Publications by authors named "Song-Liang Cai"

45 Publications

Covalent Cross-Linking of Metal-Organic Cages: Formation of an Amorphous Cationic Porous Extended Framework for the Uptake of Oxo-Anions from Water.

Chempluschem 2021 Mar 18;86(5):699. Epub 2021 Mar 18.

School of Chemistry, South China Normal University, Guangzhou, 510006, P. R. China.

Invited for this month's cover are the collaborating groups of Sheng-Run Zheng and Wei-Guang Zhang from South China Normal University, China. The cover picture shows an amorphous cationic porous metal-organic material that constructed from the covalent linking of large cationic metal-organic cage for the removal of toxic oxo-anions from water with high capacities and rapid kinetics. Read the full text of the article at 10.1002/cplu.202000570.
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http://dx.doi.org/10.1002/cplu.202100056DOI Listing
March 2021

Covalent Cross-Linking of Metal-Organic Cages: Formation of an Amorphous Cationic Porous Extended Framework for the Uptake of Oxo-Anions from Water.

Chempluschem 2020 Nov 24;86(5):709-715. Epub 2020 Nov 24.

School of Chemistry, South China Normal University, Guangzhou, 510006, P. R. China.

Cationic amorphous metal-organic cage (MOC)-based materials capable of removing anionic pollutants from water are receiving increasing attention but they are still relatively less reported. Herein, for the first time, a cationic porous MOC-based extended framework, namely, CL-aMOC-1, was constructed by covalent linking of a cationic Pd L (L=3,5-di-pyridin-4-yl-benzaldehyde) cage with a 1,4-bis(4-aminophenyl)benzene (BAPB) linker. Interestingly, the reaction could be completed within 15 min using an amorphous MOC-based solid (aMOC-1) and BAPB as reactant via a low-temperature solid-state reaction. The CL-aMOC-1 showed improved stability, lower solubility and higher oxo-anion uptake in water compared with the original aMOC-1. The adsorption capacities for CrO , Cr O and ReO on CL-aMOC-1 were 245.1, 311.5 and 452.5 mg/g, respectively, in which the uptake of Cr(VI)-containing oxo-anions was among the highest compared with those of other metal-organic materials. The CL-aMOC-1 can selectively capture oxo-anions in the presence of competitive anions. It exhibits good reusability as over 85 % of the uptake capacity is retained after 5 cycles. Finally, it shows the ability to remove Cr(VI) ions from electroplating wastewater.
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http://dx.doi.org/10.1002/cplu.202000570DOI Listing
November 2020

A Mn(II)-MOF with inherent missing metal-ion defects based on an imidazole-tetrazole tripodal ligand and its application in supercapacitors.

Dalton Trans 2020 Sep;49(35):12150-12155

School of Chemistry, South China Normal University, Guangzhou, 510006, China. zhengsr-scnu.edu.cn wgzhang-scnu.edu.cn.

A metal-organic framework (MOF), namely SCNU-Z3, based on an imidazole-tetrazole tripodal ligand and Mn(ii), has been constructed. It exhibits a porous 3D framework composed of truncated octahedron cage subunits. Unexpected ligand-induced missing metal-ion defects were observed in the framework. In addition, the application of SCNU-Z3 in a supercapacitor was performed.
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http://dx.doi.org/10.1039/d0dt01666gDOI Listing
September 2020

A new QCM signal enhancement strategy based on [email protected] framework complex for miRNA detection.

Anal Chim Acta 2020 Jan 19;1095:212-218. Epub 2019 Oct 19.

School of Chemistry, South China Normal University, Guangzhou, 510006, China. Electronic address:

Sensitive and selective detection of miRNA is of great significance for the early diagnosis of human diseases, especially for cancers. Quartz crystal microbalance (QCM) is an effective tool for detecting biological molecules; however, the application of QCM for miRNA detection is still very limited. One of the great needs for QCM detection is to further improve the QCM signal. Herein, for the first time, we promote a new signal enhancement strategy for the detection of miRNA by QCM. First, a hairpin biotin-modified DNA was used as a probe DNA, which exposes the biotin site when interacting with target miRNA. Then, a [email protected] framework ([email protected]) complex formed by electrostatic attractions between SA and a MOF was introduced into the QCM detection system. The [email protected] complexes serve as both a signal amplifier and a specific recognition element via specific biotin-SA interactions. The strategy was applied to the detection of a colorectal cancer marker, miR-221, by using a stable Zr(IV)-MOF, UiO-66-NH. The detection linear range was 10 fM-1 nM, the detection limit was 6.9 fM, and the relative standard deviation (RSD) (n = 5) was lower than 10% in both simulated conditions and the real serum environment. Furthermore, the detection limit reached 0.79 aM when coupled with the isothermal exponential amplification reaction (EXPAR).
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http://dx.doi.org/10.1016/j.aca.2019.10.034DOI Listing
January 2020

An unprecedented 2D covalent organic framework with an htb net topology.

Chem Commun (Camb) 2019 Nov 24;55(89):13454-13457. Epub 2019 Oct 24.

School of Chemistry, South China Normal University, Guangzhou 510006, P. R. China.

