Sophie Brouard

Sophie Brouard

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Sophie Brouard

Publications by authors named "Sophie Brouard"

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Interleukin-7 receptor blockade by an anti-CD127 monoclonal antibody in nonhuman primate kidney transplantation.

Am J Transplant 2020 Jan 14;20(1):101-111. Epub 2019 Aug 14.

Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, INSERM, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1111/ajt.15543DOI Listing
January 2020

Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients.

Am J Transplant 2020 Jan 9;20(1):145-158. Epub 2019 Sep 9.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1111/ajt.15549DOI Listing
January 2020

Neutrophils cause a "NET" increase in skin allograft allogenicity.

Am J Transplant 2019 Dec 17. Epub 2019 Dec 17.

Centre de Recherche en Transplantation et Immunologie, UMR 1064, INSERM, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1111/ajt.15746DOI Listing
December 2019

CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?

Front Immunol 2018 9;9:2316. Epub 2018 Oct 9.

Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02316
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http://dx.doi.org/10.3389/fimmu.2018.02316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189363PMC
October 2019

BOB.1 controls memory B-cell fate in the germinal center reaction.

J Autoimmun 2019 Jul 30;101:131-144. Epub 2019 Apr 30.

Amsterdam UMC, University of Amsterdam, Department of Rheumatology & Clinical Immunology, Amsterdam Infection & Immunity Institute, Amsterdam, the Netherlands; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam, the Netherlands; Amsterdam Rheumatology & Immunology Center (ARC), Amsterdam UMC, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.04.011DOI Listing
July 2019

Early Identification of Chronic Lung Allograft Dysfunction: The Need of Biomarkers.

Front Immunol 2019 17;10:1681. Epub 2019 Jul 17.

Centre de Recherche en Transplantation et Immunologie (CRTI), INSERM, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.3389/fimmu.2019.01681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650588PMC
July 2019

Role of JAK inhibitors and immune cells in transplantation.

Cytokine Growth Factor Rev 2019 06 11;47:62-73. Epub 2019 May 11.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2019.05.002DOI Listing
June 2019

High circulating CD4CD25FOXP3 T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome.

J Heart Lung Transplant 2018 06 20;37(6):770-781. Epub 2018 Mar 20.

Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie, CHU Nantes, Nantes, France; Centre d'Investigation Clinique Biothérapie, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.01.1306DOI Listing
June 2018

Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance.

Kidney Int 2018 05 15;93(5):1154-1164. Epub 2018 Feb 15.

Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; LabEx IGO "Immunotherapy, Graft, Oncology," Nantes, France; Centre d'Investigation Clinique (CIC) Biothérapie, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.12.004DOI Listing
May 2018

An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8 T cells involved in multiple sclerosis.

J Autoimmun 2018 03 18;88:61-74. Epub 2017 Oct 18.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; Faculté de Médecine, Université de Nantes, Nantes, France; Service de Neurologie, CHU Nantes, Nantes, France; INSERM 015, Centre d'Investigation Clinique, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.10.005DOI Listing
March 2018

Anti-Gal and Anti-Neu5Gc Responses in Nonimmunosuppressed Patients After Treatment With Rabbit Antithymocyte Polyclonal IgGs.

Transplantation 2017 10;101(10):2501-2507

1 Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France. 2 Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France. 3 Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France. 4 Xenothera, Nantes, France. 5 Biomarker Discovery Research, Immune Tolerance Network, Bethesda, MD, USA. 6 IECM, Immuno-endocrinology, EA4644 Oniris, University of Nantes, USC1383 INRA, Oniris, Nantes, France. 7 Clinical Trials Group, Immune Tolerance Network, San Francisco, CA. 8 Division of Pediatric Endocrinology and Diabetes, University of California San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1097/TP.0000000000001686DOI Listing
October 2017

A composite score associated with spontaneous operational tolerance in kidney transplant recipients.

Kidney Int 2017 06 24;91(6):1473-1481. Epub 2017 Feb 24.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; CIC Biotherapy, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432017PMC
June 2017

Alloantigen gene transfer to hepatocytes promotes tolerance to pancreatic islet graft by inducing CD8 regulatory T cells.

J Hepatol 2017 04 30;66(4):765-777. Epub 2016 Nov 30.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.11.019DOI Listing
April 2017

Immune monitoring in renal transplantation: The search for biomarkers.

