Publications by authors named "Sophia Y Tsai"

113 Publications

Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction.

PLoS Genet 2020 06 24;16(6):e1008868. Epub 2020 Jun 24.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.

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June 2020

Opposing Functions of BRD4 Isoforms in Breast Cancer.

Mol Cell 2020 06 23;78(6):1114-1132.e10. Epub 2020 May 23.

Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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June 2020

Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway.

Sci Adv 2019 10 9;5(10):eaax6366. Epub 2019 Oct 9.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

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October 2019

SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription.

Mol Cell 2018 05;70(4):679-694.e7

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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May 2018

Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice.

Science 2017 08;357(6352):717-720

Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.

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August 2017

Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development.

Sci Rep 2017 06 9;7(1):3136. Epub 2017 Jun 9.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.

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June 2017

Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment.

Biol Reprod 2017 02;96(2):313-326

Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA.

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February 2017

Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer.

Nat Commun 2016 04 25;7:11418. Epub 2016 Apr 25.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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April 2016

Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.

Mol Endocrinol 2016 May 28;30(5):518-32. Epub 2016 Mar 28.

Department of Molecular and Cellular Biology (Y.M.V., S.Y.T., M.-J.T., J.P.L., F.J.D.), Baylor College of Medicine, Houston, Texas 77030; Department of Obstetrics and Gynecology (M.L.A., S.M.H.), Baylor College of Medicine, Houston, Texas 77030; Dan L. Duncan Cancer Center (M.L.A., C.J.C.), Division of Biostatistics, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030; and Pregnancy and Female Reproduction Group (S.-P.W., M.R., M.J.D.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

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May 2016

MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer.

Oncotarget 2016 Mar;7(12):14673-83

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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March 2016

Choose your destiny: Make a cell fate decision with COUP-TFII.

J Steroid Biochem Mol Biol 2016 Mar 2;157:7-12. Epub 2015 Dec 2.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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March 2016

CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC.

PLoS Genet 2015 Apr 1;11(4):e1005116. Epub 2015 Apr 1.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America.

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April 2015

The critical roles of COUP-TFII in tumor progression and metastasis.

Cell Biosci 2014 1;4(1):58. Epub 2014 Oct 1.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 USA ; Program in Developmental Biology, Baylor College of Medicine, Houston, TX USA.

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October 2014

The role of the orphan nuclear receptor COUP-TFII in tumorigenesis.

Acta Pharmacol Sin 2015 Jan 6;36(1):32-6. Epub 2014 Oct 6.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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January 2015

Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function.

PLoS One 2014 6;9(6):e98664. Epub 2014 Jun 6.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.

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January 2015

COUP-TFs and eye development.

Biochim Biophys Acta 2015 Feb 27;1849(2):201-9. Epub 2014 May 27.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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February 2015

E2/Estrogen receptor/sjogren syndrome-associated autoantigen relieves coactivator activator-induced G1/S arrest to promote breast tumorigenicity.

Mol Cell Biol 2014 May 24;34(9):1670-81. Epub 2014 Feb 24.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.

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May 2014

NR2F1 mutations cause optic atrophy with intellectual disability.

Am J Hum Genet 2014 Feb 23;94(2):303-9. Epub 2014 Jan 23.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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February 2014

Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis.

J Clin Endocrinol Metab 2014 Mar 1;99(3):E427-37. Epub 2014 Jan 1.

Department of Physiology (S.-C.L., Y.-F.C., S.-J.T.), Institute of Basic Medical Sciences (Y.-H.L., S.-J.T.), and Department of Obstetrics and Gynecology (M.-H.W.), College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; and Department of Molecular and Cellular Biology (D.-K.L., S.Y.T., M.-J.T.), Baylor College of Medicine, Houston, Texas 77030.

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March 2014

COUP-TFII regulates human endometrial stromal genes involved in inflammation.

Mol Endocrinol 2013 Dec 31;27(12):2041-54. Epub 2013 Oct 31.

Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.

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December 2013