Publications by authors named "Siwei Sun"

21 Publications

  • Page 1 of 1

Prevalence and Risk Factors for Anxiety and Depression in Patients With COVID-19 in Wuhan, China.

Psychosom Med 2021 05;83(4):368-372

From the Surgery Intensive Care Unit (Li, Liu, Wang, Zhang, Gong, Duan) China-Japan Friendship Hospital; and Peking University Institute of Mental Health (Sun), National Clinical Research Center for Mental Disorders, Beijing, China.

Objective: Infectious diseases can cause psychological changes in patients. This study aimed to evaluate the prevalence and related risk factors for anxiety and depression in patients with COVID-19.

Methods: A cross-sectional study was performed on patients with COVID-19 admitted to the Sino-French New City branch of Wuhan Tongji Hospital from January to February 2020. The Zung Self-Rating Anxiety and Depression Scales were used to evaluate the prevalence of anxiety and depression. Demographic, clinical, and sociological data were also collected. Multivariable logistic regression analysis was used to identify independent risk factors of anxiety and depression in patients with COVID-19.

Results: In the current study, 183 patients were enrolled (mean age = 53 ± 9 years; 41.1% women). The prevalences of anxiety and depression were 56.3% and 39.3%, respectively. Logistic regression analysis revealed that older age, female sex, being divorced or widowed, COVID-19 disease duration, renal disease, and depression were identified as independent risk factors for anxiety in patients with COVID-19. Factors that were associated with depression were female sex, being widowed, COVID-19 disease duration, and anxiety.

Conclusions: This study demonstrates a high prevalence of anxiety and depression in patients with COVID-19 at the peak of the epidemic in Wuhan, China. The identification of demographic, clinical, and social factors may help identify health care professionals to provide psychological care as part of treatment for patients with COVID-19 and other life-threatening infectious diseases.
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http://dx.doi.org/10.1097/PSY.0000000000000934DOI Listing
May 2021

Effects of COVID-19 on career and specialty choices among Chinese medical students.

Med Educ Online 2021 Dec;26(1):1913785

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China.

Coronavirus disease 2019 (COVID-19) pandemic has brought unprecedented challenges to medical education systems and medical students. The aim of this study was to investigate the effects of COVID-19 pandemic on medical career and specialty choices among medical students. An online cross-sectional survey of Chinese medical students was conducted during the COVID-19 pandemic from February to April 2020. The students' willingness to be a doctor before and after the COVID-19 pandemic and changed willingness to specialize in respiratory medicine and infectious diseases were investigated. Multiple linear regression and binary logistic regression was used to explore factors that were associated with changes of willingness. A total of 1,837 medical students, including 1,227 females (66.8%), with a median age of 21.0 years, were recruited. Of the participants, 10.6% and 6.9% showed increased and decreased willingness to be a doctor after the COVID-19 outbreak, respectively. Moreover, 11.7% showed increased willingness and 9.5% showed decreased willingness to major in respiratory medicine and infectious diseases. Students with younger age, lower household income, fewer depressive symptoms, less exposure to negative pandemic information and more satisfaction with their own major after the pandemic were associated with increased willingness to be a doctor. Students who engaged in regular exercise, were males and undergraduate level, were interested in medicine, paid more attention to positive information, were satisfied with their majors, and had increased willingness to be a doctor after the pandemic were more likely to choose to specialize in respiratory medicine and infectious disease. However, the severity of anxiety symptoms was associated with decreased willingness to work in the specialties of respiratory medicine and infectious diseases. Psychological problems and professional satisfaction appear to be independent factors that affect medial career and specialty choices. The impacts of the COVID-19 pandemic on medical students require further research.
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http://dx.doi.org/10.1080/10872981.2021.1913785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057072PMC
December 2021

Association of Symptoms of Attention Deficit and Hyperactivity with Problematic Internet Use among University Students in Wuhan, China During the COVID-19 Pandemic.

J Affect Disord 2021 05 5;286:220-227. Epub 2021 Mar 5.

National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China. Electronic address:

Background: COVID-19 is still spreading worldwide and posing a threat to individuals' physical and mental health including problematic internet use (PIU). A potentially high-risk group for PIU are those with symptoms of attention deficit and hyperactivity (ADHD symptoms), because of restrictions in their physical activity levels and engagement in computer diversions requiring only short attention spans.