A 2D imine-linked COF with a hitherto unreported htb type topology was synthesized from a linear diamine linker and a judiciously designed tetra-aldehyde building block. This work opens the door to the development of COFs with unprecedented topologies and may broaden the scope of COF functional materials by pore size and pore surface engineering.
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http://dx.doi.org/10.1039/c9cc06780aDOI Listing
November 2019

Homochiral Cu(I) Coordination Polymers Based on a Double-Stranded Helical Building Block from Achiral Ligands: Symmetry-Breaking Crystallization, Photophysical and Photocatalytic Properties.

Inorg Chem 2019 Nov 14;58(21):14660-14666. Epub 2019 Oct 14.

School of Chemistry , South China Normal University , Guangzhou , 510006 , P. R. China.

A pair of homochiral coordination polymers, [Cu(DPT)] ( and , HDPT = 3,5-di-4-pyridinyl-2H-tetrazole), were assembled from achiral precursors. Crystal structure analysis showed that they are chiral three-dimensional (3D) coordination polymers based on a new double-stranded helical building block that is composed of two different 1D helices. Interestingly, rare symmetry-breaking crystallization was observed, in which the possibility of obtaining enantio-enriched bulk product with excessive enantiomers () was obviously higher than that for enantiomers () as demonstrated in multiple, repeated experiments with single-crystal diffraction and vibrational circular dichroism (VCD) spectra. Moreover, compound [Cu(DPT)] shows good chemical stability in water, with pH values ranging from 3 to 13, as well as in many common organic solvents. Photophysical properties, including thermochromic properties and two-photon excited luminescence, were studied, and the potential for applications in temperature sensing was exhibited. In addition, the photocatalytic degradation of methylene blue in water indicated that compound [Cu(DPT)] can be used as a photocatalyst.
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http://dx.doi.org/10.1021/acs.inorgchem.9b02341DOI Listing
November 2019

An Anionic Nanotubular Metal-Organic Framework for High-Capacity Dye Adsorption and Dye Degradation in Darkness.

Inorg Chem 2019 Oct 4;58(20):13979-13987. Epub 2019 Oct 4.

School of Chemistry , South China Normal University , Guangzhou , 510006 , P. R. China.

A metal-organic framework (MOF), named SCNU-Z2, based on a new heterotopic tripodal nitrogen-containing ligand, has been constructed. Due to the replacement of one imidazole group in the reported ligand with one tetrazole group, the charge of the framework is changed from cationic to anionic but retains the same framework structure. The framework consists of tubular channels with a diameter of 1.5 nm and exhibits satisfactory stability in water with a pH range of 3-11. The anionic nature of the framework allows the effective adsorption of the cationic dyes MLB, CV, and RhB with capacities of 455.6, 847.4, and 751.8 mg/g, respectively. Among them, the adsorption capacities for SCNU-Z2 on CV and RhB rank as the highest when compared with other reported MOFs. In contrast, SCNU-Z2 exhibits an extremely low capacity for anionic dyes MO and AO, making it useful for the separation of anionic and cationic dyes based on a charge-dependent mode. Interestingly, SCNU-Z2 can be used to degrade an anionic dye, MB, within 30 min under darkness at room temperature. The apparent activation energy of the dye degradation reaction is calculated to be approximately 18.96 kJ·mol, implying that the catalytic reaction of MB can be considered as a low-temperature thermocatalytic reaction in the dark/SCNU-Z2 system.
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http://dx.doi.org/10.1021/acs.inorgchem.9b01959DOI Listing
October 2019

Stable Hydrazone-Linked Covalent Organic Frameworks Containing O,N,O'-Chelating Sites for Fe(III) Detection in Water.

ACS Appl Mater Interfaces 2019 Apr 22;11(13):12830-12837. Epub 2019 Mar 22.

School of Chemistry and Environment , South China Normal University , Guangzhou 510006 , P. R. China.

Two stable crystalline hydrazone-linked covalent organic frameworks (COFs) (Bth-Dha and Bth-Dma) containing functional O,N,O'-chelating sites have been designed and successfully synthesized by the Schiff-base condensation reactions between benzene-1,3,5-tricarbohydrazide (Bth) and 2,5-dihydroxyterephthalaldehyde (Dha) or 2,5-dimethoxyterephthal-aldehyde (Dma), respectively. Bth-Dma exhibits strong fluorescence in the solid state and in an aqueous dispersion, while no fluorescence can be observed for Bth-Dha. Interestingly, the as-synthesized Bth-Dma can be used as a turn-off fluorescence sensor for the Fe(III) ion in aqueous solution with outstanding selectivity and sensitivity. The recognition process can be attributed to the coordination interaction between Fe(III) ion and the O,N,O'-chelating sites in the pore wall of Bth-Dma COF, as verified by X-ray photoelectron spectroscopy and H NMR spectroscopy. To the best of our knowledge, this is the first report on the rational design of luminescent COF with predesigned O,N,O'-chelating sites as a fluorescence sensor for highly selective and sensitive metal ion detection. This work may pave the way for designing luminescent COF sensors with functional binding sites for detecting specific metal ions.
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http://dx.doi.org/10.1021/acsami.9b02640DOI Listing
April 2019

Hydrolytically Stable Nanotubular Cationic Metal-Organic Framework for Rapid and Efficient Removal of Toxic Oxo-Anions and Dyes from Water.

