Snorri S Thorgeirsson

Snorri S Thorgeirsson

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Snorri S Thorgeirsson

Publications by authors named "Snorri S Thorgeirsson"

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Stemness in Liver Cancer.

Dig Dis 2017 3;35(4):387-389. Epub 2017 May 3.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1159/000456592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841535PMC
October 2017

DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration.

Hepatology 2016 08 28;64(2):582-98. Epub 2016 Apr 28.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.28563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841553PMC
August 2016

Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin.

J Cancer 2016 6;7(9):1142-51. Epub 2016 Jun 6.

1. Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;; 6. Department of Surgery, Saint Peter's Healthcare System, Rutgers University, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.7150/jca.10047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911882PMC
June 2016

Stemness and reprogramming in liver cancer.

Hepatology 2016 Apr 14;63(4):1068-70. Epub 2016 Jan 14.

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.28362DOI Listing
April 2016

A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy.

Mol Pharmacol 2016 Feb 14;89(2):263-72. Epub 2015 Dec 14.

Laboratory of Cell Biology (J-P.G., J.P.M., C-P.W., A.M.C., S.V.A., M.M.G.) and Laboratory of Experimental Carcinogenesis (J.B.A., S.S.T.), Center for Cancer Research, National Cancer Institute, and Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, Office of Science Management and Operations, National Institute of Allergy and Infectious Diseases (S.V.), National Institutes of Health, Bethesda, Maryland; and the Viral Technologies Group and Molecular Detection Group, Protein Expression Laboratory, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Marylanld (R.K.B., K.P., W.E.B.)

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http://molpharm.aspetjournals.org/content/early/2015/12/14/m
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http://molpharm.aspetjournals.org/content/89/2/263.full.pdf
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.115.10
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http://dx.doi.org/10.1124/mol.115.101360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727122PMC
February 2016

Functional and genetic deconstruction of the cellular origin in liver cancer.

Nat Rev Cancer 2015 Nov;15(11):653-67

Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrc4017DOI Listing
November 2015

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.

Proc Natl Acad Sci U S A 2015 Sep 24;112(36):11282-7. Epub 2015 Aug 24.

Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1511016112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568654PMC
September 2015

Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation.

PLoS Med 2014 Dec 23;11(12):e1001770. Epub 2014 Dec 23.

Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Kleberg Center for Molecular Markers, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Department of Biochemistry and Molecular Biology, Medical Research Center and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.

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http://dx.doi.org/10.1371/journal.pmed.1001770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275163PMC
December 2014

The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina.

J Neurosci 2014 Nov;34(46):15356-68

Department of Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, Departments of Molecular Biology and Genetics, Neuroscience, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, and Institut de la Vision, University Pierre and Marie Curie, Paris 75012, France

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2089-14.2
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http://dx.doi.org/10.1523/JNEUROSCI.2089-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228138PMC
November 2014

MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.

Cancer Res 2014 Oct 4;74(20):5903-13. Epub 2014 Sep 4.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199878PMC
October 2014

The biological and clinical challenge of liver cancer heterogeneity.

Hepat Oncol 2014 Oct 11;1(4):349-353. Epub 2014 Dec 11.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2217/hep.14.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096446PMC
October 2014

Epigenetic reprogramming modulates malignant properties of human liver cancer.

Hepatology 2014 Jun 1;59(6):2251-62. Epub 2014 May 1.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.27026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043911PMC
June 2014

Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends.

J Hepatol 2014 Apr 3;60(4):855-65. Epub 2013 Dec 3.

Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2013.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960348PMC
April 2014

Next-generation genomic profiling of hepatocellular adenomas: a new era of individualized patient care.

Cancer Cell 2014 Apr;25(4):409-11

Laboratory of Experimental Carcinogenesis (LEC), Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Room 4146, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078407PMC
April 2014

SnapShot: Hepatocellular carcinoma.

Cancer Cell 2014 Apr;25(4):550.e1

Laboratory of Experimental Carcinogenesis, CCR/NCI/NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ccr.2014.04.002DOI Listing
April 2014

A perspective on molecular therapy in cholangiocarcinoma: present status and future directions.

Hepat Oncol 2014 Jan;1(1):143-157

National Cancer Institute, Laboratory of Experimental Carcinogenesis, NIH, Building 37, Room 4146A, 37 Convent Drive, Bethesda, MD 20892-4262, USA.

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http://dx.doi.org/10.2217/hep.13.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997260PMC
January 2014

Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair.

Fibrogenesis Tissue Repair 2013 Dec 20;6(1):21. Epub 2013 Dec 20.

Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1186/1755-1536-6-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892118PMC
December 2013

An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer.

BMC Med Genomics 2013 Sep 22;6:33. Epub 2013 Sep 22.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1755-8794-6-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849454PMC
September 2013

Genomic copy number alterations with transcriptional deregulation at 6p identify an aggressive HCC phenotype.

Carcinogenesis 2013 Jul 18;34(7):1543-50. Epub 2013 Mar 18.

Department of Physiology, Ajou University School of Medicine, Suwon 443-721, Korea.

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http://dx.doi.org/10.1093/carcin/bgt095DOI Listing
July 2013

Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types.

Gastroenterology 2013 Jul 19;145(1):221-231. Epub 2013 Mar 19.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2013.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913051PMC
July 2013

Linking MLL and the HGF-MET signaling pathway in liver cancer.

J Clin Invest 2013 Jul 24;123(7):2780-3. Epub 2013 Jun 24.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1172/JCI70235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696572PMC
July 2013

Biphasic regulation of the NADPH oxidase by HGF/c-Met signaling pathway in primary mouse hepatocytes.

Biochimie 2013 Jun 16;95(6):1177-84. Epub 2013 Jan 16.

Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina S-351, 09340 Iztapalapa, México, D.F., Mexico; PhD program on Experimental Biology, Universidad Autónoma Metropolitana Iztapalapa, México, D.F., Mexico.

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http://dx.doi.org/10.1016/j.biochi.2013.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646903PMC
June 2013

Sall4 in "stemness"-driven hepatocarcinogenesis.

N Engl J Med 2013 Jun;368(24):2316-8

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http://dx.doi.org/10.1056/NEJMe1303026DOI Listing
June 2013

Genomic decoding of intrahepatic cholangiocarcinoma reveals therapeutic opportunities.

Gastroenterology 2013 Apr 24;144(4):687-90. Epub 2013 Feb 24.

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http://dx.doi.org/10.1053/j.gastro.2013.02.018DOI Listing
April 2013

Comparative testing of various pancreatic cancer stem cells results in a novel class of pancreatic-cancer-initiating cells.

Stem Cell Res 2012 Nov 19;9(3):249-60. Epub 2012 Aug 19.

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.scr.2012.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490042PMC
November 2012

Genetic profiling of intrahepatic cholangiocarcinoma.

Curr Opin Gastroenterol 2012 May;28(3):266-72

Laboratory of Experimental Carcinogenesis, NCI/CCR, NIH, Bethesda, Maryland 20892-4262, USA.

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http://dx.doi.org/10.1097/MOG.0b013e3283523c7eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017233PMC
May 2012

Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice.

Hepatology 2012 Apr;55(4):1215-26

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4262, USA.

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http://dx.doi.org/10.1002/hep.24796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299882PMC
April 2012

Tumor-initiating label-retaining cancer cells in human gastrointestinal cancers undergo asymmetric cell division.

Stem Cells 2012 Apr;30(4):591-8

Gastrointestinal and Hepatobiliary Malignancies Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1002/stem.1061
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http://dx.doi.org/10.1002/stem.1061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492937PMC
April 2012

Genes associated with recurrence of hepatocellular carcinoma: integrated analysis by gene expression and methylation profiling.

J Korean Med Sci 2011 Nov 27;26(11):1428-38. Epub 2011 Oct 27.

Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.3346/jkms.2011.26.11.1428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207045PMC
November 2011

Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer.

Carcinogenesis 2011 Oct 18;32(10):1434-40. Epub 2011 Jul 18.

National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgr133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179421PMC
October 2011

Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways.

Hepatology 2011 Sep 27;54(3):1031-42. Epub 2011 Jul 27.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/hep.24454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179780PMC
September 2011

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

J Exp Med 2011 Sep 29;208(10):1963-76. Epub 2011 Aug 29.

Department of Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA; Department of Medical Chemistry, University of Liège, B-4000 Liège, Belgium.

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http://dx.doi.org/10.1084/jem.20110198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182062PMC
September 2011

The almighty MYC: orchestrating the micro-RNA universe to generate aggressive liver cancer.

J Hepatol 2011 Aug 22;55(2):486-7. Epub 2011 Feb 22.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016882781100178
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http://dx.doi.org/10.1016/j.jhep.2011.01.042DOI Listing
August 2011

Wild-type p53 controls cell motility and invasion by dual regulation of MET expression.

Proc Natl Acad Sci U S A 2011 Aug 9;108(34):14240-5. Epub 2011 Aug 9.

Department of Biomedical Sciences, Microarray Core Facility, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1073/pnas.1017536108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161601PMC
August 2011

Exploring genomic profiles of hepatocellular carcinoma.