Methods: We used convenience sampling in a cross-sectional survey of university students from 30 universities in Wuhan, Hubei Province, China. We assessed PIU using the Internet Addiction Test and ADHD symptoms using the WHO Adult ADHD Self-Report Screening Scale. Using logistic regression and linear regression analyses we adjusted for demographic, epidemic-related and psychological covariates in models of the association between ADHD symptoms and PIU.

Results: Among 11,254 participants, we found a 28.4% (95% CI, 27.5%-29.2%) prevalence of PIU, relatively higher than before the pandemic. In our final logistic regression model, participants with ADHD symptoms had approximately two times the risk for PIU (OR: 2.31, 95% CI: 1.89-2.83). Similarly, individuals with depression, anxiety, insomnia, PTSD symptoms and feeling stress during the pandemic had a higher risk of PIU, while those exercising regularly during the pandemic had a lower risk.

Limitations: The cross-sectional design and reliance on internet based self-reports for ADHD symptoms and PIU assessments, without direct structured interviews for validation, are limitations.

Conclusions: The prevalence of PIU was high during COVID-19, and those people with ADHD symptoms and other mental illness symptoms appear to be at higher risk of PIU. Regular exercise may reduce that PIU risk and hence should be recommended during the COVID-19 pandemic.
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http://dx.doi.org/10.1016/j.jad.2021.02.078DOI Listing
May 2021

Multi-Yolk-Shell [email protected] Nanopomegranates with Internal Buffer Space as a Lithium Ion Battery Anode.

Langmuir 2021 Feb 3;37(6):2195-2204. Epub 2021 Feb 3.

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, P. R. China.

Multi-yolk-shell [email protected] carbon ([email protected]) nanopomegranates, featuring MnO nanoparticles within cavities of m-carbon with internal space between the MnO nanoparticle and a cavity carbon shell, were subtly constructed. Moreover, the buffer space was well controlled by means of regulating the size of the cavity in m-carbon or the content of MnO. The results of electrochemical measurements demonstrated that MnO(10)@m-carbon(22) nanopomegranates (MnO nanoparticle, 15 nm; cavity size, 22 nm) had the best cycling and rate performance for lithium ion storage. The pomegranate-like [email protected] nanostructures have shown several advantages for their excellent performance: the nanocavity in m-carbon can restrict the growth and agglomeration of MnO nanoparticles; the well-interconnected mesoporous carbon matrix provides a "highway" for electrons and lithium ion transport; the voids between the MnO nanoparticle and cavity shell can alleviate the volume expansion.
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http://dx.doi.org/10.1021/acs.langmuir.0c03523DOI Listing
February 2021

Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression.

J Med Chem 2020 11 13;63(22):13994-14016. Epub 2020 Nov 13.

Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

We report herein the discovery of a class of potent small-molecule inhibitors of anaplastic lymphoma kinase (ALK) containing a fused indoloquinoline scaffold. The most promising compound CJ-2360 has an IC value of 2.2 nM against wild-type ALK and low-nanomolar potency against several clinically reported ALK mutants. This compound is capable of achieving complete tumor regression in the ALK-positive KARPAS-299 xenograft model with oral administration in mice. CJ-2360 represents a promising ALK inhibitor for advanced preclinical development.
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http://dx.doi.org/10.1021/acs.jmedchem.0c01550DOI Listing
November 2020

A novel eco-friendly imidazole ionic liquids based amphoteric polymers for high performance fatliquoring in chromium-free tanned leather production.

J Hazard Mater 2020 Nov 28;399:123048. Epub 2020 May 28.

College of Chemistry and Chemical Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi, 710021, PR China.

The potential environmental pollution of chrome tanned leather results in the development of ecological chromium-free leather tanning production in leather industry. However, with weakly positive charge, chromium-free tanned leather cannot strongly bind to anionic dyes, thus causing low quality of finished leather. Herein, p(DM-co-[DDVIM]Br)PS was synthesized by free radical polymerization method. The structure and properties of the targeted products were synthetically characterized. The results indicated that the use of p(DM-co-[DDVIM]Br)PS fatliquoring agent can not only make leather fibers become loose, but also improve the binding affinity between leather and anionic dye during the fatliquoring process. The fatliquoring agent adsorption rates and the dye absorption rate of the leather were as high as 99.26% and 99.01%, respectively; the fatliquoring and dye solutions were clear, so they can be used as clean materials in the fatliquoring process of chromium-free tanned leather. Leather treated with p(DM-co-[DDVIM]Br)PS fatliquoring agent had higher K/S value (12.80) and is softer than those treated with commercial fatliquoring agent. Consequently, this study can not only help improve the absorption rate of anionic wet finishing materials, but also reduce the pollution caused by chrome tanning agents, thus providing a new way for the cleaner production in leather industry.
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http://dx.doi.org/10.1016/j.jhazmat.2020.123048DOI Listing
November 2020

Structural and physicochemical properties of lotus seed starch nanoparticles prepared using ultrasonic-assisted enzymatic hydrolysis.

