Dr. Sonia Villapol, PhD - Georgetown University - Assistant Professor

Dr. Sonia Villapol

PhD

Georgetown University

Assistant Professor

Washington DC | United States

Main Specialties: Neurology

Additional Specialties: Neuroscience

Dr. Sonia Villapol, PhD - Georgetown University - Assistant Professor

Dr. Sonia Villapol

PhD

Introduction

Primary Affiliation: Georgetown University - Washington DC , United States

Specialties:

Additional Specialties:

Publications

22Publications

183Reads

321Profile Views

283PubMed Central Citations

Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy?

Exp Neurol 2016 Jan 16;275 Pt 3:381-388. Epub 2015 Jun 16.

Laboratory for Brain Injury and Dementia, Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2015.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681695PMC
January 2016
11 Reads
17 Citations
4.700 Impact Factor

Neurorestoration after traumatic brain injury through angiotensin II receptor blockage.

Brain 2015 Nov 26;138(Pt 11):3299-315. Epub 2015 Jun 26.

1 Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 2 Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/brain/awv172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731413PMC
November 2015
15 Reads
13 Citations
9.200 Impact Factor

Neuroprotective effects of angiotensin receptor blockers.

Am J Hypertens 2015 Mar 31;28(3):289-99. Epub 2014 Oct 31.

Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1093/ajh/hpu197DOI Listing
March 2015
4 Reads
20 Citations
2.852 Impact Factor

Temporal dynamics of cerebral blood flow, cortical damage, apoptosis, astrocyte-vasculature interaction and astrogliosis in the pericontusional region after traumatic brain injury.

Front Neurol 2014 4;5:82. Epub 2014 Jun 4.

Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences , Bethesda, MD , USA ; Department of Pharmacology, Uniformed Services University of the Health Sciences , Bethesda, MD , USA.

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http://dx.doi.org/10.3389/fneur.2014.00082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044679PMC
June 2014
12 Reads
25 Citations

Temporal patterns of cortical proliferation of glial cell populations after traumatic brain injury in mice.

ASN Neuro 2014 May 8;6(3):159-70. Epub 2014 May 8.

‡Developmental Neurobiology Section, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, U.S.A.

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http://dx.doi.org/10.1042/AN20130034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013687PMC
May 2014
12 Reads
17 Citations
4.020 Impact Factor

Commercially available angiotensin II At₂ receptor antibodies are nonspecific.

PLoS One 2013 1;8(7):e69234. Epub 2013 Jul 1.

Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069234PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698141PMC
February 2014
6 Reads
22 Citations
3.234 Impact Factor

Smad3 deficiency increases cortical and hippocampal neuronal loss following traumatic brain injury.

Exp Neurol 2013 Dec 9;250:353-65. Epub 2013 Oct 9.

Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA; Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.1016/j.expneurol.2013.10.008DOI Listing
December 2013
5 Reads
2 Citations
4.700 Impact Factor

TGF-β superfamily gene expression and induction of the Runx1 transcription factor in adult neurogenic regions after brain injury.

PLoS One 2013 21;8(3):e59250. Epub 2013 Mar 21.

Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059250PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605457PMC
September 2013
7 Reads
21 Citations
3.234 Impact Factor

Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice.

Neuropsychopharmacology 2012 Dec 15;37(13):2817-29. Epub 2012 Aug 15.

Center for Neuroscience and Regenerative Medicine, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/npp.2012.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499714PMC
December 2012
12 Reads
22 Citations
7.050 Impact Factor

Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model.

Stroke 2012 Nov 4;43(11):3078-84. Epub 2012 Sep 4.

University Paris Diderot, Sorbonne Paris Cité, INSERM U676 and NICU, Robert Debré Children's Hospital, 48 Bd Sérurier 75019 Paris, France.

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http://dx.doi.org/10.1161/STROKEAHA.112.664243DOI Listing
November 2012
10 Reads
18 Citations
5.723 Impact Factor

Dual action of NO synthases on blood flow and infarct volume consecutive to neonatal focal cerebral ischemia.

Exp Neurol 2012 Jul 12;236(1):50-7. Epub 2012 Apr 12.

Univ Paris Diderot, Sorbonne Paris Cité, AP-HP, Hôpital Lariboisière, Physiologie Clinique - Explorations-Fonctionnelles, 75010 Paris, France.

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http://dx.doi.org/10.1016/j.expneurol.2012.04.001DOI Listing
July 2012
14 Reads
8 Citations
4.700 Impact Factor

Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke.

Pediatr Res 2011 Jan;69(1):51-5

INSERM AVENIR R05230HS (U676), Université Paris, Faculté de Médecine Denis Diderot, 75019 Paris, France.

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http://dx.doi.org/10.1203/PDR.0b013e3181fcb40bDOI Listing
January 2011
22 Reads
19 Citations
2.314 Impact Factor

Astrocytic demise in the developing rat and human brain after hypoxic-ischemic damage.

Dev Neurosci 2009 11;31(5):459-70. Epub 2009 Aug 11.

Département de Neuropathologie, Service d'Anatomie et Cytologie Pathologiques, Hôpital A. Trousseau, Paris, France.

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http://dx.doi.org/10.1159/000232564DOI Listing
November 2009
6 Reads
11 Citations
2.700 Impact Factor

Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain.

Am J Pathol 2009 Nov 8;175(5):2111-20. Epub 2009 Oct 8.

UMR-Centre de la Recherche Scientifique, Equipe Hypoxie et Ischemie du Cerveau en Development, Paris, France.

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http://dx.doi.org/10.2353/ajpath.2009.090257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774074PMC
November 2009
4 Reads
9 Citations
4.591 Impact Factor

Astrocyte responses after neonatal ischemia: the yin and the yang.

