Slobodan M Todorovic

Slobodan M Todorovic

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Slobodan M Todorovic

Slobodan M Todorovic

Publications by authors named "Slobodan M Todorovic"

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The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development.

Mol Neurobiol 2020 Jan 6;57(1):208-216. Epub 2019 Sep 6.

Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Mail Stop 8130, 12801 E. 17th Avenue, Rm L18-4100, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1007/s12035-019-01770-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273833PMC
January 2020

Neonatal general anesthesia causes lasting alterations in excitatory and inhibitory synaptic transmission in the ventrobasal thalamus of adolescent female rats.

Neurobiol Dis 2019 07 28;127:472-481. Epub 2019 Feb 28.

Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, United States of America; Neuroscience Graduate Program, University of Colorado, Anschutz Medical Campus, Aurora, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588498PMC
July 2019

Neurosteroids in Pain Management: A New Perspective on an Old Player.

Front Pharmacol 2018 2;9:1127. Epub 2018 Oct 2.

Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States.

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https://www.frontiersin.org/article/10.3389/fphar.2018.01127
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http://dx.doi.org/10.3389/fphar.2018.01127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176051PMC
October 2018

Ca3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons.

Neuropharmacology 2018 06 23;135:343-354. Epub 2018 Mar 23.

Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, United States; Neuroscience Graduate Program, University of Colorado, Anschutz Medical Campus, Aurora, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975125PMC
June 2018

Is Diabetic Nerve Pain Caused by Dysregulated Ion Channels in Sensory Neurons?

Diabetes 2015 Dec;64(12):3987-9

Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA

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http://dx.doi.org/10.2337/dbi15-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860262PMC
December 2015

Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus.

Mol Neurobiol 2015 Oct 6;52(2):952-8. Epub 2015 Jun 6.

Department of Anesthesiology, University of Virginia School of Medicine, PO 800710, Charlottesville, VA, 22908-0710, USA.

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http://dx.doi.org/10.1007/s12035-015-9247-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558348PMC
October 2015

Silencing the α2 subunit of γ-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury.

Anesthesiology 2015 Sep;123(3):654-67

From the Departments of Anesthesiology (A.L.O., J.S., H.P.O., J.L.W., J.-Y.P., S.P., A.P., Y.L., M.M.J., S.M.T., V.J.-T.) and Neuroscience (S.M.T., V.J.-T.), University of Virginia Health System, Charlottesville, Virginia; Department of Physiology, University of Belgrade School of Pharmacy, Belgrade, Serbia (A.L.O.); Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (J.S.); Department of Anesthesiology and Pain Medicine, College of Medicine, Korea University, Seoul, Republic of Korea (J.-Y.P.); and Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea (Y.L.).

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http://dx.doi.org/10.1097/ALN.0000000000000767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568754PMC
September 2015

Redox and trace metal regulation of ion channels in the pain pathway.

Biochem J 2015 Sep;470(3):275-80

Department of Anesthesiology, Neuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A. Department of Neuroscience, Neuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A.

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http://dx.doi.org/10.1042/BJ20150522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613504PMC
September 2015

CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy.

PLoS One 2014 4;9(4):e91467. Epub 2014 Apr 4.

Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, United States of America; Department of Neuroscience, University of Virginia Health System, Charlottesville, Virginia, United States of America; Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091467PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976247PMC
June 2015

Redox regulation of neuronal voltage-gated calcium channels.

Antioxid Redox Signal 2014 Aug 25;21(6):880-91. Epub 2013 Oct 25.

1 Department of Anesthesiology, University of Virginia School of Medicine , Charlottesville, Virginia.

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http://dx.doi.org/10.1089/ars.2013.5610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116091PMC
August 2014

Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy.

Pflugers Arch 2014 Apr 31;466(4):701-6. Epub 2014 Jan 31.