Inorg Chem 2019 Feb 5;58(4):2899-2909. Epub 2019 Feb 5.

School of Chemistry and Environment , South China Normal University , Guangzhou , 510006 , PR China.

Cationic framework materials capable of removing anionic pollutants from wastewater are highly desirable but relatively rarely reported. Herein, a cationic MOF (SCNU-Z1-Cl) possessing tubular channels with diameter of 1.5 nm based on Ni(II) and a nitrogen-containing ligand has been synthesized and applied to capture hazardous anionic contaminants from water. The SCNU-Z1-Cl exhibits high BET surface area of 1636 m/g, and shows high hydrolytically stability in pH range from 4 to 10. Owing to the large tubular channels and the uncoordinated anions in the framework, the aqueous-phase anion-exchange applications of SCNU-Z1-Cl were explored with environmentally toxic oxo-anions including CrO, CrO, MnO, and ReO, and organic dyes. The adsorption of oxoanions exhibits high uptake kinetics and the adsorption capacities of CrO, CrO, MnO, and ReO are 126, 241, 292, and 318 mg/g, respectively, which were some of the highest values in the field of MOF/COF. In additional, the selectively is high when other concurrent anions are exist. The anionic dyes with different sizes including methyl orange, acid orange A, congo red, as well as methyl blue can be adsorbed by SCNU-Z1-Cl in few minutes to about 1 h. The adsorption capacities for them are 285, 180, 585, and 262 mg/g, respectively. In contrast, the adsorption kinetics for catinionic dyes with different sizes is obviously lower and exhibit a size-selectively adsorption that only cationic dye with suitable size (rhodamine B) can be adsorbed by SCNU-Z1-Cl. Consequently, SCNU-Z1-Cl can sepearate organic dyes in three different modes: size-dependent, charge-dependent, and kinetics-dependent selective adsorption. The excellent adsorption and separation properties of SCNU-Z1-Cl is attribute to the cationic framework, large tubular channel, as well as the high positive Zeta potential.
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http://dx.doi.org/10.1021/acs.inorgchem.9b00104DOI Listing
February 2019

Construction of a hydrazone-linked chiral covalent organic framework-silica composite as the stationary phase for high performance liquid chromatography.

J Chromatogr A 2017 Oct 5;1519:100-109. Epub 2017 Sep 5.

School of Chemistry and Environment, South China Normal University, Guangzhou, 510006, PR China; Guangdong YanJie Pharmatech Co. Ltd., Guangzhou, 510663, PR China. Electronic address:

Covalent organic frameworks (COFs), as an emerging class of crystalline porous organic polymers, have great potential for applications in chromatographic separation owning to their fascinating crystalline structures and outstanding properties. However, development of COF materials as novel stationary phases in high performance liquid chromatography (HPLC) is just in its infancy. Herein, we report the design and construction of a new hydrazone-linked chiral COF, termed BtaMth COF, from a chiral hydrazide building block (Mth) and present a one-pot synthetic method for the fabrication of [email protected] composite for HPLC separation of isomers. The as-synthesized BtaMth chiral COF displays good crystallinity, high porosity, as well as excellent chemical stability. Meanwhile, the fabricated HPLC column by using [email protected] composite as the new stationary phase exhibits high resolution performances for the separation of positional isomers including nitrotoluene and nitrochlorobenzene, as well as cis-trans isomers including beta-cypermethrin and metconazole. Additionally, some effects such as the composition of the mobile phase and column temperature for HPLC separations on the [email protected] packed column also have been studied in detail. The successful applications indicate the great potentials of hydrazone-linked chiral COF-silica composite as novel stationary phase for the efficient HPLC separation.
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http://dx.doi.org/10.1016/j.chroma.2017.09.007DOI Listing
October 2017

LC-UV-Guided Isolation and Structure Determination of Lancolide E: A Nortriterpenoid with a Tetracyclo[5.4.0.0(2,4).0(3,7)]undecane-Bridged System from a "Talented" Schisandra Plant.

Org Lett 2016 Jan 17;18(1):100-3. Epub 2015 Dec 17.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.

Lancolide E (1) featuring a complex tetracyclo[5.4.0.0(2,4).0(3,7)]undecane-bridged system that is constructed by an eight-, a three-, and two five-membered carbon rings in a sterically congested region was obtained in trace amounts from a "talented" schinortriterpenoid producer Schisandra lancifolia. Its structure was fully characterized by combining 2D NMR spectroscopy, theoretical calculations, and X-ray diffraction analysis. The biogenetic pathway of 1 was proposed to involve a Prins cyclization.
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http://dx.doi.org/10.1021/acs.orglett.5b03334DOI Listing
January 2016

[Diagnosis and treatment of prostatic malignant mesenchymal tumors: Analysis of 20 cases].

