Sook Wah Yee

Sook Wah Yee

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Sook Wah Yee

Publications by authors named "Sook Wah Yee"

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Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.

Clin Pharmacol Ther 2019 Sep 23;106(3):623-631. Epub 2019 May 23.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1002/cpt.1439DOI Listing
September 2019

Pharmacogenetics of Antidiabetic Drugs.

Adv Pharmacol 2018 14;83:361-389. Epub 2018 May 14.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10543589183002
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http://dx.doi.org/10.1016/bs.apha.2018.04.005DOI Listing
July 2019

Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.

Hum Mutat 2019 07 25;40(7):983-995. Epub 2019 Apr 25.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1002/humu.23758DOI Listing
July 2019

Unveiling the Genetic Architecture of Human Disease for Precision Medicine.

Clin Transl Sci 2019 01 26;12(1):3-5. Epub 2018 Nov 26.

Department of Pharmacy Practice and Science, University of Arizona College of Pharmacy, Tucson, Arizona, USA.

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http://doi.wiley.com/10.1111/cts.12593
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http://dx.doi.org/10.1111/cts.12593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342243PMC
January 2019

Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium.

Clin Pharmacol Ther 2018 11 31;104(5):803-817. Epub 2018 May 31.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, San Francisco, California, USA.

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http://doi.wiley.com/10.1002/cpt.1098
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http://dx.doi.org/10.1002/cpt.1098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348109PMC
November 2018

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.

Mol Pharmacol 2018 07 2;94(1):689-699. Epub 2018 May 2.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California (L.Z., A.S., H.-C.C., S.W.Y., K.M.G.); Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (A.G.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., L.W., J.D.U.); and Safety and ADME Translational Sciences, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK (S.H.S., K.S.F.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
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http://dx.doi.org/10.1124/mol.117.111153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987998PMC
July 2018

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.

PLoS Biol 2018 04 16;16(4):e2002907. Epub 2018 Apr 16.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2002907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919692PMC
April 2018

Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.

J Chem Inf Model 2017 06 15;57(6):1402-1413. Epub 2017 Jun 15.

Department of Pharmaceutical Chemistry and California Institute of Quantitative Biosciences (QB3), University of California San Francisco , San Francisco, California 94158, United States.

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http://dx.doi.org/10.1021/acs.jcim.6b00720DOI Listing
June 2017

Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).

J Med Chem 2017 04 15;60(7):2685-2696. Epub 2017 Mar 15.

Department of Bioengineering and Therapeutic Sciences, University of California , San Francisco, California 94143, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01317DOI Listing
April 2017

Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.

Nat Rev Drug Discov 2017 Jan 25;16(1). Epub 2016 Nov 25.

RIKEN Center for Integrative Medical Science, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1038/nrd.2016.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443656PMC
January 2017

Genomic Characterization of Metformin Hepatic Response.

PLoS Genet 2016 Nov 30;12(11):e1006449. Epub 2016 Nov 30.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130177PMC
November 2016

Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.

Front Pharmacol 2016 14;7:135. Epub 2016 Jun 14.

Department of Psychiatry and Behavioral Sciences, Duke UniversityDurham, NC, USA; Duke Institute for Brain Sciences, Duke UniversityDurham, NC, USA.

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http://journal.frontiersin.org/Article/10.3389/fphar.2016.00
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http://dx.doi.org/10.3389/fphar.2016.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906013PMC
July 2016

The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.

Clin Pharmacokinet 2016 06;55(6):711-21

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, 1550 4th St, RH 584, Box 2911, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1007/s40262-015-0346-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876051PMC
June 2016

Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.

Drug Metab Dispos 2016 Mar 23;44(3):356-64. Epub 2015 Dec 23.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts

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http://dx.doi.org/10.1124/dmd.115.066647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047207PMC
March 2016

OCT1 in hepatic steatosis and thiamine disposition.

Cell Cycle 2015 ;14(3):283-4

a Department of Pharmacology and Pharmaceutical Sciences, School of Medicine , Tsinghua University ; Beijing , China.

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http://dx.doi.org/10.1080/15384101.2015.1006532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353231PMC
December 2015

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).

Mol Pharm 2015 Dec 16;12(12):4301-10. Epub 2015 Nov 16.

Department of Bioengineering and Therapeutic Sciences, University of California , San Francisco, California 94158, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800991PMC
December 2015

Prediction and validation of enzyme and transporter off-targets for metformin.

J Pharmacokinet Pharmacodyn 2015 Oct 3;42(5):463-75. Epub 2015 Sep 3.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, 94158-2911, USA.

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http://dx.doi.org/10.1007/s10928-015-9436-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656030PMC
October 2015

SLC transporters as therapeutic targets: emerging opportunities.

Nat Rev Drug Discov 2015 Aug 26;14(8):543-60. Epub 2015 Jun 26.

1] Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California 94158, USA. [2] Institute for Human Genetics, University of California San Francisco, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1038/nrd4626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698371PMC
August 2015

Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.

