Sophia Ran

Sophia Ran

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Sophia Ran

Sophia Ran

Publications by authors named "Sophia Ran"

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Myeloid-Derived Lymphatic Endothelial Cell Progenitors Significantly Contribute to Lymphatic Metastasis in Clinical Breast Cancer.

Am J Pathol 2019 Nov 15;189(11):2269-2292. Epub 2019 Aug 15.

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois; Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892188PMC
November 2019

Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome.

Breast Cancer Res Treat 2019 Aug 4;177(1):77-91. Epub 2019 Jun 4.

Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA.

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http://dx.doi.org/10.1007/s10549-019-05307-8DOI Listing
August 2019

Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4.

PLoS One 2017 9;12(6):e0179257. Epub 2017 Jun 9.

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179257PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466303PMC
September 2017

Novel role of immature myeloid cells in formation of new lymphatic vessels associated with inflammation and tumors.

J Leukoc Biol 2017 08 13;102(2):253-263. Epub 2017 Apr 13.

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, and Simmons Cancer Institute, Springfield, Illinois, USA.

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http://doi.wiley.com/10.1189/jlb.1MR1016-434RR
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http://dx.doi.org/10.1189/jlb.1MR1016-434RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505745PMC
August 2017

IRF5 is a novel regulator of CXCL13 expression in breast cancer that regulates CXCR5(+) B- and T-cell trafficking to tumor-conditioned media.

Immunol Cell Biol 2015 May-Jun;93(5):486-99. Epub 2014 Dec 23.

1] Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers Biomedical and Health Sciences, Newark, NJ, USA [2] Rutgers Biomedical and Health Sciences, New Jersey Medical School-Cancer Center, UMDNJ, Newark, NJ, USA.

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http://dx.doi.org/10.1038/icb.2014.110DOI Listing
February 2016

The Role of TLR4 in Chemotherapy-Driven Metastasis.

Authors:
Sophia Ran

Cancer Res 2015 Jun 21;75(12):2405-10. Epub 2015 May 21.

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470764PMC
June 2015

CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.

Cancer Res 2014 Nov 29;74(22):6419-29. Epub 2014 Aug 29.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin. Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247541PMC
November 2014

Paclitaxel therapy promotes breast cancer metastasis in a TLR4-dependent manner.

Cancer Res 2014 Oct;74(19):5421-34

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185415PMC
October 2014

E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B.

J Mol Cell Biol 2013 Dec 6;5(6):391-403. Epub 2013 Sep 6.

Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, 18057 Rostock, Germany.

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http://dx.doi.org/10.1093/jmcb/mjt035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888194PMC
December 2013

TLR4 is a novel determinant of the response to paclitaxel in breast cancer.

Mol Cancer Ther 2013 Aug 29;12(8):1676-87. Epub 2013 May 29.

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-1019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742631PMC
August 2013

Novel model for basaloid triple-negative breast cancer: behavior in vivo and response to therapy.

Neoplasia 2012 Oct;14(10):926-42

Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, IL 62794-9626, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479838PMC
http://dx.doi.org/10.1593/neo.12956DOI Listing
October 2012

Macrophage-mediated lymphangiogenesis: the emerging role of macrophages as lymphatic endothelial progenitors.

Cancers (Basel) 2012 Sep 27;4(3):618-57. Epub 2012 Jun 27.

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 801 N. Rutledge, Springfield, IL 62794, USA.

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http://dx.doi.org/10.3390/cancers4030618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430523PMC
September 2012

New model of macrophage acquisition of the lymphatic endothelial phenotype.

PLoS One 2012 2;7(3):e31794. Epub 2012 Mar 2.

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031794PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292559PMC
July 2012

WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway.

Mol Cancer Res 2012 Mar 9;10(3):469-82. Epub 2012 Jan 9.

Department of Physiology, Southern Illinois University School of Medicine, 1135 Lincoln Drive, Carbondale, IL 62901, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307825PMC
March 2012

Synergy of nab-paclitaxel and bevacizumab in eradicating large orthotopic breast tumors and preexisting metastases.

Neoplasia 2011 Apr;13(4):327-38

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071081PMC
http://dx.doi.org/10.1593/neo.101490DOI Listing
April 2011

Development of a mouse model for assessing fatigue during chemotherapy.

Comp Med 2011 Apr;61(2):119-30

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079813PMC
April 2011

Characterization of Prox1 and VEGFR-3 expression and lymphatic phenotype in normal organs of mice lacking p50 subunit of NF-κB.

Microcirculation 2011 Feb;18(2):85-101

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794-9626, USA.

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http://dx.doi.org/10.1111/j.1549-8719.2010.00057.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058545PMC
February 2011

Lymphangiogenesis and lymphatic metastasis in breast cancer.

Pathophysiology 2010 Sep 24;17(4):229-51. Epub 2009 Dec 24.

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 801 N. Rutledge, Springfield, IL 62794-9678, USA.

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http://dx.doi.org/10.1016/j.pathophys.2009.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891887PMC
September 2010

Tumor suppressor function of Rab25 in triple-negative breast cancer.

