Sophie E Legge

Sophie E Legge

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Sophie E Legge

Sophie E Legge

Publications by authors named "Sophie E Legge"

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Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.

Nat Genet 2019 Jul;51(7):1193

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1038/s41588-019-0450-7DOI Listing
July 2019

Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism.

Am J Psychiatry 2019 Jun 29;176(6):477-486. Epub 2019 Mar 29.

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, Wales (Pardiñas, Nalmpanti, Pocklington, Legge, Medway, Zammit, Owen, O'Donovan, Walters); Magna Laboratories, Ross-on-Wye, U.K. (King); Leyden Delta, Nijmegen, the Netherlands (Jansen, Helthuis); the Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, U.K. (Zammit); the National Institute for Health Research, Biomedical Research Centre, University of Bristol, Bristol, U.K. (Zammit); and the Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (MacCabe).

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http://dx.doi.org/10.1176/appi.ajp.2019.18050589DOI Listing
June 2019

Clinical indicators of treatment-resistant psychosis.

Br J Psychiatry 2019 Jun 3:1-8. Epub 2019 Jun 3.

Professor,MRC Centre for Neuropsychiatric Genetics and Genomics,Division of Psychological Medicine and Clinical Neurosciences,School of Medicine, Cardiff University,UK.

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http://dx.doi.org/10.1192/bjp.2019.120DOI Listing
June 2019

A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia.

Mol Psychiatry 2019 03 15;24(3):328-337. Epub 2019 Jan 15.

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.

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http://www.nature.com/articles/s41380-018-0335-7
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http://dx.doi.org/10.1038/s41380-018-0335-7DOI Listing
March 2019

Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective.

Pharmacogenomics 2019 Mar 15;20(4):279-290. Epub 2019 Feb 15.

MRC Centre for Neuropsychiatric Genetics & Genomics, Division of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK.

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http://dx.doi.org/10.2217/pgs-2018-0188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563116PMC
March 2019

Examining cognition across the bipolar/schizophrenia diagnostic spectrum.

J Psychiatry Neurosci 2018 07;43(4):245-253

From the MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK (Lynham, Hubbard, Hamshere, Legge, Owen, Jones, Walters); and the College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK (Tansey).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019354PMC
July 2018

Examining cognition across the bipolar/schizophrenia diagnostic spectrum.

J Psychiatry Neurosci 2018 Apr 5;43(3):170076. Epub 2018 Apr 5.

From the MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK (Lynham, Hubbard, Hamshere, Legge, Owen, Jones, Walters); and the College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK (Tansey).

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http://dx.doi.org/10.1503/jpn.170076DOI Listing
April 2018

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.

Nat Genet 2018 03 26;50(3):381-389. Epub 2018 Feb 26.

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1038/s41588-018-0059-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918692PMC
March 2018

Predictors of Nonhospitalization and Functional Response in Clozapine Treatment: A Nationwide, Population-Based Cohort Study.

J Clin Psychopharmacol 2017 Apr;37(2):148-154

From the *National Centre for Register-based Research; †CRESTAR, Aarhus University, Aarhus, Denmark; ‡Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark; §Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff; ∥Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom; ¶Centre for Integrated Register-Based Research at Aarhus University (CIRRAU); and #iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.

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http://dx.doi.org/10.1097/JCP.0000000000000649DOI Listing
April 2017

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.

