Publications by authors named "Slawomir Milewski"

65Publications

Anthra[1,2-][1,2,3]triazine-4,7,12(3)-triones as a New Class of Antistaphylococcal Agents: Synthesis and Biological Evaluation.

Molecules 2019 Dec 13;24(24). Epub 2019 Dec 13.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 80-233 Gdańsk, Poland.

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December 2019

Correction to "Emerging Anticancer Activity of Candidal Glucosamine-6-Phosphate Synthase Inhibitors upon Nanoparticle-Mediated Delivery".

Langmuir 2019 Nov 24;35(44):14397. Epub 2019 Oct 24.

Department of Pharmaceutical Technology and Biochemistry , Gdansk University of Technology , G. Narutowicza 11/12 , 80-233 Gdansk , Poland.

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November 2019

Voriconazole-Based Salts Are Active against Multidrug-Resistant Human Pathogenic Yeasts.

Molecules 2019 Oct 9;24(20). Epub 2019 Oct 9.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 G. Narutowicza Str., 80-233 Gdańsk, Poland.

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October 2019

Emerging Anticancer Activity of Candidal Glucoseamine-6-Phosphate Synthase Inhibitors upon Nanoparticle-Mediated Delivery.

Langmuir 2019 04 3;35(15):5281-5293. Epub 2019 Apr 3.

Department of Pharmaceutical Technology and Biochemistry , Gdansk University of Technology , G. Narutowicza 11/12 , 80-233 Gdansk , Poland.

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April 2019

Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties.

J Struct Biol 2019 03 8;205(3):26-33. Epub 2019 Feb 8.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland. Electronic address:

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March 2019

The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents.

Med Chem 2020 ;16(1):128-139

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 Narutowicza St., 80-233 Gdańsk, Poland.

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February 2020

Modification of quaternary structure of Candida albicans GlcN-6-P synthase and its desensitization to inhibition by UDP-GlcNAc by site-directed mutagenesis.

Biochim Biophys Acta Proteins Proteom 2018 11 18;1866(11):1181-1189. Epub 2018 Aug 18.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza Str., Gdańsk, Poland. Electronic address:

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November 2018

The Antimicrobial Potential of Bacteria Isolated from Honey Samples Produced in the Apiaries Located in Pomeranian Voivodeship in Northern Poland.

Int J Environ Res Public Health 2018 09 14;15(9). Epub 2018 Sep 14.

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, ul. G. Narutowicza 11/12, 80-233 Gdańsk, Poland.

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September 2018

Isolation of Bacteriocin-producing Staphylococcus spp. Strains from Human Skin Wounds, Soft Tissue Infections and Bovine Mastitis.

Pol J Microbiol 2018 Jun;67(2):163-169

Gdansk University of Technology, Department of Pharmaceutical Technology and Biochemistry,Gdansk,Poland.

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June 2018

Antifungal Activity and Synergism with Azoles of Polish Propolis.

Pathogens 2018 Jun 19;7(2). Epub 2018 Jun 19.

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12 Str., 80-233 Gdańsk, Poland.

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June 2018

Light-Induced Transformation of the Aromatic Heptaene Antifungal Antibiotic Candicidin D into Its All-Trans Isomer.

J Nat Prod 2018 07 14;81(7):1540-1545. Epub 2018 Jun 14.

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry , Gdańsk University of Technology , Gabriela Narutowicza Street 11/12 , 80-233 Gdańsk , Poland.

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July 2018

Investigation of the Antifungal Activity and Mode of Action of Thymus vulgaris, Citrus limonum, Pelargonium graveolens, Cinnamomum cassia, Ocimum basilicum, and Eugenia caryophyllus Essential Oils.

Molecules 2018 May 8;23(5). Epub 2018 May 8.

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12 Str., 80-233 Gdańsk, Poland.

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May 2018

Molecular Umbrellas Modulate the Selective Toxicity of Polyene Macrolide Antifungals.

Bioconjug Chem 2018 04 5;29(4):1454-1465. Epub 2018 Mar 5.