Zhonghua Nan Ke Xue 2015 Apr;21(4):308-14

Objective: To explore the diagnosis, treatment, and prognosis of prostatic malignant mesenchymal tumors (PMMT).

Methods: We retrospectively analyzed the clinical and follow-up data about 20 cases of PMMT and reviewed the literature relevant to the diagnosis, treatment, and prognosis of the disease.

Results: Based on the results of pathology and immunohistochemistry, the 20 PMMT cases included leiomyosarcoma (n = 7), rhabdomyosarcoma (n = 5), prostatic stromal sarcoma (n = 3), chondrosarcoma (n = 1), and undifferentiated PMMT (n = 4). Twelve of the patients were treated by radical prostatectomy (3 concurrently by sigmoid colostomy and 1 by cystostomy), 2 by pelvic tumor resection following arterial embolization, 1 by total pelvic exenteration, 1 by colostomy with pelvic lymph node biopsy, and 4 by conservative therapy because of metastasis to the lung, pelvis and bone. Of the 20 patients, 9 died of systemic metastasis within 3 months after treatment, 3 died at 6, 7, and 14 months, respectively, 3 survived with tumor for 5, 11, and 12 months, respectively, 2 survived without tumor for 12 and 24 months so far, all subjected to periodic chemotherapy postoperatively, and 3 lost to follow-up.

Conclusion: PMMT is a tumor of high malignancy and rapid progression, for which transrectal ultrasound-guided biopsy remains the main diagnostic method. The clinical stage of the tumor is an important factor influencing its prognosis and the survival rate of the patients can be improved by early diagnosis and combined therapy dominated by radical prostatectomy.
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April 2015

The Organic Flatland-Recent Advances in Synthetic 2D Organic Layers.

Adv Mater 2015 Oct 3;27(38):5762-70. Epub 2015 Mar 3.

The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, US.

Ultrathin, 2D organic layers of sub-ten nanometer thicknesses and high aspect ratios have received a great deal of attention for their graphene-like topological features and emerging properties. Rational synthetic strategies have led to the realization of periodic 2D layers with unprecedented structural precision. Herein, recent progress on the synthesis of 2D organic layers, including methods based on both non-covalent and covalent interactions, is summarized, and potential applications are highlighted. Such 2D organic nanostructures have a brilliant future as prospective multifunctional materials, showing great promise as platforms for engineering novel optoelectronic, interfacial, and bioactive properties.
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http://dx.doi.org/10.1002/adma.201500124DOI Listing
October 2015

A case report of retroperitoneal pararenal Castleman's disease associated with myasthenia gravis.

World J Surg Oncol 2014 Nov 7;12:331. Epub 2014 Nov 7.

The first affiliated hospital of Zhejiang University School of Medcine, Qingchun Road NO,79, Hangzhou, Zhejiang 310003, China.

Background: Castleman's disease (CD) is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue. The combination of an occurrence of retroperitoneal pararenal CD with myasthenia gravis (MG) is extremely rare.

Case Presentation: The patient was admitted to our hospital for investigation of a retroperitoneal pararenal tumor which had been coincidentally diagnosed at a local hospital where he was admitted because of MG. The patient subsequently underwent an exploratory laparotomy and suffered from postoperative myasthenic crisis. Pathological examination revealed a left retroperitoneal mass of CD (hyaline vascular type). There was no recurrence of disease found after 7 months.

Conclusions: CD with MG is a rare condition. Postoperative myasthenic crisis is a severe complication. The possibility of its occurrence must be in physicians' minds and the risk of postoperative myasthenic crisis must be carefully considered when evaluating MG patients undergoing surgery.
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http://dx.doi.org/10.1186/1477-7819-12-331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234864PMC
November 2014

External iliac vein - transplant ureteral fistula combined with renal cell carcinoma: an unusual case of hematuria.

Onco Targets Ther 2014 23;7:1339-42. Epub 2014 Jul 23.

Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, People's Republic of China.

Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique case of an external iliac vein - transplant ureteral fistula. A 48 year-old female complained of recurrent gross hematuria. She underwent transplant nephrectomy and radical left nephrectomy because of rejection of transplanted kidney and cystic renal cell carcinoma when the hematuria arose for the first time. Ten months later, the hematuria recurred again, and cystoscopy showed bleeding from the right transplant ureteral orifice. Open exploration confirmed the diagnosis of external iliac vein - transplant ureteral fistula. Diagnostic difficulties and treatment dilemma of such a rare cause of hematuria are also discussed.
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http://dx.doi.org/10.2147/OTT.S64685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114910PMC
August 2014

Tubular metal-organic framework-based capillary gas chromatography column for separation of alkanes and aromatic positional isomers.

J Chromatogr A 2013 Apr 16;1285:132-8. Epub 2013 Feb 16.

Institute of Special Materials & School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China.

