Sophia Y Breusegem

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Sophia Y Breusegem

Publications by authors named "Sophia Y Breusegem"

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15Publications

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Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.

Cell Mol Life Sci 2018 Jul 24;75(14):2613-2625. Epub 2018 Jan 24.

Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK.

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July 2018

Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex.

J Cell Sci 2018 Jun 21;131(12). Epub 2018 Jun 21.

Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Addenbrookes Biomedical Campus, Cambridge, CB2 0XY, UK

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June 2018

Genome-wide RNAi screen reveals a role for multipass membrane proteins in endosome-to-golgi retrieval.

Cell Rep 2014 Dec 20;9(5):1931-1945. Epub 2014 Nov 20.

Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK. Electronic address:

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December 2014

Image-based and biochemical assays to investigate endosomal protein sorting.

Methods Enzymol 2014 ;534:155-78

Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom. Electronic address:

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July 2014

Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.

Nat Commun 2014 May 13;5:3828. Epub 2014 May 13.

Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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May 2014

Inorganic phosphate modulates the expression of the NaPi-2a transporter in the trans-Golgi network and the interaction with PIST in the proximal tubule.

Biomed Res Int 2013 14;2013:513932. Epub 2013 Feb 14.

Department of Medicine, University of Colorado, and VA Eastern Colorado Health Care System, Denver, CO 80220, USA.

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November 2013

Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35.

Biochem J 2012 Feb;442(1):209-20

Cambridge Institute for Medical Research/Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0XY, UK.

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February 2012

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.

J Cell Sci 2010 Nov 5;123(Pt 21):3703-17. Epub 2010 Oct 5.

Department of Clinical Biochemistry, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrookes Hospital, Cambridge CB2 0XY, UK.

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November 2010

Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi.

Am J Physiol Renal Physiol 2007 Jan 22;292(1):F230-42. Epub 2006 Aug 22.

Laboratory of Molecular Toxicology, Univ. of Zaragoza, Veterinary Faculty, Calle Miguel Servet 177, 50013 Zaragoza, Spain.

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January 2007

Fluorescence correlation spectroscopy and fluorescence lifetime imaging microscopy.

Nephron Exp Nephrol 2006 10;103(2):e41-9. Epub 2006 Mar 10.

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colo 80262, USA.

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April 2006

Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells.

Am J Physiol Cell Physiol 2005 Oct 25;289(4):C1042-51. Epub 2005 May 25.

Department of Medicine, University of Colorado Health Sciences Center, 4200 E. 9th St., Denver, Colorado 80262, USA.

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October 2005

Acute and chronic changes in cholesterol modulate Na-Pi cotransport activity in OK cells.

Am J Physiol Renal Physiol 2005 Jul 15;289(1):F154-65. Epub 2005 Mar 15.

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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July 2005

Partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaPi protein diffusion, clustering, and activity.

J Biol Chem 2004 Nov 7;279(47):49160-71. Epub 2004 Sep 7.

Department of Medicine, University of Colorado Health Sciences Center and Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA.

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November 2004

Base-sequence specificity of Hoechst 33258 and DAPI binding to five (A/T)4 DNA sites with kinetic evidence for more than one high-affinity Hoechst 33258-AATT complex.

J Mol Biol 2002 Feb;315(5):1049-61

Laboratory for Biochemistry Department of Biochemistry Physiology and Microbiology, Ghent University, Gent, B-9000, Belgium.

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February 2002