Publications by authors named "Smita S Patel"

93Publications

Cryo-EM Structures Reveal Transcription Initiation Steps by Yeast Mitochondrial RNA Polymerase.

Mol Cell 2021 01 4;81(2):268-280.e5. Epub 2020 Dec 4.

Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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January 2021

Structure, mechanism, and regulation of mitochondrial DNA transcription initiation.

J Biol Chem 2020 Dec 30;295(52):18406-18425. Epub 2020 Oct 30.

Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA

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December 2020

The dynamic landscape of transcription initiation in yeast mitochondria.

Nat Commun 2020 08 27;11(1):4281. Epub 2020 Aug 27.

School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.

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August 2020

Phosphorylation of mitochondrial transcription factor B2 controls mitochondrial DNA binding and transcription.

Biochem Biophys Res Commun 2020 07 3;528(3):580-585. Epub 2020 Jun 3.

Hope College, Department of Chemistry, 35 E. 12th Street, Holland, MI, 49423, United States. Electronic address:

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July 2020

The C-terminal tails of the mitochondrial transcription factors Mtf1 and TFB2M are part of an autoinhibitory mechanism that regulates DNA binding.

J Biol Chem 2020 05 2;295(20):6823-6830. Epub 2020 Apr 2.

Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey 08854

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May 2020

Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles.

EMBO J 2020 03 9;39(6):e103367. Epub 2020 Feb 9.

Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.

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March 2020

The C-terminal tail of the yeast mitochondrial transcription factor Mtf1 coordinates template strand alignment, DNA scrunching and timely transition into elongation.

Nucleic Acids Res 2020 03;48(5):2604-2620

Department of Biochemistry and Molecular Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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March 2020

Time-resolved analysis of transcription through chromatin.

Methods 2019 04 29;159-160:90-95. Epub 2019 Jan 29.

Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Biology Faculty, Lomonosov Moscow State University, Moscow 119992, Russia. Electronic address:

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April 2019

RIG-I Uses an ATPase-Powered Translocation-Throttling Mechanism for Kinetic Proofreading of RNAs and Oligomerization.

Mol Cell 2018 10 27;72(2):355-368.e4. Epub 2018 Sep 27.

Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:

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October 2018

Helicase promotes replication re-initiation from an RNA transcript.

Nat Commun 2018 06 13;9(1):2306. Epub 2018 Jun 13.

Howard Hughes Medical Institute, Cornell University, Ithaca, NY, 14853, USA.

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June 2018

Correlating Transcription Initiation and Conformational Changes by a Single-Subunit RNA Polymerase with Near Base-Pair Resolution.

Mol Cell 2018 05;70(4):695-706.e5

Department of Physics and Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA; Departments of Biophysics and Biophysical Chemistry, Biophysics, and Biomedical Engineering, Johns Hopkins University, MD 21205, USA. Electronic address:

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May 2018

Transcriptional fidelities of human mitochondrial POLRMT, yeast mitochondrial Rpo41, and phage T7 single-subunit RNA polymerases.

J Biol Chem 2017 11 7;292(44):18145-18160. Epub 2017 Sep 7.

From the Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School and

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November 2017

Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation.

Nucleic Acids Res 2017 01 29;45(2):861-874. Epub 2016 Nov 29.

Department of Biochemistry and Molecular Biology, Rutgers, Robert Wood Johnson Medical school, Piscataway, NJ 08854, USA

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January 2017

Overcoming a nucleosomal barrier to replication.

Sci Adv 2016 Nov 11;2(11):e1601865. Epub 2016 Nov 11.

Fox Chase Cancer Center, Philadelphia, PA 19111, USA.; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.

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November 2016

DNA looping mediates nucleosome transfer.

Nat Commun 2016 11 3;7:13337. Epub 2016 Nov 3.

Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA.

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November 2016

The Yeast Mitochondrial RNA Polymerase and Transcription Factor Complex Catalyzes Efficient Priming of DNA Synthesis on Single-stranded DNA.

J Biol Chem 2016 08 16;291(32):16828-39. Epub 2016 Jun 16.

From the Department of Biochemistry and Molecular Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854,

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August 2016

Methods to study the coupling between replicative helicase and leading-strand DNA polymerase at the replication fork.

Methods 2016 10 9;108:65-78. Epub 2016 May 9.

Department of Biochemistry and Molecular Biology, Rutgers, Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway 08854, NJ, USA. Electronic address:

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October 2016

Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE.

Nucleic Acids Res 2016 05 16;44(9):4200-10. Epub 2016 Feb 16.

Rutgers University, Robert Wood Johnson Medical School, Department of Biochemistry and Molecular Biology, NJ 08854, USA

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May 2016