In this work, a tubular metal-organic framework, MOF-CJ3, with a large one-dimensional channel was chosen as stationary phase to prepare a capillary gas chromatographic column via a verified dynamic coating procedure. The column offered good separations of linear and branched alkanes, as well as aromatic positional isomers (ethylbenzene, xylene, cresol, hydroquinone, dichlorobenzene, bromobenzonitrile, chloronitrobenzene, and nitrotoluene) based on a combination of host-guest interactions and adsorption effects. Elution sequence of most of the analytes followed an increasing order of their boiling points, except for the separation of n-heptanes/isooctane, cresol, and hydroquinone isomers. Separation behavior of the column upon different organic substances may be related to the tubular pore structure of MOF-CJ3, in which the van der Waals forces between the alkanes and the hydrophobic inner surfaces might have great effect on separation of n-heptanes and isooctane, whereas the separation of cresol and hydroquinone isomers were affected by (OH⋯O) hydrogen bonds formed between the analytes and the 1,3,5-benzenetricarboxylate ligands on the pore wall. The effects of temperature on separation of aromatic positional isomers were investigated to elucidate entropy and enthalpy controlling of the separation process.
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http://dx.doi.org/10.1016/j.chroma.2013.02.024DOI Listing
April 2013

[Stromal tumor of the seminal vesicle: a case report and literature review].

Zhonghua Nan Ke Xue 2012 Dec;18(12):1119-22

Department of General Surgery, Yiwu Hospital Affiliated to Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China.

Objective: To investigate the clinical manifestations, pathological features, diagnosis and treatment of stromal tumor in the seminal vesicle.

Methods: We retrospectively analyzed 1 case of stromal tumor of the seminal vesicle, reviewed relevant domestic and international literature, and summarized the clinical manifestations, pathological features, diagnosis and treatment of the tumor.

Results: The patient was a 50 years old male, who underwent excision of the tumor together with the seminal vesicle. Pathology showed it to be stromal tumor of the seminal vesicle. Ultrasonography and CT found no recurrence 10 months after surgery.

Conclusion: Stromal tumor of the seminal vesicle is rare and easy to be misdiagnosed. Digital rectal examination, and ultrasonography, CT and MRI of the urinary system are useful for its diagnosis. The currently accepted treatment is surgical removal of the tumor, and the prognosis is good.
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December 2012

Hand-assisted-drawing-needle running suture with a curved needle: an effective technique to create a W-ileal neobladder.

Chin Med J (Engl) 2012 Jun;125(12):2225-7

Department of Urology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.

Background: An important milestone in the area of urinary diversion was the advent of a series of orthotopic bladder substitution (OBS). However, reconstruction of OBS by the traditional hand suture method (THSM) is a time-consuming process. Stapling techniques are considered to be inferior to hand-sewn methods. We report our experience and functional results in patients with W-ileal neobladder by a hand-assisted-drawing-needle running suture (HADNRS).

Methods: Between April 1993 and December 2011, 347 patients (338 men and 9 women) aged 28 - 77 years (median age: 59 years) underwent radical cystectomy, followed by the creation of a modified W-ileal neobladder by HADNRS with a curved needle. A total of 347 (20 patients in 2003) were evaluated by urodynamic tests.

Results: The operative time ranged from 110 to 310 minutes (mean 148 minutes), and the mean time of reconstruction by HADNRS, excluding ureterointestinal and ileouretral anastomosis, was (20.2 ± 4.3) minutes. Histopathological analysis of removed specimens showed that 317 patients had transitional cell bladder carcinoma. Of these 317 patients, 19 also had squamous carcinoma and 13 had adenocarcinoma. Glandularis and prostate cancer occurred in 16 and 14 patients, respectively. Three patients (0.8%) had neobladder abdominal fistula. No other early complications or injury to the surgeon's hands occurred due to HADNRS. Of the 20 cases with urodynamic examinations in 2003, two suffered from daytime incontinence and six had nocturnal incontinence. The maximum capacity of the neobladder was (492.9 ± 177.8) ml, and the maximum pressure within the reservoir at the end of filling was (32.1 ± 8.6) cmH2O.

Conclusion: Reconstruction of W-ileal neobladder by HADNRS is effective and economical.
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June 2012

A new two-dimensional cadmium coordination polymer with 1H-imidazole-4-carboxylate and oxalate.

Acta Crystallogr C 2012 Jul 13;68(Pt 7):m177-80. Epub 2012 Jun 13.

School of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China.

The title compound, poly[aqua(μ(2)-1H-imidazole-4-carboxylato-κ(3)N(3),O:O')hemi(μ(2)-oxalato-κ(4)O(1),O(2):O(1'),O(2'))cadmium(II)], [Cd(C(4)H(3)N(2)O(2))(C(2)O(4))(0.5)(H(2)O)](n), exhibits a two-dimensional network. The Cd(II) cation is coordinated to one N atom and two carboxylate O atoms from two 1H-imidazole-4-carboxylate (Himc) ligands, two carboxylate O atoms from the bridging oxalate anion and one ligated water molecule; these six donor atoms form a distorted octahedral configuration. The oxalate anion lies on a centre of inversion. The Himc ligands connect the Cd(II) cations to form -Cd-Himc-Cd-Himc-Cd- zigzag chains, with a Cd···Cd separation of 5.8206 (6) Å along the b direction, which are further linked by tetradentate oxalate anions to generate a two-dimensional herringbone architecture in the ab plane. These layers are extended to form a three-dimensional supramolecular framework via O-H···O and N-H···O hydrogen bonds and π-π stacking interactions. The solid-state photoluminscent behaviour of the title compound has been investigated at room temperature.
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http://dx.doi.org/10.1107/S0108270112023153DOI Listing
July 2012

Two mononuclear octahedral complexes with benzimidazole-2-carboxylate: supramolecular networks constructed by hydrogen bonds.