Department of Biomedical Chemistry , University of Gdańsk , 63 Wita Stwosza Str. , 80-308 Gdańsk , Poland.

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April 2018

Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase.

J Pept Sci 2018 Jan;24(1)

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza St, 80-233, Gdańsk, Poland.

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January 2018

Versatility of putative aromatic aminotransferases from Candida albicans.

Fungal Genet Biol 2018 01 2;110:26-37. Epub 2017 Dec 2.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza Str., 80-233 Gdańsk, Poland. Electronic address:

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January 2018

Transport Deficiency Is the Molecular Basis of Resistance to Antifungal Oligopeptides.

Front Microbiol 2017 7;8:2154. Epub 2017 Nov 7.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Gdańsk, Poland.

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November 2017

Synthesis and antimicrobial activity of 6-sulfo-6-deoxy-D-glucosamine and its derivatives.

Carbohydr Res 2017 Aug 12;448:79-87. Epub 2017 Jun 12.

Department of Organic Chemistry, Gdańsk University of Technology, Gdańsk, Poland.

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August 2017

Two Small RNAs Conserved in Enterobacteriaceae Provide Intrinsic Resistance to Antibiotics Targeting the Cell Wall Biosynthesis Enzyme Glucosamine-6-Phosphate Synthase.

Front Microbiol 2016 15;7:908. Epub 2016 Jun 15.

Department of Microbiology, Immunobiology and Genetics, Max F. Perutz Laboratories, University of Vienna, Vienna Biocenter Vienna, Austria.

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July 2016

Antimicrobial molecular nanocarrier-drug conjugates.

Nanomedicine 2016 11 23;12(8):2215-2240. Epub 2016 Jun 23.

Department of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland. Electronic address:

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November 2016

Characterization of recombinant homocitrate synthase from Candida albicans.

Protein Expr Purif 2016 09 9;125:7-18. Epub 2015 Sep 9.

Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 11/12 Narutowicza Str., 80-233 Gdansk, Poland.

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September 2016

Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives.

Front Microbiol 2015 5;6:783. Epub 2015 Aug 5.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology Gdańsk, Poland.

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October 2015

Mechanisms of azole resistance among clinical isolates of Candida glabrata in Poland.

J Med Microbiol 2015 Jun 27;64(6):610-619. Epub 2015 Mar 27.

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233 Gdansk, Poland.

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June 2015

Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates.

Indian J Microbiol 2015 Jun 9;55(2):175-83. Epub 2014 Dec 9.

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, ul. G. Narutowicza 11/12, 80-233 Gdansk, Poland.

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June 2015

Isolation of the GFA1 gene encoding glucosamine-6-phosphate synthase of Sporothrix schenckii and its expression in Saccharomyces cerevisiae.

Protein Expr Purif 2015 Jun 13;110:57-64. Epub 2014 Dec 13.

Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Apartado Postal 187, Guanajuato, Gto. 36000, Mexico. Electronic address:

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June 2015

Heterogeneity of quaternary structure of glucosamine-6-phosphate deaminase from Giardia lamblia.

Parasitol Res 2015 Jan 19;114(1):175-84. Epub 2014 Oct 19.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza Str., 80-233, Gdańsk, Poland.

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January 2015

Evaluation of possibilities in identification and susceptibility testing for Candida glabrata clinical isolates with the Integral System Yeast Plus (ISYP).

Acta Microbiol Immunol Hung 2014 Jun;61(2):161-72

Gdansk University of Technology Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry ul. G. Narutowicza 11/12 80-233 Gdansk Poland.

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June 2014

Novel Nystatin A₁ derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis.

Med Microbiol Immunol 2014 Oct 13;203(5):341-55. Epub 2014 Jun 13.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology (GUT), 11/12 Narutowicza Street, 80-233, Gdańsk, Poland.

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October 2014

Phenotypic consequences of LYS4 gene disruption in Candida albicans.

Yeast 2014 Aug 11;31(8):299-308. Epub 2014 Jul 11.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Poland.

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August 2014

Preparation and characterization of genipin cross-linked porous chitosan-collagen-gelatin scaffolds using chitosan-CO2 solution.