Ultrason Sonochem 2020 Nov 1;68:105199. Epub 2020 Jun 1.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, PR China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fuzhou, Fujian, PR China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, PR China. Electronic address:

Lotus seed starch nanoparticles were prepared by ultrasonic (ultrasonic power: 200 W, 600 W, 1000 W; time: 5 min, 15 min, 25 min; liquid ratio (starch: buffer solution): 1%, 3%, 5%) assisted enzymatic hydrolysis (LS-SNPs represent lotus seed starch nanoparticles prepared by enzymatic hydrolysis and U-LS-SNPs represent lotus seed starch nanoparticles prepared by high pressure homogenization-assisted enzymatic hydrolysis). The structure and physicochemical properties of U-LS-SNPs were studied by laser particle size analysis, scanning electron microscope, X-ray diffraction, Raman spectroscopy, nuclear magnetic resonance and gel permeation chromatography system. The results of scanning electron microscopy showed that the surface of U-LS-SNPs was cracked and uneven after ultrasonic-assisted enzymolysis, and there was no significant difference from LS-SNPs. The results of particle size analysis and gel permeation chromatography showed that the particle size of U-LS-SNPs (except 5% treatment group) was smaller than that of LS-SNPs. With the increase of ultrasonic power and time, the weight average molecular gradually decreased. The results of X-ray diffraction and Raman spectroscopy showed that ultrasonic waves first acted on the amorphous region of starch granules. With the increase of ultrasonic power and time, the relative crystallinity of U-LS-SNPs increased first and then decreased. The group (600 W, 15 min, 3%) had the highest relative crystallinity. The results of nuclear magnetic resonance studies showed that the hydrogen bond and double helix structure of starch were destroyed by ultrasound, and the double helix structure strength of U-LS-SNPs was weakened compared with LS-SNPs. In summary, U-LS-SNPs with the small-sized and the highest crystallinity can be prepared under the conditions of ultrasonic power of 600 W, time of 15 min and material-liquid ratio of 3%.
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http://dx.doi.org/10.1016/j.ultsonch.2020.105199DOI Listing
November 2020

Structural and physicochemical properties of lotus seed starch nanoparticles.

Int J Biol Macromol 2020 Aug 25;157:240-246. Epub 2020 Apr 25.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, PR China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fuzhou, Fujian, PR China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, PR China. Electronic address:

Lotus seed starch (LS) was enzymatically hydrolyzed by pullulanase, β-amylase and α-amylase to obtain three types of starch nanoparticles (SNPs): P-SNPs, β-SNPs and α-SNPs, respectively. The structure and physicochemical properties of lotus seed starch nanoparticles (LS-SNPs) were systematically studied by Laser particle size analysis, Scanning electron microscope (SEM), X-ray diffraction (XRD), Raman spectrometry, Nuclear magnetic resonance (NMR) and Gel permeation chromatography (GPC). The results showed that compared to LS (10,466.7 ± 230.9 nm), the D [3,2] of P-SNPs were (334.7 ± 16.2), which indicated that LS was decomposed into LS-SNPs with low degree of polymerization. P-SNPs showed the highest efficiency, with 81.74% of samples reaching the nanoscale. The particle size order was LS > β-SNPs (α-SNPs) > P-SNPs. XRD results showed P-SNPs had the highest crystallinity 65.07%. During preparation of LS-SNPs, crystal region was destroyed, and double helix structure became stronger, but no new functional groups were introduced. P-SNPs had the smallest amorphous area and also showed a minimal molecular weight and the broadest molecular weight distribution. P-SNPs had the smallest particle size and the highest crystallinity, so P-SNPs were the best of all LS-SNPs.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.04.155DOI Listing
August 2020

Protective role of dryland rearing on netting floors against mortality through gut microbiota-associated immune performance in Shaoxing ducks.

Poult Sci 2019 Oct;98(10):4530-4538

College of Animal Science, Wenzhou Vocational College of Science & Technology, Wenzhou 325006, China.