Acta Crystallogr C 2011 Nov 25;67(Pt 11):m346-50. Epub 2011 Oct 25.

School of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China.

The title compounds, trans-bis(1H-benzimidazole-2-carboxylato-κ(2)N(3),O)bis(ethanol-κO)cadmium(II), [Cd(C(8)H(5)N(2)O(2))(2)(C(2)H(6)O)(2)], (I), and trans-bis(1H-benzimidazole-κN(3))bis(1H-benzimidazole-2-carboxylato-κ(2)N(3),O)nickel(II), [Ni(C(8)H(5)N(2)O(2))(2)(C(7)H(6)N(2))(2)], (II), are hydrogen-bonded supramolecular complexes. In (I), the Cd(II) ion is six-coordinated by two O atoms from two ethanol molecules, and by two O and two N atoms from two bidentate benzimidazole-2-carboxylate (HBIC) ligands, giving a distorted octahedral geometry. The combination of O-H···O and N-H···O hydrogen bonds results in two-dimensional layers parallel to the ab plane. In (II), the six-coordinated Ni(II) atom, which lies on an inversion centre, shows a similar distorted octahedral geometry to the Cd(II) ion in (I); two benzimidazole molecules occupy the axial sites and the equatorial plane contains two chelating HBIC ligands. Pairs of N-H···O hydrogen bonds between pairs of HBIC anions connect adjacent Ni(II) coordination units to form a one-dimensional chain parallel to the a axis. Moreover, these one-dimensional chains are further linked via N-H···O hydrogen bonds between HBIC anions and benzimidazole molecules to generate a three-dimensional supramolecular framework. The two compounds show quite different supramolecular networks, which may be explained by the fact that different co-ligands occupy the axial sites in the coordination units.
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http://dx.doi.org/10.1107/S0108270111041837DOI Listing
November 2011

(5S)-3-Chloro-5-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclo-hex-yloxy]-4-(4-methyl-piperidin-1-yl)furan-2(5H)-one.

Acta Crystallogr Sect E Struct Rep Online 2011 Feb 19;67(Pt 3):o656. Epub 2011 Feb 19.

School of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China.

The title compound, C(20)H(32)ClNO(3), was obtained via a tandem asymmetric Michael addition-elimination reaction of (5S)-3,4-dichloro-5-(l-menth-yloxy)furan-2(5H)-one and 4-methyl-piperidine in the presence of potassium fluoride. The furan-one ring is approximately planar [maximum atomic deviation = 0.022 (2) Å] while the cyclo-hexane ring adopts a chair conformation. Weak inter-molecular C-H⋯O hydrogen bonding is present in the crystal structure.
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http://dx.doi.org/10.1107/S1600536811005216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051989PMC
February 2011

Laparoscopic approach of Castleman's disease in the pararenal retroperitoneum: report of two cases.

Chin Med J (Engl) 2010 Jul;123(13):1809-11

Department of Urology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310031, China.

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July 2010

Highly aggressive epithelioid renal angiomyolipoma with a very poor prognosis.

Chin Med J (Engl) 2010 Mar;123(6):765-6

Department of Urology, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang 310003, China.

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March 2010

Nephrogenic diabetes insipidus with dilatation of bilateral renal pelvis, ureter and bladder.

Scand J Urol Nephrol 2009 ;43(1):73-5

Department of Urology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objective: Nephrogenic diabetes insipidus (NDI) with dilatation of upper urinary tract and bladder is rarely reported. This study evaluated the urological manifestations and treatment results of this rare condition.

Material And Methods: According to a fluid deprivation test, seven men and two women were diagnosed as NDI, and underwent ultrasonography, magnetic resonance urography, cystography, and urodynamic and laboratory examination. A micturition diary and symptoms were recorded before and during treatment. All patients were given hydrochlorothiazide and followed up with ultrasonography, the postvoiding residual volume (PVR), urinalysis and kidney function tests.

Results: All patients presented with polydipsia and polyuria with severe dilatation of upper urinary tract and bladder. Urodynamics showed that the mean values of the bladder capacity, bladder pressure at the end of filling, maximum flow rate (Q(max)), detrusor pressure and PVR were 1056.3 ml, 40.5 cmH(2)O, 30.8 ml/s, 51.3 cmH(2)O, 436.3 ml, respectively. The total urine volume in all patients decreased by more than 50% after administration of hydrochlorothiazide, which improved the symptoms and hydronephrosis in seven cases. The symptoms of other two cases were relieved after treatment with an electric transurethral incision of the bladder neck and a cystostomy.