Eur J Immunol 2016 12;46(12):2695-2704

Inserm, , Center for Research in Transplantation and Immunology (CRTI) U1064, Nantes, France.

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http://dx.doi.org/10.1002/eji.201545963DOI Listing
December 2016

Sialylation of antibodies in kidney recipients with de novo donor specific antibody, with or without antibody mediated rejection.

Hum Immunol 2016 Nov 10;77(11):1076-1083. Epub 2015 Nov 10.

Institut National de la Sante Et de la Recherche Médicale INSERM U1064, and Institut de Transplantation Urologie Néphrologie du Centre Hospitalier Universitaire Hôtel Dieu, LabEx Transplantex, CHU de Nantes, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 01, France; CIC Biothérapie, 5, allée de l'Ile Gloriette, 44093 Nantes Cedex 0144035, Nantes, France; CHU Nantes, CRB, 9 quai Moncousu, 44093 Nantes Cedex 1, Nantes F-44093, France. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2015.10.021DOI Listing
November 2016

The DESCARTES-Nantes survey of kidney transplant recipients displaying clinical operational tolerance identifies 35 new tolerant patients and 34 almost tolerant patients.

Nephrol Dial Transplant 2016 06 12;31(6):1002-13. Epub 2016 Jan 12.

Nephrology-Renal Transplantation Department, Universitair Ziekenhuis Antwerp, Antwerp, Belgium Université Libre de Bruxelles (ULB), Brussels, Belgium.

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http://dx.doi.org/10.1093/ndt/gfv437DOI Listing
June 2016

Role of TLRs and DAMPs in allograft inflammation and transplant outcomes.

Nat Rev Nephrol 2016 May 30;12(5):281-90. Epub 2016 Mar 30.

Department of Internal Medicine, 333 Cedar St, Yale School of Medicine, New Haven, Connecticut 06525, USA.

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http://dx.doi.org/10.1038/nrneph.2016.41DOI Listing
May 2016

Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis.

Clin Immunol 2016 05 2;166-167:1-11. Epub 2016 Apr 2.

INSERM, UMR 1064, Nantes F-44093, France; Nantes Hospital, Department of Neurology, Nantes, France; INSERM 015, Centre d'Investigation Clinique, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.03.014DOI Listing
May 2016

Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation.

Front Immunol 2016 24;7:89. Epub 2016 Mar 24.

UMR 1064, INSERM, Nantes, France; Faculté de Médecine, Université de Nantes, Nantes, France; LabEx Transplantex, Nantes, France.

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http://dx.doi.org/10.3389/fimmu.2016.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805583PMC
April 2016

Phenotype and functions of B cells in patients with acute brain injuries.

Mol Immunol 2015 Dec 9;68(2 Pt A):350-6. Epub 2015 Sep 9.

Intensive Care Unit, Anesthesia and Critical Care Department, Nantes University Hospital, Nantes, France; Thérapeutiques Cliniques et Expérimentales des Infections, EA 3826 Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2015.09.001DOI Listing
December 2015

The Author Replies.

Authors:
Sophie Brouard

Kidney Int 2015 Dec;88(6):1448-1449

INSERM, UMR 1064, Nantes, France.

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http://dx.doi.org/10.1038/ki.2015.297DOI Listing
December 2015

Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents.

J Immunol 2015 Nov 2;195(10):5035-44. Epub 2015 Oct 2.

INSERM, Unité 1064, 44000 Nantes, France; Institut de Transplantation et de Recherche en Transplantation Urologie Nephrologie, Centre Hospitalier Universitaire de Nantes, 44000 Nantes, France; and Faculté de Médecine, Université de Nantes, 44000 Nantes, France

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http://dx.doi.org/10.4049/jimmunol.1500429DOI Listing
November 2015

Targeting CD8 T-Cell Metabolism in Transplantation.

Front Immunol 2015 23;6:547. Epub 2015 Oct 23.

UMR 1064, INSERM , Nantes , France ; CHU de Nantes, ITUN , Nantes , France.

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http://dx.doi.org/10.3389/fimmu.2015.00547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617050PMC
November 2015

Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties.

J Am Soc Nephrol 2015 Oct 2;26(10):2588-98. Epub 2015 Feb 2.