Departments of Anesthesiology and Neuroscience, University of Virginia School of Medicine, Mail Box 800710, Charlottesville, VA, 22908-0710, USA,

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http://dx.doi.org/10.1007/s00424-014-1452-zDOI Listing
April 2014

Redox mechanism of S-nitrosothiol modulation of neuronal CaV3.2 T-type calcium channels.

Mol Neurobiol 2013 Oct 28;48(2):274-80. Epub 2013 Jun 28.

Department of Anesthesiology and Pain Medicine, College of Medicine, Busan Paik Hospital, Inje University, Busan, South Korea.

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http://dx.doi.org/10.1007/s12035-013-8493-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779485PMC
October 2013

Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling.

Pflugers Arch 2013 Jul 16;465(7):921-7. Epub 2013 Jan 16.

Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.

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http://dx.doi.org/10.1007/s00424-012-1211-yDOI Listing
July 2013

Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane.

Neuropharmacology 2012 Aug 2;63(2):266-73. Epub 2012 Apr 2.

Department of Anesthesiology, University of Virginia Health System, School of Medicine, Charlottesville, VA, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2012.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372673PMC
August 2012

Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons.

J Neurosci 2012 Jul;32(27):9374-82

Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.0068-12.2
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http://dx.doi.org/10.1523/JNEUROSCI.0068-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398424PMC
July 2012

T-type voltage-gated calcium channels as targets for the development of novel pain therapies.

Br J Pharmacol 2011 Jun;163(3):484-95

Department of Anesthesiology and Neuroscience, University of Virginia School of Medicine, Charlottesville, 22908-0710, USA.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01256.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101611PMC
June 2011

Are neuronal voltage-gated calcium channels valid cellular targets for general anesthetics?

Channels (Austin) 2010 Nov-Dec;4(6):518-22. Epub 2010 Nov 1.

Department of Anesthesiology, University of Virginia School of Medicine and Health System, Charlottesville, VA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021099PMC
http://dx.doi.org/10.4161/chan.4.6.12873DOI Listing
May 2011

Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway.

J Physiol 2011 Jan 8;589(Pt 1):135-48. Epub 2010 Nov 8.

Department of Anaesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1113/jphysiol.2010.196220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039265PMC
January 2011

Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols.

Neuropharmacology 2010 Jul-Aug;59(1-2):58-69. Epub 2010 Apr 2.

Department of Anesthesiology, University of Virginia Health System, School of Medicine, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2010.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879975PMC
October 2010

Isoflurane modulates neuronal excitability of the nucleus reticularis thalami in vitro.

Ann N Y Acad Sci 2010 Jun;1199:36-42

Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05172.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906252PMC
June 2010

Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway.

Mol Pharmacol 2010 Jan 21;77(1):87-94. Epub 2009 Oct 21.

Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1124/mol.109.059931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802428PMC
January 2010

A modeling study of T-type Ca2+ channel gating and modulation by L-cysteine in rat nociceptors.

Biophys J 2010 Jan;98(2):197-206

Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1016/j.bpj.2009.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808491PMC
January 2010

Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?

Psychoneuroendocrinology 2009 Dec;34 Suppl 1:S178-85

Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA, USA.

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http://dx.doi.org/10.1016/j.psyneuen.2009.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795041PMC
December 2009

Role of voltage-gated calcium channels in ascending pain pathways.

Brain Res Rev 2009 Apr 31;60(1):84-9. Epub 2008 Dec 31.

Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada T2N 4N1.

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http://dx.doi.org/10.1016/j.brainresrev.2008.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692704PMC
April 2009

Mechanisms and functional significance of inhibition of neuronal T-type calcium channels by isoflurane.

Mol Pharmacol 2009 Mar 26;75(3):542-54. Epub 2008 Nov 26.

Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908-0710, USA.

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http://dx.doi.org/10.1124/mol.108.051664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645928PMC
March 2009

Isoflurane-sensitive presynaptic R-type calcium channels contribute to inhibitory synaptic transmission in the rat thalamus.

