Sofiya Yashchuk

Sofiya Yashchuk

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Sofiya Yashchuk

Sofiya Yashchuk

Publications by authors named "Sofiya Yashchuk"

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Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Bioorg Med Chem 2017 10 9;25(19):5114-5127. Epub 2017 Apr 9.

Department of Hematology, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Department of Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Department of Refractory Viral Infection, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173073
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http://dx.doi.org/10.1016/j.bmc.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617771PMC
October 2017

Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.

Bioorg Med Chem Lett 2015 Nov 30;25(21):4903-4909. Epub 2015 May 30.

Departments of Hematology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA; Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2015.05.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607586PMC
November 2015

Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20.

J Med Chem 2015 Jun 4;58(12):5088-95. Epub 2015 Jun 4.

†Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b00474
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http://dx.doi.org/10.1021/acs.jmedchem.5b00474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522690PMC
June 2015

Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.

J Med Chem 2012 Apr 22;55(7):3387-97. Epub 2012 Mar 22.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, P.O. Box 4010, Atlanta, Georgia 30302-4010, USA.

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http://dx.doi.org/10.1021/jm300072dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355519PMC
April 2012