Joint Research Unit 1064, French Institute of Health and Medical Research, Nantes, France; Faculty of Medicine, Nantes University, Nantes, France; and Institute of Transplantation Urology and Nephrology, Nantes University Hospital, Nantes, France

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http://dx.doi.org/10.1681/ASN.2014040404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587683PMC
October 2015

Deciphering the role of TRIB1 in regulatory T-cells.

Biochem Soc Trans 2015 Oct;43(5):1075-8

Institut National de la Santé et de la Recherche Médicale (INSERM) U1064 and Research Institute on Transplantation, Urology and Nephrology (ITUN), 30 boulevard Jean Monnet, 44093 Nantes Cedex 01, France

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http://www.biochemsoctrans.org/content/ppbiost/43/5/1075.ful
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http://dx.doi.org/10.1042/BST20150097DOI Listing
October 2015

Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance.

J Am Soc Nephrol 2015 Aug 2;26(8):1795-805. Epub 2015 Jan 2.

French Institute of Health and Medical Research Unit 1064, Research Institute on Urology, Nephrology, and Transplantation, and Biotherapy Clinical Investigation Center, Hôtel Dieu University Hospital, Nantes, France; and

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http://dx.doi.org/10.1681/ASN.2014050480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520169PMC
August 2015

Reconsidering the detection of tolerance to individualize immunosuppression minimization and to improve long-term kidney graft outcomes.

Transpl Int 2015 Aug 21;28(8):938-59. Epub 2015 Apr 21.

INSERM, UMR 1064, Nantes, France.

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http://dx.doi.org/10.1111/tri.12578DOI Listing
August 2015

Current status of immunosuppressive minimization and tolerance strategies.

Transpl Int 2015 Aug;28(8):889-90

Department of Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/tri.12624DOI Listing
August 2015

Prevention of allergic asthma through Der p 2 peptide vaccination.

J Allergy Clin Immunol 2015 Jul 11;136(1):197-200.e1. Epub 2015 Feb 11.

INSERM, UMR1087, l'institut du thorax, Nantes, France; CNRS, UMR 6291, Nantes, France; Université de Nantes, Nantes, France; DHU2020 médecine personnalisée des maladies chroniques, Nantes, France; CHU de Nantes, l'institut du thorax, Service de Pneumologie, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.12.1938DOI Listing
July 2015

Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model.

J Allergy Clin Immunol 2015 Jun 30;135(6):1643-1643.e3. Epub 2015 Jan 30.

INSERM, U1087, l'institut du thorax, Nantes, France; CNRS, U6291, Nantes, France; Université de Nantes, Nantes, France; CHU Nantes, l'institut du thorax, Service de Pneumologie, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.12.1872DOI Listing
June 2015

Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis.

Ann Clin Transl Neurol 2015 Jun 28;2(6):609-22. Epub 2015 Apr 28.

INSERM, UMR 1064 Nantes, F-44093, France ; Neurology Department, Nantes Hospital Nantes, F-44093, France ; INSERM 004, Centre d'Investigation Clinique Nantes, F-44093, France.

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http://dx.doi.org/10.1002/acn3.199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479522PMC
June 2015

Unaltered regulatory B-cell frequency and function in patients with multiple sclerosis.

Clin Immunol 2014 Dec 28;155(2):198-208. Epub 2014 Sep 28.

INSERM, UMR 1064, Nantes, F-44093, France; Universite de Nantes, Faculte de Medecine, Nantes, F-44035, France; CHU de Nantes, ITUN, Nantes, F-44093, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616140022
Publisher Site
http://dx.doi.org/10.1016/j.clim.2014.09.011DOI Listing
December 2014

IL-17 in severe asthma. Where do we stand?

Am J Respir Crit Care Med 2014 Nov;190(10):1094-101

1 Institut national de la santé et de la recherche médicale (INSERM), Unité mixte de recherche (UMR) 1087, l'Institut du Thorax, Nantes, France.

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http://dx.doi.org/10.1164/rccm.201405-0859PPDOI Listing
November 2014

Expansion of highly differentiated cytotoxic terminally differentiated effector memory CD8+ T cells in a subset of clinically stable kidney transplant recipients: a potential marker for late graft dysfunction.