Authors:
Christian R Marshall Daniel P Howrigan Daniele Merico Bhooma Thiruvahindrapuram Wenting Wu Douglas S Greer Danny Antaki Aniket Shetty Peter A Holmans Dalila Pinto Madhusudan Gujral William M Brandler Dheeraj Malhotra Zhouzhi Wang Karin V Fuentes Fajarado Michelle S Maile Stephan Ripke Ingrid Agartz Margot Albus Madeline Alexander Farooq Amin Joshua Atkins Silviu A Bacanu Richard A Belliveau Sarah E Bergen Marcelo Bertalan Elizabeth Bevilacqua Tim B Bigdeli Donald W Black Richard Bruggeman Nancy G Buccola Randy L Buckner Brendan Bulik-Sullivan William Byerley Wiepke Cahn Guiqing Cai Murray J Cairns Dominique Campion Rita M Cantor Vaughan J Carr Noa Carrera Stanley V Catts Kimberley D Chambert Wei Cheng C Robert Cloninger David Cohen Paul Cormican Nick Craddock Benedicto Crespo-Facorro James J Crowley David Curtis Michael Davidson Kenneth L Davis Franziska Degenhardt Jurgen Del Favero Lynn E DeLisi Dimitris Dikeos Timothy Dinan Srdjan Djurovic Gary Donohoe Elodie Drapeau Jubao Duan Frank Dudbridge Peter Eichhammer Johan Eriksson Valentina Escott-Price Laurent Essioux Ayman H Fanous Kai-How Farh Martilias S Farrell Josef Frank Lude Franke Robert Freedman Nelson B Freimer Joseph I Friedman Andreas J Forstner Menachem Fromer Giulio Genovese Lyudmila Georgieva Elliot S Gershon Ina Giegling Paola Giusti-Rodríguez Stephanie Godard Jacqueline I Goldstein Jacob Gratten Lieuwe de Haan Marian L Hamshere Mark Hansen Thomas Hansen Vahram Haroutunian Annette M Hartmann Frans A Henskens Stefan Herms Joel N Hirschhorn Per Hoffmann Andrea Hofman Hailiang Huang Masashi Ikeda Inge Joa Anna K Kähler René S Kahn Luba Kalaydjieva Juha Karjalainen David Kavanagh Matthew C Keller Brian J Kelly James L Kennedy Yunjung Kim James A Knowles Bettina Konte Claudine Laurent Phil Lee S Hong Lee Sophie E Legge Bernard Lerer Deborah L Levy Kung-Yee Liang Jeffrey Lieberman Jouko Lönnqvist Carmel M Loughland Patrik K E Magnusson Brion S Maher Wolfgang Maier Jacques Mallet Manuel Mattheisen Morten Mattingsdal Robert W McCarley Colm McDonald Andrew M McIntosh Sandra Meier Carin J Meijer Ingrid Melle Raquelle I Mesholam-Gately Andres Metspalu Patricia T Michie Lili Milani Vihra Milanova Younes Mokrab Derek W Morris Bertram Müller-Myhsok Kieran C Murphy Robin M Murray Inez Myin-Germeys Igor Nenadic Deborah A Nertney Gerald Nestadt Kristin K Nicodemus Laura Nisenbaum Annelie Nordin Eadbhard O'Callaghan Colm O'Dushlaine Sang-Yun Oh Ann Olincy Line Olsen F Anthony O'Neill Jim Van Os Christos Pantelis George N Papadimitriou Elena Parkhomenko Michele T Pato Tiina Paunio Diana O Perkins Tune H Pers Olli Pietiläinen Jonathan Pimm Andrew J Pocklington John Powell Alkes Price Ann E Pulver Shaun M Purcell Digby Quested Henrik B Rasmussen Abraham Reichenberg Mark A Reimers Alexander L Richards Joshua L Roffman Panos Roussos Douglas M Ruderfer Veikko Salomaa Alan R Sanders Adam Savitz Ulrich Schall Thomas G Schulze Sibylle G Schwab Edward M Scolnick Rodney J Scott Larry J Seidman Jianxin Shi Jeremy M Silverman Jordan W Smoller Erik Söderman Chris C A Spencer Eli A Stahl Eric Strengman Jana Strohmaier T Scott Stroup Jaana Suvisaari Dragan M Svrakic Jin P Szatkiewicz Srinivas Thirumalai Paul A Tooney Juha Veijola Peter M Visscher John Waddington Dermot Walsh Bradley T Webb Mark Weiser Dieter B Wildenauer Nigel M Williams Stephanie Williams Stephanie H Witt Aaron R Wolen Brandon K Wormley Naomi R Wray Jing Qin Wu Clement C Zai Rolf Adolfsson Ole A Andreassen Douglas H R Blackwood Elvira Bramon Joseph D Buxbaum Sven Cichon David A Collier Aiden Corvin Mark J Daly Ariel Darvasi Enrico Domenici Tõnu Esko Pablo V Gejman Michael Gill Hugh Gurling Christina M Hultman Nakao Iwata Assen V Jablensky Erik G Jönsson Kenneth S Kendler George Kirov Jo Knight Douglas F Levinson Qingqin S Li Steven A McCarroll Andrew McQuillin Jennifer L Moran Bryan J Mowry Markus M Nöthen Roel A Ophoff Michael J Owen Aarno Palotie Carlos N Pato Tracey L Petryshen Danielle Posthuma Marcella Rietschel Brien P Riley Dan Rujescu Pamela Sklar David St Clair James T R Walters Thomas Werge Patrick F Sullivan Michael C O'Donovan Stephen W Scherer Benjamin M Neale Jonathan Sebat

Nat Genet 2017 01 21;49(1):27-35. Epub 2016 Nov 21.

Beyster Center for Psychiatric Genomics, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/ng.3725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737772PMC
January 2017

Reasons for discontinuing clozapine: A cohort study of patients commencing treatment.

Schizophr Res 2016 07 19;174(1-3):113-119. Epub 2016 May 19.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

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http://dx.doi.org/10.1016/j.schres.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756540PMC
July 2016

The penetrance of copy number variations for schizophrenia and developmental delay.

Biol Psychiatry 2014 Mar 28;75(5):378-85. Epub 2013 Aug 28.

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2013.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229045PMC
March 2014

Analysis of copy number variations at 15 schizophrenia-associated loci.

Br J Psychiatry 2014 Feb 5;204(2):108-14. Epub 2013 Dec 5.

Elliott Rees, MRes, James T. R. Walters, PhD, MRCPsych, Lyudmila Georgieva, PhD, Anthony R. Isles, PhD, MRC, Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK; Kimberly D. Chambert, MS, Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachuetts, USA; Alexander L. Richards, PhD, Gerwyn Mahoney-Davies, BSc, Sophie E. Legge, BSc, Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK; Jennifer L. Moran, PhD, Steven A. McCarroll, PhD, Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachuetts, USA; Michael C. O'Donovan, FRCPsych, PhD, Michael J. Owen, FRCPsych, PhD, George Kirov, MRCPsych, PhD, Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1192/bjp.bp.113.131052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909838PMC
February 2014