Mol Carcinog 2011 Apr;50(4):235-43

Department of Physiology, Ajou University School of Medicine, Suwon, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496176PMC
http://dx.doi.org/10.1002/mc.20691DOI Listing
April 2011

Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma.

Gastroenterology 2011 Mar 19;140(3):1063-70. Epub 2010 Nov 19.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057345PMC
March 2011

Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer.

J Hepatol 2011 Feb 7;54(2):311-9. Epub 2010 Sep 7.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4262, USA.

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http://dx.doi.org/10.1016/j.jhep.2010.06.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031080PMC
February 2011

Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival.

Genes Chromosomes Cancer 2011 Feb;50(2):122-35

Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN, USA.

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http://dx.doi.org/10.1002/gcc.20838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253341PMC
February 2011

An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer.

Sci Transl Med 2010 Oct;2(54):54ra77

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4262, USA.

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http://dx.doi.org/10.1126/scitranslmed.3001338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077922PMC
October 2010

Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice.

PLoS One 2010 Sep 16;5(9). Epub 2010 Sep 16.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012739PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940888PMC
September 2010

Progenitor-derived hepatocellular carcinoma model in the rat.

Hepatology 2010 Apr;51(4):1401-9

Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/hep.23488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914300PMC
April 2010

Stem cells in hepatocarcinogenesis: evidence from genomic data.

Semin Liver Dis 2010 Feb 19;30(1):26-34. Epub 2010 Feb 19.

Laboratory of Experimental Carcinogenesis (LEC), Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0030-1247130
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http://dx.doi.org/10.1055/s-0030-1247130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492884PMC
February 2010

Acquired genetic and functional alterations associated with transforming growth factor beta type I resistance in Hep3B human hepatocellular carcinoma cell line.

J Cell Mol Med 2009 Sep 1;13(9B):3985-92. Epub 2009 May 1.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4262, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2009.00769.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516545PMC
September 2009

Genome-based predictors for HCC outcomes: a matter of tumor and/or stroma.

J Hepatol 2009 Sep;51(3):596-597

Center for Cancer Research, National Cancer Institute, 37 Convent Drive, MSC 4258, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.jhep.2009.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897756PMC
September 2009

Transcriptome analysis of liver cancer: ready for the clinic?

J Hepatol 2009 May 9;50(5):1062-4. Epub 2009 Mar 9.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20982, USA.

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http://dx.doi.org/10.1016/j.jhep.2009.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696489PMC
May 2009

Identification of potential driver genes in human liver carcinoma by genomewide screening.

Cancer Res 2009 May 14;69(9):4059-66. Epub 2009 Apr 14.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4262, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-09-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750086PMC
May 2009

Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.

Cancer Genet Cytogenet 2009 May;191(1):17-26

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, 37 Convent Drive MSC 4262, Building 37, Room 4128B, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016546080900043
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http://dx.doi.org/10.1016/j.cancergencyto.2008.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693875PMC
May 2009

Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.

Cancer Res 2009 Apr 10;69(7):2775-82. Epub 2009 Mar 10.

Laboratory of Experimental Carcinogenesis, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680077PMC
April 2009

Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes.

Histochem Cell Biol 2008 Nov 29;130(5):1005-14. Epub 2008 Jul 29.

First Department of Pathology and Experimental Cancer Research, Semmelweis University, Ullõi út 26, 1085, Budapest, Hungary.

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http://dx.doi.org/10.1007/s00418-008-0482-zDOI Listing
November 2008

E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer.

Gastroenterology 2008 Oct 17;135(4):1322-32. Epub 2008 Jul 17.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4262, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614075PMC
October 2008

Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer.

Hepatology 2008 Jun;47(6):2059-67

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://doi.wiley.com/10.1002/hep.22283
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http://dx.doi.org/10.1002/hep.22283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762280PMC
June 2008

Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis.

J Biol Chem 2008 May 18;283(21):14581-9. Epub 2008 Mar 18.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1074/jbc.M707733200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386934PMC
May 2008

Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro.

Am J Pathol 2008 May 1;172(5):1238-47. Epub 2008 Apr 1.

Department Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal S/N, 28040-Madrid, Spain.

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http://dx.doi.org/10.2353/ajpath.2008.070793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329833PMC
May 2008

DLC-1:a Rho GTPase-activating protein and tumour suppressor.

J Cell Mol Med 2007 Sep-Oct;11(5):1185-207

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2007.00098.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401278PMC
January 2008

Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.

Cancer Res 2007 Oct;67(20):9844-51

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4262, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1905DOI Listing
October 2007