Dryland rearing on netting floors (DRNF) is a new rearing method for ducks, which could prevent duck excreta from polluting water bodies. However, the influence of DRNF on duck production and immune performance remains poorly understood. In this study, 2,280 Shaoxing ducks, an egg-type breed of Sheldrake in China, were chosen and randomly divided into 2 groups to investigate the effects of DRNF on duck farming. During the experimental laying rates, feed-egg ratios, and mortality rates of the 2 groups were calculated and recorded. Serum immune parameters, including thymus index, spleen index, levels of immunoglobulin G (IgG), interleukin 1β (IL-1β), and tumor necrosis factor α (TNF-α), were determined. Sequencing of the 16S rRNA gene was used to analyze the variability of gut microbiota in the duck ileum and cecum. The results showed that DRNF significantly reduced the mortality rate of the ducks and increased the thymus index (P < 0.05), compared to the control. No other significant differences were detected in productional and immune indices (P > 0.05). The 16S rRNA sequencing results revealed differentially enriched microbial compositions in the ileum and cecum, which might be responsible for the improved immune function of Shaoxing ducks. For example, an increase in Lactobacillaceae (family), Anaerotruncus (genus), Saccharibacteria (phylum), Flavobacteriaceae (family), and a reduction in Anaerobiospirillum (genus), Lachnospiraceae (family), Blautia (genus) was revealed in the DRNF ducks. In conclusion, DRNF could alter gut microflora, enhance duck immune system, and reduce mortality in Shaoxing ducks.
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http://dx.doi.org/10.3382/ps/pez268DOI Listing
October 2019

Insight into the formation, structure and digestibility of lotus seed amylose-fatty acid complexes prepared by high hydrostatic pressure.

Food Chem Toxicol 2019 Jun 2;128:81-88. Epub 2019 Apr 2.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, PR China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fuzhou, Fujian, PR China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, PR China. Electronic address:

Lotus seed amylose-fatty acid complexes were prepared using high hydrostatic pressure and the relationship between their structural properties and digestibility was investigated. The formation of lotus seed amylose-fatty acid complexes increased the values of weight molar mass (Mw), number molar mass (Mn), polydispersity index and resistant starch content compared to those of amylose controls. Mw and Mn values of lotus seed amylose and complexes decreased with an increase in high hydrostatic pressure from 500 MPa to 600 MPa, suggesting that the lotus seed amylose was decomposed into short glucan chains. The presence of single helical lotus seed amylose-fatty acid complexes and double helical retrograded amylose was investigated using Raman spectroscopy and imaging. The results from Raman spectra and in vitro digestion showed that the content of both single helical LSA-fatty acid complexes and double helical retrograded LSA were responsible for digestibility of the complex matrix.
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http://dx.doi.org/10.1016/j.fct.2019.03.052DOI Listing
June 2019

Physicochemical properties and digestion of the lotus seed starch-green tea polyphenol complex under ultrasound-microwave synergistic interaction.

Ultrason Sonochem 2019 Apr 2;52:50-61. Epub 2018 Nov 2.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address:

Complex starch is gaining research attention due to its unique physicochemical and functional properties. Lotus seed starch (LS) suspensions (6.7%, w/v) with added green tea polyphenols (GTPs) (10%, w/w) were subjected to ultrasound (200-1000 W)-microwave (150-225 W) (UM) treatment for 15 min. The effects of UM treatment on the physicochemical properties of the LS-GTP system were investigated and exceeded that of microwave or ultrasound alone. The properties (morphology, X-ray diffraction pattern and so on) were affected by GTPs to various extents, depending on ultrasonic power. These influences may be explained by the non-covalent interactions between GTPs and LS. V-type LS-GTP inclusion complex and non-inclusive complex formation were observed. Their morphology and the distribution of GTPs molecules within them were estimated using scanning electron microscopy and confocal laser scanning microscopy. Furthermore, the digestion of LS-GTP complex was investigated by a dynamic in vitro rat stomach-duodenum (DIVRSD) model, lower digestion efficiency of LS has been achieved and the residues showed gradual improvement in morphology. These all experimental results do provide new insight into the complex starch production.
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http://dx.doi.org/10.1016/j.ultsonch.2018.11.001DOI Listing
April 2019

Understanding the crystal structure of lotus seed amylose-long-chain fatty acid complexes prepared by high hydrostatic pressure.