Conclusions: NDI should be considered in patients with dilatation of the urinary tract and polyuria. Higher bladder pressure at the end of filling may contribute to the dilatation of urinary tract. Normal detrusor contractility with large PVR is a unique manifestation of this condition. Controlling the urine volume and reducing the PVR are of key importance in the treatment of this condition.
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http://dx.doi.org/10.1080/00365590802580208DOI Listing
March 2009

[Feasibility and safety evaluation of retrograde inserting of ureteric catheter via flexible cystoscope].

Zhonghua Yi Xue Za Zhi 2008 Jun;88(24):1687-9

Department of Urology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Objective: To introduce a method of retrograde ureteric catheter placement via flexible cystoscope , and to evaluate the feasibility and safety of this method.

Methods: 112 patients, 62 males and 50 females undergoing retrograde ureteropyelography by 2 same physicians in cooperation were randomly divided into two equal groups with 31 males and 25 females each: one group via flexible cystoscope and the other group via rigid cystoscope. The catheterizing time, visual analogue scale (VAS) pain score, gross hematuria rate, and fever rate were compared between these 2 groups.

Results: Fifty-five patients underwent ureteric catheter placement successfully via flexible cystoscope (98%, 55/56), while 53 cases were technically successful by rigid cystoscope (95%, 53/56). The inserting time in women patients of the flexible cystoscopy group was (7.6 +/- 1.8) min, significantly shorter than that of the men [(8.0 +/- 1.8) min, P < 0.05]. The inserting time in women patients of the rigid cystoscopy group was (7.4 +/- 1.5) min, significantly shorter than that of the men [(8.2 +/- 1.2) min, P < 0.05]. However, there were not significant differences in the inserting times in both men and women between these 2 groups (both P > 0.05). The VAS pain scores in men and women of the flexible cystoscope group were 3. 5 and 2. 3 respectively, both significantly lower than those of the rigid cystoscopy group (7.2 and 3.3 respectively, both P < 0.05). The gross hematuria rate of the flexible cystoscope group was 8.6% (5/56), significantly lower than that of the rigid cystoscopy group (25.0%, 14/56, P < 0.05). Four patients had a fever after flexible cystoscopy while 6 cases did after rigid cystoscopy, however, without significant difference between these 2 groups (P > 0.05).

Conclusions: Retrograde placement of ureteric catheter via flexible cystoscope is safe and reliable as rigid cystoscopy. Meanwhile, inserting ureteric catheter via flexible cystoscope causes the patients less pain and less chance of hematuria.
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June 2008

Incidental prostate cancer in radical cystoprostatectomy specimens.

Asian J Androl 2008 Sep;10(5):809-14

Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Aim: To investigate the rates of prostate cancer (PCa) in radical cystoprostatectomy (RCP) specimens for bladder cancer in mainland China. To determine the follow-up outcome of patients with two concurrent cancers and identify whether prostate-specific antigen (PSA) is a useful tool for the detection of PCa prior to surgery.

Methods: From January 2002 to January 2007, 264 male patients with bladder cancer underwent RCP at our center. All patients underwent digital rectal examination (DRE) and B ultrasound. Serum PSA levels were tested in 168 patients. None of the patients had any evidence of PCa before RCP. Entire prostates were embedded and sectioned at 5 mm intervals.

Results: Incidental PCa was observed in 37 of 264 (14.0%) RCP specimens. Of these, 12 (32.4%) were clinically significant according to an accepted definition. The PSA levels were not significantly different between patients with PCa and those without PCa, nor between patients with significant PCa and those with insignificant PCa. Thirty-four patients with incidental PCa were followed up. During a mean follow-up period of 26 months, two patients with PSA > 4 ng/mL underwent castration. None of the patients died of PCa.

Conclusion: The incidence of PCa in RCP specimens in mainland China is lower than that in most developed countries. PSA cannot identify asymptomatic PCa prior to RCP. In line with published reports, incidental PCa does not impact the prognosis of bladder cancer patients undergoing RCP.
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http://dx.doi.org/10.1111/j.1745-7262.2008.00420.xDOI Listing
September 2008

[A multi-center clinical trial of Qianlieantong tablets for chronic prostatitis].

Zhonghua Nan Ke Xue 2007 Oct;13(10):950-2

Department of Urology, Peopleś Hospital of Sichuan Province, Chengdu, Sichuan 610072, China.

Objective: To observe the efficacy and safety of Qianlieantong Tablets in the treatment of chronic prostatitis.

Methods: A multi-center, self-controlled open clinical trial was conducted. A total of 280 subjects with chronic prostatitis were enrolled and treated by Qianlieantong Tablets, 3 times a day, 5 tablets each time. Before and after 2 and 4 weeks after the administration, NIH-CPSI scores and white blood cell counts in the prostate secretion were recorded.

Results: Of the 273 subjects evaluated, the rates of excellence, effectiveness and ineffectiveness were 35.2% (n = 96), 47.6% (n = 130) and 17.2% (n = 47), respectively, with a total effectiveness rate of 82.8%. After 4 weeks'medication, the scores of the subjects on NIH-CPSI pain, voiding and quality of life and white blood cell counts in prostate secretion were significantly decreased compared with pre-treatment (P < 0.01). No adverse events or laboratory abnormality related to the medication were observed.