Carbohydr Polym 2014 Feb 2;102:901-11. Epub 2013 Nov 2.

Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gabriela Narutowicza Street 11/12, Gdansk 80-233, Poland.

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February 2014

Efficient production of Staphylococcus simulans lysostaphin in a benchtop bioreactor by recombinant Escherichia coli.

Prep Biochem Biotechnol 2014 ;44(4):370-81

a Department of Pharmaceutical Technology and Biochemistry , Gdansk University of Technology , Gdansk , Poland.

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August 2014

Antifungal activity of homoaconitate and homoisocitrate analogs.

Molecules 2012 Nov 27;17(12):14022-36. Epub 2012 Nov 27.

Department of Organic Chemistry, Gdańsk University of Technology, 11/12 Narutowicza Str., 80-233 Gdańsk, Poland.

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November 2012

Engineering Candida albicans glucosamine-6-phosphate synthase for efficient enzyme purification.

J Mol Recognit 2012 Nov;25(11):564-70

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Poland.

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November 2012

Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug.

FEMS Yeast Res 2013 Mar 17;13(2):143-55. Epub 2012 Dec 17.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Gdańsk, Poland.

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March 2013

Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus.

Appl Microbiol Biotechnol 2012 Dec 18;96(5):1157-74. Epub 2012 Oct 18.

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, ul. G. Narutowicza 11/12, 80-233, Gdańsk, Poland.

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December 2012

Biofilm production and presence of ica and bap genes in Staphylococcus aureus strains isolated from cows with mastitis in the eastern Poland.

Pol J Microbiol 2012 ;61(1):65-9

Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland.

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July 2012

Novel dendrimeric lipopeptides with antifungal activity.

Bioorg Med Chem Lett 2012 Feb 17;22(3):1388-93. Epub 2011 Dec 17.

Institute of Industrial Research, L. Rydygiera 8, 01-793 Warsaw, Poland.

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February 2012

Inactivation of glucosamine-6-phosphate synthase by N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid.

Chembiochem 2012 Jan 28;13(1):85-96. Epub 2011 Nov 28.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Gdańsk, Poland.

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January 2012

Antifungal action of the oxathiolone-fused chalcone derivative.

Mycoses 2011 Sep 18;54(5):e407-14. Epub 2010 Jul 18.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Gdańsk, Poland.

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September 2011

Chemical reactivity and antimicrobial activity of N-substituted maleimides.

J Enzyme Inhib Med Chem 2012 Feb 25;27(1):117-24. Epub 2011 May 25.

Department of Organic Chemistry, Gdansk University of Technology, Organic Chemistry, Gdansk, Poland.

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February 2012

Long range molecular dynamics study of regulation of eukaryotic glucosamine-6-phosphate synthase activity by UDP-GlcNAc.

J Mol Model 2011 Dec 2;17(12):3103-15. Epub 2011 Mar 2.

Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, ul. Narutowicza 11/12, 80-233 Gdańsk, Poland.

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December 2011

Disruption of homocitrate synthase genes in Candida albicans affects growth but not virulence.

Mycopathologia 2010 Dec 23;170(6):397-402. Epub 2010 Jun 23.

Department of Pharmaceutical Technology & Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza St., 80-233, Gdańsk, Poland.

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December 2010

Role for chitin and chitooligomers in the capsular architecture of Cryptococcus neoformans.

Eukaryot Cell 2009 Oct 17;8(10):1543-53. Epub 2009 Jul 17.

Universidade Federal do Rio de Janeiro, Instituto de Microbiologia, Avenida Carlos Chagas Filho, 373, Cidade Universitária CCS, Bloco I, Rio de Janeiro, RJ 21941-902, Brazil.

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October 2009

Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps.

Antimicrob Agents Chemother 2008 Nov 15;52(11):4057-63. Epub 2008 Sep 15.

Department of Pharmaceutical Technology & Biochemistry, Gdańsk University of Technology, Gdańsk, Poland.

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November 2008

Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents.