Food Res Int 2018 09 22;111:334-341. Epub 2018 May 22.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, PR China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fuzhou, Fujian, PR China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, PR China. Electronic address:

This paper presents an innovative approach using high hydrostatic pressure to prepare lotus seed amylose-long-chain fatty acid (stearic acid, oleic acid, and linoleic acid) complexes. The aim of this work was to investigate the spherocrystal structure and distribution of fatty acid within complexes. Wide-angle X-ray diffraction diffractograms indicated the presence of typical V-type polymorphs and B-type non-complexed amylose. The V-type complexes were further confirmed as V polymorph from nuclear magnetic resonance. The degree of crystallinity and the complex index value decreased as the preparation pressure of the complexes increased, and the amylose-oleic acid complexes exhibited the highest relative crystallinity and complex index value in all of the conditions. Small-angle X-ray scattering indicated a larger proportion of crystalline and more compact structure within complexes than that of lotus seed amylose. The morphology of complexes with the spherulite form was determined from scanning electron microscopy images, and the distribution of fatty acid molecules within the spherulites of complexes was estimated using nuclear magnetic resonance, confocal laser scanning microscopy, and small-angle X-ray scattering. The results demonstrated that the fatty acids were within and between the amylose helix, and they were also trapped inside the amorphous lamellae of the complexes. This work provides an in-depth study of the spherocrystal structure within lotus seed amylose-long-chain fatty acid complexes and proposes a new model for spherulites.
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http://dx.doi.org/10.1016/j.foodres.2018.05.053DOI Listing
September 2018

MicroRNA profiling and bioinformatics analyses reveal the potential roles of microRNAs in chordoma.

Oncol Lett 2017 Nov 28;14(5):5533-5539. Epub 2017 Aug 28.

Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Chordoma is a rare aggressive bone tumor arising from remnants of the notochord, and patients with chordoma have a poor prognosis. However, the unique expression profiles of microRNAs (miRNAs/miRs) and their downstream signaling pathways in chordoma remain incompletely characterized. The aim of the present study was to delineate the global miRNA expression profile and associated signaling networks in chordoma. miRNA profiling was performed on chordoma and fetal notochord tissues. Differentially expressed miRNAs in chordoma were analyzed using microarrays with hierarchical clustering analysis. The target genes of the differentially expressed miRNAs were predicted, and Gene Ontology (GO) and pathway analyses were performed for the intersecting genes. A total of 42 miRNAs were significantly dysregulated in chordoma compared with that in fetal nucleus pulposus tissues. The expression of hsa-miR-21-3p, hsa-miR-150-5p, hsa-miR-1290 and hsa-miR-623 were validated using the reverse transcription-quantitative polymerase chain reaction. On the basis of the intersection predicted by three databases (Targetscan, microRNA.org and PITA), 10,292 potential miRNA targets were identified. Bioinformatic analyses suggested that these dysregulated miRNAs and their predicted targets were functions of signaling pathways in cancer, the mitogen-activated protein kinase signaling pathway, regulation of actin cytoskeleton, focal adhesion and endocytosis. In particular, human (hsa-)miR-185-5p was identified as a crucial miRNA in chordoma development via the Wnt signaling pathway. The results of the present study provide a comprehensive expression and functional profile of differentially expressed miRNAs associated with chordoma. This profile may serve as a potential tool for biomarker and therapeutic target identification in patients with chordoma.
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http://dx.doi.org/10.3892/ol.2017.6839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654481PMC
November 2017

Prognostic value of microRNA-9 in cancers: a systematic review and meta-analysis.

Oncotarget 2016 Oct;7(41):67020-67032

Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, P.R. China.

Recent studies revealed that different microRNA-9 (miR-9) expressions were associated with prognoses of different cancers. We conducted this meta-analysis to evaluate the prognostic value of miR-9. PubMed, Embase, Web of Science, and Cochrane Library (last update by November 30, 2015) were searched for literatures. A total of 17 studies from 16 articles were finally qualified and enrolled in this meta-analysis. Pooled analyses showed that a higher expression of miR-9 might predict poor overall survival (HR: 2.17, 95% CI: 1.39 - 3.41, P < 0.001 (7.23 * 10-4)), disease-free survival (HR: 5.22, 95% CI: 2.17 - 12.53, P < 0.001 (2.21 * 10-4)), and recurrence-free survival (HR: 1.57, 95% CI: 1.32 - 1.85, P < 0.001 (1.80*10-7)) in various carcinomas. However, results of subgroup analyses revealed that down-regulated miR-9 was associated with poor overall survival (HR: 0.45, 95% CI: 0.28 - 0.73, P < 0.001 (1.13*10-3)) and progress-free survival (HR: 0.46, 95% CI: 0.34 - 0.62, P < 0.001 (5.03*10-7)) in ovarian cancer patients. By subgroup analyses we also found that sample collecting time and patients' origin had little influence on the result of OS. These results indicate that in most cancer types the highly expressed miR-9 is associated with poor survival of patients, whereas the down-regulated miR-9 may predict poor prognosis in patients with ovarian cancer.
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http://dx.doi.org/10.18632/oncotarget.11466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341854PMC
October 2016