Conclusion: Qianlieantong Tablets has a significant effect on chronic prostatitis with high safety, particularly indicated in chronic prostatitis with pelvic pain.
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October 2007

[Predictive factors for conversion of transurethral resection of the prostate to open prostatectomy].

Zhonghua Nan Ke Xue 2007 Jul;13(7):613-6

Department of Urology, First Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.

Objective: To evaluate the factors for the conversion of transurethral resection of the prostate (TURP) to open prostatectomy and to provide clinical evidence for surgical options.

Methods: From January 1997 to March 2005, we performed 1 086 TURP and made retrospective analyses of 11 risk factors concerning the demographics, clinical history, laboratory data, ultrasound results, and intraoperative complications of the patients. In addition, multivariate logistic regression was used to determine those variables predicting the conversion of TURP.

Results: Thirty-nine (3.59%) of the TURP cases required conversion, mostly because of uncontrollable hemorrhage (71.79%). Multivariate analyses showed that a prostate volume > 85.2 ml (OR = 2.568, P < 0.01), intraoperative slit of capsula prostatic (OR = 1.916, P < 0.01) and a second midstream bladder specimen (VB2) white blood cell count of the urine > 13.5/HP (OR = 1.486, P < 0.01) predicted the conversion to open prostatectomy.

Conclusion: Benign prostatic hyperplasia (BPH) patients with a huge prostate and those with intraoperative slit of capsula prostatic undergoing TURP are more likely to be converted. And uncontrollable hemorrhage, huge prostate and poor endoscopic vision are the major reasons for the conversion.
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July 2007

[The effect of Yunnan Baiyao on reduction of intra-operative bleeding of the patients undergoing transurethral resection of prostate].

Zhonghua Yi Xue Za Zhi 2007 Apr;87(15):1017-20

Institute of Urology, Peking University First Hospital, Beijing 100034, China.

Objective: To investigate the effect of Yunnan Baiyao on reduction of intra-operative bleeding of the patients undergoing transurethral resection of prostate (TURP).

Methods: A randomized placebo-control double-blind multi-center trial was conducted. 203 patients with benign prostate hyperplasia (BPH), aged 50 - 80, who were to undergo TURP were randomly divided into 2 groups: Yunnan Baiyao group, given 500 mg Yunnan Baiyao four times daily since the third day before the operation for 3 days, and placebo group, given empty capsules for 3 days. The amount of intra-operative bleeding, bleeding index and bleeding intensity were compared. The side effect of Yunnan Baiyao was also evaluated.

Results: The amount of intra-operative bleeding of the Yunnan Baiyao group was 147 ml +/- 144 ml, significantly less than that of the control group (182 ml +/- 157 ml, P < 0.05). The amount of intra-operative bleeding of the per protocol (PP) population in the Yunnan Baiyao group (n = 58) was 146 ml +/- 116 ml, significantly less than the PP population in the control group (n = 66) (220 ml +/- 207 ml, P = 0.0361). When the weight of the resected prostate tissue was more than 20 gram, the amount of intraoperative bleeding, bleeding index, and bleeding intensity of the ITT population in the Yunnan Baiyao group (n = 60) were all significantly lower than those of the ITT population in the control group (n = 68) (all P < 0.05); the bleeding intensity of the PP population in the Yunnan Baiyao group was 2.4 ml/min +/- 1.8 ml/min, significantly lower than that of the PP population in the control group (3.6 ml/min +/- 3.7 ml/min, P = 0.0072); the bleeding index of the PP population in the Yunnan Baiyao group was 4.7 ml/g +/- 4.6 ml/g, significantly lower than that of the PP population in the control group (7.1 ml/g +/- 8.3 ml/g, P = 0.025). No side effect was found in the 2 groups.

Conclusion: Yunnan Baiyao is effective on reducing the amount of intraoperative bleeding of TURP without side effect.
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April 2007

[Penile squamous carcinoma in circumcised patients: a report 17 cases].

Zhonghua Nan Ke Xue 2006 Dec;12(12):1108-9

Department of Urology, First Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.

Objective: To discuss the diagnosis and treatment of penile carcinoma in circumcised men.

Methods: We reviewed 17 cases of penile carcinoma detected 1 month to 16 years after circumcision performed in our hospital from January, 1997 to December, 2004.

Results: Of the total number, 11 cases were diagnosed as penile carcinoma 1 - 12 months and the others 3 - 16 years after the circumcision. Sixteen of them were treated by partial penectomy, anti 1 first by extensive circumcision and later by partial and total penectomy successively after recurrence. Cloquet nodes biopsy showed 16 cases to be pathologically well-differentiated and I case moderately differentiated penile squamous carcinoma. One died of extensive metastasis, but the other 16 remained disease-free survivals.

Conclusion: Circumcised adult men, especially those over 40 years of age, are likely to develop penile carcinoma. Patients with inflammation, plaque or ulcer in the prepuce should be checked by pathological biopsy and followed up closely. For Stage-I penile squamous carcinoma, partial penectomy is shown to be an effective therapeutic option, and Cloquet's nodes biopsy is necessary for all patients.
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December 2006