2):114-22

Department of Physiology and Pharmacology, Karolinska Institute, SE 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1002/syn.20008DOI Listing
May 2004

Inhibitory action of clozapine on rat ventral tegmental area dopamine neurons following increased levels of endogenous kynurenic acid.

Neuropsychopharmacology 2003 Oct;28(10):1770-7

Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

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http://www.nature.com/articles/1300255
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http://dx.doi.org/10.1038/sj.npp.1300255DOI Listing
October 2003

Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine.

Synapse 2002 Mar;43(4):227-37

Department of Physiology and Pharmacology, Karolinska Institute, SE 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1002/syn.10044DOI Listing
March 2002

GABA(B) receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo.

Naunyn Schmiedebergs Arch Pharmacol 2002 Mar 6;365(3):173-80. Epub 2002 Feb 6.

Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00210-001-0519-5DOI Listing
March 2002