Analysis of miRNAs and their target genes associated with lipid metabolism in duck liver.

Sci Rep 2016 06 8;6:27418. Epub 2016 Jun 8.

Department of Animal Science, Wenzhou Vocational College of Science &Technology, Wenzhou 325006, P.R. China.

Fat character is an important index in duck culture that linked to local flavor, feed cost and fat intake for costumers. Since the regulation networks in duck lipid metabolism had not been reported very clearly, we aimed to explore the potential miRNA-mRNA pairs and their regulatory roles in duck lipid metabolism. Here, Cherry-Valley ducks were selected and treated with/without 5% oil added in feed for 2 weeks, and then fat content determination was performed on. The data showed that the fat contents and the fatty acid ratios of C17:1 and C18:2 were up-regulated in livers of oil-added ducks, while the C12:0 ratio was down-regulated. Then 21 differential miRNAs, including 10 novel miRNAs, were obtain from the livers by sequencing, and 73 target genes involved in lipid metabolic processes of these miRNAs were found, which constituted 316 miRNA-mRNA pairs. Two miRNA-mRNA pairs including one novel miRNA and one known miRNA, N-miR-16020-FASN and gga-miR-144-ELOVL6, were selected to validate the miRNA-mRNA negative relation. And the results showed that N-mir-16020 and gga-miR-144 could respectively bind the 3'-UTRs of FASN and ELOVL6 to control their expressions. This study provides new sights and useful information for future research on regulation network in duck lipid metabolism.
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http://dx.doi.org/10.1038/srep27418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897641PMC
June 2016

Does Subacromial Osteolysis Affect Shoulder Function after Clavicle Hook Plating?

Biomed Res Int 2016 29;2016:4085305. Epub 2016 Feb 29.

Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, Jiangsu 215006, China.

Purpose: To evaluate whether subacromial osteolysis, one of the major complications of the clavicle hook plate procedure, affects shoulder function.

Methods: We had performed a retrospective study of 72 patients diagnosed with a Neer II lateral clavicle fracture or Degree-III acromioclavicular joint dislocation in our hospital from July 2012 to December 2013. All these patients had undergone surgery with clavicle hook plate and were divided into two groups based on the occurrence of subacromial osteolysis. By using the Constant-Murley at the first follow-up visit after plates removal, we evaluated patients' shoulder function to judge if it has been affected by subacromial osteolysis.

Results: We have analyzed clinical data for these 72 patients, which shows that there is no significant difference between group A (39 patients) and group B (33 patients) in age, gender, injury types or side, and shoulder function (the Constant-Murley scores are 93.38 ± 3.56 versus 94.24 ± 3.60, P > 0.05).

Conclusion: The occurrence of subacromial osteolysis is not rare, and also it does not significantly affect shoulder function.
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http://dx.doi.org/10.1155/2016/4085305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789368PMC
December 2016

Characterization of Flocs and Floc Size Distributions Using Image Analysis.

Environ Eng Sci 2016 Jan;33(1):25-34

School of Civil and Environmental Engineering, Cornell University , Ithaca, New York.

A nonintrusive digital imaging process was developed to study particle size distributions created through flocculation and sedimentation. Quantification of particle size distributions under different operating conditions can be of use in the understanding of aggregation mechanisms. This process was calibrated by measuring standardized polystyrene particles of known size and was utilized to count and measure individual kaolin clay particles as well as aggregates formed by coagulation with polyaluminum chloride and flocculation. Identification of out-of-focus flocs was automated with LabVIEW and used to remove them from the database that was analyzed. The particle diameter of the test suspension of kaolinite clay was measured to be 7.7 ± 3.8 μm and a linear relationship was obtained between turbidity and the concentration of clay particles determined by imaging. The analysis technique was applied to characterize flocs and floc particle size distribution as a function of coagulant dose. Removal of flocs by sedimentation was characterized by imaging, and the negative logarithm of the fraction of turbidity remaining after settling had a linear relationship with the logarithm of aluminum dose. The maximum floc size observed in the settled water was less than 120 μm, which was in accordance with the value predicted by a model for the capture velocity of the experimental tube settler of 0.21 mm/s.
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http://dx.doi.org/10.1089/ees.2015.0311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752185PMC
January 2016

[The status of diabetes prevention awareness among Chinese residents in six provinces].