J Am Soc Nephrol 2014 Aug 20;25(8):1856-68. Epub 2014 Mar 20.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1064, Nantes, France; Centre Hospitalier Universitaire de Nantes, Institut de Transplantation Urologie-Néphrologie, Nantes, France; Faculté de Médecine, Université de Nantes, Nantes, France;

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http://dx.doi.org/10.1681/ASN.2013080848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116064PMC
August 2014

MicroRNAs, Major Players in B Cells Homeostasis and Function.

Front Immunol 2014 11;5:98. Epub 2014 Mar 11.

Institut National de la Santé et de la Recherche Médicale, U1064, Institut de Transplantation Urologie Néphrologie , Nantes , France ; Faculté de Médecine, Université de Nantes , Nantes , France ; Centre Hospitalier Universitaire, Hôtel Dieu , Nantes , France.

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http://dx.doi.org/10.3389/fimmu.2014.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949129PMC
June 2014

Biomarkers and possible mechanisms of operational tolerance in kidney transplant patients.

Immunol Rev 2014 Mar;258(1):208-17

INSERM UMR 1064, Nantes, France; Centaure, Nantes, France.

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http://dx.doi.org/10.1111/imr.12156DOI Listing
March 2014

Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype.

Eur Respir Rev 2014 Mar;23(131):118-30

UMRS 1087 CNRS UMR6291, l'Institut du Thorax, Université de Nantes, CHU de Nantes, Nantes, and 3 UMRS 1064, Institut de Transplantation Urologie Néphrologie, CHU de Nantes, Nantes, France. 2 Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich and Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1183/09059180.00004413DOI Listing
March 2014

Reconsidering the bio-detection of tolerance in renal transplantation.

Chimerism 2013 Jan-Mar;4(1):15-7

Institut National de la Santé et de la Recherche Médicale INSERM U643, Nantes, France.

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http://dx.doi.org/10.4161/chim.23347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654731PMC
December 2013

Regulatory B cells and tolerance in transplantation: from animal models to human.

Front Immunol 2013 Dec 31;4:497. Epub 2013 Dec 31.

Institut National de la Santé et de la Recherche Médicale U1064, Institut de Transplantation Urologie Néphrologie , Nantes , France ; Université de Nantes , Nantes , France ; Centre Hospitalier Universitaire , Nantes , France.

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http://dx.doi.org/10.3389/fimmu.2013.00497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876023PMC
December 2013

The role of B lymphocytes in the progression from autoimmunity to autoimmune disease.

Clin Immunol 2013 Jan 22;146(1):34-45. Epub 2012 Oct 22.

Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.clim.2012.10.005DOI Listing
January 2013

Gene expression signature in transplantation tolerance.

Clin Chim Acta 2012 Sep 9;413(17-18):1414-8. Epub 2012 May 9.

University of Nantes, Nantes, France.

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http://dx.doi.org/10.1016/j.cca.2012.04.024DOI Listing
September 2012

Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant.

J Am Soc Nephrol 2012 Apr 26;23(4):597-606. Epub 2012 Jan 26.

Institut National de la Santé Et de la Recherche Médicale UMR643 and Institut de Transplantation Urologie, Néphrologie, Nantes, France.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2011060543
Publisher Site
http://dx.doi.org/10.1681/ASN.2011060543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312506PMC
April 2012

TNF blockade abrogates the induction of T cell-dependent humoral responses in an allotransplantation model.

J Leukoc Biol 2011 Aug 11;90(2):367-75. Epub 2011 May 11.

Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1189/jlb.0710392DOI Listing
August 2011

AKT1 leader gene and downstream targets are involved in a rat model of kidney allograft tolerance.

J Cell Biochem 2010 Oct;111(3):709-19

Institut National de la Santé Et de la Recherche Médicale INSERM U643, Institut de Transplantation et de Recherche en Transplantation ITERT, Nantes F-44093, France.

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http://dx.doi.org/10.1002/jcb.22757DOI Listing
October 2010

What can we learn from the transcriptional characterization of spontaneously tolerant transplant recipients?

Curr Opin Organ Transplant 2010 Aug;15(4):435-40

INSERM U643, U643-ITERT, 30 Boulevard Jean Monnet, Nantes Cedex 1, France.

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http://dx.doi.org/10.1097/MOT.0b013e32833bfac9DOI Listing
August 2010