Mol Pharmacol 2015 Jul 28;88(1):75-83. Epub 2015 Apr 28.

Department of Bioengineering and Therapeutic Sciences (E.C.C., X.L., S.W.Y., E.G.G, S.L.S., K.M.G.) and Institute for Human Genetics (K.M.G.),University of California, San Francisco, California; and Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, China (L.C.)

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http://dx.doi.org/10.1124/mol.114.096776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468641PMC
July 2015

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

Proc Natl Acad Sci U S A 2014 Jul 24;111(27):9983-8. Epub 2014 Jun 24.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;Institute for Human Genetics, University of California, San Francisco, CA 94143

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http://dx.doi.org/10.1073/pnas.1314939111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103324PMC
July 2014

Pharmacogenomics and patient care: one size does not fit all.

Sci Transl Med 2012 Sep;4(153):153ps18

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963516PMC
September 2012

Pharmacogene regulatory elements: from discovery to applications.

Genome Med 2012 May 25;4(5):45. Epub 2012 May 25.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.

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http://www.genomemedicine.com/content/pdf/gm344.pdf
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http://genomemedicine.com/content/4/5/45
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http://dx.doi.org/10.1186/gm344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506911PMC
May 2012

SLC19A1 pharmacogenomics summary.

Pharmacogenet Genomics 2010 Nov;20(11):708-15

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

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https://insights.ovid.com/crossref?an=01213011-201011000-000
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http://dx.doi.org/10.1097/FPC.0b013e32833eca92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956130PMC
November 2010

Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides.

Bioorg Med Chem 2010 Jul 9;18(14):4939-46. Epub 2010 Jun 9.

Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.

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http://dx.doi.org/10.1016/j.bmc.2010.06.011DOI Listing
July 2010

Pharmacogenomics of membrane transporters: past, present and future.

Pharmacogenomics 2010 Apr;11(4):475-9

School of Pharmacy, University of California San Francisco, CA 94143-2911, USA.

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https://www.futuremedicine.com/doi/10.2217/pgs.10.22
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http://dx.doi.org/10.2217/pgs.10.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234298PMC
April 2010

Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.

Mol Cancer Ther 2010 Apr 6;9(4):1058-69. Epub 2010 Apr 6.

Department of Bioengineering and Therapeutic Sciences, University of California, 1550 4th Street, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-1084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258025PMC
April 2010

Comparison of human solute carriers.

Protein Sci 2010 Mar;19(3):412-28

Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California.

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http://salilab.org/pdf/Schlessinger_ProteinSci_2010.pdf
Web Search
http://mpec.ucsf.edu/pdfs_new/Pubs_50.pdf
Web Search
http://doi.wiley.com/10.1002/pro.320
Publisher Site
http://dx.doi.org/10.1002/pro.320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866268PMC
March 2010

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.

Pharmacogenomics J 2009 Apr 27;9(2):127-36. Epub 2009 Jan 27.

Division of Clinical Pharmacology and Experimental Therapeutics, Department of Biopharmaceutical Sciences, University of California at San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1038/tpj.2008.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949062PMC
April 2009

Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.

Mol Pharmacol 2008 Apr 23;73(4):1151-8. Epub 2008 Jan 23.

Department of Biopharmaceutical Sciences, 1550 4th Street, RH584, Box 2911, University of California, San Francisco, CA 94158-2911, USA.

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http://dx.doi.org/10.1124/mol.107.043117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698938PMC
April 2008

Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding.

J Enzyme Inhib Med Chem 2006 Aug;21(4):361-9

Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.

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http://dx.doi.org/10.1080/14756360600742014DOI Listing
August 2006

Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.

Bioorg Med Chem 2006 Jun 3;14(11):3643-53. Epub 2006 Feb 3.

Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.

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http://dx.doi.org/10.1016/j.bmc.2006.01.018DOI Listing
June 2006

Inhibition of Vitamin D3 metabolism enhances VDR signalling in androgen-independent prostate cancer cells.

J Steroid Biochem Mol Biol 2006 Mar 14;98(4-5):228-35. Epub 2006 Feb 14.

Division of Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, UK.

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http://dx.doi.org/10.1016/j.jsbmb.2005.11.004DOI Listing
March 2006

Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation.

J Med Chem 2006 Feb;49(3):1016-22

Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, Wales, U.K.

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http://dx.doi.org/10.1021/jm0508282DOI Listing
February 2006

Synthesis and antimycobacterial activity of 7-O-substituted-4-methyl-2H-2-chromenone derivatives vs Mycobacterium tuberculosis.

J Enzyme Inhib Med Chem 2005 Apr;20(2):109-13

Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.

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http://dx.doi.org/10.1080/14756360400002015DOI Listing
April 2005

Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives.

Bioorg Med Chem Lett 2004 Nov;14(22):5651-4

Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, Wales, UK.

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http://dx.doi.org/10.1016/j.bmcl.2004.08.040DOI Listing
November 2004