Zhonghua Yu Fang Yi Xue Za Zhi 2014 Jul;48(7):576-80

Chinese Center for Health Education, Beijing 100011, China.

Objective: To explore the status of diabetes prevention awareness among Chinese residents in order to provide the scientific basis for making intervention strategy.

Methods: A sample of 18-60 years old residents in six provinces was investigated from March to April in 2013.

Results: Totally, 17.8% of respondents answered all questions correctly about the awareness of diabetes. As for "Diabetes is a common chronic disease" got highest recognition rate (86.2%), and "Diabetes can be cured" got the lowest rate, 48.3%. 50.6% of respondents answered all questions correctly about the diabetes symptoms; and "thirsty, drink more water" got the highest recognition rate (75.3%). 17.8% of respondents answered all questions correctly about the complications of diabetes; and "causes of diabetes ketoacidosis" got the lowest rate of 31.6%. 12.3% of respondents answered all questions correctly about the diabetes high-risk group; the correct recognition rate for "family history" was the highest (75.1%); and the "macrosomia" got the lowest rate of 20.4%. 74.2% of respondents answered all questions correctly about the diabetes preventive measure;the correct cognition rate of a reasonable diet was the highest (92.0%), and the weight control was the lowest (81.5%). In addition, there are significant differences of knowledge score between different areas and genders. City residents' knowledge score about diabetes related views (6.2 ± 1.8), typical symptoms (2.9 ± 1.4), complication (4.1 ± 2.3), high-risk groups (3.4 ± 1.7), prevention measures (3.7 ± 0.9) were higher than rural residents (respectively 5.2 ± 2.2, 2.7 ± 1.5, 3.2 ± 2.3, 2.9 ± 1.8, 3.3 ± 1.2) (P < 0.05). Female residents' knowledge score about diabetes related views (5.7 ± 2), typical symptoms (2.9 ± 1.4), complication (3.8 ± 2.3), high-risk groups (3.1 ± 1.8), prevention measures (3.5 ± 1) were higher than male residents (respectively 5.5 ± 2.1, 2.7 ± 1.5, 3.5 ± 2.4, 3.1 ± 1.8, 3.4 ± 1.2, 18.1 ± 6.8) (P < 0.05).

Conclusion: The public is lack of diabetes prevention awareness, and city residents' knowledge score is higher than rural residents', females are higher than males.
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July 2014

[The study of diabetes-related behavior status and affecting factors among urban and suburban residents in six provinces in China].

Zhonghua Yu Fang Yi Xue Za Zhi 2014 Jul;48(7):571-5

Chinese Center for Health Education, Beijing 100011, China.

Objective: To explore the status of diabetes-related behaviors and affecting factors among urban and suburban residents in China.

Methods: A sample of 18-60 years old residents from Zhejiang, Jiangsu, Shanxi, Henan, Yunnan and Qinghai provinces was investigated by using stratified cluster random sampling method from March to May in 2013, and 4 282 residents were recruited. The Questionnaire of Health Literacy of Diabetes Mellitus of the Public in China was used to conduct the survey. χ(2) test was used to compare the different risk behavior characteristics of diabetes. The results of the survey were standardized by the 6th national census data. Multiple regression analysis was used to understand the affecting factors to related behaviors.