Neuroscientist 2008 Aug 8;14(4):339-44. Epub 2008 Jul 8.

Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1177/1073858408316003DOI Listing
August 2008
7 Reads
7 Citations
6.840 Impact Factor

Substantial migration of SVZ cells to the cortex results in the generation of new neurons in the excitotoxically damaged immature rat brain.

Mol Cell Neurosci 2008 Jun 4;38(2):170-82. Epub 2008 Mar 4.

Medical Histology, Department of Cell Biology, Physiology and Immunology, Neuroscience Institute, Autonomous University of Barcelona, Spain.

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http://dx.doi.org/10.1016/j.mcn.2008.02.002DOI Listing
June 2008
11 Reads
10 Citations
3.840 Impact Factor

Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain.

Neuroscience 2008 Apr 14;153(1):108-19. Epub 2008 Feb 14.

Medical Histology, Torre M5, Department of Cell Biology, Physiology and Immunology, Institute of Neuroscience, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra 08193, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.neuroscience.2008.01.054DOI Listing
April 2008
6 Reads
8 Citations
3.360 Impact Factor

Distinct spatial and temporal activation of caspase pathways in neurons and glial cells after excitotoxic damage to the immature rat brain.

J Neurosci Res 2007 Dec;85(16):3545-56

Medical Histology, Faculty of Medicine, Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.

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http://dx.doi.org/10.1002/jnr.21450DOI Listing
December 2007
5 Reads
8 Citations
2.594 Impact Factor

Distinct spatial and temporal activation of caspase pathways in neurons and glial cells after excitotoxic damage to the immature rat brain.

J Neurosci Res 2007 Dec;85(16):3545-56

J. Neurosci. Res.

Although cleaved caspase-3 is known to be involved in apoptotic cell death mechanisms in neurons, it can also be involved in a nonapoptotic role in astrocytes after postnatal excitotoxic injury. Here we evaluate participation of upstream pathways activating caspase-3 in neurons and glial cells, by studying the intrinsic pathway via caspase-9, the extrinsic pathway via caspase-8, and activation of the p53-dependent pathway. N-methyl-D-aspartate (NMDA) was injected intracortically in 9-day-old postnatal rats, which were sacrificed at several survival times between 4 hr postlesion (pl) and 7 days pl. We analyzed temporal and spatial expression of caspase-8, caspase-9, and p53 and correlation with neuronal and glial markers and caspase-3 activation. Caspase-9 was significantly activated at 10 hpl, strongly correlating with caspase-3. It was present mainly in damaged cortical and hippocampal neurons but was also seen in astrocytes and oligodendrocytes in layer VI and corpus callosum (cc). Caspase-8 showed a diminished correlation with caspase-3. It was present in cortical neurons at 10-72 hpl, showing layer specificity, and also in astroglial and microglial nuclei, mainly in layer VI and cc. p53 Expression increased at 10-72 hpl but did not correlate with caspase-3. p53 Was seen in neurons of the degenerating cortex and in some astrocytes and microglial cells of layer VI and cc. In conclusion, after neonatal excitotoxicity, mainly the mitochondrial intrinsic pathway mediates neuronal caspase-3 and cell death. In astrocytes, caspase-3 is not widely correlated with caspase-8, caspase-9, or p53, except in layer VI-cc astrocytes, where activation of upstream cascades occurs.

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December 2007
8 Reads

Caspase-3 activation in astrocytes following postnatal excitotoxic damage correlates with cytoskeletal remodeling but not with cell death or proliferation.

Glia 2007 Jul;55(9):954-65

Medical Histology, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine and Institute of Neurosciences, Autonomous University of Barcelona, Spain.

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http://dx.doi.org/10.1002/glia.20518DOI Listing
July 2007
6 Reads
22 Citations
6.031 Impact Factor

Bilateral changes after neonatal ischemia in the P7 rat brain.

J Neuropathol Exp Neurol 2007 Jun;66(6):481-90

Université Pierre et Marie Curie-Paris6, Unité Mixte de Recherche-Centre National de la Recherche Scientifique 7102, Paris, France.

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http://jnen.oxfordjournals.org/content/jnen/66/6/481.full.pd
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http://jnen.oxfordjournals.org/cgi/doi/10.1097/01.jnen.00002
Publisher Site
http://dx.doi.org/10.1097/01.jnen.0000263875.22306.3cDOI Listing
June 2007
4 Reads
4 Citations
3.800 Impact Factor

Antioxidant Cu/Zn SOD: expression in postnatal brain progenitor cells.

Neurosci Lett 2006 Jun 29;401(1-2):71-6. Epub 2006 Mar 29.

Department of Cell Biology, Physiology and Immunology, Unit of Medical Histology, and Institute of Neurosciences, Universitat Autònoma de Barcelona, Spain.

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http://dx.doi.org/10.1016/j.neulet.2006.03.010DOI Listing
June 2006
4 Reads
2.060 Impact Factor

Top co-authors

Christiane Charriaut-Marlangue
Christiane Charriaut-Marlangue

Université Pierre et Marie Curie-Paris6

7
Sylvain Renolleau
Sylvain Renolleau

Université Pierre et Marie Curie

7
Aviva J Symes
Aviva J Symes

Uniformed Services University of the Health Sciences

6
Maryam Faiz
Maryam Faiz

1Mount Sinai Hospital

4
Laia Acarin
Laia Acarin

Autonomous University of Barcelona

4
Bernardo Castellano
Bernardo Castellano

Autonomous University of Barcelona

4
Juan M Saavedra
Juan M Saavedra

National Institutes of Health

4
Olivier Baud
Olivier Baud

Université Paris Diderot

4
Philippe Bonnin
Philippe Bonnin

Lariboisière Hospital

3