Int J Cancer 2010 Jun;126(12):2799-812

Division of Hematology and Oncology, Department of Internal Medicine, Southern Illinois University School of Medicine and SimmonsCooper Cancer Institute at SIU, Springfield, IL 62794-9678, USA.

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http://doi.wiley.com/10.1002/ijc.24900
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http://dx.doi.org/10.1002/ijc.24900DOI Listing
June 2010

Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.

Blood 2010 Jan 9;115(2):418-29. Epub 2009 Nov 9.

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794-9626, USA.

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http://dx.doi.org/10.1182/blood-2008-12-196840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808162PMC
January 2010

Regulation of tumor angiogenesis by the local environment.

Front Biosci (Landmark Ed) 2010 Jan 1;15:195-212. Epub 2010 Jan 1.

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and SimmonsCooper Cancer Institute, Springfield, IL 62794-9678, USA.

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http://dx.doi.org/10.2741/3615DOI Listing
January 2010

Expression of a novel marker, Ubc9, in squamous cell carcinoma of the head and neck.

Head Neck 2009 Jul;31(7):845-55

Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA.

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http://dx.doi.org/10.1002/hed.21048DOI Listing
July 2009

Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.

Cancer Res 2008 Oct;68(20):8295-303

Departments of Internal Medicine, Hamon Center for Therapeutic Oncology Research-Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760388PMC
October 2008

Nab-paclitaxel efficacy in the orthotopic model of human breast cancer is significantly enhanced by concurrent anti-vascular endothelial growth factor A therapy.

Neoplasia 2008 Jun;10(6):613-23

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 801 N Rutledge, Springfield, IL, 62794-9678, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386546PMC
http://dx.doi.org/10.1593/neo.08302DOI Listing
June 2008

Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model.

Int J Cancer 2007 Nov;121(10):2181-91

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA.

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http://doi.wiley.com/10.1002/ijc.22937
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http://dx.doi.org/10.1002/ijc.22937DOI Listing
November 2007

Molecular profile and proliferative responses of rat lymphatic endothelial cells in culture.

Lymphat Res Biol 2006 ;4(3):119-42

Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62702-9678, USA.

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http://dx.doi.org/10.1089/lrb.2006.4.119DOI Listing
December 2006

The vascular-ablative agent VEGF(121)/rGel inhibits pulmonary metastases of MDA-MB-231 breast tumors.

Neoplasia 2005 May;7(5):486-96

Simmons Comprehensive Cancer Center and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501168PMC
http://dx.doi.org/10.1593/neo.04631DOI Listing
May 2005

Antitumor effects of a monoclonal antibody that binds anionic phospholipids on the surface of tumor blood vessels in mice.

Clin Cancer Res 2005 Feb;11(4):1551-62

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 2201 Inwood Road NC7.304, Dallas, TX 75390, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-04-1645DOI Listing
February 2005

Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect.

Proc Natl Acad Sci U S A 2004 Aug 23;101(31):11432-7. Epub 2004 Jul 23.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0403969101
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http://dx.doi.org/10.1073/pnas.0403969101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC509218PMC
August 2004

Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression.

Oncogene 2004 Jul;23(33):5675-81

Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.

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http://dx.doi.org/10.1038/sj.onc.1207734DOI Listing
July 2004

Evaluation of novel antimouse VEGFR2 antibodies as potential antiangiogenic or vascular targeting agents for tumor therapy.

Neoplasia 2003 Jul-Aug;5(4):297-307

Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-8594, USA.

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http://dx.doi.org/10.1016/S1476-5586(03)80023-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502417PMC
April 2004

Tumor oxygen dynamics: correlation of in vivo MRI with histological findings.

Neoplasia 2003 Jul-Aug;5(4):308-18

Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1016/S1476-5586(03)80024-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502418PMC
April 2004

Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and antibody-directed infarction.

Adv Exp Med Biol 2003 ;530:197-204

Department of Radiology, U.T. Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1007/978-1-4615-0075-9_19DOI Listing
November 2003

Quantitative assessment of tumor oxygen dynamics: molecular imaging for prognostic radiology.

J Cell Biochem Suppl 2002 ;39:45-53

Department of Radiology, U.T. Southwestern Medical Center, Dallas, Texas, USA.

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http://doi.wiley.com/10.1002/jcb.10404
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http://dx.doi.org/10.1002/jcb.10404DOI Listing
October 2003

A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model.

Angiogenesis 2002 ;5(1-2):35-44

Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8594, USA.

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http://dx.doi.org/10.1023/a:1021540120521DOI Listing
July 2003

Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapy.

Int J Radiat Oncol Biol Phys 2002 Dec;54(5):1479-84

Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8594, USA.

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http://dx.doi.org/10.1016/s0360-3016(02)03928-7DOI Listing
December 2002

Increased exposure of anionic phospholipids on the surface of tumor blood vessels.

Cancer Res 2002 Nov;62(21):6132-40

Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas 75390-8594, USA.

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November 2002

In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors.

Proc Natl Acad Sci U S A 2002 Jun;99(12):7866-71

Immunopharmacology and Targeted Therapy Section, Department of Bioimmunotherapy, Univ. of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA.

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http://dx.doi.org/10.1073/pnas.122157899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122986PMC
June 2002