Results: After data standardization, 14.3% sat more than 6 hours every day, 57.6% exercised less than 3 times every week, 21.3% had no regularly daily diet, 58.7% paid no attention to diet control, 15.7% and 7.8% residents preferred salty and oily diet, 51.4% had physical examination less than 1 time every year, 29.7% were smokers, and 9.2% often drank. Urban residents spent much more time on sitting (18.2%) than rural residents (8.4%) (P < 0.05), and the rates of lack of physical exercise(52.7%), irregular diet (17.2%), paying no attention to diet control (51.9%), smokers (23.6%) among urban residents were lower than rural residents (60.1%, 21.4%, 62.5% and 32.1% respectively) (P < 0.05). The rates of irregular diet (24.6%), paying no attention to diet control (63.5%), high-salt and high-fat diet (30.1%), smokers (57.7%), drinking (18.7%) among men were higher than those in females (15.5%, 52.1%, 23.2%, 2.2%, and 0.8% respectively) (P < 0.05); regions, genders, educational levels, occupations were related to relative behaviors of diabetes, residents in rural areas (t = 7.829, P < 0.01), males (t = -21.760, P < 0.01), lower education level (t = 0.771, P < 0.01), as well as institution personnel (t = -4.240, P < 0.01) had lower behavior scores, which meant they had more risk behaviors related to diabetes.

Conclusion: There were diabetes-related risk behaviors among both urban and suburban residents in China, such as insufficient physical exercise, no diet control and regular medical examinations. These risk behaviors happened more in rural areas than in urban areas, men than women, older age group than lower age group.
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July 2014

[A study on risk factors and perceptions of diabetes among urban and suburban residents from six provinces in China].

Zhonghua Yu Fang Yi Xue Za Zhi 2014 Jul;48(7):555-60

Division of Monitoring and Evaluation, Chinese Center for Health Education (Health News Communication Center, Ministry of Health), Beijing 100011, China.

Objective: To study the epidemiological status of diabetes' risk factors among urban and suburban residents and their perceptions of their own health status and risk of diabetes.

Methods: Stratified multi-stage sampling method was used to conduct the survey among 18-60 years old residents from Zhejiang, Jiangsu, Shanxi, Henan, Yunnan, and Qinghai provinces in China from March to May in 2013. The Questionnaire of Health Literacy of Diabetes Mellitus of the Public in China was used to conduct the survey, and then the data were analyzed. The main contents of the questionnaire included diabetes mellitus knowledge, diabetes mellitus risk factors and diabetes mellitus risk self-assessment. The results of the survey were standardized by the 6(th) national census data.

Results: A total of 4 416 respondents were surveyed, and 4 282 valid questionnaires were successfully collected during the survey and the response rate was 97.0%. After weighted adjustment, the overweight and obesity rate of the residents in 6 provinces was 35.3%, abdominal obesity rate was 54.7%. 77.8% of the residents without diabetes had more than one risk factor, but only 8.5% thought they might got diabetes. The residents with high risk behavior possessing rates of diabetes were in eastern areas (79.7%), urban areas (80.7%), men (84.1%), aged from 45 to 60(100.0%), below primary school education level (83.4%) and enterprise personnel (79.7%). The residents with high risk consciousness of getting diabetes were in eastern areas (11.0%), urban areas (9.7%), men (9.7%), aged from 45 to 60 (12.3%), over college education level (12.7%) and the offices (14.7%). The results of logistic regression showed that residents in the middle areas (OR = 2.148, 95% CI: 1.633-2.920), urban residents (OR = 2.100, 95% CI: 1.611-2.738), male (OR = 2.488, 95% CI: 1.962-3.154), the older (OR = 1.102, 95% CI: 1.090-1.115) had a higher risk behavior rate of diabetes mellitus. Urban residents (OR = 2.784, 95% CI: 1.497-5.175), male (OR = 1.522, 95% CI: 1.152-2.011), the older (OR = 1.022, 95% CI: 1.009-1.035), college educational level (OR = 1.685, 95% CI: 1.033-2.749), with a higher score of health awareness(OR = 1.090, 95% CI: 1.061-1.120)had a higher risk consciousness to being diabetes mellitus.

Conclusion: The urban and suburban residents in China had a high risk behavior possessing rates of diabetes, and a low risk consciousness of being diabetes.
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July 2014

Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine.

Bioorg Med Chem 2011 Sep 14;19(17):5190-8. Epub 2011 Jul 14.

Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong, PR China.

Aminopeptidase N (APN) is involved in different physiological and pathological processes of tumor cells, including proliferation, invasion, apoptosis and metastasis. Herein one series of compounds derived from commercially available (1S,2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol have been designed and synthesized. Furthermore, preliminary activity evaluation showed that some compounds elicited moderate inhibitory activity against APN with compounds 10e (IC(50)=6.1±0.5 μM) possessing the best efficacy, which could be used as the lead compound in the future for anticancer agents research.
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http://dx.doi.org/10.1016/j.bmc.2011.07.008DOI Listing
September 2011