Bioorg Med Chem Lett 2007 Dec 25;17(23):6602-6. Epub 2007 Sep 25.

Department of Chemistry, University of Gdańsk, 18 Sobieskiego Street, 80-952 Gdańsk, Poland.

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December 2007

The crystal and solution studies of glucosamine-6-phosphate synthase from Candida albicans.

J Mol Biol 2007 Sep 12;372(3):672-88. Epub 2007 Jul 12.

Institute of Bioorganic Chemistry, Polish Academy of Sciences, ul. Noskowskiego 12/14, 61-704 Poznan, Poland.

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September 2007

Functional domains and interdomain communication in Candida albicans glucosamine-6-phosphate synthase.

Biochem J 2007 May;404(1):121-30

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza St., 80-952 Gdańsk, Poland.

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May 2007

Voriconazole and multidrug resistance in Candida albicans.

Mycoses 2007 Mar;50(2):109-15

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Gdańsk, Poland.

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March 2007

Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase.

Arch Biochem Biophys 2006 Jun 5;450(1):39-49. Epub 2006 Apr 5.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza St., 80-952 Gdańsk, Poland.

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June 2006

Crystallization and preliminary X-ray analysis of the isomerase domain of glucosamine-6-phosphate synthase from Candida albicans.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Nov 20;61(Pt 11):994-6. Epub 2005 Oct 20.

Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, ul. Narutowicza 11/12, 80-952 Gdansk, Poland.

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November 2005

Enzymes of UDP-GlcNAc biosynthesis in yeast.

Yeast 2006 Jan;23(1):1-14

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Gdańsk, Poland.

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January 2006

Construction, purification, and functional characterization of His-tagged Candida albicans glucosamine-6-phosphate synthase expressed in Escherichia coli.

Protein Expr Purif 2006 Apr 24;46(2):309-15. Epub 2005 Aug 24.

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza St., 80-952 Gdańsk, Poland.

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April 2006

Glucosamine-6-phosphate synthase, a novel target for antifungal agents. Molecular modelling studies in drug design.

Acta Biochim Pol 2005 4;52(3):647-53. Epub 2005 Aug 4.

Gdańsk University of Technology, Department of Pharmaceutical Technology and Biochemistry, Gdańsk, Poland.

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May 2006

N-Alkyl derivatives of 2-amino-2-deoxy-D-glucose.

Carbohydr Res 2005 Aug;340(11):1876-84

Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, PL-80-952 Gdańsk, Poland.

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August 2005

Phosphorylation of glucosamine-6-phosphate synthase is important but not essential for germination and mycelial growth of Candida albicans.

FEMS Microbiol Lett 2004 Jun;235(1):73-80

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 Narutowicza St., 80-952 Gdańsk, Poland.

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June 2004

Hydrophobic derivatives of 2-amino-2-deoxy-D-glucitol-6-phosphate: a new type of D-glucosamine-6-phosphate synthase inhibitors with antifungal action.

Bioorg Med Chem 2003 Apr;11(8):1653-62

Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 11/12Narutowicza St., 80-952 Gdańsk, Poland.

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April 2003

Structure-activity relationships for a series of peptidomimetic antimicrobial prodrugs containing glutamine analogues.

J Antimicrob Chemother 2003 Apr 13;51(4):821-31. Epub 2003 Mar 13.

School of Biological Sciences, University of Wales Bangor, Gwynedd LL57 2UW, UK.

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April 2003

Facilitated diffusion of glucosamine-6-phosphate synthase inhibitors enhances their antifungal activity.

Acta Biochim Pol 2002 ;49(1):77-86

Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Poland.

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January 2003

Glucosamine-6-phosphate synthase--the multi-facets enzyme.

Biochim Biophys Acta 2002 Jun;1597(2):173-92

Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, ul. Narutowicza 11/12, 80-952 Gdańsk, Poland.

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June 2002

A diffusible analogue of N(3)-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid with antifungal activity.

Microbiology (Reading) 2001 Jul;147(Pt 7):1955-1959

Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, 11/12 Narutowicza St, 80-952 Gdańsk, Poland1.

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July 2001