J Neurosci 2009 Feb;29(5):1434-45

Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0710, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5574-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659547PMC
February 2009

Regulation of T-type calcium channels in the peripheral pain pathway.

Channels (Austin) 2007 Jul-Aug;1(4):238-45. Epub 2007 Oct 1.

Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.4161/chan.4953DOI Listing
October 2008

Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve.

J Neurophysiol 2008 Jun 16;99(6):3151-6. Epub 2008 Apr 16.

Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1152/jn.01031.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667888PMC
June 2008

Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid.

Ann N Y Acad Sci 2007 Dec;1122:83-94

Department of Anesthesiology, University of Virginia Health System, P.O. Box 800710, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1196/annals.1403.006DOI Listing
December 2007

Functional regulation of T-type calcium channels by s-nitrosothiols in the rat thalamus.

J Neurophysiol 2007 Apr 7;97(4):2712-21. Epub 2007 Feb 7.

Dept. of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908-0710, USA.

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http://jn.physiology.org/content/jn/97/4/2712.full.pdf
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http://jn.physiology.org/cgi/doi/10.1152/jn.00926.2006
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http://dx.doi.org/10.1152/jn.00926.2006DOI Listing
April 2007

The role of T-type calcium channels in peripheral and central pain processing.

CNS Neurol Disord Drug Targets 2006 Dec;5(6):639-53

Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA 22908-0710, USA.

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http://chemistry47.com/PDFs/Cognition/Schizophrenia%20and%20
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http://dx.doi.org/10.2174/187152706779025490DOI Listing
December 2006

Is there a role for T-type calcium channels in peripheral and central pain sensitization?

Mol Neurobiol 2006 Dec;34(3):243-8

Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA, USA.

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http://dx.doi.org/10.1385/MN:34:3:243DOI Listing
December 2006

Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats.

Pain 2006 Nov 19;125(1-2):53-64. Epub 2006 Jun 19.

Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.

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http://dx.doi.org/10.1016/j.pain.2006.04.024DOI Listing
November 2006

The role of peripheral T-type calcium channels in pain transmission.

Cell Calcium 2006 Aug 13;40(2):197-203. Epub 2006 Jun 13.

Department of Anesthesiology and Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1016/j.ceca.2006.04.024DOI Listing
August 2006

CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus.

J Physiol 2006 Jul 27;574(Pt 2):415-30. Epub 2006 Apr 27.

Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1113/jphysiol.2006.110395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1817755PMC
July 2006

The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors.

J Neurosci 2005 Sep;25(38):8766-75

Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2527-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725512PMC
September 2005

Different kinetic properties of two T-type Ca2+ currents of rat reticular thalamic neurones and their modulation by enflurane.

J Physiol 2005 Jul 21;566(Pt 1):125-42. Epub 2005 Apr 21.

Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1113/jphysiol.2005.086579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464735PMC
July 2005

Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels.

Br J Pharmacol 2005 Jan;144(1):59-70

Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908-0710, U.S.A.

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http://dx.doi.org/10.1038/sj.bjp.0706020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575974PMC
January 2005

Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia.

Pain 2004 Jun;109(3):328-39

Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1016/j.pain.2004.01.026DOI Listing
June 2004

Mechanical and thermal anti-nociception in rats after systemic administration of verapamil.

Neurosci Lett 2004 Apr;360(1-2):57-60

Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908-0710, USA.

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http://dx.doi.org/10.1016/j.neulet.2004.02.049DOI Listing
April 2004

Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats.

Br J Pharmacol 2003 Sep 4;140(2):255-60. Epub 2003 Aug 4.

Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908, U.S.A.

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http://dx.doi.org/10.1038/sj.bjp.0705434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574030PMC
September 2003

Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker.

Brain Res 2002 Oct;951(2):336-40

Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1016/s0006-8993(02)03350-4DOI Listing
October 2002